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García-Carrasco M Fuentes-Alexandro S Escárcega RO Salgado G Riebeling C Cervera R 《Archives of medical research》2006,37(8):921-932
The term Sj?gren's syndrome refers to keratoconjunctivitis sicca and xerostomia due to lymphocytic infiltrates of lachrymal and salivary glands. The current used criteria for diagnosis of primary Sj?gren's syndrome is the American-European consensus. Primary Sj?gren's syndrome is an autoimmune disorder characterized by lymphocytic infiltrates and destruction of the salivary and lachrymal glands and systemic production of autoantibodies to the ribonucleoprotein particles SS-A/Ro and SS-B/La. The infiltrating cells (T- and B-cells, dendritic cells) interfere with glandular function at several points: destruction of glandular elements by cell-mediated mechanisms; secretion of cytokines that activate pathways bearing the signature of type 1 and 2 interferons; production of autoantibodies that interfere with muscarinic receptors; and secretion of metalloproteinases (MMPs) that interfere with the interaction of the glandular cell with its extracellular matrix, which is necessary for efficient glandular function. As the process progresses, the mucosal surfaces become sites of chronic inflammation and the start of a vicious circle. Despite extensive study of the underlying cause of Sj?gren's syndrome, the pathogenesis remains obscure. In broad terms, pathogenesis is multifactorial; environmental factors are thought to trigger inflammation in individuals with a genetic predisposition to the disorder. 相似文献
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D A Isenberg L Hammond C Fisher M Griffiths J Stewart G F Bottazzo 《British medical journal (Clinical research ed.)》1982,284(6331):1738-1740
As part of a screening programme several patients were identified with antibodies to the nuclear antigen SS-B. Fifteen were examined and 11 found to have Sj?gren's syndrome, though this had not been suspected by most of the referring physicians. In contrast, among a group of 17 patients with overt Sj?gren's syndrome, most of whom also had rheumatoid arthritis, only one had antibodies to SS-B. Patients presenting with polyarthralgia found to be SS-B positive may be likely to develop Sj?gren's syndrome but unlikely to develop rheumatoid arthritis. The detection of SS-B antibodies may antedate clinical evidence of Sj?gren's syndrome by months or even years. These results emphasise the clinical heterogeneity of Sj?gren's syndrome. 相似文献
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为了探索早期诊断干燥综合征患者合并恶性淋巴瘤,作者采用B细胞恶性淋巴瘤基因探针检测了45例干燥综合征患者的泪腺组织及患眼附属器B恶性淋巴瘤组织。结果4例干燥综合征患者泪腺组织阴性,而5例恶性淋巴瘤患者的瘤组织扩增阳性。结果表明,一般的原发或继发性干燥综合征患者泪腺中的淋巴细胞中无恶性B淋巴瘤基因。 相似文献
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OBJECTIVE: To evaluate the incidence, severity, clinical manifestations and immunological features relevant to liver involvement in 135 cases of primary Sj?gren's syndrome. METHODS: One hundred and thirty-five patients with definite primary Sj?gren's syndrome were analyzed retrospectively for liver involvement by the abnormalities of the liver enzymes, bilirubin level and liver biopsied section. RESULTS: The liver involvement in 30 patients (22.2%) could be etiologically ascribed to Sj?gren's syndrome itself. The clinical spectrum and severity of this entity differed widely, 36.6% showed no relevant clinical symptoms, however jaundice was found in 46.7% of patients. Six patients showed pathological changes of chronic active hepatitis. 73.3% of all patients with liver involvement responded to steroid and immunosuppressive drugs, yet with a tendency to relapse (two cases). Liver cirrhosis was developed in five cases. The spectrum of serum autoantibodies in the patients with liver involvement showed no difference from those without liver involvement. Most of them were compatible with the serum profile of autoimmune hepatitis type-1. CONCLUSIONS: Liver involvement was complicated in 22.2% patients of primary Sj?gren's syndrome. Clinical manifestations were non-specific and the main pathological change was chronic active hepatitis. The differential diagnosis between Sj?gren's syndrome with liver involvement and type-1 autoimmune hepatitis could be only ascribed to other systemic clinical manifestations of Sj?gren's syndrome. 相似文献
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唾液β2微球蛋白浓度检测对Sjogren综合征的诊断价值 总被引:3,自引:2,他引:1
In this paper we measured salivary beta 2 microglobulin (beta 2 m) concentration in 40 patients with Sj?gren's syndrome, including 20 patients with systemic lupus erythematosus, 12 patients with recurrent aphthous ulceration and 16 patients with single xerostomia, and in 40 normal controls. The results showed that salivary beta 2 m concentration was more significantly elevated in Sj?gren's syndrome patients, compared with that in both normals and other patients. The measurement of beta 2 m concentration in saliva may offer a simple and valuable method for diagnosis of Sj?gren's syndrome. 相似文献
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近年来毒邪致病理论在干燥综合征的认识和治疗中得到越来越多的应用和研究.对干燥综合征毒邪致病学说的中医观点和现代学研究进行总结,探讨了中医毒邪致病理论与现代医学干燥综合征发病机制的联系,以期为干燥综合征的治疗与研究提供新思路、新方法. 相似文献
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Primary Sj?gren's syndrome is a chronic autoimmune disease that can lead to systemic manifestations. At present, immunomodulatory agents have not shown good ef?cacy, many patients in China seek Chinese medicine treatment. Chinese medicine can comprehensively improve the symptoms of patients through Chinese pattern diagnosis and individualized treatment. Fundamental researches are providing scienti?c bases for the therapeutic effect of Chinese medicine. Professional Chinese medicine treatment can be integrated into the conventional management of primary Sj?gren's syndrome. 相似文献
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干燥综合征(Sj-gren’s syndrome,SS)是一种以泪腺和唾液腺慢性炎症为主要特征的系统性自身免疫性疾病,上皮炎症是其最基本的病理改变。在干燥综合征病程中,心脏损害并不多见,而以主动脉瓣狭窄为主要表现的干燥综合征更是罕见。本文报道1例以主动脉瓣狭窄为突出表现的干燥综合征患者。 相似文献
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目的:了解干燥综合征患者外周血中CD5+B细胞的变化及其B淋巴细胞CD5在基因水平上的表达,探讨CD5+B细胞与干燥综合征的关系。方法:采用免疫荧光双标记技术和流式细胞仪检测了20例干燥综合征患者和10例健康对照者外周血中CD5+B细胞(CD5+CD19+)的百分率。应用流式细胞仪分选B淋巴细胞的基础上,运用Real-time RT-PCR方法检测7例干燥综合征患者外周血CD5 mRNA的表达水平。结果:干燥综合征患者外周血CD5+B(CD5+CD19+)细胞的百分率高于健康对照组(P<0.05)。86%的患者CD5 mRNA高于正常人水平。结论:干燥综合征患者外周血CD5+B细胞及CDS转录水平和干燥综合征的发病有一定的关联。 相似文献
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A fatal case of Lactobacillus rhamnosus septicaemia after prolonged oral vancomycin for recalcitrant Clostridium difficile infection is reported. The patient was immunosuppressed with cyclophosphamide and steroids for Sj?gren's syndrome. The administration of Lactobacillus spp as "biotherapy" may be hazardous in such circumstances. 相似文献
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Chen HA Lai SL Kwang WK Liu JC Chen CH Huang DF 《The Medical journal of Australia》2006,184(6):294-295
Middle lobe syndrome - recurrent atelectasis and/or bronchiectasis involving the right middle lobe and/or lingula - has, up to now, not been reported as the pulmonary manifestation of primary Sj?gren's syndrome. We describe a patient in whom lymphocytic bronchiolitis in the atelectatic lobes was proved histologically from two separate transbronchial biopsies. The atelectasis responded well to glucocorticoid treatment, suggesting that the peribronchiolar lymphocytic infiltrates may have played an important role in the development of middle lobe syndrome in this patient. 相似文献
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分析原发性干燥综合征(pSS)合并肌炎患者的临床特点,并与原发性多发性肌炎(PM)患者比较。结果示202例pSS患者中有4例(2.0%)在诊断pSS后5—20年出现肌炎表现,其中2例无明显肌痛和肌无力症状;肌酸肌酶(CK)最高值为(480—2702)IU/L,中位数为789.5IU/L,抗Jo-抗体均阴性;糖皮质激素治疗1周后CK下降13.9%~71.5%,中位数为48.9%;随访8个月至5年,无一例肌炎病情反复。与15例PM患者资料比较分析,两组在肌痛发生率、CK最高值、激素治疗后CK下降率、抗Jo-1抗体阳性率等方面差异有统计学意义。提示pSS患者合并肌炎较为少见,多在干燥综合征多年之后出现,肌痛和肌无力表现较轻,使用激素效果较好。 相似文献
14.
干燥综合征是一种以口眼干燥为特征,主要累及外分泌腺的弥漫性结缔组织病。其发病可能与病毒感染、遗传和性激素异常等多种因素有关,在这些因素的共同作用下,机体免疫异常,组织损伤。与该病关系较密切的病毒有EB病毒、丙型肝炎病毒、巨细胞病毒、反转录病毒等。病毒在干燥综合征的发病机制中可能起重要的作用。 相似文献
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Primary Sj?gren's syndrome(pSS) is a chronic autoimmune disease with a long duration of illness, for which there is no cure. Patients often suffer from anxiety and depression due to various reasons, exhibiting a decline in their quality of life. Chinese medicine(CM) has certain advantages in the treatment of pSS, which not only helps relieve clinical symptoms and improve treatment outcomes, but also reduces anxiety and depression and improves the quality of life. Therefore, CM should be considered as early as possible given its effectiveness and synergistic effects in treating p SS. 相似文献
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原发性干燥综合征的临床首发症状分析 总被引:1,自引:0,他引:1
目的:了解原发性干燥综合征(pSS)的临床首发症状的特点,提高口腔科医生对此病的认识水平,以减少误诊漏诊。方法:对66例pSS的临床资料进行回顾性分析。结果:口腔首发症状出现频率为:口干47/66例,猛性龋19/66例,口腔溃疡6/66例,腮腺肿大6/66例;眼干38/66例,关节肿痛46/66例,唇腺活检阳性率最高为59/66,ANA、抗SSA、抗SSB、ESR、RF阳性分别为28/66,29/66,26/66,32/66,28/66,高γ-球蛋白血症57/66,IgG、IgA异常率为16/66,10/66。结论:pSS为全身性免疫性疾病,80%以上有高γ-球蛋白血症,口腔表现为口干、猛性龋。口干、眼干、关节肿痛依旧是pSS最常见首诊症状,唇腺活检,腮腺造影及抗核抗体谱对诊断有重要意义。 相似文献
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Charalabopoulos K Mittari E Peschos D Golias C Charalabopoulos A Tsanou E Batistatou A 《Archives of medical research》2006,37(4):563-565
Autoimmune thyroid disease (AITD) has been associated with other autoimmune diseases such as chronic urticaria, insulin-dependent diabetes mellitus, Sj?gren's syndrome, inflammatory bowel disease, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, psoriasis, ankylosing spondylitis, and dermatomyositis (DM). AITD is a common disorder affecting primarily women, and both genetic and environmental factors are included in its pathogenesis. DM is considered an autoimmune disease of the muscles and skin. Although AITD is the most common cause of hypothyroidism, to the best of our knowledge, only three cases of DM and AITD in the same patient have been reported in the last 40 years. We consider that both are developed from the same autoimmune background. Herein, we present a case of a 30-year-old man with a 4-year history of AITD who was diagnosed as suffering as well from DM. 相似文献
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中医药治疗干燥综合征,从病因病机、辨证论治、专方治疗、中药复方治疗、针灸治疗、实验研究等方面均取得了较大进展。干燥综合征多以阴虚津亏为本,燥热瘀毒为标。中医辨证施治可调节机体免疫力及各脏腑间的功能,中医针灸治疗取穴方便、灵活,且无不良反应,能显著改善干燥综合征的临床症状。 相似文献
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OBJECTIVE: To explore the effect of mucosal administration of alpha-fodrin in inhibition of autoimmunity in Sj?gren's syndrome (SS). METHODS: Thirty-four 4-week-old NOD mice were randomly divided into 4 equal groups: to be immunized by nasal administration of alpha-fodrin 1 microg/dose and 10 microg/dose respectively every two days (experimental groups), and phophate-buffered saline (PBS) or glutathion2 S-tansferase4 (GST) (control groups). The weekly volume of water drinking was calculated. The salivary flow was maintained. Serum samples were obtained to detect the anti-SSA, anti-SSB, RF, ANA, anti- -fodrin and anti-type 3 muscarinic acetylcholie receptor polypeptide (M3RP) by immunofluorescence or ELISA. The cytokines of IFN-gamma and IL-10 were measured with ELISA. The salivary glands were examined by HE staining and immunohistochemical analysis. Flow cytometry was used to detect the proportion of Foxp3+ CD4+ CD25+ T cells. RESULTS: The titers of anti- -fodrin antibody and M3RP antibody of the mice immunized with-fodrin were lower than those of the 2 control groups (all P < 0.05), however, there was not significant differences between these two a-fodrin immunized groups. Five of the 8 mice in the GST group, 5 mice in the PBS group, 2 mice in the alpha-fodrin 1 microg/dose group, and 3 mice in the alpha-fodrin 10 microg/dose showed ANA positive. The serum IFN-gamma levels in the mice of alpha-fodrin 1 microg/dose and 10 microg/dose groups, PBS group, and GST group were (42 +/- 16), (37 +/- 15), (87 +/- 18), and (72 +/- 11) pg/ml respectively, those of the fodrin groups being significantly lower than those of the control groups (all P < 0.05). There were not significant differences in the level of serum IL-10 among these four groups. The numbers of Foxp3+ CD4 CD25+ regulatory T cells were higher in the fodrin groups than in the PBS and GST control groups (all P < 0.05). The lymphocytic infiltration and expression of alpha-fodrin were decreased in the alpha-fodrin administrated groups. The volume of water drinking of the alpha-fodrin 1 microg/dose group, alpha-fodrin 10 microg/dose group, PBS group, and GST group were (39.2 +/- 2.1), (40.4 +/- 2.5), (49.3 +/- 3.1), and (51.6 +/- 2.8) ml respectively. CONCLUSION: Mucosal administration of alpha-fodrin effectively inhibits the progression of experimental Sj?gren's syndrome autoimmunity. 相似文献