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1.
全国21家医院急性肺栓塞诊治情况的调查分析   总被引:40,自引:0,他引:40  
He J  Cheng X  Gao M 《Zhonghua yi xue za zhi》2001,81(24):1490-1492
目的:初步了解我国部分医院急性肺栓塞的诊治情况。方法:1997年8月至1999年7月在全国21家医院开展了“急性肺栓塞尿激酶溶栓(栓复欣抗凝)治疗多中心临床试验”,各医院对试验期间确诊的急性肺栓塞患者填表登记,记录其基本情况和诊断、治疗情况。试验结果后收集登记表进行统计分析。结果:2年间21家医院诊断急性肺栓塞297例,溶栓治疗总有效率80.8%(231/286),病死率9.8%(28/286)。结论:急性肺栓塞是一常见疾病,增强诊断意识是减少误、漏诊的关键,溶栓治疗是有效的急救措施。  相似文献
2.
CONTEXT: Lowering low-density lipoprotein cholesterol (LDL-C) is known to reduce risk of recurrent coronary heart disease in middle-aged men. However, this effect has been uncertain in elderly people and women. OBJECTIVE: To estimate the risk reduction of coronary heart disease and total mortality associated with statin drug treatment, particularly in elderly individuals and women. DATA SOURCES: Trials published in English-language journals were retrieved by searching MEDLINE (1966-December 1998), bibliographies, and authors' reference files. STUDY SELECTION: Studies in which participants were randomized to statin or control treatment for at least 4 years and clinical disease or death was the primary outcome were included in the meta-analysis (5 of 182 initially identified). DATA EXTRACTION: Information on sample size, study drug duration, type and dosage of statin drug, participant characteristics at baseline, reduction in lipids during intervention, and outcomes was abstracted independently by 2 authors (J.H. and S.V.) using a standardized protocol. Disagreements were resolved by consensus. DATA SYNTHESIS: Data from the 5 trials, with 30 817 participants, were included in this meta-analysis. The mean duration of treatment was 5.4 years. Stati n drug treatment was associated with a20% reduction in total cholesterol, 28% reduction in LDL-C, 13% reduction in triglycerides, and 5% increase in high-density lipoprotein cholesterol. Overall, statin drug treatment reduced risk 31 % in major coronary events (95% confidence interval [CI], 26%-36%) and 21 % in all-cause mortality (95% CI, 14%-28%). The risk reduction in major coronary events was similar between women (29%; 95% Cl, 13 %-42 %) and men (31 %; 95% CI, 26%-35%), and between persons aged at least 65 years (32%; 95% CI, 23%-39%) and persons younger than 65 years (31 %; 95% CI, 24%-36%). CONCLUSIONS: Our meta-analysis indicates that reduction in LDL-C associated with statin drug treatment decreases the risk of coronary heart disease and all-cause mortality. The risk reduction was similar for men and women and for elderly and middle-aged persons.  相似文献
3.
CONTEXT: Dietary sodium is positively associated with blood pressure, and ecological and animal studies both have suggested that high dietary sodium intake increases stroke mortality. OBJECTIVE: To examine the risk of cardiovascular disease associated with dietary sodium intake in overweight and nonoverweight persons. DESIGN: Prospective cohort study. SETTING: The first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study, conducted in 1982-1984, 1986, 1987, and 1992. PARTICIPANTS: Of those aged 25 to 74 years when the survey was conducted in 1971 -1975 (14407 participants), a total of 2688 overweight and 6797 nonoverweight persons were included in the analysis. MAIN OUTCOME MEASURES: Dietary sodium and energy intake were estimated at baseline using a single 24-hour dietary recall method. Incidence and mortality data for cardiovascular disease were obtained from medical records and death certificates. RESULTS: For overweight and nonoverweight persons, over an average of 19 years of follow-up, the total number of documented cases were as follows: 680 stroke events (210 fatal), 1727 coronary heart disease events (614 fatal), 895 cardiovascular disease deaths, and 2486 deaths from all causes. Among overweight persons with an average energy intake of 7452 kJ, a 100 mmol higher sodium intake was associated with a 32% increase (relative risk [RR], 1.32; 95% confidence interval [CI], 1.07-1.64; P = .01) in stroke incidence, 89% increase (RR, 1.89; 95% CI, 1.31-2.74; P<.001) in stroke mortality, 44% increase (RR, 1.44; 95% CI, 1.14-1.81; P = .002) in coronary heart disease mortality, 61% increase (RR, 1.61; 95% CI, 1.32-1.96; P<.001) in cardiovascular disease mortality, and 39% increase (RR, 1.39; 95% CI, 1.23-1.58; P<.001) in mortality from all causes. Dietary sodium intake was not significantly associated with cardiovascular disease risk in nonoverweight persons. CONCLUSIONS: Our analysis indicates that high sodium intake is strongly and independently associated with an increased risk of cardiovascular disease and all-cause mortality in overweight persons.  相似文献
4.
刺五加注射液对肺肿瘤化疗患者免疫调节作用的研究   总被引:10,自引:0,他引:10  
目的:研究刺五加辅助化疗对肿瘤患者的免疫调节作用,以寻找肿瘤治疗新途径。方法:以FACS、ELISA双抗体夹心法及LDH稀放法分别检测淋巴细胞的表面标志、血清细胞因子、sIL-2R的分泌水平及外周血淋巴细胞(PBL)的抗肿瘤活性。结果:应用刺五加辅助治疗后,患者PBL的CD3、CD4分子表达升高;Th1型细胞因子分泌增加,sIL-2R下降;淋巴细胞的抗肿瘤活性(NK和LAK活性)均显著增强。结论:刺五加可改善肺肿瘤化疗患者的免疫状况,提高机体的抗肿瘤效应,在临床抗肿瘤辅助治疗中具有广阔的应用前景。  相似文献
5.
170例乳腺癌标本药物敏感性分析   总被引:7,自引:0,他引:7  
检测了170例原代乳腺癌细胞常用化疗药物的体外敏感性,发现:(1)乳腺癌细胞对5-氟脲嘧啶(5-Fu)、丝裂霉素C(MMC)、顺铂(DDP)及泰素(taxol)的高度敏感率(HSR)明显高于其它受试药物;(2)药物敏感性与乳癌的病理分型和临床分期、以及雌激素受体(ER)和表皮生长因子受体(EGFR)表达状况无明显关系;(3)环孢素A(CsA)能提高部分耐药乳腺癌对阿霉素(ADM)的敏感性。  相似文献
6.
长程吸入一氧化氮对大鼠缺氧性肺动脉高压的影响   总被引:6,自引:0,他引:6  
目的探讨长程吸入一氧化氮(NO)对慢性缺氧性肺动脉高压的阻抑效应及其机制。方法将32只雄性Wistar大鼠分为(1)正常对照组;(2)缺氧组;每天缺氧12小时,共3周;(3)吸入NO组:缺氧同时每天吸入20ppmNO12小时,共3周。观察肺动脉压力、右心室肥厚、血浆内皮素-1(ET-1)和环磷酸鸟苷(cGMP)变化以及肺组织病理学改变。结果(1)缺氧组大鼠肺动脉压力明显升高(4.3±0.9kPa),右心室肥厚显著(P均<0.001),吸入NO组肺动脉压力降低(3.0±0.4kPa),右心室肥厚减轻;(2)缺氧组腺泡内肌型肺动脉增多,无肌肺动脉明显减少,与对照组相比,差异显著(P<0.01),吸入NO组明显改善三型血管比例失调。(3)缺氧组血浆ET-1含量明显升高,(197±15pg/ml),cGMP水平显著降低。吸入NO组ET-1含量降低(163±14pg/ml);cGMP含量升高。结论长程吸入20ppmNO能阻抑慢性缺氧性肺动脉压力升高,且无明显毒副作用。  相似文献
7.
补阳还五汤抗家兔动态粥样硬化形成的实验研究   总被引:5,自引:0,他引:5  
在家兔动脉粥样经的模型上观察补阳还五汤抗动脉粥样硬化的作用。结果表明:该汤剂具有明显降低血清总胆固醇和甘油三酯的作用,显著延缓主动脉及腹主动脉粥样硬化斑块的形成,减缓冠脉血管受累的数目和程度。还具有升高6-keto-PGF1α和降低vWF的作用,但对血浆中ET的含量并无影响。提示补阳还五汤的抗动脉粥样硬化与抗血栓形成的作用有关。  相似文献
8.
吸入一氧化氮治疗肺动脉高压的量-效关系   总被引:5,自引:0,他引:5  
目的探讨吸入一氧化氮(NO)治疗肺动脉高压的量-效关系。方法用右心导管检查术测定血流动力学与心功能指标,观察吸入20、40、60和80ppm不同浓度NO对16例肺动脉高压患者血流动力学和心功能的作用。结果吸入20、40、60和80ppmNO均有显著降低肺动脉高压和肺血管阻力的作用。吸入20ppmNO即达到最大扩血管效应,肺动脉平均压和肺血管阻力分别降低26.5%和40.3%(P<0.0001);增加吸入NO的浓度,肺动脉压力和肺血管阻力不再进一步降低。结论患者吸入NO的最佳浓度以不超过20ppm为宜。  相似文献
9.
INTRODUCTIONRadiationisextensivelyappliedinthemedicalfieldandotherresearchareas.Humansareoftenexposedtoenvironmentalionizingradiationatdifferentlevels.Itisimportanttoconsiderthegeneticeffectscausedbylowlevelsofradiationinadditiontotheacuteeffects(Cai,19…  相似文献
10.
一氧化氮治疗肺动脉高压临床应用中的几个问题   总被引:4,自引:0,他引:4  
一氧化氮治疗肺动脉高压临床应用中的几个问题程显声何建国自1987年认识到内皮细胞舒张因子(EDRF)的化学本质即一氧化氮(NO)以来,至今已走过了10年的历程。国内外许多学者在NO的各个领域,包括吸入NO在肺动脉高压治疗中的临床应用,做了大量的工作,...  相似文献
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