99mTc-MIBI心肌SPECT显像诊断冠心病及检测存活心肌

目的:评估99mTc-甲氧基异丁基异腈（MIBI）心肌断层显像诊断冠心病及检测存活心肌的临床应用价值。方法:24例患者行潘生丁药物负荷及静息心肌断层显像;20例心肌梗死患者在血管重建术前行静息及硝酸甘油介入心肌断层显像,血管重建术后1个月重复行静息心肌断层显像。44例患者均行冠状动脉造影。分析对比心肌断层显像与冠状动脉造影结果以及血管重建术前后的心肌断层显像结果。结果:99mTc-MIBI心肌断层显像对冠心病诊断敏感性为94％,阳性预测值为86％;硝酸甘油介入99mTc-MIBI心肌断层显像对存活心肌的阳性预测值为86％,阴性预测值为79％,预测准确率为83％。结论;99mTc-MIBI心肌断层显像在诊断冠心病,检测存活心肌方面有较大的临床应用价值。     

腺苷负荷99mTc-MIBI门控心肌显像诊断冠心病临床价值

[摘要] 目的 以冠状动脉造影（Coronary angiography, CAG）为“金标准”,探讨在腺苷负荷下99mTc-MIBI SPECT门控心肌血流灌注显像（Myocardial perfusion imaging, MPI）对冠心病(Coronary artery disease, CAD)的诊断效能。方法 43例怀疑CAD患者而进行CAG检查的患者,检查前均接受了腺苷99mTc-MIBI负荷门控MPI,观察患者心脏室壁血流灌注情况。与CAG检查结果相对照,比较腺苷负荷介入下MPI对CAD诊断的效能。结果 腺苷负荷MPI诊断CAD的灵敏度为84.6%,特异度为88.2%,准确性为86.0%,对左前降支、回旋支、右冠状动脉狭窄（≥50%）的检测灵敏度和特异度分别为 95.0%和82.6%,77.8%和88.2%,84.6%和70.0%。对单支、双支、3支冠脉病变诊断的灵敏度分别为71.4%,87.5%,100%。结论 腺苷负荷99mTc-MIBI MPI对CAD的诊断准确率高,对诊断无法进行运动患者的冠脉血管病变具有重要临床价值。     

核素心肌灌注显像在冠心病危险度分层中的临床意义

目的 评价核素心肌灌注显像在冠心病危险度分层中的临床价值及意义.方法 对均进行了核素心肌灌注显像[核素选用99mTc-甲氧基异腈(MIBI),心肌灌注显像采用静息-腺苷药物负荷试验]及冠状动脉(简称冠脉)造影的13例患者进行观察和对比,对核素心肌灌注显像阳性者10例、核素心肌灌注显像阴性者3例与各自的冠脉造影对比,评判核素心肌灌注显像对胸闷、胸痛等不同症状患者心肌缺血程度初步估测,并进行危险评估.结果 核素心肌灌注显像提示严重心肌缺血6例,在相应冠脉造影中均发现冠脉病变多为2支以上,且狭窄程度多在70%以上,均进一步行球囊扩张和(或)支架置入术;提示轻度心肌缺血4例,随后冠脉造影发现多为1支病变,狭窄程度多为50%～70%,均进行药物治疗;另3例核素心肌灌注显像阴性者冠脉造影无明显异常发现.结论 核素心肌灌注显像对冠心病进行危险度分层及选择治疗、评估预后有重要意义.     

肝胆湿热证患者血浆β-内啡肽的临床研究

用放射免疫法测定７５例肝胆湿热证患者，２３例肝气（阳）虚证患者，１３例脾气虚证患者和３０例健康人的血浆β－内啡肽含量。结果表明：肝胆湿热证及肝气（阳）虚证患者血浆β－内啡肽均较健康人明显升高；且不同疾病的肝胆湿热证患者有共同的病理及生化变化。     

99mTc-MIBI心肌灌注断层显像与冠状动脉造影的对比研究

目的　探讨99mTc-甲氧基异丁基异腈 (MIBI)心肌灌注断层显像对冠心病的诊断价值。方法　 34例99mTc -MIBI心肌灌注断层显像与冠状动脉造影 (CAG)结果进行对比。结果　99mTc-MIBI心肌灌注断层显像对冠心病诊断的敏感性为 91.7%,特异性为 80 .0 %。对右冠状动脉、左冠状动脉前降支和左冠状动脉回旋支的诊断阳性率分别为 85 .7%、92 .3%和 71.4%,总的阳性预测值为 91.7%,阴性预测值为 80 .0 %。结论　99mTc -MIBI心肌灌注断层显像对冠心病的诊断有较大价值。     

Clinical evaluation of 99mTc-MIBI myocardial tomography for detecting coronary artery disease.

To evaluate the clinical efficacy of 99mTc-MIBI myocardial tomography for detecting coronary artery disease, 34 consecutive patients who underwent both 99mTc-MIBI study and coronary arteriography were included in the present study. Ten without and 24 with significant coronary artery disease were documented by coronary arteriography. The overall sensitivity and specificity of 99mTc-MIBI study for detecting coronary artery disease were 91.8% (22/24) and 80.0% (8/10), respectively. In subset studies, 16 of 17 (94.1%) patients with previous myocardial infarction and 6 of 7 (85.7%) patients with significant CAD but without MI were identified as abnormal. Reversible perfusion abnormalities were shown in 4 of 5 patients undergoing both exercise and rest studies. Rest perfusion abnormalities were shown in 2 patients with unstable angina pectoris who underwent only rest study. In conclusion, 99mTc-MIBI myocardial tomography provides a reliable method for detecting coronary artery disease. Rest study has high sensitivity for identifying patients with MI, and exercise/rest study can identify patients with significant CAD but without MI.     

心肌灌注显像对疑诊冠心病的胸痛患者的诊断价值

目的评估运动负荷实验心肌灌注显像对可疑冠心病的胸痛患者的诊断价值及对冠脉造影病例筛查的价值。方法105例有胸痛、胸闷不适，临床疑诊冠心病的患者，行常规心电图、超声心动图和201T1运动负荷心肌灌注显像，结果与冠状动脉造影检查对比，并分析心肌灌注显像的图象特点。结果心肌灌注显像诊断冠心病的灵敏度、特异性、阳性预测值和阴性预测值分别为91％、82．4％、89．9％、84、8％。心肌灌注异常组，冠脉造影阳性率达91．3％。结论201T1运动负荷心肌灌注显像对胸痛患者有很好的诊断价值，对冠脉造影病例的选择有很好的参考价值。     

Evaluation of 99mTc- MIBI myocardial perfusion imaging with intravenous infusion of adenosine triphosphate in diagnosis of coronary artery disease

Objective To evaluate the feasibility, safety and diagnostic accuracy of pharmacologic stress of 99m Technetium- MIBI single- photon emission computed tomography (SPECT) with intravenous adenosine triphosphate (ATP) in patients with suspected coronary artery disease.Methods The study group included 263 patients who were suspected of having coronary artery disease. All patients underwent (99m)Tc- MIBI myocardial perfusion imaging with ATP infusion (0. 16 mg/kg body weight per min for 5 min). 20 mCi of (99m)Tc- MIBI were injected 3 minutes after the start of ATP infusion. Myocardial SPECT images were obtained 60 minutes later. Then, two days later, 20 mCi of(99m)Tc- MIBI were administered at rest and myocardial SPECT was repeated. 51 patients also underwent coronary angiography within two weeks for evaluation of sensitivity and specificity of ATP- myocardial perfusion imaging in detection of coronary artery disease. The occurrence of cardiac and non- cardiac adverse effects was carefully monitored during and after intravenous ATP infusion. Results The ATP infusion protocol was completed in all patients. Although 59% of the patients had various kinds of adverse effects, most of them were mild. No patient required aminophyline. The most severe adverse effect was second degree type Ⅱ atria- ventricular block (4/263), but all events were transient. The sensitivity and specificity of ATP- myocardial perfusion imaging were 97% and 82%, respectively. Conclusions It is shown that 99m Technetium- MIBI SPECT with intravenous ATP is a safe and feasible technique for detecting coronary artery disease in patients unable to perform the exercise test.     

Technetium-99m-Sestamibi SPECT myocardial perfusion imaging in patients with complete left bundle branch block

BACKGROUND: Diagnosis of coronary artery disease (CAD) in patients with left bundle branch block (LBBB) is considered a challenge in cardiology due to low accuracy of noninvasive methods such as basal and exercise stress test. Recently, myocardial perfusion imaging showed attainment of higher sensitivity and specificity. Scintigraphy with thallium-201 has been widely used in these patients. Few have used technetium-99m-Sestamibi and single photon emission computed tomography (SPECT). The aim of the study was to assess the diagnostic value of Tc-99m Sestamibi SPECT myocardial perfusion imaging in patients with complete LBBB. METHODS: We studied 57 consecutive patients with complete LBBB using Tc-99m-Sestamibi SPECT and treadmill or dipyridamole stress to evaluate CAD. Eighteen patients also underwent coronary angiography. Perfusion defects were classified as fixed or reversible. RESULTS: Prevalence of resting perfusion abnormalities in anterior, septal, and apical regions was 51, 56, and 19%, respectively. Sensitivity for detecting >50% left anterior descending artery (LAD) stenosis was 67 and 56% for anterior or septal defects, and 56% for specificity. Apical perfusion abnormality showed 21% sensitivity and 89% specificity. Among six patients with reversibility and who underwent coronary angiography, all had >50% LAD stenosis. CONCLUSIONS: With Tc-99m-MIBI SPECT imaging, prevalence of anteroseptal perfusion abnormalities was >50% in patients with LBBB. The test has moderate sensitivity and specificity for LAD disease. Absence of apical defect is specific for excluding LAD disease. Reversible changes in anteroseptal wall should be considered as an indicator of ischemia in this territory.     

核素心肌灌注显像对扩张型心肌病和缺血性心肌病的鉴别诊断价值

目的探讨^99mTc-MIBI心肌灌注显像（MPI）对扩张型心肌病（DCM）和缺血性心肌病（ICM）的鉴别诊断价值。方法55例确诊心肌病患者,根据病史、超声心动图检查,分成扩张型心肌病组（25例）和缺血性心肌病组（30例）。同时完成核素^99mTc-MIBI心肌灌注显像与冠脉造影（CAG）检查。观察^99mTc-MIBI在心肌的分布情况,分析病损心肌、病变血管之间的关系。结果①所有55例患者,心肌灌注显像都^99mTc-MIBI放射性分布异常：DCM组节段性灌注完全缺损2例（8%）,均匀减低14例（56%）,不均匀减低3例（12%）,花斑样改变6例（24%）;ICM组节段性灌注完全缺损29例（96.67%）,均匀减低1例（3.33%）。冠脉造影检查：DCM组仅1例（4%）发现冠脉异常,但狭窄程度〈50%,ICM组30例（100%）都有不同程度的冠脉狭窄（≥50%）;②以核素^99mTc-MIBI在心肌不均匀减低和/或花斑样分布为标准,MPI诊断DCM的敏感性为96.15%,特异性为95.6%,以核素^99mTc-MIBI在心肌呈节段性灌注完全缺损分布为标准,MPI诊断ICM的敏感性是96.7%,特异性是92%。结论核素^99mTc-MIBI心肌灌注显像在心肌的这种特征性分布,对扩张型心肌病和缺血性心肌病的诊断和鉴别诊断有较高的临床价值,与冠脉造影有很好的相关性,值得在临床推广应用。     

SPECT/CT显像在评估缺血性心肌病患者的存活心肌中的应用价值

目的 以2-氟-18-氟-2-脱氧-D-葡萄糖(¹⁸F-fluorodeoxyglucose,¹⁸F-FDG)PET/CT心肌代谢显像为金标准,探讨锝-99m-4,9-二氮-3,3,10,10-四甲基十二烷-2,11-二酮肟(technetium-99m labeled 4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione dioxime,^99mTc-HL91)SPECT/CT乏氧显像结合锝-99m-甲氧基异丁基异腈(technetium-99m labeled sestamibi,^99mTc-MIBI)SPECT/CT心肌灌注显像评估缺血性心肌病(ischemic cardiomyopathy,ICM)患者不同缺血程度及不同冠状动脉供血区存活心肌的价值。方法 纳入66例ICM患者,于^99mTc-MIBI心肌灌注显像当日行^99mTc-HL91乏氧显像、次日行¹⁸F-FDG心肌代谢显像。将左...     

Detecting residual ischemia and identifying coronary artery disease after myoc ardial infarction using dobutamine technetium-99m-MIBI SPECT

Objective To evaluate dobutamine technetium-99m methoxy isobutyl nitrile (sestamibi) single-photon emission computed tomography (Dobu-ECT) in detecting residual ischemia and identifying coronary vessel disease after myocardial infarction.Methods Sixty-two patients with confirmed myocardial infarction were studied with Dobu-ECT at the time of coronary artery angiography. Dobutamine was administered intravenously in incremental rates from 5 to 40 μg· kg(-1)·min (-1) at 3-minute intervals. At the highest infusion rate, 7.4×10[8] Bq (99m) Tc-MIBI was injected intravenously, and tomographic imaging was performed after one hour. Resting images were taken after 24 hours, with a second dose of (99m)Tc-MIBI.Results The sensitivity of Dobu-ECT in detecting residual ischemia of myocardial infarction was 76%, which was higher than dobutamine electrocardiography (Dobu-ECG). Regardless of the single-, double- or triple-vessel diseases, Dobu-ECT was superior to Dobu-ECG in identifying residual ischemia (56% vs 4%, 86% vs 27%, 100% vs 47%, P<0.01, respectively). The incidence of residual ischemia in patients receiving thrombolytic therapy was 67%, lower than patients without thrombolysis (72%) or those with an old myocardial infarction (94%).But the differences were not statistically significant. Dobu-ECT detected only 56% of ischemias in non-infarct related myocardium. Eighty-two percent of all significantly stenosed vessels were detected with Dobu-ECT, and 84% of patients with multivessel disease could be accurately identified. The sensitivity of Dobu-ECT was significantly greater for detecting severe stenosis over moderate stenosis. The sensitivity for detecting stenosis in the right coronary artery was greater than left anterior descending or left circumflex, but its specificity was lower.Conclusion Dobu-ECT can identify residual ischemia, as well as its location and extent after myocardial infarction. Dobu-ECT can also accurately detect significantly stenosed vessels.     

潘生丁~（99m）Tc－MIBI心肌灌注显像对冠心病诊断价值的研究

目的探讨ＤＰ９９ｍＴｃ－ＭＩＢＩ心肌灌注显像在冠心病诊断中的应用价值。材料和方法应用新型９９ｍＴｃ－标记异腈类心肌灌注显像剂９９ｍＴｃ－甲氧基异腈（９９ｍＴｃ－ＭＩＢＩ），结合潘生丁（ＤＰ）试验，对１６名陈旧性心肌梗塞患者、１７名冠心病心绞痛患者及９名正常对照者进行了平面心肌灌注显像检查，并与心电图改变加以对比研究。结果在１６名陈旧性心肌梗塞患者中，有１５例（９３．８％）表现为固定性缺损，其中６例（３７．５％）同时合并有可逆性缺损。１７例心绞痛患者中，共检出可逆性缺损１４例，２例合并有固定性缺损，１例单独表现为固定性缺损。９９ｍＴｃ－ＭＩＢＩ心肌显像对冠心病诊断的敏感性为９０．９％，特异性为８８．８％。结论潘生丁９９ｍＴｃ－ＭＩＢＩ心肌灌注显像对于冠心病的诊断较心电图具有更全面的临床实用价值。     

门控核素心肌灌注显像诊断左束支传导阻滞合并冠心病的价值研究

目的:探讨99Tcm-MIBI门控心肌灌注显像(G-MPI)在左束支传导阻滞(LBBB)病人中诊断冠心病的价值.方法:50例LBBB患者均完成二日法门控负荷/静息MPI、心电图平板运动试验(ETT)、超声心动图检查.比较NG-MPI和G-MPI在LBBB病人中诊断冠心病的准确性,并对各种无创性诊断技术的诊断价值进行比较.结果:G-MPI诊断的特异性和准确性方面要明显高于NG-MPI(P<0.05),G-MPI与NG-MPI相比能明显提高对LAD病变诊断的特异性和准确性(P<0.05).G-MPI诊断的敏感性要高于ETT,P<0.05.在诊断的准确性方面G-MPI与ETT相比有极显著性差异(P<0.01).结论:门控心肌灌注显像在LBBB病人中诊断冠心病具有较高的准确性,与非门控心肌显像和其它无创性诊断技术相比具有一定的优势.     

99mTc-MIBI心肌静息显像在川崎病中的应用价值

目的:探讨99mTc-MIBI心肌静息显像在诊断小儿川崎病(Kawasaki disease,KD)心肌损害中的应用价值.方法:KD患儿32例行99mTc-MIBI心肌静息显像,按心肌内放射性分布情况和病变累及室壁段评分;于6个月后复查心肌静息显像.结果:32例KD患儿中23例(占72%)共33个节段阳性,其中计分为1分的13例患儿中8例为轻度,4例为中度,1例为重度;计分为2分的10例患儿中6例为轻度,4例为中度;6个月后复查结果显示23例阳性患儿中明显改善11例,恢复正常12例,1例阴性患儿显像阳性.结论:99mTc-MIBI心肌静息显像能较直观地表现病变心肌的部位、范围和程度,可作为KD患儿心肌损害早期诊断和远期随访过程中的一项常规的无创性检查方法.     

~（99m）Tc-MIBI心肌灌注显像在川崎病心肌缺血诊断及疗效判断中的价值

目的探讨99mTc-MIBI（甲氧异腈）静息心肌灌注显像在川崎病心肌缺血及疗效评价中的临床价值。方法 41例川崎病根据病程分为急性发热期、亚急性期和恢复期3组。对照组8例系怀疑川崎病患儿,后经实验室检查排除川崎病和其他心肌疾病者。两组病例均行99mTc-MIBI静息心肌灌注显像,阳性者于治疗后6～12个月随访复查,并与其临床转归进行比较。结果对照组静息心肌灌注显像未见异常。41例川崎病患儿静息心肌灌注显像阳性率为39.02%（16/41）。其中急性期、亚急性期和恢复期患儿的阳性率分别为36.84%（7/19）、41.67%（5/12）和40%（4/10）。10例显像阳性者经治疗后6～12个月行静息心肌灌注显像复查,缺血明显改善5例,恢复正常4例,1例仍见明显心肌缺血。结论 99mTc-MIBI静息心肌灌注显像能无创、直接、客观地评价川崎病心肌缺血的部位、范围和程度,对川崎病心肌缺血的诊断和随访有一定的临床价值。     

99mTc-甲氧基异丁基异腈心肌断层显象诊断无症状性心肌缺血

采用99mTc-MIBI 对心肌进行单光子发射性计算机断层显象,观察72例。其中:冠心组18例;可疑冠心组22例;单纯高血压组16例;对照组16例。受检者进行运动显象和静态显象,然后进行图象重建比较。结果:（1）对照组全部正常;（2）冠心组全部异常,其中心肌梗塞者图象显示缺血区为完全缺     

多巴酚丁胺加阿托品负荷试验~(99m)Tc-MIBI心肌断层显像对冠状动脉性心脏病的诊断价值

[目的 ]探讨多巴酚丁胺加阿托品负荷试验99mTc MIBI心肌断层显像对冠状动脉性心脏病的诊断价值 .[方法 ]采用分级递增多巴酚丁胺负荷量和多巴酚丁胺加用阿托品介入的方法对 2 2例冠状动脉性心脏病患者进行99mTc MIBI心肌断层显像 .[结果 ]单用多巴酚丁胺和多巴酚丁胺加阿托品负荷试验99mTc MIBI心肌断层显像对冠状动脉性心脏病的敏感性分别为 81% ( 18/2 2 )和 95 % ( 2 1/2 2 ) ,在试验过程中未发现严重不良反应 .[结论 ]多巴酚丁胺负荷试验99mTc MIBI心肌断层显像时 ,加用阿托品可进一步提高因不同原因达不到预计心率的冠状动脉性心脏病患者诊断敏感性 ,并安全、有效 .     

负荷MR心肌灌注成像检测冠心病心肌缺血与冠状动脉造影及99mTc-SPECT对比的初步研究

目的 探讨负荷MR首过心肌灌注成像检测冠心病的临床价值.方法 33例经冠状动脉造影确诊的冠心病患者,男22例,女11例,平均年龄58.32岁.其中15例常规行静息-负荷99m^Tc-SPECT心肌灌注显像.采用IR-turboFLASH序列行静息-负荷MR首过心肌灌注成像及延迟期心肌灌注成像,目测定性分析心肌灌注图像,将分析结果与冠脉造影及99m^Tc-SPECT进行比较,计算其敏感性和特异性.结果 28例（28/33）191段心肌灌注减低,其中92段（92/191）可逆性灌注减低,99段（99/191）固定灌注减低;51支冠状动脉主干或其主要分支狭窄,MR首过心肌灌注成像42支狭窄冠脉供血区心肌灌注减低.以冠脉造影为参考标准,MR首过心肌灌注成像检测狭窄50%以上冠状动脉病变的敏感性及特异性分别为：82.35%和91.67%.MR首过心肌灌注成像与99m^TC-MIBI SPECT具有很好的一致性,两者符合率为：92.5%.以99m^TC-MIBI SPECT为参考标准,MR首过心肌灌注成像检测冠心病的敏感性及特异性分别为：94.74%、92.55%.结论 负荷MR首过心肌灌注成像能有效检测冠心病心肌缺血;MR首过心肌灌注成像定性评价冠心病心肌缺血具有较高的临床实用价值.     

多巴酚丁胺负荷试验~(99m)Tc-MIBI心肌断层显像对冠状动脉性心脏病的诊断价值

[目的 ]探讨多巴酚丁胺负荷试验99mTc MIBI心肌断层显像对冠状动脉性心脏病的诊断价值 .[方法 ]采用分级递增多巴酚丁胺负荷量至最高负荷量时静脉注射99mTc MIBI行心肌断层显像的方法 ,间隔 4 8h再行静息断层显像 .将 2 2例冠状动脉性心脏病患者和 12例正常对照组进行比较 .[结果 ]多巴酚丁胺99mTc MIBI心肌断层显像对冠状动脉性心脏病的敏感性和特异性分别为 82 % ( 18/ 2 2 )和 92 %( 11/ 12 ) ,在整个试验过程中未发现严重的不良反应 .[结论 ]多巴酚丁胺负荷心肌断层显像对冠状动脉性心脏病具有较高的诊断价值 ,并安全可行 ,无创伤性 .