不同腔内方法治疗膀胱结石的疗效观察

目的：研究Punch碎石钳碎石和U100激光碎石治疗膀胱结石的安全性及有效性，并进一步比较两种碎石方法的有效性差异。方法：回顾性分析82例膀胱结石患者临床资料，其中Punch碎石钳碎石43例，U100激光碎石39例。结果：碎石成功率U100激光组（97．2％）较碎石钳组（62．8％）显著性增高，差异有统计学意义（P〈0．01）。直径在2．5cm以上结石，U100激光组较碎石钳组碎石效率及成功率均明显增高，差异有显著统计学意义（P〈0．05）。结论：对直径1．5cm以下结石，Punch碎石钳与U-100激光在碎石效果方面差异无统计学意义。对直径2．5cm以上结石，推荐首选U-100激光。U100激光碎石联合TURP是治疗BPH并膀胱结石的安全、有效的方法。     

局部晚期宫颈癌CT图像引导下192Ir三维腔内后装治疗剂量体积参数与疗效关系

目的探讨CT图像引导下192Ir三维腔内后装治疗剂量体积参数与局部晚期宫颈癌临床疗效的相关关系。方法选取我院2011年1月到2013年12月间50例局部晚期宫颈癌患者为研究对象,对其进行盆腔外照射40Gy和同期化疗后进行CT图像引导下192Ir三维腔内后装治疗,且每次均在治疗前进行CT扫描定位,探讨剂量体积参数与局部晚期宫颈癌临床疗效的相关关系。结果 90.0%GTV的BED与EQD分别为(101.3±6.6)Gy、(85.3±5.6)Gy(α/β=10);90.0%CTV的BED与EQD分别为(95.2±6.3)Gy、(79.3±5.4)Gy(α/β=10);90.0%处方剂量对GTV和CTV的V90分别为(91.4±4.5)%、(88.4±7.3)%。1-2级放射性肠炎患者乙状结肠D2cm3剂量明显的高于其他危及器官的D2cm3剂量(P<0.05),统计学有意义。三维治疗计划中D90和V90明显的高于二维治疗计划D90和V90,数据的比较差异有统计学意义(P<0.05)。二维治疗计划拟合CT图像上显示其直肠参考点剂量和D2cm3以及A点剂量无明显的差异(P>0.05),统计学无意义;三维治疗计划仅仅提高膀胱参考点的剂量。结论 CT图像引导下192Ir三维腔内后装治疗能够提高其处方剂量对肿瘤靶区的覆盖率,提高临床治疗效果。     

Biomarkers of joint metabolism and bone mineral density are associated with early knee osteoarthritis in premenopausal females

Clinical Rheumatology - Biomarkers of bone and cartilage metabolism were proposed as early diagnosis indicators for knee osteoarthritis (OA), however, which were influenced by disease stage, age,...     

Evaluation of adalimumab biosimilar candidate (HS016) in Chinese patients with active ankylosing spondylitis based on a health survey: sub-analysis of a phase 3 study

Clinical Rheumatology - The equivalence of the biosimilar HS016 to adalimumab (Humira) for the treatment of active ankylosing spondylitis (AS) patients has been previously validated. The aim was to...     

Comparison of the efficacy and safety of the adalimumab biosimilar TQ-Z2301 and adalimumab for the treatment of Chinese patients with active ankylosing spondylitis: a multi-center,randomized, double-blind,phase III clinical trial

Clinical Rheumatology - To assess the clinical equivalence of TQ-Z2301, a biosimilar of adalimumab, to the reference adalimumab in the treatment of Chinese patients with active ankylosing...     

肝癌组织Bcl-2的检测及小干扰RNA抑制

目的探究肝癌组织中Bcl-2的表达与肝癌临床病理特征、患者预后之间的关系;观察siRNA抑制Bcl-2表达后,SMMC-7721增殖能力的变化。方法通过反转录PCR、免疫组织化学SP法以及Western blot法检测68例肝癌组织中Bcl-2的表达;根据Bcl-2表达水平的高低进行分组,比较不同组中肝癌临床病理特征及患者预后;通过siRNA抑制Bcl-2在SMMC-7721细胞中的表达,应用MTT法检测细胞增殖能力的变化。结果相较于癌旁组织,Bcl-2肝癌中表达明显升高;Bcl-2在肝癌组织中表达水平与肝癌临床病理特征存在明显相关性,Bcl-2表达水平较高的患者预后较差;siRNA抑制SMMC-7721细胞中Bcl-2的表达后细胞增殖能力显著降低。结论 Bcl-2的表达在肝癌组织中异常增高,且与肝癌临床病例特征及患者预后存在相关性;抑制Bcl-2的表达可降低肝癌细胞的增殖能力。     

Naturally occurring bactericidal antibodies specific for Haemophilus influenzae Lipooligosaccharide are present in healthy adult individuals

Nontypeable Haemophilus influenzae (NTHi), a typical mucosal pathogen largely responsible for respiratory infections and pediatric otitis media, has been increasingly recognized as a significant cause of invasive disease, especially in immunocompromised individuals. Lipooligosaccharide (LOS) is a conserved molecule with an important role in H. influenzae virulence and immune evasion, and it may be considered as a vaccine candidate. However, abilities of H. influenzae LOS to induce protective immune response are poorly understood. The goal of this study was to determine whether antibodies against LOS isolated from H. influenzae strains Eagan, Rd and NTHi 375 are present in the sera of normal individuals. Antigen specific IgG and IgM were studied in sera of 71 and 30 healthy adults, respectively. IgG specific for LOS of all three strains was ubiquitously present in our sample population while IgM specific for Eagan, Rd and NTHi 375 LOS compounds was detected in 37%, 63%, and 40% of samples, respectively. All tested serum samples exhibited bactericidal activity against all three H. influenzae strains; the removal of anti-LOS antibodies from the sera resulted in significant increases in bacterial survival of the corresponding strain. NTHi 375 exhibited the highest serum resistance, whereas the Rd strain was the least resistant. Serum bactericidal activity of anti-LOS antibody was mediated via the classical complement pathway. These findings suggest that in healthy adults, naturally acquired complement-activating anti-LOS antibodies significantly contribute to the overall serum bactericidal activity against both encapsulated and non-encapsulated strains of H. influenzae.     

The Great Recession in Portugal: Impact on hospital care use

The Great Recession started in Portugal in 2009, coupled with severe austerity. This study examines its impact on hospital care utilization, interpreted as caused by demand-side effects (related to variations in population income and health) and supply-side effects (related to hospitals’ tighter budgets and reduced capacity).The database included all in-patient stays at all Portuguese NHS hospitals over the 2001–2012 period (n = 17.7 millions). We analyzed changes in discharge rates, casemix index, and length of stay (LOS), using a before–after methodology. We additionally measured the association of health care indicators to unemployment.A 3.2% higher rate of discharges was observed after 2009. Urgent stays increased by 2.5%, while elective in-patient stays decreased by 1.4% after 2011. The LOS was 2.8% shorter after the crisis onset, essentially driven by the 4.5% decrease among non-elective stays. A one percentage point increase in unemployment rate was associated to a 0.4% increase in total volume, a 2.3% decrease in day cases, and a 0.1% decrease in LOS.The increase in total and urgent cases may reflect delayed out-patient care and health deterioration; the reduced volume of elective stays possibly signal a reduced capacity; finally, the shorter stays may indicate either efficiency-enhancing measures or reduced quality.