Neoadjuvant chemotherapy increases the 5-year overall survival of patients with resectable cervical cancer: A systematic review and meta-analysis

Cervical cancer is a global health challenge in women. Neoadjuvant chemotherapy (NACT) is a recent prospect for alternative cervical cancer treatments. This study investigated the efficacy of NACT against resectable cervical cancer based on the medium and long-term survival of patients with the disease. We searched through PubMed, Web of Science, EBSCO and Cochrane Library for relevant reports published by June 2020. The primary outcomes were 3-year and 5-year progression-free survival (PFS) and overall survival (OS) of patients with resectable cervical cancer. Overall, 22 publications encompassing 5627 patients fulfilled the inclusion criteria. We found NACT not to affect both 3-year PFS and OS as well as 5-year PFS of patients with resectable cervical cancer. However, NACT significantly improves the 5-year OS of patients with resectable cervical cancer (HR = 0.83, 95% CI: 0.73–0.94, p = 0.013). Subgroup analysis (RCTs, non-RCTs, NACT + surgery + AT vs. surgery + AT, NACT + surgery + AT vs. CCRT/RT/CRT) further revealed NACT had no significant effect on 5-year PFS of patients with resectable cervical cancer, converse to the 5-year OS subgroup analysis, which validated the beneficial effect of NACT in patients with resectable cervical cancer. In addition, the effect of NACT was most significant in the non-RCTs subgroup (p = 0.012). NACT may improve the long-term prognosis of patients with resectable cervical cancer. However, further large-scale multicenter studies are needed to validate this finding.     

带植入腓肠神经的游离骨间背皮瓣修复指腹皮肤缺损

目的探讨带植入腓肠神经的骨间背游离皮瓣修复指腹皮肤缺损,同时吻接植入神经重建指腹感觉功能的可行性。方法对11例(11指)指腹创面在未能带有前臂后侧皮神经的游离骨间背皮瓣皮下植入腓肠神经,然后移植修复指腹创面,同时吻接植入神经重建指腹感觉功能。结果 11例(11指)指腹创面均修复中皮瓣切取面积最小2 cm×1 cm,最大4 cm×3.8 cm。术后随访12~24个月,11例皮瓣均成活,感觉功能得到较好修复。结论带有植入腓肠神经的游离骨间背皮瓣既能修复指腹创面,同时吻接植入神经能重建指腹感觉功能,效果满意。     

糖尿病患者血液流变性的改变及其临床意义

本文报告50例糖尿病患者血液流变学及血脂生化指标的检测结果，同时检查了部分病例的血小板伸展功能。检测发现，糖尿病患者血液流变性明显异常，全血及血浆粘度增高、血沉增快、纤维蛋白原含量增加、血小板粘附率升高。电镜下血小板伸展分型改变，血小板表面活性与聚集性增高。血脂生化指标亦高于正常。根据检测结果，对糖尿病血液流变性异常的机理及临床意义作了初步探讨。     

男性和女性类风湿关节炎对比研究

目的；探讨不同性别类风湿关节炎（ＲＡ）的临床特点，方法：对８７例男生和９０例女性ＲＡ患者的临床和实验室检查结果进行了对比研究，结果：与女性相比，男性ＲＡ患者的平均发病年龄，关节外表现（包括全身症状，皮下结节，淋巴结肿大和浆膜炎等）和关节Ｘ线表现相似，但是展僵时间较短（Ｐ〈０．０５），关节压痛指数较少（Ｐ〈０．０５），双手平均握力较优（Ｐ〈０．０１），关节功能Ⅲ级至Ⅳ级和继发干燥综合征（ＳＳ）的患者     

危重症患者应激性高血糖影响因素回归分析

目的：探讨应激性高血糖的危险因素。方法：将研究对象分为危重症应激高血糖组（A1组）、危重症应激非高血糖组（A2组）与健康对照组，分别采用双抗体夹心化学发光免疫法、单克隆双抗体酶联免疫吸附法及放免法测定3组在静脉精氨酸刺激下胰岛素分泌第一时相的真胰岛素、C肽、胰岛素原及免疫反应性胰岛素，采用多元回归分析危重症应激性高血糖的危险因素。结果：危重症应激性高血糖APACHEⅡ评分、空腹C肽水平及补体C3水平的回归系数分别为0．121、1．416、～0．071。结论：APACHEⅡ评分、空腹C肽水平、血浆补体C3水平是应激性高血糖的危险因素。     

Evaluation of adalimumab biosimilar candidate (HS016) in Chinese patients with active ankylosing spondylitis based on a health survey: sub-analysis of a phase 3 study

Clinical Rheumatology - The equivalence of the biosimilar HS016 to adalimumab (Humira) for the treatment of active ankylosing spondylitis (AS) patients has been previously validated. The aim was to...     

Dynamic trends in skin barrier function from birth to age 6 months and infantile atopic dermatitis: A Chinese prospective cohort study

BackgroundSkin barrier functions develop after birth and may be related to skin disorders in infants. We aimed to assess associations between dynamic trends of four skin barrier functional parameters in early life with infant atopic dermatitis (AD).MethodsBased on the prospective cohort MKNFOAD ({"type":"clinical-trial","attrs":{"text":"NCT02889081","term_id":"NCT02889081"}}NCT02889081), we examined transepidermal water loss (TEWL), stratum corneum hydration (SCH), skin pH, and sebum content at five anatomical sites (cheek, forehead, forearm, abdomen, and lower leg) in 418 term infants at birth, 42 days, and 6 months. Trend differences by sex and association with AD at age 1 year were tested using variance analyses. Associations of the parameters with AD risk were tested using discrete time survival analysis, adjusting extensive covariates including parental history of allergy, infant’s sex, birth weight (kg), and delivery mode. Odds ratios (ORs) and 95% confidence interval (CIs) were reported.ResultsOverall TEWL and SCH appeared trends of increase while skin surface pH and sebum content showed trends of decrease within the first six postnatal months. Sex differences were significant for sebum content only (p < 0.001). After adjustment for parental and children covariates, cheek TEWL at birth (OR = 1.26, 95% CI 1.00–1.57, p = 0.045) and 42 days (OR = 1.52, 95% CI 1.17–1.97, p = 0.002) were significantly associated with increased AD risk. Associations were not observed between SCH, skin pH, and sebum content at birth or 42 days with AD.ConclusionsSkin barrier functions of Chinese term infants varied nonlinearly after birth. Higher postnatal TEWL levels in early life indicate higher risk of early‐onset AD.     

化学法与免疫法测定便潜血的临床应用评价

目的：探讨粪便潜血二种检测方法的优劣和应用。方法：用邻联甲苯（O-tolidine）法和免疫肢体金法分别检测300例粪便标本进行对照实验并分析。结果：二种方法测得结果一致性符合率在90％以上。结论：受饮食影响因素，化学法灵敏度、特异性较免疫胶体金法低；免疫胶体金法有假阴性结果，故建议二者结合判断。