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排序方式: 共有219条查询结果,搜索用时 15 毫秒
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目的研究血清胰岛素样生长因子Ⅰ(IGFⅠ)与非酒精性脂肪肝的关系。方法采用夹心酶联免疫分析的方法测定60例非酒精性脂肪肝患者和40名健康对照血清IGFⅠ水平,并比较两组IGF1、血脂[胆固醇(Chol)、三酰甘油(TG)]、空腹血糖(Glu)、丙氨酸转氨酶(ALT)的测定结果。结果脂肪肝组的血清IGF1水平为(162.0±46.6)ng/ml,健康组血清IGF1水平为(189.0±37.4)ng/ml,结果差异具有显著性(P<0.01)。两组的TG、Glu差异也有显著性(P<0.05),其他指标差异无显著性。结论非酒精性脂肪肝患者的IGF1水平下降与脂肪肝的形成有关,同时可能加重凋亡对已发生脂肪变性的肝细胞的损伤。 相似文献
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Regional healthcare platforms collect clinical data from hospitals in specific areas for the purpose of healthcare management. It is a common requirement to reuse the data for clinical research. However, we have to face challenges like the inconsistence of terminology in electronic health records (EHR) and the complexities in data quality and data formats in regional healthcare platform. In this paper, we propose methodology and process on constructing large scale cohorts which forms the basis of causality and comparative effectiveness relationship in epidemiology. We firstly constructed a Chinese terminology knowledge graph to deal with the diversity of vocabularies on regional platform. Secondly, we built special disease case repositories (i.e., heart failure repository) that utilize the graph to search the related patients and to normalize the data. Based on the requirements of the clinical research which aimed to explore the effectiveness of taking statin on 180-days readmission in patients with heart failure, we built a large-scale retrospective cohort with 29647 cases of heart failure patients from the heart failure repository. After the propensity score matching, the study group (n=6346) and the control group (n=6346) with parallel clinical characteristics were acquired. Logistic regression analysis showed that taking statins had a negative correlation with 180-days readmission in heart failure patients. This paper presents the workflow and application example of big data mining based on regional EHR data. 相似文献
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Ideal halogen-free instinct flame-retardant waterborne polyurethanes have high flame-retardant efficiency, environmental friendliness, fine compatibility, and good thermostability. Phosphorus flame-retardants are currently widely used in halogen-free instinct flame-retardant waterborne polyurethanes (HIFWPU), especially those with phosphorous–nitrogen co-structures. Phosphorous–nitrogen HIFWPU have become a hotspot because their co-structures provide higher flame-retardance as compared to waterborne polyurethanes. This review introduces three main types of HIFWPU based on composition, performance and application. HIFWPU not only have improved flame-retardance but also satisfy the various requirements for functionality. HIFWPU have been widely developed in textile, furniture, automobile, and aerospace applications.Ideal halogen-free instinct flame-retardant waterborne polyurethanes have high flame-retardant efficiency, environmental friendliness, fine compatibility, and good thermostability. 相似文献
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目的:分析结缔组织相关性间质性肺疾病(CTD-ILD)和特发性间质性肺疾病(IIP)合并肺血栓栓塞症(PTE)患者的临床特征。方法收集2011~2014年在广州呼吸疾病研究所住院的CTD-ILD合并PTE及IIP合并PTE的患者17例(ILD合并PTE组),并募集同期肺通气功能相匹配的CTD-ILD及IIP共20例患者(单纯ILD组)作为对照,对其临床资料进行分析。并在此基础上再对比ILD合并PTE组中的CTD-ILD亚组及IIP亚组。结果①与单纯ILD组比较,在ILD合并PTE组中,患者出现近期新发呼吸困难或呼吸困难加重的发生率有增高的趋势;ILD合并PTE组的动脉血氧分压更低,分别为(76.4±22.3)mmHg和(63.4±19.2)mmHg(P<0.05);气体交换功能(DLCO%预计值)更差,分别为(48.5±11.6)%和(37.9±12.8)%。②ILD合并PTE组中,CTD-ILD亚组和IIP亚组的平均年龄分别为(59.83±13.40)岁和(71.90±4.68)岁,病程中出现PTE症状的时间分别为(18.07±16.71)个月和(34.75±14.69)个月,CTD-ILD患者发病年龄更小(P<0.05),病程中出现PTE症状的时间更短(P<0.05);IIP亚组患者共5例(71.43%)出现下肢水肿,CTD-ILD亚组中没有患者出现下肢水肿;IIP亚组中3例(30.00%)患者长期口服糖皮质激素,而CTD-ILD亚组共5例(71.43%)患者长期口服糖皮质激素。结论 ILD合并PTE可使患者气体交换功能障碍进一步加重,CTD本身的发生进展和长期口服糖皮质激素是PTE发生的高危因素。与IIP合并PTE比较,CTD-ILD合并PTE患者起病年龄更小,出现PTE的病程更短。 相似文献
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目的评价中药与西药治疗冠心病合并糖尿病的疗效差异及安全性。方法检索PubMed、CBM、CNKI、VIP、万方等数据库,纳入治疗组采用中药或联合西药,对照组采用西药的临床随机对照试验。采用RevMan5.1.6软件作Meta分析。结果 6项Jadad评分较高研究的临床症状改善合并效应量OR=5.6,95%CI[3.11,10.05],P<0.01;5项研究的心电图疗效有效率合并效应量OR=2.66,95%CI[1.71,4.12],P<0.01;其中1项报道了对照组有2例病情加重,治疗组未发生不良反应,其余研究均报道未发生任何肝肾损伤的不良反应。结论现有证据提示中药联合西药治疗冠心病合并糖尿病时,其临床症状和心电图改善情况均优于单纯西药治疗,且不良反应少。 相似文献
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Li Jia Xue Zhixin Wu Zhenbiao Bi Liqi Liu Huaxiang Wu Lijun Liu Shengyun Huang Xiangyang Wang Yong Zhang Yan Qi Wufang He Lan Dai Lie Sun Lingyun Li Xiaomei Shuai Zongwen Zhao Yi Wang Yanyan Xu Jian Zhang Hao Yu Hao Chen Xiaoxiang Bao Chunde 《Clinical rheumatology》2022,41(10):3005-3016
Clinical Rheumatology - To assess the clinical equivalence of TQ-Z2301, a biosimilar of adalimumab, to the reference adalimumab in the treatment of Chinese patients with active ankylosing... 相似文献
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Lisi Peng Lu Zhuang Kun Lin Yao Yao Yang Zhang Thiruvengadam Arumugam Takahiko Fujii Hui Jiang Liqi Sun Zhendong Jin Zhaoshen Li Craig Logsdon Baoan Ji Haojie Huang 《Pancreatology》2021,21(1):115-123
Glutathione-S-transferases (GSTs) not only show cytoprotective role and their involvement in the development of anticancer drug resistance, but also transmit signals that control cell proliferation and apoptosis. However, the role of GST isoforms in chemotherapy resistance remains elusive in pancreatic cancer. Here, we demonstrated that gemcitabine treatment increased the GSTM2 expression in pancreatic cancer cell lines. Knockdown of GSTM2 by siRNA elevated apoptosis and decreased viability of pancreatic cancer cells treated with gemcitabine. Moreover, in vivo experiments further showed that shRNA induced GSTM2 downregulation enhanced drug sensitivity of gemcitabine in orthotopic pancreatic tumor mice. We also found that GSTM2 levels were lower in tumor tissues than in non-tumor tissues and higher GSTM2 expression was significantly associated with longer overall survival. In conclusion, our findings indicate that GSTM2 expression is essential for the survival of pancreatic cancer cells undergoing gemcitabine treatment and leads to chemo resistance. Downregulation of GSTM2 in pancreatic cancer may benefit gemcitabine treatment. GSTM2 expression in patients also shows significant correlation with overall survival. Thus, our study suggests that GSTM2 is a potential target for chemotherapy optimization and prognostic biomarker of pancreatic cancer. 相似文献