慢性肾脏病5期患者血清铁调素水平与钙磷代谢的相关性

目的 探讨慢性肾脏病(CKD)5期患者血清铁调素水平及与钙磷代谢的关系.方法 检测56例CKD 5期患者(CKD组)及20例健康人(对照组)血清铁调素水平,以及CKD组患者的25-羟维生素D、甲状旁腺素(PTH)、血磷、血钙、血清碱性磷酸酶(ALP)、血清铁、铁蛋白、总铁结合力(TIBC)水平,分析CKD 5期患者铁调素水平及与其他指标的相关性.结果 CKD组血清铁调素水平为(22.69±18.54)mg/L,明显高于对照组的(13.56±8.02) mg/L(P ＜0.05).血清铁调素水平与铁蛋白、转铁蛋白饱和度、血磷、ALP及PTH水平呈正相关(P＜0.05),与TIBC呈负相关(P＜0.05),与血清铁、血钙、25-羟维生素D水平之间无明显相关性(P＞0.05).多元线性回归分析显示,血磷、PTH、铁蛋白水平是CKD 5期患者血清铁调素水平的独立影响因素(P＜0.05).结论 CKD 5期患者的钙磷代谢异常和高铁调素水平密切相关.     

Serum hepcidin is associated with iron status and micro-inflammation in hemodialysis patients

目的 探讨维持性血液透析(MHD)患者血清铁调素水平与铁负荷及微炎症状态的关系.方法 选取治疗6个月以上的稳定的MHD患者48例(MHD组),以体格检查健康人20名为健康对照组.采用酶联免疫吸附法(EI.ISA)测定血清铁调素和白细胞介素(IL)-6水平.采用Spearman相关和线性回归分析铁调素与其他指标的相关性.结果 MHD组患者血清铁调素水平为146.4～455.9 μg/L,中位值为225.6 μg/L,IL-6水平为35.0～97.2 ng/L,中位值为48.0 ng/L;健康对照组患者血清铁调素水平为54.5～171.5 μg/L,中位值为90.4 μg/L,IL-6水平为26,5～51.6 ng/L,中位值为43.9 ng/L.MHD组患者血清铁调素和IL-6水平均显著高于健康对照组(P值均＜0.05).Spearman相关分析显示,血清铁调素水平与铁蛋白(ρ=0.892)、转铁蛋白饱和度(ρ=0.289)及IL-6(ρ=0.439)水平呈正相关(P值均＜0.05),与不饱和铁结合力(ρ=-0.570)、总铁结合力(ρ=-0.552)及转铁蛋白(ρ=-0.532)水平呈负相关(P值均＜0.05).线性回归分析显示,MHD患者血清铁蛋白(未标准化回归系数=0.761,标准化回归系数=0.736,P＜0.001)及总铁结合力(未标准化回归系数=-5.654,标准化回归系数=-0.204,P=0.034)水平与铁调素水平独立相关.结论 MHD患者血清铁调素水平显著升高;血清铁调素水平与MHD患者铁负荷及微炎症状态相关;ELISA方法检测铁调素可以应用于临床,结合超敏C反应蛋白及铁代谢指标等指导肾性贫血中铁剂的应用.     

血清铁调素与血液透析患者铁负荷及微炎症状态相关

目的探讨维持性血液透析(MHD)患者血清铁调素水平与铁负荷及微炎症状态的关系。方法选取治疗6个月以上的稳定的MHD患者48例(MHD组),以体格检查健康人20名为健康对照组。采用酶联免疫吸附法(ELISA)测定血清铁调素和白细胞介素(IL)-6水平。采用Spearman相关和线性回归分析铁调素与其他指标的相关性。结果 MHD组患者血清铁调素水平为146.4～455.9μg/L,中位值为225.6μg/L,IL-6水平为35.0～97.2ng/L,中位值为48.0ng/L;健康对照组患者血清铁调素水平为54.5～171.5μg/L,中位值为90.4μg/L,IL-6水平为26.5～51.6ng/L,中位值为43.9ng/L。MHD组患者血清铁调素和IL-6水平均显著高于健康对照组(P值均<0.05)。Spearman相关分析显示,血清铁调素水平与铁蛋白(ρ=0.892)、转铁蛋白饱和度(ρ=0.289)及IL-6(ρ=0.439)水平呈正相关(P值均<0.05),与不饱和铁结合力(ρ=-0.570)、总铁结合力(ρ=-0.552)及转铁蛋白(ρ=-0.532)水平呈负相关(P值均<0.05)。线性回归分析显示,MHD患者血清铁蛋白(未标准化回归系数=0.761,标准化回归系数=0.736,P<0.001)及总铁结合力(未标准化回归系数=-5.654,标准化回归系数=-0.204,P=0.034)水平与铁调素水平独立相关。结论 MHD患者血清铁调素水平显著升高;血清铁调素水平与MHD患者铁负荷及微炎症状态相关;ELISA方法检测铁调素可以应用于临床,结合超敏C反应蛋白及铁代谢指标等指导肾性贫血中铁剂的应用。     

单纯性肥胖儿童血清瘦素及胰岛素测定

目的:探讨儿童肥胖与激素水平变化的关系.方法:分别检测肥胖和正常儿童血清瘦素和胰岛素水平,并分析二者之间的关系.结果:单纯性肥胖儿童体内瘦素平均水平为(34.21±15.92)μg/L,胰岛素平均水平为(14.56±7.23)mIU/L;正常儿童体内瘦素平均水平为(12.40±3.77) μg/L,胰岛素平均水平为(5.75±5.07)mIU/L,2组比较差异有统计学意义(P＜0.01);肥胖儿童体内瘦素与胰岛素呈正相关(r=0.37,P＜0.01).结论:单纯性肥胖儿童体内瘦素与胰岛素的分泌明显高于正常儿童,2激素水平在肥胖儿童中呈正相关.     

腹膜透析患者血清瘦素清除情况分析

目的:探讨腹膜透析对血清瘦素的清除作用.方法:采用放免法测定20例腹膜透析患者血清、24 h尿、24 h腹透液标本中的瘦素浓度.同时测定腹膜透析充分性指标和其它生化指标.结果:患者组血清瘦素浓度为(20.03±10.12)μg·L-1,明显高于正常对照组(P<0.01).腹膜透析液的瘦素浓度为(5.68±4.72)μg·L-1,与血清瘦素浓度呈正相关(r=0.821,P<0.001).24 h腹膜透析对瘦素的清除量为(41.95±32.89)μg,亦与血清瘦素浓度呈正相关(r=0.795,P<0.001).而腹膜透析的每周瘦素清除率与血瘦素水平无明显相关性(r=0.122,P>0.05).患者有低白蛋白血症[(33.03±5.28)g·L-1],但无明显血脂异常.结论:腹膜透析患者中存在低白蛋白血症和高瘦素血症;腹膜透析可以清除瘦素,其清除量与血瘦素浓度呈正相关.     

柴胡疏肝散联合他莫昔芬对大鼠乳腺增生的干预作用

目的:观察柴胡疏肝散联合他莫昔芬对大鼠乳腺增生的干预作用。方法:50只随机大鼠分为对照组,模型组,柴胡疏肝散(6.3 g·kg~(-1))组,他莫昔芬(1.67 mg·kg~(-1))组,柴胡疏肝散+他莫昔芬组。采用夹尾激怒法制备大鼠乳腺增生模型,灌胃给药30d。酶联免疫法测定血清雌二醇,孕酮和催乳素,免疫组化法检测乳腺组织中雌激素受体及孕激素受体的表达。结果:与模型组比较,柴胡疏肝散联合他莫昔芬组大鼠血清中催乳素[(837.223±34.163)μg·L-1vs(346.215±43.114)μg·L-1,P0.05]、雌二醇[(15.713±1.231)ng·L-1vs(4.973±0.278)ng·L-1,P0.05)]的含量有效降低,孕酮[(0.423±0.031)μg·L-1vs(1.235±0.096)μg·L-1,P0.05)]的含量提高;乳腺组织中雌激素受体表达显著被抑制(7.462±0.534 vs 4.889±0.343,P0.05),孕激素受体的表达显著增强(1.212±0.53 vs 2.232±0.415,P0.05)。结论:柴胡疏肝散联合他莫昔芬对大鼠乳腺增生有明显干预作用。     

吡格列酮对2型糖尿病患者血清脂联素、内脂素水平的影响

目的 观察吡格列酮对2型糖尿病(T2DM)患者血清脂联素、内脂素的影响.方法 对新诊断的49例T2DM患者(T2DM组)和50例健康体检者(对照组)采用病例对照及治疗前后自身对照的方法,比较2组治疗前及T2DM组经吡格列酮治疗12周后空腹血清脂联素、内脂素的水平.结果 T2DM组治疗前与对照组相比,脂联素水平下降[(6.4±1.1)mg·L-1 vs (12.3±2.8)mg·L-1,P＜0.01],内脂素水平升高[(36.2±10.6)μg·L-1 vs (13.5±9.2)μg·L-1,P＜0.01];治疗后T2DM组与治疗前比较,脂联素明显升高[(9.1±1.4)mg·L-1 vs (6.4±1.1)mg·L-1,P＜0.05],而内脂素无明显变化[(34.5 ±11.4)μg·L-1 vs (36.2±10.6)μg·L-1,fquP＞0.05].结论 吡格列酮治疗可改善T2DM所导致的脂联素水平改变,而对内脂素水平无明显影响.     

高磷诱导及膦甲酸钠干预血管平滑肌细胞钙化的研究

目的 观察不同浓度磷对体外培养的牛主动脉平滑肌细胞钙沉积及骨钙素表达的影响,同时观察膦甲酸钠对高磷诱导该细胞钙化的干预作用.方法 体外培养牛主动脉平滑肌细胞,观察不同磷浓度(Pi 1.5、2.0 mmol·L-1)、不同培养时间(3、6、9 d)血管平滑肌细胞的钙沉积,以及不同磷浓度(Pi 1.5、2.0、2.5 mmol·L-1)培养血管平滑肌细胞72 h骨钙素的表达.同时观察不同浓度膦甲酸钠对高磷(Pi 2.0 mmol·L-1)诱导的钙沉积和骨钙素增加的抑制作用.用甲O-酚酞络合酮方法测定钙含量;放射免疫法测定培养上清液中骨钙素的浓度;BCA法测定蛋白含量,用蛋白含量标化钙含量与骨钙素浓度;RT-PCR测定骨钙素mRNA的表达.结果 在相当于正常血磷浓度(1.5 mmol·L-1)的培养基中,平滑肌细胞钙沉积量小;而在相当于高磷血症(2.0 mmol·L-1)的培养基中,钙沉积明显增加[培养6 d,(77.187±11.692) vs(25.768±1.750) μg·(mg蛋白)-1,P＜0.01],并呈时间和剂量依赖性.与Pi 1.5 mmol·L-1组相比,Pi 2.0 mmol·L-1组培养上清液中骨钙素的水平明显增高[(1.503×10-2±2.601×10-3) vs(2.981×10-3±8.382×10-4) ng·(μg蛋白)-1,P＜0.001];Pi 2.0 mmol·L-1组平滑肌细胞骨钙素mRNA的表达也明显增加(OC/GAPDH,1.906±0.132 vs 0.748±0.0366,P＜0.001).膦甲酸钠能有效地抑制钙沉积[培养6 d,Pi 2.0 mmol·L-1 PFA 1.0 mmol·L-1组vs Pi 2.0 mmol·L-1组,(37.729±5.899) vs(77.187±11.692)μg·(mg蛋白)-1,P＜0.001]和上清液中骨钙素的表达[(4.529×10-3±1.250×10-3) vs(1.503×10-2±2.601×10-3) ng·(μg蛋白)-1,P＜0.001]及平滑肌细胞骨钙素mRNA的表达(OC/GAPDH,0.642±0.092 vs 1.885±0.165,P＜0.01).结论 高磷能直接促进血管平滑肌细胞钙沉积和骨钙素表达的增加,说明高磷血症可能是促进血管钙化的独立危险因素;膦甲酸钠能有效地抑制高磷诱导的血管平滑肌细胞钙沉积和骨钙素表达的增加,可以作为一种新的防治高磷诱导血管钙化的药物.     

青春期肥胖儿童血清瘦素及相关激素的测定

目的:探讨瘦素(LEP)、可溶性瘦素受体(sOB-R)、睾酮(T)、雌二醇(E2)、卵泡刺激素(FSH)、黄体生成素(LH)在青春期肥胖儿童体内的变化规律及其相互关系,为儿童肥胖的防治提供依据.方法:以13岁的肥胖(n=79,男54例,女25例)和正常(n=85,男58例,女27例)儿童为对象,用放射免疫法测定血清LEP、T、E2、FSH、LH含量,用酶联免疫吸附分析法测定sOB-R含量,分析2组儿童间各指标的差异和相互关系.结果:肥胖儿童LEP(男(27.47±15.48)μg/L,女(33.44±15.80)μg/L)高于对照组(男(6.76±4.64)μg/L,女(10.35±5.56)μg/L)(P＜0.01);男生肥胖组T((320.52±148.05)μg/L)低于对照组((398.94±154.32)μg/L),女生肥胖组E2、LH((46.03±18.68)ng/L、(15.45±7.29)IU/L)高于对照组((29.25±14.23)ng/L、(7.64±3.26)IU/L)(P＜0.01).对照组男生游离瘦素指数(FLI)与T呈负相关,与E2、LH、FSH呈正相关,肥胖组FLI仅与T呈负相关(P＜0.05或0.01);对照组女生sOB-R与LH呈负相关(P＜0.05),FLI与LH呈正相关(P＜0.01),肥胖组女生sOB-R与T呈正相关,FLI与FSH呈正相关(P＜0.05).结论:青春期肥胖儿童体内性发育相关激素分泌水平相对于正常儿童发生了变化,男生雄性激素水平下降,女生雌性激素水平上升;肥胖儿童体内LEP水平的增高可影响体内E2、T及LH分泌的变化.     

多囊卵巢综合征患者血清脂肪细胞因子与胰岛素抵抗的相关性研究

目的 探讨PCOS患者血清脂肪细胞因子与胰岛素敏感性的相关性.方法 将PCOS患者60例分为肥胖组PCOS36例、非肥胖组PCOS24例,将同期就诊的男方因素不孕症患者(正常体重)26例作对照组.进行内分泌代谢指标测定,采用空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)评估胰岛素敏感性;并应用酶联免疫吸附法测定血清游离脂肪酸(FFA)、瘦素及C反应蛋白(CRP),放射免疫法测定血清脂联素(APN)、肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6.结果 (1)肥胖组PCOS的血清APN为(10±7)mg/L,低于非肥胖组PCOSE(17±9)mg/L]和对照组,均P＜0.01;FFA为(548±105)μmol/L,高于非肥胖组PCOS[(427±67)μmoL/L]和对照组,P＜0.01;血清瘦素水平为(42±21)μg/L,高于非肥胖组PCOS[(24±13)μg/L]和对照组,均P＜0.01.非肥胖组PCOS与对照组间APN、FFA和瘦素差异无统计学意义.血清IL-6肥胖组PCOS[(173 4-184)ng/L]和非肥胖组PCOS[(184±44)ng/L]均高于对照组(P＜0.05、P＜0.01);血清TNF-α非肥胖组PCOS[(0.97±0.33)μg/L]和肥胖组PCOS[(0.82 4-0.21)μg/L]均高于对照组(P＜0.01,P＜0.05);非肥胖组PCOS TNF-α高于肥胖组(P＜0.05).非肥胖组和肥胖组的PCOS患者血清中CRP高于对照组,但差异无统计学意义(P＞0.05).(2)瘦素与人体质量指数(BMI)、腰臀比及HOMA-IR呈正相关(P＜0.01),APN与BMI、腰臀比及HOMA-IR呈负相关(P＜0.01).(3)BMI和TNF-α是FINS的独立影响因素,APN是除FINS、空腹血葡萄糖、BMI外,对HOMA-IR的独立影响因素.结论 炎性因子可能参与了非肥胖型PCOS患者IR的发生;而肥胖型PCOS IR的进一步加重可能与其脂肪组织分泌瘦素、FFA增多及分泌APN减少相关.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.