| Research of combined liver-kidney transplantation model in rats |
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| 作者姓名： | Jiageng Zhu Jun Li Ruipeng Ji Jianghao Su Mingshun Shen Zhigang Cao |
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| 作者单位： | Department of Urology, Nanjing First Hospital of Nanjng Medical University, Nanjing 210006, China |
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| 摘 要： | Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.
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| 关 键 词： | 肾移植 动物实验 小鼠 手术治疗 |
| 收稿时间： | 2006-10-18 |
Research of combined liver-kidney transplantation model in rats |
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| Jiageng Zhu,Jun Li,Ruipeng Ji,Jianghao Su,Mingshun Shen,Zhigang Cao.Research of combined liver-kidney transplantation model in rats[J].Acta Universitatis Medicinalis Nanjing,2007,21(2):125-128. |
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| Authors: | Jiageng Zhu Jun Li Ruipeng Ji Jianghao Su Mingshun Shen and Zhigang Cao |
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| Abstract: | Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment. |
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| Keywords: | liver kidney transplantation rat rats model renal transplantation combined established common laboratory conditions high meet needs experiment function liver normal success rate late cases Results |
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