PET/CT显像与全身骨扫描诊断转移性骨肿瘤的比较研究

目的:评价正电子发射计算机断层扫描(positron emission tomography/computed tomography,PET/CT)18F标记的氟脱氧葡萄糖(18F-fluorodeoxyglucose,18F-FDG)全身显像与99mTc标记的亚甲基二磷酸盐(99mTc-methylene diphosphonate,99mTc-MDP)全身骨扫描(bone scintigraphy,BS)诊断转移性骨肿瘤的效能。方法:共计75例临床确诊的恶性肿瘤患者纳入本研究,平均年龄(59.85±13.50)岁。所有患者在2周内接受18F-FDG PET/CT显像和99mTc-MDP BS,以病例为单位,分别计算PET/CT显像与全身BS诊断骨转移的敏感度、特异度、阳性预测值(positive predictive value,PPV)、阴性预测值(negative predictive value,NPV)和准确度,并分析两者在全身不同区域的显像特点。结果:75例患者最终诊断为有骨转移者34例,无骨转移者41例。PET/CT显像诊断骨转移的敏感度和特异度分别为94.1%(32/34)和95.1%(39/41),诊断的PPV、NPV和准确性分别为94.1%、95.1%和94.7%。BS诊断的敏感度和特异度分别为91.2%(31/34)和65.9%(27/41),PPV、NPV和准确性分别为68.9%、90.0%和77.3%。PET/CT显像发现病灶数量较多的部位依次为脊柱、肋骨和骨盆,BS发现病灶数量较多的部位依次为肋骨、脊柱和四肢。结论:18F-FDG PET/CT显像诊断骨转移的特异性、准确性和PPV均明显高于BS,但两者在诊断敏感度和NPV方面并无明显差异。     

联合应用磁共振灌注成像和弥散成像对前列腺癌的诊断价值研究

目的：探讨联合应用磁共振灌注加权成像（PWI）和弥散加权成像（DWI）对前列腺癌的诊断和鉴别诊断价值。方法：收集行PWI和DWI检查的前列腺癌（PCa）38例、良性前列腺增生（BPH）33例及慢性前列腺炎11例,利用灌注参数相对负性强化积分（rNEI）、弥散参数表观弥散系数（ADC）及综合应用两者进行诊断,并与病理诊断相比较,分别通过ROC曲线分析比较,并计算各诊断方法的敏感度、特异度、准确度、阳性预测值及阴性预测值等指标。结果：应用PWI、DWI及联合应用两者诊断前列腺癌的敏感度、特异度、准确度、阳性预测值及阴性预测值分别是79．2％、89．1％、86．2％、75．0％、91．2％;84．0％、92．5％、90．0％、82.3％、93.3％和90．1％、94．8％、93．7％、92．9％、94．0％。结论：PWI及DWI2种方法均可以有效诊断前列腺癌;两种成像方法综合应用可提高诊断的准确度。     

DIAGNOSTIC VALUE OF WHOLE BODY DIFFUSION WEIGHTED IMAGING FOR SCREENING PRIMARY TUMORS OF PATIENTS WITH METASTASES

Objective To evaluate the values of whole body diffusion weighted imaging （DWI） in screenmg pnmary unknown tumor in patients with metastases.
Methods Totally, 34 patients with metastases of primary unknown tumors were scanned with whole body DWI, and conventional magnetic resonance （MR） imaging was performed if suspected lesions were detected. All the metastases including 27 cases of osseous metastases, 2 brain metastases, 2 liver metastases, 1 pulmonary multiple metastasis, 1 neck metastasis and 1 malignant ascites, were diagnosed by computed tomography, single photon emission computed tomography, or MR imaging. For the proven primary tumors diagnosed by biopsy or pathology of surgical specimens, apparent diffusion coefficient （ADC） values of the primary and metastatic lesions were measured respectively. The sensitivity and specificity of this technique for screening primary tumors were cvaluated.
Results We found 24 cases with suspected primary lesions, in which 23 lesions were proved to be primary tumors, and 1 was proved to be benign lesion. And no definite primary lesion was found in 10 cases on whole body DWI, but in which 1 case was diagnosed with primary tumor by biopsy later, and the other 9 cases remained unknown within follow-up of over halfa year. The difference was not significant in ADC values between primary and metastatic lesions （P〉0.05）. The sensitivity and specificity of whole body DWI for searching primary tumors was 95.8% and 90.0%, respectively.
Conclusion Combined with conventional MR scanning, whole body DWI can help to search primary lesions of patients with metastases.     

抗环瓜氨酸肽抗体在类风湿性关节炎诊断中的应用评价

目的评价抗环瓜氨酸肽抗体(抗CCP抗体)在类风湿性关节炎(RA)诊断中的意义。方法选取类风湿性关节炎106例,其他疾病对照组223例(其中非RA的风湿性疾病132例,非风湿性疾病91例),正常对照组50例。对上述379份人群血清进行抗CCP抗体及IgM-RF检测,分析抗CCP抗体、IgM-RF及两者联合检测的敏感性、特异性、阳性预告值和阴性预告值。结果抗CCP抗体及IgM-RF对诊断RA的敏感性、特异性、阳性预告值和阴性预告值分别为:抗CCP抗体(66.04%,98.90%,95.89%,88.24%),IgM-RF(74.53%,79.49%,58.52%,88.93%)。抗CCP抗体与IgM-RF联合检测敏感性和特异性分别为58.49%、99.27%,阳性预告值和阴性预告值分别为96.88%、86.03%。提示抗CCP抗体特异性、阳性预告值明显高于IgM-RF,IgM-RF较抗CCP抗体敏感性、阴性预告值高,两者联合检测可提高诊断的特异性和阳性预告值,但不能提高敏感性和阴性预告值。结论抗CCP抗体对RA诊断特异性高,IgM-RF特异性相对较低,两者联合检测可提高诊断的特异性及阳性预告值,但不能提高敏感性和阴性预告值。     

PRELIMINARY STUDY OF FEASIBILITY OF WHOLE BODY DIFFUSION WEIGHTED IMAGING IN DIAGNOSIS OF METASTASIS OF TUMOR

Objective To evaluate the feasibility of whole body diffusion weighted imaging （DWI） in the diagnosis of metastatic tumor.
Methods Fifty-six patients （40 males and 16 females, age ranging from 29 to 84 years with a mean age of 57 years） with a variety of primary tumors were investigated by whole body DWI combined with computed tomography （CT） and/or conventional magnetic resonance imaging （MRI） scans. Twelve patients underwent positron emission tomography. The final diagnosis was made on the basis of CT or high resolution CT result for lung lesion and MRI or CT result for skull, abdomen and other parts. All tumors were classified into four groups by their diameter： below 1.0 cm, 1.0-1.9 cm, 2.0-2.9 cm, and above 3.0 cm. The sensitivity and specificity of whole body DWI in the detection of metastatic tumor were analyzed.
Results The sensitivities of whole body DWI for screening metastasis of the four groups were 38%, 75%, 97%, and 100%, respectively. Whole body DWI showed the highest sensitivity and specificity for detecting metastasis of the skeletal system. It was difficult to find metastatic tumor whose diameter was below 1.0 cm, or lymph nodes located in the pelvis with diameter below 2.0 cm.
Conclusions Whole body DWI is a promising method in the diagnosis ofmetastastic tumors. With the perfection of scanning parameter, whole body DWI should be a new effective whole body technique for tumor detection.     

抗环瓜氨酸肽抗体与类风湿因子联合检测对类风湿性关节炎诊断价值

目的探讨抗环瓜氨酸肽抗体(anti-CCP)与类风湿因子(RF)联合检测对类风湿性关节炎的诊断价值。方法分析133例类风湿性关节炎患者、67例非类风湿性关节炎者的血清anti-CCP、RF检测结果,其中anti-CCP测定采用微粒子酶免分析法测定,RF测定采用免疫散射比浊法测定。结果①anti-CCP单独检测诊断类风湿性关节炎的灵敏度、特异度、阳性预测值、阴性预测值、诊断准确度分别为80.5%、89.5%、93.9%、70.0%、83.5%。②RF单独检测诊断类风湿性关节炎的灵敏度、特异度、阳性预测值、阴性预测值、诊断准确度分别为78.9%、64.2%、81.4%、60.6%、74.0%。③anti-CCP与RF联合检测诊断类风湿性关节炎的灵敏度、特异度、阳性预测值、阴性预测值、诊断准确度分别为77.4%、98.5%、99.0%、68.8%、84.5%。结论 Anti-CCP与RF联合检测可使类风湿性关节炎的诊断特异度得到有效提高,有利于类风湿性关节炎的鉴别诊断。     

联合MR动态增强扫描、弥散加权成像在乳腺良恶性病变诊断中的应用价值

目的：探讨MR动态增强扫描、弥散加权成像及其联合应用在乳腺良恶性病变诊断中的应用价值。方法选择71例乳腺病变患者,另选择50名健康志愿者为对照组。所有纳入对象均接受磁共振常规扫描、增强扫描、弥散加权成像。计算不同方法诊断乳腺良恶性疾病的敏感度、特异度、阳性预测值、阴性预测值。结果 MR形态学在乳腺良恶性诊断中敏感度90.0%,特异度73.7%,阳性预测值78.3%,阴性预测值87.5%。乳腺多期动态增强扫描对乳腺癌良恶性诊断的敏感度92.5%,特异度66.4%,阳性预测值74.0%,阴性预测值89.3%。联合形态学、强化表现、DWI对乳腺良恶性病变诊断的敏感度95.0%,特异度89.5%,阳性预测值90.5%,阴性预测值94.4%。结论联合形态学、强化表现、DWI对乳腺良恶性病变进行诊断能够显著提高诊断的敏感度、特异度、阳性预测值以及阴性预测值。     

18F-PET-CT显像在肺癌纵隔淋巴结转移中临床应用价值

目的：探讨PET-CT显像在判断肺癌纵隔淋巴结转移中的临床应用价值。方法：回顾性分析67例肺癌患者在手术前CT、PET、PET-CT显像结果。67例肺癌患者均经手术治疗，手术共取出不同大小淋巴结319枚，其中转移淋巴结68枚，且所有取出淋巴结均经病理证实。以病理结果作为标准，分析CT、PET、PET-CT检查结果的准确性，分别计算CT、PET、PET-CT诊断的准确率、灵敏度、特异性、阳性预测值和阴性预测值等指标，并对CT、PET、PET-CT的诊断准确率进行比较。结果：CT、PET、PET-CT判断肺癌纵隔淋巴结转移的分别为74.6%、80.9%、88.7%；61.8%、80.9%、86.8%；78.1%、79.4%、89.2%；43.3%、53.4%、68.6%；88.3%、93.4%、96.1%。CT诊断纵隔淋巴结的准确率低于PET，差异无统计学意义，PET-CT诊断的准确率高于PET，P＜0.05。结论：PET-CT显像对判断肺癌淋巴结转移的准确率高。     

Application of Computed Tomographic Colonography in Diagnosis of Colonic Polyps

Objective To assess the clinical values of computed tomographic colonography （CTC） in diagnosis of colonic polyps. Methods Forty-two patients who were clinically suspicious of colonic polyps or underwent colonic polyps screening received examinations with both CTC and conventional colonoscopy. Sixteen- or 64-slice spiral computed tomography and professional imaging processing techniques were used for evaluation. Per-polyp and per-patient results were analyzed. Those by per-polyp were subsequently divided into ≥10 mm group, 5-10 mm group, and ≤5 mm group. Sensitivity, positive predictive value （PPV）, specificity, negative predictive value （NPV）, and accuracy were calculated using statistical method for diagnostic studies, with conventional colonoscopy as a gold standard. Results Ninety and 61 polyps were found by CTC and conventional colonoscopy, respectively. The per-polyp sensitivity/PPV were 80.3%/55.6% in total, and 100%/92.9%, 93.8%/65.2%, and 68.8%/ 41.5% in the ≥10 mm group, 5-10 mm group, and ≤5 turn group, respectively. The per-patient sensitivity, PPV, specificity, NPV, and accuracy were 97.1%, 89.5%, 42.9%, 75.0%, and 88.1%, respectively. Conclusion CTC can clearly reveal the morphology of colonic polyps and be used as a routine monitoring method for the clinical diagnosis of polyps.     

HPV E6/E7 mRNA联合液基细胞学检查在宫颈癌筛查中的意义

目的 探讨宫颈E6/E7 mRNA和液基细胞学(TCT)两种方法联合应用在宫颈癌筛查中的意义。方法 选取宫颈有高危HPV感染者311例,进行TCT、E6/E7 mRNA及组织学检查,以组织学病理结果作为金标准。结果 两种方法联合检测对高级别鳞状上皮内病变(HSIL)组的敏感性为72.97%,特异性为90.08%,阳性预测值为81.82%,阴性预测值为85.51%;E6/E7 mRNA检查对HSIL组诊断的敏感性为69.64%,特异性为59.30%,阳性预测值和阴性预测值分别为47.56、80.27%。TCT对HSIL组诊断的敏感性为56.25%,特异性为88.94%,阳性预测值、阴性预测值分别为74.12、81.94%。结论 E6/E7 mRNA检查的敏感性比TCT高,而TCT检测特异性高于E6/E7 mRNA。E6/E7 mRNA与TCT联合后敏感性和特异性都显著提高,阳性预测值、阴性预测值都在80%以上。E6/E7 mRNA及TCT两种方法联合检测可以提高宫颈癌筛查的敏感性及特异性。     

稀疏欠采样和迭代重建的3.0T时间飞跃法磁共振血管成像用于颅内未破裂动脉瘤诊断

  目的  以数字减影血管造影（digital subtraction angiography,DSA）检查为金标准,探讨使用稀疏欠采样和迭代重建的3.0T时间飞跃法磁共振血管成像（time-of-flight with sparse undersampling and iterative reconstruction magnetic resonance angiography,TOFu-MRA）对颅内未破裂动脉瘤的诊断价值。  方法  前瞻性纳入我院65例疑似动脉瘤患者,进行TOFu-MRA、DSA检查,以DSA为金标准,计算TOFu-MRA诊断动脉瘤的敏感度、特异度、阳性预测值及阴性预测值,并计算2名医生间检查的一致性。在最大信号强度投影和容积再现的重建图像上比较两方法在测量动脉瘤形态学参数间的一致性,包括动脉瘤颈宽度（D_neck）、动脉瘤高度（H）和动脉瘤宽度（D_width）。  结果  DSA检测出46例确诊患者,共计55个动脉瘤。两名医生利用TOFu-MRA诊断颅内动脉瘤的敏感度、特异度、阳性预测值及阴性预测值分别为基于患者（95.7%,95.7%）、（94.7%,94.7%）、（97.8%,97.8%）及（90.0%,90.0%）;基于动脉瘤（96.4%,94.5%）、（94.7%,94.7%）、（98.1%,98.1%）及（90.0%,85.7%）,且两者间的诊断一致性较高,kappa值分别为0.93、0.97。Bland-Altman分析发现,在D_neck、H及D_width的测量中,超过95%以上的点位于一致限范围内,两种检查方式对动脉瘤形态学参数测量的一致性较好。  结论  TOFu-MRA对颅内未破裂动脉瘤具有较好的诊断效能,并在颅内未破裂动脉瘤形态学参数的测量方面与影像金标准之间有较好的一致性,可用作颅内未破裂动脉瘤诊断的首选无创检查方案。     

1.5T MR多序列对前列腺增生与前列腺癌诊断价值

目的探究飞利浦Intera 1.5T MR多序列对前列腺增生与前列腺癌的诊断价值,筛选最佳序列组合应用于临床。方法对收集的187例前列腺增生患者、86例前列腺癌患者行飞利浦Intera 1.5T MR检查。选用序列有常规序列(T1WI/T2WI)、脂肪抑制(SPAIR)、弥散成像(DWI)、单体素波谱成像(MRS),52例前列腺癌加扫全身弥散成像(WB-DWI)。对比分析常规序列、常规序列+SPAIR、常规序列+DWI、常规序列+SPAIR+DWI、常规序列+DWI+MRS的应用价值以及WB-DWI对前列腺癌骨转移的筛查价值。结果 BPH组:常规序列、常规序列+SPAIR、常规序列+SPAIR+DWI诊断准确率高(100%)。PCa组:常规序列+SPAIR+DWI、常规序列+DWI+MRS诊断准确率分别为94%和95%,高于其他序列组合。WB-DWI对前列腺癌骨转移检出率高。结论常规序列能够诊断前列腺增生,常规序列+DWI+MRS对前列腺癌诊断准确率更高,WB-DWI是无辐射污染、重复性好、检查步骤不繁琐、一站式筛查全身转移病变的最好序列。     

64层螺旋CT联合平板运动试验对冠心病的诊断价值

目的 评价64层螺旋CT联合平板运动试验对冠心病的诊断价值。方法 86例疑似冠心病患者根据验前概率分为低危、中危和高危三组。所有患者均行冠状动脉造影、64层螺旋CT冠状动脉显像和平板运动试验。以冠状动脉造影作为“金标准”（冠状动脉狭窄>50%作为阳性结果）,分别计算64层螺旋CT与64层螺旋CT联合平板运动试验对冠心病诊断的敏感性、特异性、阳性预测值、阴性预测值及准确率。结果 64层螺旋CT诊断冠心病的敏感性、特异性、阳性预测值、阴性预测值及准确率分别为95.2%、88.6%、88.9%、95.1%、91.9%。其中低危组、中危组和高危组的敏感性分别为100%、100%、92.6%;特异性为94.4%、94.1%、66.7%;阳性预测值为80.0%、91.7%、89.3%;阴性预测值为100%、100%、75.0%;准确率为95.5%、96.4%、86.1%。64层螺旋CT联合运动平板诊断冠心病的敏感性、特异性、阳性预测值、阴性预测值及准确率分别为97.6%、97.7%、97.6%、97.7%、97.7%。结论 64层螺旋CT联合平板运动试验对冠心病患者（尤其是验前概率低者）具有较高的筛选价值。     

64层螺旋CT联合平板运动试验对冠心病的诊断价值

目的 评价64层螺旋CT联合平板运动试验对冠心病的诊断价值.方法 86例疑似冠心病患者根据验前概率分为低危、中危和高危三组.所有患者均行冠状动脉造影、64层螺旋CT冠状动脉显像和平板运动试验.以冠状动脉造影作为"金标准"(冠状动脉狭窄>50%作为阳性结果),分别计算64层螺旋CT与64层螺旋CT联合平板运动试验对冠心病诊断的敏感性、特异性、阳性预测值、阴性预测值及准确率.结果 64层螺旋CT诊断冠心病的敏感性、特异性、阳性预测值、阴性预测值及准确率分别为95.2%、88.6%、88.9%、95.1%、91.9%.其中低危组、中危组和高危组的敏感性分别为100%、100%、92.6%;特异性为94.4%、94.1%、66.7%;阳性预测值为80.0%、91.7%、89.3%;阴性预测值为100%、100%、75.0%;准确率为95.5%、96.4%、86.1%.64层螺旋CT联合运动平板诊断冠心病的敏感性、特异性、阳性预测值、阴性预测值及准确率分别为97.6%、97.7%、97.6%、97.7%、97.7%.结论 64层螺旋CT联合平板运动试验对冠心病患者(尤其是验前概率低者)具有较高的筛选价值.     

全身弥散加权成像诊断骨转移瘤的初步临床应用研究

目的探讨全身MR弥散加权（WB-DWI）对恶性肿瘤远处骨转移的临床应用价值。方法经病理确诊,且SPECT全身核素骨显像诊断骨转移瘤的恶性肿瘤患者11例,1.5THDMR进行全身MR-DWI,然后重建全身图像。结果所有患者均获得良好的全身WB-DWI图像,重组3D-MIP全身图像对骨转移瘤均显示较敏感。结论全身弥散加权成像是诊断恶性肿瘤全身骨转移的一种快速、有效的技术,具有一定的临床应用价值。     

超声光散射成像与超声弹性成像技术联合应用在乳腺癌诊断中的价值

目的：探讨超声光散射成像（diffused optical tomography,DOT）与超声弹性成像技术（ultrasonic elastography,UE）联合应用在乳腺诊断中的价值。方法：通过117例患者的179个病灶分别进行DOT和UE检查,并与病理结果对照,对比分析DOT及UE在乳腺癌超声诊断中的敏感度、特异度、准确度、阳性预测值、阴性预测值。结果：DOT对乳腺癌诊断的敏感度87．14％、特异度79．82％、准确率82．68％、阳性预测值73．49％、阴性预测值90．62％。UE对乳腺癌诊断的敏感度72．86％,特异度90．83％、准确率83．80％、阳性预测值83．61％、阴性预测值83．90％。联合应用DOT和UE的敏感度91．43％、特异度92．66％、准确率92．18％、阳性预测值88．89％,阴性预测值94．39％。结论：DOT和UE检查均为有效的诊断方法,联合应用DOT和UE可以提高乳腺癌的诊断效能,对临床治疗方案的选择及患者的预后具有重要的意义。     

320排CT用于风湿性左房室瓣病变伴房颤患者术前筛查冠心病

目的 探讨风湿性二尖瓣病变伴房颤患者术前320排CT冠脉成像检查（CTCA）诊断冠心病准确性,探索其运用于心脏瓣膜病术前筛查冠心病的可行性。方法 选取35例风湿性二尖瓣病变伴持续性房颤患者,瓣膜术前先后接受320排CT冠脉成像检查和选择性冠状动脉造影检查(CCA)。通过Pearson积差相关系数评价CT图像质量与平均心率的相关性。以冠脉造影为对照,从节段、血管及患者3方面计算CT诊断冠脉管腔内狭窄≥50%的灵敏度、特异度、阳性预测值、阴性预测值。采用Kappa值评价CTCA与CCA诊断冠心病的一致性。结果 35位患者平均心率94.7±21.4次/分,右冠状动脉中段与平均心率相关系数r=0.554、P=0.002,回旋支中段与平均心率相关系数r=0.558,P=0.016。在节段水平CT诊断冠心病的灵敏度,特异度、阳性预测值及阴性预测值分别为：87.5%、99.4%、82.4%和 99.6%;血管水平：87.5%、97.6% 、82.4%和98.4%;患者水平：84.6%, 86.3%,78.6%和90.5%。Kappa值分别为0.843、0.828及0.699。结论 320排CT冠脉成像检查诊断冠心病准确性较高,可运用于风湿性心脏病二尖瓣病变伴房颤患者术前筛查。     

电化学发光法检测抗CCP抗体的临床价值

目的研究电化学发光法检测抗CCP抗体的临床应用价值。方法对48名临床确诊为类风湿关节炎的患者、22例其他疾病患者、20例健康成人用电化学发光法检测抗CCP抗体,并同时用免疫散射速率法检测RF。结果抗CCP抗体对RA诊断敏感性为72.92%,特异性为97.61%,阳性预测值97.22%,阴性预测值75.92%;RF对RA诊断的敏感性为85.42%,特异性为71.43%,阳性预测值77.36%,阴性预测值81.08%;抗CCP抗体与RF联合平行试验对RA诊断的敏感性为96.05%,特异性69.72%,阳性预测值78.18%,阴性预测值85.71%。结论在RA患者中,抗CCP抗体较RF有更高的特异性。电化学发光法检测抗CCP抗体与RF联合检测可提高诊断RA的敏感性,为患者早期诊断提供实验室依据。     

盆腔磁共振成像和快速冰冻病理检查对子宫内膜癌肌层浸润的诊断价值

  目的  子宫肌层浸润程度影响子宫内膜癌患者治疗的效果和预后,通过分析术前盆腔磁共振成像(MRI)、术中快速冰冻切片(frozen section,FS)与术后石蜡病理对子宫内膜癌肌层浸润的检查结果,比较盆腔MRI及FS对子宫内膜癌肌层浸润的诊断价值。  方法  采用回顾性分析的研究方法,选取2009年1月—2017年1月安徽医科大学附属巢湖医院进行手术治疗并且术后经石蜡病理诊断为Ⅰ期子宫内膜癌的89例患者,收集社会人口学与临床资料,将术前盆腔MRI及术中FS对子宫肌层及深肌层浸润状况的检查结果,分别与术后石蜡病理结果进行比较,并计算敏感性、特异性、准确率、阳性预测值(PPV)与阴性预测值(NPV),比较术前盆腔MRI和术中FS对子宫肌层浸润的诊断价值。  结果  术中FS病理检查对子宫肌层浸润的敏感性(86.76% vs. 63.24%)、准确率(84.27% vs. 62.92%)及NPV(64.00% vs. 34.21%)高于术前MRI(均P < 0.05)。术中FS病理检查对深肌层浸润的特异性(100.00% vs. 90.41%)、准确率(95.51% vs. 86.52%)及PPV(100.00% vs. 61.11%)高于术前MRI(均P < 0.05)。  结论  对于术前MRI检查子宫肌层浸润阴性的子宫内膜癌患者,应在术中行快速FS病理检查,以进一步更加准确地评估肌层浸润情况。      

Pre-operative assessment of benign and malignant ovarian tumours using colour Doppler ultrasonography

Ultrasonography of 56 women with adenexal masses who were admitted for laparotomy were done mainly by transvaginal route. Though Gray scale morphologic evaluations of masses were done routinely, only colour Doppler imaging criteria were taken into consideration in this study. These are pulsatility index (PI), resistance index (RI), peak systolic velocity (PSV), timed average maximal velocity (TAMXV), vessels localisation and dicrotic notch. Histopathological examination was done and considered as gold standard. In 83.78% cases of benign tumour PI is equal or greater than 1, whereas it was less than 1 in 84.21% in malignant ovarian tumour. The sensitivity, specificity, PPV and NPV were respectively 84.21%, 83.78%, 72.72% and 91.11%. RI in benign tumours were equal to or more than 0.4 in 81.08% and less than 0.4 in 68.42% in case of malignant tumours. The sensitivity, specificity, PPV and NPV were respectively 68.42%, 81.08%, 65% and 83.33%. Considering the TAMXV>12 cm/second as a criterion for malignancy the sensitivity, specificity, PPV and NPV were respectively 89.45%, 89.19%, 80.95% and 94.28%, and also considering septal/central localisation of vessels as a criterion for malignancy, it was found the sensitivity, specificity, PPV and NPV were 89.47%, 62.16%, 54.84% and 92% respectively. Considering absence of dicrotic notch for malignant tumours we found sensitivity, specificity, PPV and NPV were 89.47%, 81.08%, 70.83% and 93.75% respectively. The above findings of the PI, TAMXV and dicrotic notch evaluation show most useful was colour Doppler parameters for pre-operative screening for ovarian malignancy in this study.