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褪黑素(melatonin,MEL)主要由松果腺分泌,它是一种吲哚类激素,其功能之一能抑制下丘脑的促性腺释放激素和垂体前叶的促性腺激素。本工作利用原位杂交方法,观察了MEL对促甲状腺释放激素(thyrotropinreleasinghormone,TRH)兴奋垂体前叶激素-催乳素(prolactin,PRL)表达的影响。结果表明,在一定浓度范围内,MEL不但可抑制TRH刺激PRL基因表达的效应,还可直接抑制垂体前叶细胞PRL基因的表达。这为进一步探讨在体条件下MEL对PRL合成与分泌的调节,提供了实验依据。  相似文献
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目的:探讨亚甲基四氢叶酸还原酶(MTHFR) C677T和甲硫氨酸合成酶(MS) A2756G基因多态性与我国男性精液质量的相关性.方法:选取特发性少、弱、畸精症患者75例为实验组,有正常孕育史和精液质量正常的男性72例为对照组,分析MTHFR C677T及MS A2756G基因多态性在两组中分布的差异,检测两组中血同型半胱氨酸(homocysteine,Hcy)水平.结果:精液异常组中MTHFR基因C677T多态性CT,TT及CT+TT型的分布频率均高于对照组中相应基因型的分布频率(P<0.05),T等位基因在精液异常组中的分布频率亦高于对照组(P<0.05).MSA2756G基因多态性各基因型及等位基因在对照组和精液异常组中的分布频率差异无统计学意义(P>0.05).精液异常组的Hcy水平高于对照组(P<0.05).所有研究对象中,MTHFR677CT,TT及CT+TT型的Hcy水平均高于CC型(分别P<0.05,P<0.01,P<0.01).MS2756AA,AG及GG型的Hcy水平比较无明显差异(P>0.05) .结论:MTHFR C677T基因的CT型及TT型多态性改变与我国男性精液异常密切相关,可能是导致精液异常的原因之一;T等位基因可能是导致精液异常的危险因素.MTHFR C677T基因多态性的改变可能通过高Hcv途径影响男性精液质量.MS A2756G基因多态性与我国男性精液质量无关.  相似文献
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Objective:To determine epidemiologic features of an Escherichia coli O157:H7 outbreak occurred in Xuzhou,Jiangsu Province,China in 1999,and assess the incidence of E. coli O157:H7 in diarrhea patients and host animals and its relationship with disease onset,and provide a scientific basis for establishing prevention and control strategies. Methods: Epidemiological,microbiological,and molecular methods were performed to identify risk factors and describe the ecology of E. coli O157:H7 in the environment. Resu...  相似文献
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Streptococcus suis(S.suis)is a Gram-positive,facultatively anaerobic coccus that has been implicated as the cause of a wide range of clinical disease syndromes in swine and other domestic animals.S.suis has also been implicated in disease in humans,especially among abattoir workers,swine and pork handlers.Here we report a case of streptococcal toxic shock syndrome(STSS)caused by S.suis in a 59-year-old man.Despite of intensive treatment,the patient died of shock with multiple organ failure 14 h after admission.One bacterial isolate obtained from blood culture was identified to the species level by biochemical tests and serological tests as S.suis serotype 2.Identification was confirmed by PCR amplification of genes encoding 16sRNA of S.suis and the capsule of S.suis serotype 2(cps 2J).Genes encoding virulence factors were also detected.An investigation to identify the source of S.suis revealed that several days before admission the affected man had been handling sick pigs or their meat.Transmission may occur through breaks in the skin of feet with tinea due to that no measures for personal protection was taken.This case should highten awareness of the potential for occupational exposure and human infection with S.suis.  相似文献
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目的 探讨调脂通脉颗粒对ApoE 基因敲除(ApoE-/-)小鼠血脂、富含甘油三酯脂蛋白残粒、细胞黏附分子的影响.方法 将30只ApoE-/-小鼠随机分为模型组、非诺贝特组及调脂通脉颗粒组,每组10只,另取10只C57BL/6J小鼠作为正常组.模型组及给药组小鼠以高脂饲料饲养,同时给予调脂通脉颗粒或非诺贝特,12周后测富含甘油三酯脂蛋白残粒(RLP-C)及血脂四项;采用ELISA 法检测血清细胞间黏附分子-1(sICAM-1)、血管细胞黏附分子-1(sVCAM-1)水平;取主动脉根部做石蜡切片,行HE染色观察形态学变化.结果 第12周,与模型组比较,调脂通脉颗粒组和非诺贝特组小鼠体重下降.与正常组比较,模型组、非诺贝特组、调脂通脉颗粒组血清RLP-C、TC、TG、HDL-C、LDL-C升高,差异有统计学意义(P<0.05);与模型组比较,非诺贝特组、调脂通脉颗粒组血清RLP-C、TG降低,差异有统计学意义(P<0.05).与正常组比较,模型组血清sICAM-1、sV-CAM-1水平升高,差异有统计学意义(P<0.05);与模型组比较,非诺贝特组、调脂通脉颗粒组血清sICAM-1、sVCAM-1水平降低,差异有统计学意义(P<0.05);非诺贝特组与调脂通脉颗粒组SV-CAM-1与正常组比较,差异无统计学意义.HE染色表明模型组主动脉内膜增厚伴易损斑块形成,调脂通脉颗粒组内膜增厚伴稳定斑块.结论 调脂通脉颗粒可通过降低RLP-C的水平,减少细胞黏附分子表达,延缓动脉粥样硬化进展.  相似文献
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