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排序方式: 共有102条查询结果,搜索用时 31 毫秒
1.
Validity of Asthma Control Test in Chinese patients   总被引:17,自引:1,他引:16       下载免费PDF全文
Background So far, in China, there has been no effective or easy procedure to define the control of asthma. This study assesses the validity of Asthma Control Test in Chinese patients. Methods Three questionnaires (Asthma Control Test, Asthma Control Questionnaire and the 30 second asthma test) were administered to 305 asthma patients from 10 teaching hospitals across China. Spirometry was also used. Asthma specialists rated the control of asthma according to patients’ symptoms, medications and forced expiratory volume in first second. The patients were divided into noncontrolled group and controlled group according to the specialists’ rating. Reliability, empirical validity and screening accuracy were conducted for Asthma Control Test scores. Screening accuracy was compared among 3 questionnaires. The patients’ self rating and the specialists’ rating were also compared.Results The internal consistency reliability of the 5-item Asthma Control Test was 0.854. The correlation coefficient between Asthma Control Test and the specialists’ rating was 0.729, which was higher than other instruments. Asthma Control Test scores discriminated between groups of patients differing in the percent predicted forced expiratory volume in first second (F=26.06, P<0.0001), the specialists’ rating of asthma control (F=88.24, P<0.0001) and the Asthma Control Questionnaire scores (F=250.57, P<0.0001). Asthma Control Test showed no significant difference with Asthma Control Questionnaire in the percent correctly classified, while the percent correctly classified by Asthma Control Test was much higher than 30 second asthma test. The patients’ self rating was the same as assessment of the specialists (t=0.65, P=0.516). Conclusion The Asthma Control Test is an effective and practicable method for assessing asthma control in China.  相似文献
2.
中国五地区酒依赖者社会人口学特征及相关因素分析   总被引:10,自引:0,他引:10  
目的 了解酒依赖患者的社会人口学特征、探讨影响酒依赖发生的相关因素。方法 整群抽样 ,应用DSM III R酒依赖诊断标准 ,对 2 4992例社区普通居民诊断 ,采用单因素和Logistic多因素分析方法 ,计算多种因素与酒依赖的关联强度。结果 中年男性、大量饮酒者、体力劳动者、文化程度较低者、婚姻不稳定者、吸烟者酒依赖发生的可能性高 ,其中年饮酒量相关作用最强 ,与酒依赖发生呈“J”字型关系 ,经济收入与之呈“U”字型关系。结论 我们可以通过减少或控制危险人群的饮酒量以减轻酒相关问题的危害。  相似文献
3.
目的研制Ⅰ型登革病毒(DEN1)非结构蛋白1(NS1)蛋白特异性单克隆抗体,鉴定其特异性。方法以具有良好免疫原性的DEN1重组NS1蛋白、DEN1全病毒及两者混合免疫共3种免疫方案,分别免疫Balb/c小鼠,取其脾细胞与小鼠骨髓瘤细胞融合,杂交瘤细胞经间接ELISA法双筛I、FA和Western Blot进行mAbs的类型及亚类、特异性等鉴定。结果采用3种免疫方案免疫Balb/c小鼠,获得9株抗NS1蛋白的mAb,其亚类测定一株为IgG2a,另外8株为IgG1。这些mAbs与DEN1重组NS1蛋白和DEN1全病毒均结合,而且特异性好,仅1株杂交瘤分泌的单抗和其余3型DEN有交叉反应。结论成功获得了特异性针对DEN病毒NS1蛋白的特异性血清型mAb,将为进一步研究NS1蛋白的结构和功能及临床诊断试剂研发奠定基础。  相似文献
4.
湖南省怀化地区城乡饮酒吸烟状况及其影响因素研究   总被引:5,自引:2,他引:3  
目的了解湖南省怀化地区居民酒精、烟草使用状况及相关影响因素。方法采用分层、随机与整群抽样相结合的方法,使用定式检查问卷调查湖南怀化地区城市、农村社区中7837人(15~65岁)的酒烟使用情况。结果城市饮酒率(45.9%)高于农村(39.6%),但农村饮酒者的平均每次饮酒量、年平均消耗纯酒精量、饮酒频度、饮酒种类均显著高于或多于城区;城市、农村以及总样本人群年平均消耗纯酒精分别为2.6L,3.8L,3.2L。农村吸烟率(35.9%)高于城市(28.7%),城市吸烟者平均吸烟支数(13.3±8.1)支/d,农村(16.5±6.5)支/d。结论农村地区的饮酒、吸烟问题较城市更为严重。对农村地区的酒精、烟草的知识宣传和烟、酒使用控制上亟待进一步加强。  相似文献
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6.
Background Aspirin and clopidogrel can improve myocardial reperfusion and alleviate myocardial injury during percutaneous coronary intervention (PCI). Whether the addition of intravenous tirofiban during this procedure produces further benefit has not been clarified in ST segment elevation myocardial infarction (STEMI) patients. We evaluated this on STEMI patients who underwent primary PCI (p-PCI) via transradial artery approach. Methods Consecutive patients were randomized into tirofiban group (n=-72) or placebo group (n=-78). Angiographic analysis included initial and final thrombolysis in myocardial infarction (TIMI) flow grade (TFG), corrected TIMI frame count (CTFC) and TIMI myocardial perfusion grade (TMPG) of the thrombotic vessel. Platelet aggregation rate (PAR), creatine phosphokinase (CPK), CPK isoenzyme MB (CPK-MB) and troponin I levels were measured and TIMI definitions were used to assess bleeding complications. Left ventricular performance parameters were investigated with equilibrium radionuclide ventriculography. Major adverse cardiac events (MACE) were followed up for 6 months. Results The cases of TFG 0 and 1 before PCI, TFG 0 when first crossing of guide wire were less, and the cases of TFG 3 after PCI was more in tirofiban group than those in placebo group. The final CTFC was fewer and the incidence of no reflow phenomenon was lower, as well the percentage of final TFG 3 was higher in tirofiban group than those in placebo group (all P 〈0.05). Mean peak CPK-MB was significantly lower, while the left ventricular performance parameters 1 week after PCI were much more improved in tirofiban group than those in the placebo group. PAR was significantly decreased shortly after tirofiban infusion. The incidence of 6-month MACE in tirofiban group was obviously lower than that in the placebo group. No statistical difference was noted between the two groups with regard to bleeding complications. Conclusions Intravenous tirofiban infusion, in additi  相似文献
7.
芪参活血颗粒对脓毒症大鼠心肌保护作用的研究   总被引:4,自引:1,他引:3  
目的观察脓毒症大鼠心脏功能、心肌力学的改变并探讨中药芪参活血颗粒对心脏的保护作用。方法96只wistar大鼠随机分为对照组(32只)、脂多糖(LPS)组(32只,予LPS4mg/kg静脉注射)及LPS+芪参活血颗粒组(32只,予芪参活血颗粒8.4g生药/kg灌胃,1h后注射LPS)。各组动物均于实验前(0点)及给药后2、4及6h采血,每时间点8只。经右颈总动脉左心室内插管,监测各组动物左心室功能变化并检测血中肿瘤坏死因子(TNF-α)、血管紧张素Ⅱ(Ang-Ⅱ)、肌钙蛋白T(TNT)浓度。结果脓毒症状态下TNT显著升高,应用芪参活血颗粒后明显降低[(1.30±0.53)μg/Lvs(0.68±0.82)μg/L,P<0.05]。脓毒症状态下左心室收缩峰压(LVPP)、左心室压力上升(下降)最大速率(±dp/dt)均有不同程度变化,左心室舒张末期压(LVEDP)升高,干预治疗后可明显改善。脓毒症状态下,TNF-α、Ang-Ⅱ浓度均明显升高,芪参活血颗粒可显著降低其浓度,分别为[(10.16±1.74)pmol/Lvs(7.60±1.79)pmol/L,P<0.05]和[(1089.96±365.4)ng/Lvs(625.30±224.71)ng/LP<0.01]。结论脓毒症状态下,心肌可发生明显损伤;应用芪参活血颗粒可明显减轻内毒素对心肌的损伤。  相似文献
8.
张建国  王惠民  国华  郝天智  杨文军 《医学争鸣》2004,25(14):1266-1269
目的:设计合成靶向NF-κB的哑铃形圈套ODNs,并检测其对NF-κB转录活性和肾小球系膜细胞TGF-β1表达的抑制效应.方法:采用电泳迁移率改变实验(EMSA)体外检测哑铃形圈套ODNs对NF-κB转录活性的抑制效应.提取大鼠肾小球系膜细胞,随机分为正常对照组、LPS刺激组、哑铃形圈套ODNs处理组、无关圈套ODNs处理组和脂质体处理组.采用阳离子脂质体将2,4,8 mg/L不同剂量哑铃形圈套ODNs转染大鼠肾小球系膜细胞,6 h后用LPS刺激,收集转染后8,12,18 h上清和细胞.用酶联免疫吸附试验(ELISA)法检测上清TGF-β1蛋白表达,逆转录PCR(RT-PCR)法检测TGF-β1mRNA转录.结果:哑铃形圈套ODNs在体外能有效地抑制NF-κB与其顺式元件的结合;4,8 mg/L剂量哑铃形圈套ODNs可明显抑制LPS诱导的大鼠肾小球系膜细胞TGF-β1转录和表达.结论:靶向NF-κB的哑铃形圈套ODNs在体外可抑制NF-κB的转录活性,从而对体外培养的肾小球系膜细胞炎性因子TGF-β1的表达具有抑制效应.  相似文献
9.
十八反古今临床应用述要   总被引:4,自引:1,他引:3  
十八反虽是中药配伍禁忌,但古今临床应用颇多。对十八反临床应用的同方配伍、医案和临床报道等文献进行了整理,发现内容丰富,情况复杂。认为有关十八反临床应用的观察,依据循证医学的证据强度分类,强度较低。因此设计并实施十八反的多中心双盲随机分组对照临床试验,意义重大。  相似文献
10.
胸腔镜手术157例分析   总被引:3,自引:1,他引:2  
目的:探讨电视胸腔镜手术的适应证、手术要点、并发症的防治等。方法:开展157例电视胸腔镜及胸腔镜辅助小切口手术,病种、术式数十种。结果:全组无手术死亡,临床效果满意。发生并发症12例。结论:合理使用小切口,便于胸腔镜手术推广。  相似文献
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