Venetoclax alone or in combination with other regimens treatment achieve deep and sustained remission of relapsed/refractory chronic lymphocytic leukemia: a meta-analysis

Clinical and Experimental Medicine - Recently, the use of novel targeted drugs significantly improved the overall response rate (ORR) and survival of patients with relapsed/refractory chronic...     

Analysis on internal mechanism of zedoary turmeric in treatment of liver cancer based on pharmacodynamic substances and pharmacodynamic groups

Zedoary tumeric (Curcumae Rhizoma, Ezhu in Chinese) has a long history of application and has great potential in the treatment of liver cancer. The anti liver cancer effect of zedoary tumeric depends on the combined action of multiple pharmacodynamic substances. In order to clarify the specific mechanism of zedoary tumeric against liver cancer, this paper first analyzes the mechanism of its single pharmacodynamic substance against liver cancer, and then verifies the joint anti liver cancer mechanism of its "pharmacodynamic group". By searching the research on the anti hepatoma effect of active components of zedoary tumeric in recent years, we found that pharmacodynamic substances, including curcumol, zedoarondiol, curcumenol, curzerenone, curdione, curcumin, germacrone, β-elemene, can act on multi-target and multi-channel to play an anti hepatoma role. For example, curcumin can regulate miR, GLO1, CD133, VEGF, YAP, LIN28B, GPR81, HCAR-1, P53 and PI3K/Akt/mTOR, HSP70/TLR4 and NF-κB. Wnt/TGF/EMT, Nrf2/Keap1, JAK/STAT and other pathways play an anti hepatoma role. Network pharmacological analysis showed that the core targets of the "pharmacodynamic group" for anti-life cancer are AKT1, EGFR, MAPK8, etc, and the core pathways are neuroactive live receiver interaction, nitrogen metabolism, HIF-1 signaling pathway, etc. At the same time, by comparing and analyzing the relationship between the specific mechanisms of pharmacodynamic substance and "pharmacodynamic group", it is found that they have great reference significance in target, pathway, biological function, determination of core pharmacodynamic components, formation of core target protein interaction, in-depth research of single pharmacodynamic substance, increasing curative effect and so on. By analyzing the internal mechanism of zedoary tumeric pharmacodynamic substance and "pharmacodynamic group" in the treatment of liver cancer, this paper intends to provide some ideas and references for the deeper pharmacological research of zedoary tumeric and the relationship between pharmacodynamic substance and "pharmacodynamic group".     

钙离子通道蛋白TRPV6及其相关疾病的研究进展

瞬时受体电位亚家族V成员6 (Transient Receptor Potential Channel Subfamily V Member 6, TRPV6) 是一种钙离子高度选择性离子通道，在多种组织中均有表达，控制细胞顶端钙离子的进入，在维持钙稳态中发挥重要作用。TRPV6功能异常会影响体内钙稳态，进而引发新生儿骨骼发育异常、甲状旁腺功能亢进、骨与软骨代谢异常、肾结石和高尿钙症、 以及炎症性肠病和慢性胰腺炎等多种疾病。近年来研究也表明，TRPV6的上调与多种肿瘤的侵袭性增加有关，具有作为肿瘤检测的标志物以及治疗靶点的潜力。本综述将聚焦于TRPV6与其在相关疾病中发挥的作用，旨在为TRPV6作为药物靶点实现临床转化提供理论依据。     

Aging attenuates the ovarian circadian rhythm

ObjectiveTo study the effect of aging on ovarian circadian rhythm.DesignHuman and animal study.SettingUniversity hospital and research laboratory.Patients/animalsHuman granulosa cells were obtained by follicular aspiration from women undergoing in vitro fertilization (IVF), and ovarian and liver tissues were obtained from female C57BL/6 mice.Intervention(s)None.Main outcome measure(s)Expression of circadian genes in young and older human granulosa cells and circadian rhythm in ovaries and livers of young and older mice.Result(s)All examined circadian clock genes in human granulosa cells showed a downward trend in expression with aging, and their mRNA expression levels were negatively correlated with age (P < 0.05). Older patients (≥ 40 years of age) had significantly reduced serum anti-Müllerian hormone (AMH) levels. Except for Rev-erbα, all other examined circadian clock genes were positively correlated with the level of AMH (P < 0.05). The circadian rhythm in the ovaries of older mice (8 months) was changed significantly relative to that in ovaries of young mice (12 weeks), although the circadian rhythm in the livers of older mice was basically consistent with that of young mice.Conclusion(s)Lower ovarian reserve in older women is partially due to ovarian circadian dysrhythmia as a result of aging.Electronic supplementary materialThe online version of this article (10.1007/s10815-020-01943-y) contains supplementary material, which is available to authorized users.     

生化汤加味促进剖宫产后子宫复旧随机对照试验的系统评价及Meta分析＊

目的 对生化汤加味促进剖宫产后子宫复旧的有效性与安全性进行系统评价，为其在临床应用提供循证医学证据。方法 检索中国生物医学文献数据库（CBM）、中国知网（CNKI）、万方资源数据库（WanFang）、维普期刊数据库（VIP）、Cochrane Library、PubMed、Web of Science等，检索时限为建库至2020年7月，选择生化汤加味促进剖宫产后子宫复旧的随机对照试验（RCT），采用Cochrane系统评价员手册提供的偏倚风险评估工具进行文献质量评价，应用RevMan5.3软件进行Meta分析。结果 共纳入12篇RCT文献，共计1804例剖宫产产妇；Meta分析结果显示，生化汤加味联合缩宫素组在产后第1、3、5天子宫底高度［MD = -0.75，95%CI（-1.35， -0.15），P < 0.00001；MD = -1.92，95%CI（-3.13， -0.72），P < 0.00001；MD = -1.92，95%CI（-3.79， -0.06），P < 0.00001］低于单用缩宫素组，联合用药组血性恶露时间［MD = -1.52，95%CI（-2.71，-0.34），P < 0.00001］和产后恶露持续时间［MD = -4.47，95%CI（-6.20，-2.75），P < 0.00001］均短于单用缩宫素组。结论 生化汤加味联合缩宫素与单用缩宫素比较，更能促进产后子宫复旧；不良反应少，报道的仅有4例出现轻微腹泻，安全性较高；但由于纳入文献质量较低，上述结论尚需更多的随机对照临床研究加以证实。     

芦山地震5年后雅安市高血压患者心理卫生问题检出率及其影响因素

目的 了解芦山地震5年后雅安市高血压患者心理卫生问题检出率及其影响因素，为促进地震灾区高血压患者心理健康提供参考。方法 采用分层整群随机抽样方法，于2018年12月选取雅安市高血压患者800例作为研究对象。采用自编居民基本信息调查表收集患者的基本资料，采用12项一般健康问卷（GHQ-12）评定患者近期是否存在心理卫生问题，采用Logistic回归分析其影响因素。结果 回收有效问卷744份（93.00%），检出存在心理卫生问题者79例（10.62%）。单因素分析结果显示，不同婚姻状况（P?0.01）、家庭人均月收入（P=0.012）、是否接受社会救助（χ²=25.194，P?0.01）的高血压患者心理卫生问题检出率差异均有统计学意义。Logistic回归分析显示，未婚/分居/离异/丧偶（OR=3.879，P=0.015）以及接受社会救助（OR=4.705，P?0.01）是高血压患者存在心理卫生问题的危险因素。结论 雅安市高血压患者心理卫生问题检出率较低，未婚/分居/离异/丧偶者以及接受社会救助的高血压患者心理卫生问题可能更突出。     

一体化腹腔镜系统在单孔腹腔镜腹股沟疝全腹膜外修补术中的应用疗效分析

目的总结一体化腹腔镜摄像系统在单孔腹腔镜腹股沟疝全腹膜外修补术（SILS-TEP）的应用经验。 方法回顾性分析中山大学附属第五医院胃肠外科2017年9月至2018年4月30例采用一体化腹腔镜摄像系统进行SILS-TEP患者的临床资料。 结果所有手术均顺利进行，无一例中转开放或多孔，平均手术时间（58.6±4.3）min，平均出血量（6.5±2.4）ml，术后1 h VAS评分（3.36±0.66）分，术后8 h为（2.15±0.75）分，术后1 d出院。术后血清肿3例，其中1例多次抽液后痊愈，2例1个月后完全自行吸收。术后随访6个月，无复发、腹股沟区慢性疼痛、切口感染等情况发生。 结论使用一体化腹腔镜摄像系统进行SILS-TEP安全、可行、有效，可以减少器械在体外的对抗干扰，有利于该手术的开展。     

急诊绿色通道在创伤性膈疝中的应用体会

目的阐述急诊绿色通道在创伤性膈疝中的应用体会。 方法回顾性分析2017年5月至2018年5月，江苏省人民医院收治的25例创伤性膈疝患者的临床资料，均采用急诊创伤绿色通道进行抢救。记录患者手术情况、治疗结果及术后并发症情况。 结果25例患者到达医院立即启动创伤通，所有创伤通道人员到位时间（5±5.5）min，到达医院至手术时间（60.7±6.2）min。23例入院后行急诊手术，另外2例均于入院后第2天手术。并发症发生率为8.70%，死亡率为8.00%，治疗成功率为92.0%。 结论急诊创伤绿色通道的设立可大大缩短受伤至手术时间，以最迅速的方式使创伤性膈疝患者得到及时救治，提倡更多的医院建立"急诊创伤绿色通道"，使更多的患者在最短的时间内接受有效的治疗。     

老年腹股沟嵌顿疝全身麻醉腹腔镜手术对认知功能的影响

目的探讨腹腔镜微创手术对老年腹股沟嵌顿疝全麻术后认知功能的影响。 方法回顾性分析2015年3月至2018年6月，内江市第二人民医院接受治疗的44例腹股沟嵌顿疝老年患者临床资料，根据手术方式不同分为观察组（24例）和对照组（20例）。对照组采用开放式无张力疝修补术治疗，观察组采用腹腔镜经腹腹膜前疝修补术（TAPP）治疗。比较2组患者手术相关指标、手术前后焦虑、抑郁状态及认知功能及2组术后并发症发生情况。 结果与对照组比较，观察组术后排气时间、进食时间及自主下床活动时间均明显提前，差异有统计学意义（P<0.05）。与术前比较，术后2周2组患者焦虑自评量表、抑郁自评量表评分均明显降低，且观察组明显低于对照组，差异有统计学意义（P<0.05）。与术前比较，术后第2天2组患者即刻记忆力、回忆力、定向力、注意力及语言能力评分均明显降低，且观察组明显高于对照组，差异有统计学意义（P<0.05）。观察组总并发症发生率明显低于对照组，差异有统计学意义（P<0.05）。 结论TAPP配合围手术期精心护理可更有效地缓解腹股沟嵌顿疝老年患者不良心理情绪，对患者术后认知功能的影响更小，并发症少，有利于患者术后恢复，建议临床推广使用。