冠心病与A型行为的相关性研究

目的探讨冠心病患者与A型行为的关系。方法采用A型行为问卷(TABQ)对64名冠心病患者(观察组)及64名健康人(对照组)分别进行问卷调查,并将调查结果加以比较。结果观察组TABQ总分及TH因子分、CH因子分均显著高于对照组(P<0.01),观察组A型行为发生率显著高于对照组(P<0.01)。结论冠心病患者与A型行为有关。     

A型行为因子量表的初步修订

目的 探讨苗丹民等编制的A型行为因子(PSACIV)量表的结构维度,对其进行初步修订.方法 采用PSACIV行为量表调查968名冠心病和高血压患者,运用探索性因素分析对原量表进行修订.结果 原量表50个条目中有10个被删除,保留了40个条目6个因素结构即暴躁、时间紧迫感、时间效率、缺乏耐心、敌意和孤僻,形成初步修订的A型行为因子量表.结论 本研究将A型行为细化成6个因子,采用多级估量模糊集模型进行评分,更有效的反映被试的心理状况,对A型行为的研究具有积极意义.     

血管紧张素转换酶基因多态性与冠心病及其行为特征的关联分析

目的探索血管紧张素转换酶(angiotension converting enzyme,ACE)基因多态性与冠心病的关联分析. 方法应用聚合酶链反应(Polymerase Chain Reaction,PCR)技术对100例住院冠心病患者及90例正常对照者进行ACE基因多态性测定,并对冠心病患者进行A型行为类型问卷(Type A Behavior Pattern Scale,TABP)测定. 结果冠心病组的DD基因型频率(34%)及D等位基因频率(66%)均显著高于正常对照组(14.4%,44.4%),且RRDD=3.05,RRD=2.43,P ＜0.05,表明冠心病与ACE基因的DD基因型、D等位基因呈显著正关联;具有A型行为的冠心病患者的DD基因型频率及D等位基因频率均显著高于非A型患者(P <0.05);携带DD基因型的冠心病患者的A型行为问卷的TH因子(15.88±3.16)、CH因子分(14.88±2.89)极显著地高于携带ID及Ⅱ基因型患者的因子分(12.89±4.53,12.52±3.88,13.00±1.41,10.50±0.71)(P <0.01).结论 ACE基因多态性可能是冠心病发生发展过程中重要的危险因素之一,其DD型和D等位基因与冠心病患者的A型行为有一定的联系.     

老年高血压病、冠心病与心理社会因素

以病例对照配对法,观察了老年高血压病、冠心病和对照组各320例,试图探索心理社会因素与高血压病、冠心病的相关性。调查发现:病例组的生活事件出现率占78.75%(252/320),对照组为41.26%(132/320)。将病例组与对照组的行为方式进行比较.病例组具有时间紧迫感、生活节奏快、争强好胜等A型行为方式者明显高于对照组,两组差异颇为显著。结果提示不良的社会体验是老年高血压、冠心病不容忽视的致病因素之一并表明A型行为方式与高血压病、冠心病的发病有关。     

NOS3串联重复序列多态性与Hcy及冠心病的相关性分析

目的内皮一氧化氮合酶(NOS3)的基因串联重复序列(VNTR)多态性与血浆同型半胱氨酸(Hcy)水平及冠心病(CHD)关系。方法选取2016年12月至2019年10月本院收治的冠心病患者153例(CHD组),同时选取149名健康体检者为对照组。应用毛细管凝胶电泳检测NOS3 VNTR基因多态性,应用酶循环法测定血浆Hcy水平。结果比较两组Hcy水平,4a等位基因在CHD组中的频率明显高于对照组(P=0.003),CHD组中血浆Hcy水平在4a4a基因型中最高(P=0.002)。CHD组的4a等位基因频率及4a4a基因型显著高于对照组(P=0.003,P=0.017)。结论NOS3多态性与Hcy水平、冠心病发病有关。     

广泛性焦虑症患者的个性特征、行为模式及其可塑性研究

目的探讨广泛性焦虑症患者的个性特征、行为模式及其可塑性.方法使用EPQ、A型行为问卷及SCL-90对117名广泛性焦虑症患者治疗前后的个性特征、行为模式及症状分别进行测量.结果广泛性焦虑症患者的N、P分别为14.4±4.5,7.8±3.6,均显著高于常模(P＜0.01),L分为11.3±3.7,显著低于常模(P＜0.01),A型行为问卷评分为28.8±7.5分;治疗后SCL-90总分显著降低(P＜0.01),N分及A型行为问卷的TH因子分显著下降(P＜0.05).结论广泛性焦虑症患者具有神经质和精神质倾向的个性特征和A型行为模式.有效的治疗不仅可以改善临床症状,亦可改善其情绪的稳定性和A型行为中的时间紧迫感,但对其他的个性特征和行为模式影响不大.     

广泛性焦虑症患者的个性特征、行为模式及其可塑性研究

目的探讨广泛性焦虑症患者的个性特征、行为模式及其可塑性.方法使用EPQ、A型行为问卷及SCL-90对117名广泛性焦虑症患者治疗前后的个性特征、行为模式及症状分别进行测量.结果广泛性焦虑症患者的N、P分别为14.4±4.5,7.8±3.6,均显著高于常模(P＜0.01),L分为11.3±3.7,显著低于常模(P＜0.01),A型行为问卷评分为28.8±7.5分;治疗后SCL-90总分显著降低(P＜0.01),N分及A型行为问卷的TH因子分显著下降(P＜0.05).结论广泛性焦虑症患者具有神经质和精神质倾向的个性特征和A型行为模式.有效的治疗不仅可以改善临床症状,亦可改善其情绪的稳定性和A型行为中的时间紧迫感,但对其他的个性特征和行为模式影响不大.     

冠心病和非冠心病者心理状况、行为类型及个性特征的对比分析

目的了解冠状动脉造影诊断为冠心病和非冠心病者心理状况及影响因素.方法 131例患者行冠状动脉造影术前采用症状自评量表(SCL-90)、A型行为问卷(TABP)、艾森克个性问卷(EPQ)进行问卷调查.结果诊断冠心病87例,其中A型行为41例,占47.12%,非冠心病44例,A型行为22例,占50%,两者比较差异无显著性(P＞0.05).非冠心病组个性情绪不稳定者占52.27%,明显高于冠心病组的27.58%,差异有显著性(P＜0.05);EPQ神经质分明显高于冠心病组;SCL-90人际关系、抑郁、焦虑、敌对、恐怖、偏执、精神病性因子分均明显高于冠心病组,差异有显著性(P＜0.01).A型行为CH因子与SCL-90强迫、抑郁、焦虑、恐怖因子呈显著正相关;EPQ神经质因子与SCL-90强迫、抑郁、焦虑、恐怖、偏执因子呈正相关.结论冠状动脉造影正常的非冠心病者心理症状较冠心病者严重,A型行为的CH行为特征和个性情绪稳定性是影响心理健康的重要因素.     

A型行为高血压患者24小时动态血压分析

目的研究A型行为高血压患者24小时动态血压变化的临床意义.方法 120 例研究对象分为A型行为高血压组(A组)及单纯 高血压组(B组)、用动态血压监测(Ambulatory blood pressure monitoring,ABP M)比较其血压昼夜节律变化.结果 A组患者夜间平均收缩压高于B组 (t=2.137,P=0.035),夜间平均舒张压A组明显高于B组(t=4.215,P=0.0 00);A组患者收缩压非杓型改变率高于B组(χ2=6.400,P=0.011)、舒张压非杓型 改变率明显高于B组(χ2=13.297,P=0.000).结论血压昼夜节律与A型行为显著相关,提示A型行为可能为高血压患者靶器官损害的危险因素.     

多发家系精神分裂症患者血浆肿瘤坏死因子及白介素6水平的意义

目的检测精神分裂症多发家系成员血浆肿瘤坏死因子α(TNF-α)和白介素6(IL-6)的水平,分析其在精神分裂症的病因与发病机制中的作用.方法采用酶联免疫吸附法(ELSIA)检测43个精神分裂症多发家系181名成员(精神分裂症患者72名)和40名健康对照的血浆TNF-α和IL-6水平.结果精神分裂症患者组血浆TNF-α水平为(62.51±33.26)pg/ml,明显低于非血亲和正常对照组(P <0.05),IL-6水平为(52.58±27.28)pg/ml,未见组间差异;发作期患者TNF-α为(52.06±24.21)pg/ml,明显低于缓解期患者(P <0.05),而IL-6为(64.05±26.58)pg/ml,明显高于缓解期患者(P <0.05);TNF-α水平与阴性症状N分呈负相关,(r=-0.320, P =0.030),而IL-6水平与阴性症状呈正相关(r=0.429, P =0.003);Ⅱ型患者IL-6水平为(72.97±25.97)pg/ml,Ⅰ型患者为(41.42±22.10)pg/ml,Ⅱ型患者明显高于Ⅰ型患者和非血亲正常对照组(P <0.01).结论 TNF-α、IL-6在家族性精神分裂症的发病中有一定作用,IL-6仅与Ⅱ型精神分裂症或阴性症状有关.     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

A preliminary screening study on the associated proteins in human psoriasis vulgaris by serum proteomics technologies

Objective：To investigate the optimum screening conditions of associated proteins in human psoriasis vulgaris by serum proteomics technique, and to screen the different expression proteins related with psoriasis vulgaris. Methods：Serum samples of peripheral blood were collected from newly diagnosed psoriasis vulgaris patients in the clinic, and 20 matched healthy persons. Serum albumin IgG was removed by filtering with ProteoExtract Albumin/IgG. After comparative proteomics analysis the different protein spots were identified using 2-DE and MS. Results ：Electrophoresis figures with high resolution and reproducibility were obtained. Three different expression proteins were found only in the serum from psoriasis vulgaris patients, while nine other different proteins expressing from healthy volunteers. Conclusion：The protein expression was different in the serum between the psoriasis vulgaris patients and healthy volunteers. It was hoped that we could find the biomarkers related to psoriasis vulgaris by using proteomics.     

A CASE OF HUGE GASTRIC DISOPYROBEZOAR

PYTOBEZOARS are common bezoars in gastrontestinal tract, commonly seen in stomach and mall intestine,1but huge disopyrobezoars are     

Acupuncture Treatment of Chest Bi Syndrome

CASE HISTORY A male,a retired officer of 61 years old,paid his first visit on May 12,2006.The patient stated that 2 weeks before he suddenly got paroxysmal precordial choking pain,with irregular attacks.Each attack would last several seconds to several minutes.The attack was accompanied with heavy oppressed sensation in the precordial region,palpitation,lassitude,and in severe cases,sweating,which was once diagnosed by a hospital as'coronary heart disease'.Recalling the case history,the patient said that several days before he got angry with others because of some affairs in work,and he was not so used to the life pattern since he had just retired from his busy working post.At usual times,he was quick tempered and peevish.In recent days,he had poor appetite,and loose stool.     

Instructions to Contributors

The English edition of Chinese Journal of Integrative Medicine is edited and published by the Chinese Journal of Integrated Traditional and Western Medicine Press.Original scientific papers of advanced clinical and experimental medicine in the field of complementary/alternative medicine or integrative medicine are expected.     

Development Is A High Level Inheritance for China Time-honored Brand Products

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