单胸弯及单腰弯特发性脊柱侧凸的躯体生长参数研究

 目的 探讨单胸弯及单腰弯青少年特发性脊柱侧凸(adolescent idiopathic scoliosis, AIS) 女性患者的躯体生长发育特点。方法 研究对象包括 339例 AIS女性患者和 3914位同龄健康女孩, 实 足年龄 10~17岁。单胸弯 AIS女孩(端椎位于 T₁~T₁₂之间)220例, 单腰弯 AIS女孩(端椎位于 T₁₂~L₅之 间)119例;Cobb角为 32°±10°(15°~63°)。测量所有 AIS组和对照组女孩的身高、体重及臂长, 计算体重 指数(body mass index, BMI)及下肢长度, 并根据 Bjure校正公式计算 AIS女性患者的校正身高及校正 坐高。结果 单胸弯与单腰弯 AIS患者的身高及坐高在各年龄段间差异均无统计学意义;而两组 AIS 女性患者的校正身高及坐高均明显高于同龄对照组女孩。同时两组 AIS患者的臂长及下肢长度也显著 长于正常青少年。在 15岁年龄段, 单胸弯 AIS患者的体重显著低于正常青少年, 而单腰弯 AIS患儿的 体重在各年龄段均与正常青少年相似。结论 与同年龄段正常青少年相比, 单胸弯和单腰弯 AIS患者 可能具有共同的异常生长模式;此外, 与正常女孩及单腰弯 AIS女孩相比, 单胸弯 AIS患者体内脂肪含 量偏低的趋势更为明显。     

RANK基因多态性与女性青少年特发性脊柱侧凸的相关性

目的 :探讨核因子κB受体活化子(receptor activator of nuclear factor-κB,RANK)基因多态性与女性青少年特发性脊柱侧凸(adolescent idiopathic scoliosis,AIS)之间的相关性。方法:2009年2月~2013年7月在我院行支具或手术治疗的450例主弯Cobb角大于20°的女性AIS患儿为观察组(AIS组),年龄14.8±2.9岁(10~18岁)。对照组为例行健康体检的我院周围地区无血缘关系的健康青少年女性400名,年龄15.1±2.3岁(10~17岁)。所有AIS患儿均有身高、体重及体重指数(body mass index,BMI)等资料。AIS组和对照组每例取肘静脉血2ml,提取外周血白细胞基因组DNA。rs1805034和rs35211496作为RANK的目标位点,应用Taqman探针技术行荧光定量PCR,全部反应结束后在荧光定量PCR仪上读取终点荧光,确定各样本的基因分型结果。采用R×C表χ~2检验比较AIS组和对照组单核苷酸多态性(single nucleotide polymorphism,SNP)位点基因型及等位基因频率分布的差异。采用单因素方差分析比较AIS组患儿主弯Cobb角及BMI在不同基因型之间的差异。结果:rs1805034和rs35211496的基因型在AIS组和对照组中的分布均符合Hardy-Weinberg遗传平衡定律。rs1805034和rs35211496的基因型及等位基因频率两组间无统计学差异(P0.05)。单因素方差分析示AIS组内rs1805034和rs35211496的不同基因型患儿间的主弯Cobb角及BMI均无统计学差异(P0.05)。结论:RANK基因可能不是女性AIS的易感基因,女性AIS组内rs1805034和rs35211496的不同基因型患儿间的主弯Cobb角及BMI均无统计学差异。     

600例学龄少女前臂骨密度的研究

目的了解少女(10～11岁)前臂骨密度(BMD)年增长情况以及BMD与身高、体重的关系.方法对600例健康少女行左前臂扫描,按首次平均体重指数(BMI)分组,正常组(BMI=14.2～19.6),超重组(BMI＞19.6),偏轻组(BMI＜14.2).一年后,采用同台双能X线骨密度仪再次扫描,追踪观察一年中BMD的变化.结果600例少女前臂远端1/10、1/3处BMD年均增长率分别为3.9%和10.6%,年增长率以正常组最快,超重组次之,偏轻组最慢.前后两次前臂远端1/10、1/3处BMD与身高、体重均呈明显正相关(r=0.307～0.649,P＜0.001).结论该年龄段发育正常者身高、体重和BMD的年增长均最快.     

雌激素β受体基因多态性与青少年特发性脊柱侧凸关系的研究

目的 比较分析青少年特发性脊柱侧凸(adolescent idiopathic scoliosis,AIS)患者与对照组雌激素β受体(estrogen β receptor,ER β)基因型分布情况,探讨ER β基因多态性与AIS患者易感性、异常生长模式及低骨量之间的关系.方法 对2006年3月至2007年3月的288例(男17例,女271例)AIS患者进行人体形态学测量,记录其年龄、身高、体重、臂长、月经初潮情况、Cobb角、Risser征等指标,并收集其静脉血标本.经体检收集232名(男30名,女202名)健康青少年静脉血标本.应用聚合酶链反应-限制性片断长度多态性技术(PCR-RFLP)检测分析AIS组及正常青少年组ER β基因型,比较两组间及AIS组内各亚组ER β基因型分布情况.结果 AIS组与对照组ER β基因型分布差异无统计学意义(χ2=5.908,P＞0.05).AIS组内比较,初潮年龄≥12岁组Rr型频率高于初潮年龄＜12岁组(P＜0.05),而根据身高、体重指数(BMI)、臂长、Cobb角、Risser征等分组,基因型分布比较差异无统计学意义(P＞0.05).ER B基因两个多态性位点各基因型间所对应的骨密度比较差异无统计学意义(P＞0.05).结论 ER β基因多态性与AIS患者易感性无关联.Rr型患者存在初潮延迟现象,可能在AIS的进展中起一定作用.ER β基因多态性与骨量无相关,可能在AIS的低骨量中不起作用.     

双胞胎青少年特发性脊柱侧凸的发病特点

目的 :观察青少年特发性脊柱侧凸(adolescent idiopathic scoliosis,AIS)双胞胎的共同发病率,比较同卵双胞胎之间的发病特点。方法:2007年1月~2016年12月期间我院收录同时患有AIS的双胞胎患者21对,其中女19对(含三胞胎1例),男2对,记录其初诊年龄、女性月经初潮年龄、BMI、Cobb角、胸椎后凸角、腰椎前凸角、Risser征等资料。通过短串联重复序列检测明确区分同卵双胞胎与异卵双胞胎,比较同卵双胞胎和异卵双胞胎的AIS共同发病率。选取同卵双胞胎中两人Cobb角差值≥10°的病例,将其中度数大者纳入侧凸较大组,度数小者纳入侧凸较小组,采用配对样本t检验比较两组之间初潮年龄、BMI、Risser征临床资料的差异。结果:21对双胞胎平均初诊年龄13.2±2.5岁,女性月经初潮年龄12.2±1.4岁,初诊时平均Cobb角29.2°±14.8°,胸椎后凸角16.8°±9.2°,腰椎前凸角45.5°±7.4°,BMI 17.0±1.6kg/m2,Risser征2.3±1.6。21对双胞胎中同卵双胞胎17对,异卵双胞胎4对。同卵双胞胎中16对(94.1%)共同患有AIS,11对(68.8%)弯型一致,4对(25.0%)Cobb角差值小于10°。异卵双胞胎中3对(75.0%)共同患有AIS,1对(33.3%)弯型一致,1对(33.3%)Cobb角差值小于10°。同卵双胞胎中Cobb角差值≥10°者12对,侧凸较大组的月经初潮年龄和BMI均小于侧凸较小组(P0.05),Risser征两组之间无统计学差异(P0.05)。结论 :同卵双胞胎AIS患者共同发病率较高(94.1%)且弯型一致,但同卵双胞胎两者间畸形严重程度不一,双胞胎中畸形较重者的月经初潮年龄较小、BMI较低。     

体重、体重指数、腰围、腰臀比对绝经后2型糖尿病患者骨密度的影响

目的 探讨体重、体重指数(body mass index,BMI)、腰围、腰臀比等指标对绝经后2型糖尿病患者骨密度的影响.方法 采用双能X线骨密度仪测量162例绝经后2型糖尿病患者不同部位的骨密度,按年龄分两组(A组:＜60岁;B组:≥60岁),同一年龄段按体重指数各分为两组(L-BMI组:BMI＜25 kg/m~2;H-BMI组:BMI≥25 kg/m~2)进行分析.结果 H-BMI组多部位骨密度明显高于L-BMI组(P＜0.05或P＜0.01).年龄与骨密度呈负相关,体重与骨密度呈正相关.结论 体重及体重指数均与骨密度相关,其中体重是影响绝经后妇女骨密度的重要因素.     

青少年特发性脊柱侧凸青春期生长发育形态学特征

目的探讨青少年特发性脊柱侧凸(adolescentidiopathicscoliosis,AIS)患儿青春期生长发育的形态学特征。方法对256例12～16岁(平均14.1岁)AIS女性患儿及462例12～16岁(平均14.3岁)健康非侧凸女孩的大体形态学资料进行分析。AIS诊断标准为冠状面上>10°的脊柱侧凸畸形。观测指标包括身高、坐高、臂长及月经状况。采用Bjure公式计算校正身高及校正坐高。AIS组及对照组的各项指标进行比较分析。结果AIS组与对照组的年龄构成比较,差异无统计学意义(P>0.05)。从研究群体看,AIS组的身高、坐高以及臂长与对照组比较,差异无统计学意义(P>0.05),但校正身高、校正坐高显著高于对照组(P<0.01),且月经来潮早于对照组(P<0.01)。从各年龄组看,12岁时,AIS组的校正身高、校正坐高、臂长与对照组相比差异无统计学意义(P>0.05),甚至AIS组校正前平均身高低于对照组。13～15岁,AIS组的校正身高、校正坐高、臂长显著高于对照组(P<0.01)。16岁时,虽然AIS组的校正身高及校正坐高略高于对照组(P<0.05),但身高、坐高以及臂长与对照组比较差异无统计学意义(P>0.05)。结论AIS患儿青春期生长发育存在形态学的异常,这可能与其发病机制有关。     

青少年特发性脊柱侧凸女性患者瘦素基因启动子区-2548G/A基因多态性研究

目的:探讨瘦素基因启动子区-2548G/A(rs7799039)基因多态性与女性青少年特发性脊柱侧凸(adolescent idiopathic scoliosis,AIS)发生发展、异常生长模式及侧凸类型之间的相关性。方法:收集451例AIS女性患者及335例正常同龄女性青少年的静脉血标本,采用PCR-RFLP方法对两组的瘦素基因启动子区-2548G/A(rs7799039)多态性位点进行基因分型,比较两组间基因分型的差异,分析AIS组中基因分型与患者Cobb角和人体测量学指标的关系。结果:AIS组rs7799039位点基因型和等位基因频率与正常对照组之间无明显差异;在AIS组内,rs7799039位点不同基因型所对应的初诊Cobb角、校正身高、BMI、月经初潮年龄及Risser征均没有显著性差异;rs7799039位点等位基因多态性分布情况在不同侧凸类型AIS患者和对照组之间无统计学差异。结论:瘦素基因启动子区-2548G/A(rs7799039)基因多态性与女性AIS的发生发展、异常生长模式及不同侧凸类型之间都没有明显的相关性。     

青少年特发性脊柱侧凸交感神经系统活性左右侧对称性的观察

目的:探讨交感神经系统(sympathetic nervous system,SNS)活性在AIS病因学中可能存在的作用.方法:前瞻性研究.纳入68例右胸弯AIS女性患者为观察对象,年龄11～18岁,平均14.2±2.4岁;主弯Cobb角1 1°～64°,平均37.2°±13.5°.选取5例青少年先天性脊柱侧凸(CS)女性患者和28例正常年轻女性作为对照,CS患者年龄12～18岁,平均14.7±3.1岁;正常年轻女性11～22岁,平均17.9±4.0岁.采用交感神经皮肤反应(sympathetic skin response,SSR)评估3组的SNS活性,以上下肢潜伏期和振幅右侧/左侧的比值作为评估指标.组间及组内比较采用独立样本t检验,P＜0.05为差异有统计学意义.结果:正常年轻女性组中,上下肢潜伏期和振幅右/左比值在正常青少年(13.6±2.8岁,11～17岁)和年轻女性(20.7± 1.2岁,19～22岁)间无显著性差异(P＞0.05).女性AIS患者上肢潜伏期右侧/左侧比值(1.01±0.05)显著性大于正常年轻女性(0.98±0.04,P=0.036),上肢振幅、下肢潜伏期和下肢振幅右侧/左侧比值在女性AIS患者与正常年轻女性间无显著性差异(P＞0.05).CS患者上、下肢潜伏期和振幅的右侧/左侧比值与正常年轻女性间无显著性差异(P＞0.05);女性AIS患者上、下肢潜伏期和振幅右侧/左侧比值在小角度(＜40°)和大角度(≥40°)间亦无显著性差异(P＞0.05).结论:女性AIS患者身体两侧SNS活性存在不对称性,其可能与发病有关,但是与侧凸的严重程度无显著相关性.     

低角度青少年特发性脊柱侧凸女性患者的骨密度分析

目的分析低角度青少年特发性脊柱侧凸(adolescent idiopathic scoliosis,AIS)女性患者的骨密度(BMD)和骨矿含量(BMC),探讨其与年龄、生长发育、人体测量学和侧凸角度等的相关性。方法研究对象为218例Cobb角15～40°的女性AIS患者。运用双能X线骨密度吸收仪测定非优势侧股骨颈和腰椎的BMC/BMD。探讨这两个部位的BMC/BMD与患者的年龄、生长发育、人体测量学和侧凸角度等的相关性。结果所有患者的年龄平均为(13.4±1.4)岁,Cobb角平均为(28.3±6.2)°。股骨颈BMD平均为(0.827±0.103)g/cm2,腰椎BMD平均为(0.887±0.124)g/cm2,显著低于同龄健康女性儿童;股骨颈BMC平均为(3.49±0.56)g,腰椎BMC平均为(29.78±7.37)g。患者的BMC/BMD与Cobb角无显著相关,而与体重、身高、Risser征、月经状况、BMI和年龄显著相关。逐步回归分析显示,体重和年龄是影响患者BMD的主要因素。结论低角度女性AIS患者存在全身性的骨量减低,且与Cobb角无显著相关,而与生长发育和人体测量学相关指标显著相关。这提示AIS患者的骨量减低与生长发育和低体重有关。     

Lack of association between suppressor of cytokine signaling-3 gene polymorphism and susceptibility and curve severity of adolescent idiopathic scoliosis

Purpose

To explore whether the suppressor of cytokine signaling-3 (SOCS3) gene polymorphisms are associated with the susceptibility and abnormal growth pattern of adolescent idiopathic scoliosis (AIS).

Methods

Three hundred and ninety eight AIS girls aged 10–18 years old were enrolled, and 367 age-matched healthy girls were recruited as controls. Only patients who had Cobb angles larger than 20º were included in this study. Anthropometric parameters including body weight, height, and body mass index (BMI) were measured for AIS girls. Rs4969198 was selected as tagSNP to cover all of the related polymorphisms on SOCS3. Genotyping was performed using PCR-based Invader assay with the probe sets designed and synthesized by third wave. The genotyping results were read with an ABI PRISM7900HT sequence detection system (Applied Biosystems, Foster City, CA). A subgroup of 322 skeletally mature AIS patients who did not received bracing or any other conservative treatment previously were analyzed to define the contribution of rs4969168 on curve severity, body height, body weight, and BMI.

Results

Rs4969198 was successfully genotyped. No significant difference of genotype frequencies from the Hardy–Weinberg equilibrium (HWE) test was noted for the AIS patients or the normal controls. Neither the genotype nor the allele frequencies of rs49691968 were significantly different between the AIS patients and the normal controls. Rs4969168 was not found to be associated with age, curve severity of scoliosis, and body height. AIS patients with AA genotype had significantly higher body weight and BMI than the patients with AG and GG genotype (P = 0.014).

Conclusions

The SOCS3 gene polymorphisms are not associated with the occurrence of AIS, but the gene polymorphism (rs4969168) is associated with abnormal growth pattern of AIS, indicating that SOCS3 gene might be a disease-modifying gene of AIS.     

Generalized low bone mass of girls with adolescent idiopathic scoliosis is related to inadequate calcium intake and weight bearing physical activity in peripubertal period

Generalized low bone mass has been well documented in patients with adolescent idiopathic scoliosis (AIS). However, studies linking calcium-intake (CA), weight-bearing physical-activity (PA) and bone mass of AIS are lacking. We aimed to study the relationship between CA, PA and bone mass in AIS girls and compared to those of healthy non-AIS controls during the peripubertal period. Newly diagnosed AIS girls (n=596) aged 11–16 years with Cobb angle 10° were recruited to compare with age-matched healthy girls (n=302) in a cross-sectional study. Anthropometric parameters, pubertal status, CA and PA were assessed. Areal bone mass of lumbar spine and femoral neck, and volumetric bone mass of distal radius and tibia were determined by dual-energy X-ray absorptiometry and peripheral quantitative computed tomography, respectively. The results showed that weight and body mass index (BMI) of AIS were lower than the controls (P<0.05). Corrected height and arm span of AIS were longer than those of controls from 13 years onwards (P<0.02). Median CA of AIS was <410 mg/day across the ages and did not differ from the controls (P=0.063). Median PA of AIS (1.6 h/day) was lower than the controls (1.8 h/day) (P=0.025). Bone mass of AIS was on average 6.5% lower than controls across the ages (P<0.05). CA and PA were significantly correlated with bone mass of AIS (P<0.04). Multivariate analysis showed that AIS in girls was associated with lower bone mass, and that both CA and PA were independent predictors of bone mass in AIS. In conclusion, AIS girls were found to have lower body weight and BMI, longer segmental lengths and generalized low bone mass. Inadequate calcium intake and weight-bearing physical activity were significantly associated with low bone mass in AIS girls during the peripubertal period. The importance of preventing generalized osteopenia in the control of AIS progression during the peribubertal period warrants further study.     

Abnormal skeletal growth patterns in adolescent idiopathic scoliosis-a longitudinal study until skeletal maturity

STUDY DESIGN.: A cross-sectional and prospective longitudinal study on the anthropometric parameters and growth pattern of girls with adolescent idiopathic scoliosis (AIS). OBJECTIVE.: To investigate the growth pattern of girls with AIS with different severities, using cross-sectional and prospective longitudinal data set in comparison with age-matched healthy controls. SUMMARY OF BACKGROUND DATA.: AIS occurs in children during their pubertal growth spurt. Although there is no clear consensus on the difference in body height between girls with AIS and healthy controls, it is generally thought that the development and curve progression in girls with AIS is closely associated with their growth rate. There is no concrete prospective longitudinal study to document clearly the growth pattern and growth rate of subjects with AIS . METHODS.: A total of 611 girls with AIS and 296 healthy age-matched controls were included in the study and among them, 194 girls with AIS and 116 healthy controls were followed up until skeletal maturity. The girls with AIS were grouped into moderate (AIS20) and severe curve (AIS40) groups on the basis of maximum curve magnitude at skeletal maturity. Clinical data and detailed anthropometric parameters were recorded. In the cross-sectional analysis, the groups of subjects were compared within different age groups (from the age of 12-16 yr). In the longitudinal study, linear mixed modeling with respect to age or years since menarche was employed to formulate the growth trajectory of different anthropometric parameters. RESULTS.: In the cross-sectional analysis, the girls with AIS were generally taller, with longer arm span and lower body mass index than the healthy controls. The girls with AIS40 were found to be significantly shorter in height (P = 0.006) and arm span (P = 0.025) at the age of 12 years but caught up and overtook the control group at the age of 14 to 16 years. In the longitudinal study, the average growth rate of arm span in girls with AIS40 was significantly higher than that in girls with AIS20 (> 30%) (P = 0.004) and controls (> 70%) (P = 0.0004). The age of menarche of girls with AIS40 was significantly delayed by 5.9 months and 3.8 months when compared with the control group and girls with AIS20, respectively (P < 0.05). CONCLUSION.: The growth patterns of girls with AIS with confirmed curve severities were significantly different from healthy age-matched controls. Girls with severe AIS had delayed menarche with faster skeletal growth rate during the age of 12 to 16 years. Monitoring the rate of change of arm span of girls with AIS could be an important additional clinical parameter in helping predict curve severity in girls with AIS.     

女性青少年特发性脊柱侧凸患者维生素D受体基因多态性与低骨量的相关性研究

目的 检测青少年特发性脊柱侧凸(AIS)女性患者与对照组维生素D受体(VDR)基因型分布情况并比较AIS患者组内不同基因型的骨密度值,探讨VDR基因多态性与AIS患者低骨量之间的关系.方法 对2004年4月至2007年10月门诊就诊的146例AIS女性患者进行人体形态学测量,记录其年龄、身高、体重、Cobb角等指标,应用双能X线骨密度吸收仪测定其腰椎和股骨近端的骨密度,并收集其静脉血标本.经体检收集146名健康女性青少年静脉血标本作为对照.应用聚合酶链反应-限制性片段长度多态性技术(PCR-RFLP)检测分析AIS组及对照组VDR基因型,比较两组间基因型分布情况和AIS组内各基因型间的骨密度差异.结果 AIS组Bb基因型频率明显高于对照组,但AIS组内的各基因型骨密度之间并无差异.结论 VDR基因多态性并不影响VDR介导的骨量吸收与积累.     

金属蛋白酶组织抑制剂-2基因多态性与青少年特发性胸椎侧凸的相关研究

目的 探讨金属蛋白酶组织抑制剂-2(TIMP-2)启动子区基因多态性与青少年特发性胸椎侧凸疾病易感性和严重程度的相关性.方法 研究对象为2007年1月至2009年3月诊治的354例女性胸弯型青少年特发性脊柱侧凸(AIS)患者(AIS组)和2005年3月至2006年6月210名健康体检女性青少年(对照组).选取TIMP-2基因启动子区418G.C(rs8179090)单核苷酸多态性位点,采用聚合酶链反应一限制性片段长度多态性(PCR-RFLP)的方法对这该位点进行基因分型.比较不同基因型在AIS组与对照组之间的分布差异,并分析基因多态性与临床表型的相关性.结果 rs8179090多态性位点的等位基因及基因型分布在两组中差异无统计学意义(P>0.05).AIS组中,体质量指数(BMI)<17 kg.m~2或主弯cobb角≥40°的患者中c等位基因的比例分别显著高于BMI≥17 kg.m~2或主弯cobb角<40°者(P<0.05).已经达到骨骼成熟且自然史未受干扰的患者中,GC型和CC型患者的主弯Cobb角平均值显著大于GG型患者(卢<0.05).结论 TIMP-2基因启动子区-418G.C(rs8179090)多态性位点与女性胸弯型AIS患者青春期异常生长模式和侧凸进展有关,TIMP-2基因是胸弯型AIS的疾病修饰基因.     

北京青春期女孩低体重及其对健康影响的研究

目的：调查青春期女孩低体重率并探讨适合我国青春期女孩体重指数（BMI）的评价标准。方法：对1214名北京城乡12-13岁女学生1995年营养状况调查的样本资料进行分析,指标包括年龄、身高、体重、BMI、骨龄、月经初潮、第二性征发育、左前臂远端1/3和1/10位点桡尺骨骨矿含量、骨密度、骨宽度。BMI评价采用改良的我国卫生部和国家教委标准及世界卫生组织推荐标准。结果：低体重率（BMI＜18)为32.2%,低体重组比正常体重组生长发育指标明显滞后,尺骨远端1/3位点骨矿含量（BMC）低于平均水平的危险性增加（Odds值1.75,95%可信可间为1.04-2.95）75%。结论：高的低体重率是北京青春期女孩的主要营养健康问题,BMI＜18可作为生长发育滞后和具有低骨密度危险的分界点,月经初潮可作为营养状况的监测指标。对低体重女孩应采取营养等干预措施,以促进其生长发育和骨骼健康。     

女性青少年特发性脊柱侧凸患者自我形象评估的相关影响因素分析

目的:探讨女性青少年特发性脊柱侧凸(adolescent idiopathic scoliosis,AIS)患者自我形象评估的影响因素。方法:回顾性分析2010年9月～2011年3月在我院就诊的252例女性AIS患者,年龄12～18岁,平均14.5±1.8岁。均摄取患者站立位全脊柱正侧位X线片,并独立填写一份简体中文版SRS-22问卷。在站立位全脊柱正侧位X线片上测量Cobb角、顶椎旋转度、胸椎后凸角、腰椎前凸角、脊柱冠状面力线偏移及脊柱矢状面力线偏移等参数。采用相关分析研究各临床指标与自我形象评分的相关性。结果:患者平均Cobb角35.5°±12.8°;平均顶椎旋转度2.0°±0.7°;平均胸椎后凸角16.2°±9.0°;平均腰椎前凸角51.3°±9.8°;平均脊柱冠状面力线偏移1.2±0.7cm;平均脊柱矢状面力线偏移2.4±1.5cm;平均体重指数18.3±2.2;平均自我形象评分16.7±2.8分。胸弯和胸腰弯/腰弯的自我形象评分均与主弯Cobb角有相关性(r分别为-0.171,-0.225,P均<0.05);其中大角度胸弯组呈显著相关(r=-0.484,P=0.005)。而其他参数与患者自我形象评估均无明显相关性(P均>0.05)。结论:女性AIS患者的自我形象主要受主弯Cobb角的影响,其中大角度胸弯患者的自我形象受主弯Cobb角的影响最大。