显微手术治疗小脑海绵状血管瘤8例临床分析

目的总结小脑海绵状血管瘤的临床特征和显微手术治疗的效果。方法回顾分析淮南朝阳医院2007年7月—2014年5月经显微外科手术治疗且病理证实小脑海绵状血管瘤8例患者的临床资料,并对显微手术方式进行分析。结果本组患者急性起病7例,亚急性起病1例。所有患者临床表现均以头痛、头晕、小脑受损体征为主,其中伴有眼颤2例、癫痫1例。所有患者均行CT和MR检查,病灶位于小脑半球,均为单发病灶。其中,2例怀疑合并静脉畸形,术前行全脑血管造影,发现合并有静脉畸形1例。根据Zabramski分类,Ⅰ型2例、Ⅱ型6例。8例患者均采用常规枕下入路显微手术治疗,完整切除病灶,术后病理证实海绵状血管瘤;术后随访6~36个月,平均18.5个月,无再发及出血,疗效满意。结论小脑海绵状血管瘤常急性起病,以头痛和小脑症状为主;MR血管成像对小脑海绵状血管瘤的诊断具有较高的特异性和敏感性;显微手术治疗小脑海绵状血管瘤安全、有效。     

皮层脑电图在单发性海绵状血管瘤手术中的运用

目的:探讨术中应用皮层脑电图(ECoG)监测对提高有癫痫史的海绵状血管瘤手术疗效的作用. 方法:对ECoG监测下显微手术治疗的71例有癫痫病史的单发性海绵状血管瘤病例的临床资料进行回顾性分析.结果:71例患者均在ECoG监测下行显微手术,切除病灶及局部癫痫灶;随访58例,其中42例无癫痫发作,13例发作减少90%以上,3例效果不佳. 结论:海绵状血管瘤伴有癫痫发作者药物治疗效果不佳,应早期行外科手术治疗.术中ECoG监测对指导手术切除癫痫灶,减少术后癫痫的发作有较大帮助.     

超声引导电生理监测下手术治疗儿童海绵状血管瘤继发癫痫6例

目的探讨术中超声引导及神经电生理监测对显微手术治疗儿童海绵状血管瘤继发癫痫的指导作用和价值。方法回顾性分析显微手术治疗的6例以癫痫为临床表现的儿童海绵状血管瘤的临床资料。术中采用超声引导及皮层脑电图(ECo G)监测,显微镜下进行海绵状血管瘤全切除及致痫灶切除。结果术后随访2年以上,癫痫无发作,无神经功能障碍。结论术中超声引导及ECo G监测可精确定位海绵状血管瘤病灶及指导致痫灶切除范围,起到了既指导手术入路、减少脑组织损伤,又提高海绵状血管瘤全切率及癫痫治愈率的作用,值得临床推广。     

脑干海绵状血管瘤的显微外科手术治疗

目的：评价显微神经外科手术切除脑干海绵状血管瘤的疗效。方法：对新疆医科大学第一附属医院神经外科1999年-2005年所进行的6例脑干海绵状血管瘤（6个病灶）的手术情况进行回顾性分析,女性2例,男性4例,3个病灶位于桥脑,2个病灶位于中脑,1个病灶位于桥脑中脑结合部。通过Karnofsky评分对患者手术前后的生活质量进行评分,并分别对患者的手术前后的运动功能,感觉功能,颅神经功能分别进行评价。结果：6个病灶全部切除,对5例病人进行随访,1例死亡,随访时间10—86个月（平均34个月）均未见脑干海绵状血管瘤再出血,通过手术前后的Kamofsky评分5例病人手术后生活质量明显提高,1例无明显变化,1例手术后两天死亡,手术后运动系统损害的改善明显,感觉系统和颅神经的改善不明显。结论：1．手术切除脑干海绵状血管瘤可以预防海绵状血管瘤的再出血。2．手术治疗脑干海绵状血管瘤不加重神经功能的损害。     

56例颅内海绵状血管瘤伴癫痫手术疗效分析

目的 探讨颅内海绵状血管瘤伴癫痫的手术疗效.方法 回顾性分析2012年1月至2015年1月期间56例颅内海绵状血管瘤导致癫痫发作的患者,根据患者病史、动态-视频脑电图、影像学、功能区评估特点按照癫痫手术切除方式治疗,根据Engel评分,评价手术疗效.结果 13例患者术后早期出现发热、头痛并发症,3例早期轻偏瘫,均无远期并发症和后遗症发生.术后随访1～3年,43例患者Engel评分Ⅰ级,11例评分Ⅱ级,2例Ⅲ级.结论 颅内海绵状血管瘤伴有癫痫患者按照癫痫外科手术方式均可达到明显的控制癫痫发作效果.     

脑海绵状血管瘤的诊断与手术治疗

目的：探讨脑海绵状血管瘤的诊断,观察手术治疗脑海绵状血管瘤的疗效。方法：回顾2000~2010年诊断为脑海绵状血管瘤并手术治疗的21例患者的临床资料,对癫痫、局部神经功能障碍改善进行观察。结果：21例病灶完全切除,无死亡、无严重并发症。术前局部神经功能障碍5例,术后改善4例,1例无变化,无加重者。癫痫发作观察：术前有癫痫发作者16例,13例术后再无发作并停药,3例术后偶有发作,继续服药后再未发作。结论：MRI检查对诊断脑海绵状血管瘤具有较高的特异性,对反复出血或继发癫痫患者手术治疗效果满意。     

脑海绵状血管瘤的诊断与伽玛刀治疗

目的：探讨脑海绵状血管瘤的诊断,观察伽玛刀治疗脑海绵状血管瘤的临床效果,总结伽玛刀治疗的适应证。方法：回顾2002年1月～2008年12月诊断为脑海绵状血管瘤并实施伽玛刀治疗的49例患者的临床资料,对癫痫、出血的控制、病灶的变化及局部神经功能障碍的改善进行观察和评估。结果：随访时间3个月～7年。局部神经功能障碍观察：治疗前12例有锥体束征,治疗后8例恢复,4例无变化。癫痫发作观察：治疗前发作者25例,21例治疗后半年无发作而停药,停药后无发作。4例治疗后半年停药,偶有发作。CT及MRI复查：治疗后3～36个月,复查1～3次。病灶消失1例,缩小34例,14例无变化。其中3例灶周水肿、1例水肿伴灶内出血加重,经治疗逐渐好转。结论：MRI检查对诊断脑海绵状血管瘤具有较高的特异性,对病灶位于难以手术的部位,多发灶难以一次切除,病人难以承受手术或不接受手术且症状显著者,伽玛刀是一种安全可选择的治疗方法,对降低出血率、癫痫及病灶控制、改善症状是有效的。     

伽玛刀治疗颅内脑外型海绵状血管瘤的临床分析

目的探讨伽玛刀治疗颅内脑外型海绵状血管瘤的临床疗效,并总结伽玛刀治疗经验。方法收集2002年5月至2009年5月位于海绵窦旁颅内脑外海绵状血管瘤6例,采用直接伽玛刀治疗4例,开颅手术切除后伽玛刀治疗2例,平均有效照射剂量为12.9(11～16)Gy,视神经接受剂量均小于9.0 Gy(2.4～9.0 Gy)。全部病例随访6个月至9年。结果治疗后5例症状改善,1例仍有复视。MRI显示病灶消失1例,缩小4例,无变化1例。结论对病灶难以手术或难以耐受手术的颅内脑外型海绵状血管瘤,伽玛刀治疗是一种安全有效的治疗方法。     

Gamma knife in treatment of extracerebral cavernous hemangiomas

目的 探讨伽玛刀治疗颅内脑外型海绵状血管瘤的临床疗效,并总结伽玛刀治疗经验.方法 收集2002年5月至2009年5月位于海绵窦旁颅内脑外海绵状血管瘤6例,采用直接伽玛刀治疗4例,开颅手术切除后伽玛刀治疗2例,平均有效照射剂量为12.9(11～16)Gy,视神经接受剂量均小于9.0 Gy(2.4～9.0 Gy).全部病例随访6个月至9年.结果 治疗后5例症状改善,1例仍有复视.MRI显示病灶消失1例,缩小4例,无变化1例.结论 对病灶难以手术或难以耐受手术的颅内脑外型海绵状血管瘤,伽玛刀治疗是一种安全有效的治疗方法.     

脑干海绵状血管瘤的显微手术治疗

目的:探讨显微外科手术不同入路治疗脑干海绵状血管瘤的临床途径和疗效。方法:选取我院10例脑干海绵状血管瘤患者,并根据其病灶的不同部位分别采用不同手术入路行显微外科手术治疗,观察其临床疗效。结果:本组10例脑干海绵状血管瘤全切7例,次全切除2例,大部切除1例;术后随访6～24个月均获良好预后,脑干血管瘤原发临床症状如头痛、呕吐、肿瘤压迫症状、共济失调、偏瘫、吞咽困难等基本消失,除1例延髓海绵状血管瘤患者术后出现呼吸困难新症状,余大部分患者均能够进行正常的学习和工作,未见手术后致残、生活不能自理等后遗症的发生;手术前后的生活质量评分具有显著性差异(P<0.05)。结论:显微外科手术治疗脑干海绵状血管瘤应根据患者病灶的不同部位选择不同手术入路,能显著提高显微外科手术的临床疗效,改善患者预后,提高患者术后生活质量。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.