43例淋巴母细胞淋巴瘤患者临床特点及疗效分析

Objective To investigate the clinical features and treatment outcomes of different regimens in Chinese patients with lymphoblastic lymphoma(LBL). Methods Forty-three patients with LBL were retrospectively analysed, of which 30 were T-LBL, and 13 B-LBL. Results ①Most patients were young men with a median age of 21, and 63.0％ of the T-LBL patients had mediastinal masses. ② Treatment outcome could be assessed in 37 cases, of which the response rate (RR) was 81.1％ and complete remission (CR) rate was 67.6％. The RR and CR rates in patients treated with regimens for ALL (ALL-like group) and those treated with regimens for NHL(NHL-like group) were 94.4％ , 68.4％ and 83.3％ , 52.6％ , respectively. ③The estimated median overal survival(OS) and progression free survival (PFS) of hematopoietic stem cell transplantation (HSCT) group were significant longer than those of ALL-like group(P =0.018, P=0.025) and NHL-like group(P = 0. 016, P = 0. 011). The OS at 5 years in NHL-like group, ALL-like group and HSCT group were (14.4 ± 9.4) ％ , (20.2 ± 12.7) ％ and (79.5 ± 13.1) ％, respectively. Conclusion ①LBL is more common in young men, with less involvement of peripheral blood. Compared with B-LBL, T-LBL often has a mediastinal mass and serious cavity effusion. ② Intensive treatment regimens for ALL should be used in LBL. HSCT at CR1 can improve outcome obviously.     

神经原性膀胱误诊误治原因分析

目的:分析神经原性膀胱误诊原因并提出防范对策。方法:对我院2004~2006年误诊的3例神经原性膀胱临床资料进行回顾性分析。结果:3例中2例因肾功能损害就诊,1例因反复尿路感染就诊,均存在多次误诊史,后经膀胱造影及尿动力学检查确诊,并明确病因。结论:神经原性膀胱病因复杂,对其缺乏足够认识是导致误诊的关键所在。应加强神经系统疾病的学习,提高对该病的认识,减少误诊率。     

薏苡仁饮片、水煎液、配方颗粒的HPLC指纹图谱相关性研究

摘要：目的:对薏苡仁饮片、水煎液、配方颗粒的HPLC指纹图谱进行研究,比较其相关性和差异性。方法:采用HPLC-ELSD法测定薏苡仁饮片、水煎液、配方颗粒的指纹图谱,建立三者指纹图谱共有模式,并进行相似度分析。采用皮尔逊相关性分析、聚类分析（CA）、主成分分析（PCA）及正交偏最小二乘判别分析（OPLS-DA）评价三者HPLC指纹图谱的相关性。结果:薏苡仁饮片、水煎液、配方颗粒的HPLC指纹图谱中均确定了8个特征峰,并指认了7个峰;13批薏苡仁饮片、水煎液、配方颗粒指纹图谱与相应对照指纹图谱的相似度均大于0.95,三者对照指纹图谱的相似度均大于0.99。皮尔逊相关性分析结果显示,峰6在薏苡仁饮片、水煎液、配方颗粒之间均不存在显著相关关系。CA和PCA结果显示,薏苡仁水煎液与配方颗粒的关系更为紧密,差异较小。OPLS-DA筛选出3种成分是造成不同批次薏苡仁样品指纹图谱差异性的主要标记物。结论:薏苡仁饮片、水煎液、配方颗粒的主要化学成分组成具有一致性,可为薏苡仁配方颗粒生产过程质量控制及成品质量标准制定提供参考。     

重度妊高征子痫25例临床分析

子痫是妊娠高血压综合征发展的阶段，也是围产期母婴死亡的主要原因，我院2002年3月-2004年3月共收住孕妇2217例，其中子痫病人25例，占1．13%，现将25例子痫病人的临床资料分析如下。     

应用大网膜治疗膀胱阴道瘘1例报告

临床资料患者女性，31岁，于12年及8年前分别两次行剖宫产术，于第2次剖宫产术后并发膀胱阴道瘘，并于术后3月行经阴道修补术，术后仍漏尿。但于术后半年左右尿瘘逐渐自行消失。此次入院前2月无原因感下腹痛、腰痛，并发热、畏寒、排尿不适等症。在当地经保守治疗无好转转入本院。入院后检查阴道前壁触及1直径约2cm之瘘口。瘘口处触及1巨大膀胱结石。行IVP示膀胱巨大阳性结石，双肾及输尿管积水。入院后诊断为膀胱巨大结石并膀胱阴道瘘，考虑患者既往有经阴道修补失败病史，并且膀胱巨大结石长期压迫瘘口，上尿路梗阻并感染，瘘管周围组织炎性水肿、血供不良，不能经阴道修补，因而决定行经腹应用大网膜填塞修补术，     

经尿道内切开术治疗尿道狭窄及膀胱颈口挛缩的新进展

泌尿外科下尿路梗阻疾病中,外伤性尿道狭窄及膀胱颈口挛缩患者不在少数,此外,尿道炎性狭窄病例也较常见。上述疾病在男性下尿路梗阻疾病病因中仅次于老年性前列腺增生症。治疗方面基本上均需行手术方能取得较好疗效,以往多采用开放手术或经尿道冷刀内切开术治疗。近年来由于新技术的不断开展应用,上述疾病的治疗也有了极大的改进。回顾性总结我院近2年来治疗上述疾病28例,报道如下。