320排CT冠状动脉成像与经导管冠状动脉造影诊断冠脉狭窄的对比分析

目的 通过对比320排CT冠状动脉成像术（CTA）与经导管冠状动脉造影（CAG）的结果,探讨其评估冠脉狭窄性病变的价值.方法 搜集100例患者的320排CTA的完整资料,以冠状动脉造影（CAG）的结果作为金标准进行对比,评价冠状动脉不同节段病变诊断的一致性及对冠脉狭窄程度诊断的差异性.结果 100例患者中冠状动脉直径≥2mm共有1 423个节段,在CTA检查中能够满足诊断要求的共有1 269个节段.320排CTA显示轻度狭窄（管腔内径减少＜50％）的敏感性、特异性、阳性预测值、阴性预测值分别为97.1％、84.4％、59.3％、94.4％,中度狭窄组（≥50％）的敏感性、特异性、阳性预测值、阴性预测值分别为87.4％、94.6％、75.2％、84.6％,重度狭窄组（≥75％）的敏感性、特异性、阳性预测值、阴性预测值分别为79.7％、83.6％、82.9％、92.8％,与CAG结果对比,320排CTA对轻、中度狭窄的敏感性、特异性的评价均较高.结论 320排冠状动脉成像术是诊断冠心病的一种安全、可靠的检查方法,对冠脉轻中度狭窄的敏感性高于CAG,对中重度狭窄的特异性较高.     

非增强、自由呼吸、3D-TFE-WH序列冠状动脉成像与CTA的对比研究

目的 评价非增强、自由呼吸、3D-TFE-WH序列对冠状动脉各节段图像质量及管腔狭窄的显示能力。 方法 招募10例志愿者为研究对象,于同日依次接受冠状动脉磁共振血管造影（magnetic resonance angiography,MRA）检查和CT血管造影（CT angiography,CTA）检查。分段评价MRA检查及CTA检查图像质量,并以冠状动脉CTA作为标准,评价冠状动脉MRA显示管腔狭窄的能力。 结果 10例志愿者冠状动脉血管共90段,冠状动脉MRA检查血管满足诊断要求83段（92.2%）,CTA检查血管满足诊断要求90段（100.0%）。2种检查方法显示近中段血管图像质量差异无统计学意义（P＞0.05）,MRA检查左前降支远段、左回旋支远段、右冠状动脉远段图像质量评分低于CTA检查（P＜0.05）。MRA显示管腔狭窄6段,轻微狭窄2段,轻度狭窄4段。CTA显示管腔狭窄8段,轻微狭窄6段,轻度狭窄2段。以CTA检查为标准,MRA检查高估狭窄4段,低估狭窄5段。有2段CTA检查显示轻微狭窄MRA不能评价。2种检查方法显示管腔狭窄能力的一致性为中等（Kappa值=0.656）。 结论 非增强、自由呼吸、3D-TFE-WH序列对冠状动脉近中段图像质量及轻度以上管腔狭窄的显示能力与CTA相仿。此技术可作为造影剂禁忌人群进行冠状动脉疾病筛查的手段。     

Single coronary artery anomaly: the left main coronary artery originating from the proximal segment of right coronary artery

This case report we presented is that the anomalous left main coronary artery (LMCA) originates from the proximal segment of right coronary artery. In order to confirm the origin and course of the anomalous LMCA, a multi-slice computed tomography (MSCT) of the heart was performed on a 64-slice machine (Philips 64 Slice, Philips, USA) after 6 months of coronary angiography operation. The results showed that the anomalous LMCA originates from the proximal segment of right coronary artery, lies posteriorly to the aorta before taking acute sharply to go between the aorta and left atrium. It was classified as R-II P subtype according to Lipton’s classification. It is a rare case in the clinical practice.

     

多排螺旋CT冠状动脉成像在诊断冠状动脉狭窄中的价值

目的:探讨多排螺旋CT(MSCT)冠状动脉成像(MSCTA)在冠状动脉狭窄的诊断中的临床应用价值.方法:37例临床疑为冠心病的患者同时行MSCTA和传统选择性冠状动脉造影DSA(CAG)检查,以CAG结果为"金标准",将二者进行对照分析,了解MSCTA诊断冠心病的敏感性和特异性.结果:37例患者行CAG检查均能显示冠状动脉的各主支及其各段血管,与其相比,MSCTA检查可显示370段血管中的352段血管,显示率为95.2%.各节段冠脉重建图像中左主干、左前降支近中段和右冠近段显示率最高.经CAG证实,37例患者中确诊为冠心病者26例,冠脉未见明显病变者11例.行MSCTA检查有28例显示冠脉明显狭窄,9例未见冠脉明显病变.MSCTA判断冠状动脉狭窄假阳性者3例,假阴性者1例,敏感性96.2%,特异性72.7%,阳性预测值89.3%,阴性预测值88.9%,符合率91.7%.结论:MSCTA是一种简便易行、安全可靠的无创性检查方法,可作为临床诊断冠心病的有效筛选手段.     

N T-proBNP 在判断 ACS 患者冠状动脉病变程度和短期预后中的价值

目的：通过检测急性冠状动脉综合征（ACS）患者血清 N 端脑钠肽前体（NT-proBNP）的水平变化,观察其对评估ACS 患者冠状动脉病变严重程度和预后的诊断价值。方法选取2013年1月至2014年12月入住南通大学附属医院心内科ACS 患者作为观察对象,其中,不稳定心绞痛患者64例,非 ST 段抬高性心肌梗死患者46例,急性 ST 段抬高性心肌梗死患者22例。将其分为高 NT-proBNP 组（≥474 pg／mL）和低 NT-proBNP 组（＜474 pg ／mL）,心脏超声检测并比较各组患者射血分数;冠状动脉造影术检测两组患者冠状动脉病变情况,血清学检测两组患者心肌肌钙蛋白 I（cTnI）、肌酸激酶同工酶（CK-MB）、C-反应蛋白（CRP）和 NT-proBNP ,计算两组患者平均住院时间和心力衰竭、心源性休克发生率。结果 ACS 患者血清 NT-proBNP 和射血分数呈负相关。高 NT-proBNP 组患者心力衰竭发生率和住院天数明显高于低 NT-proBNP 组;高 NT-proBNP 组在冠状动脉病变支数、冠状动脉狭窄度方面均高于低 NT-proBNP 组;高 NT-proBNP 组 TIMI 血流分级低于低 NT-proBNP 组,差异有统计学意义（P＜0．05）。结论 NT-proBNP 作为判断 ACS 患者冠状动脉病变程度和短期预后的可靠指标值得临床进一步推广。     

Impact of uncontrolled blood pressure on diagnostic accuracy of coronary flow reserve for detecting significant coronary stenosis in hypertensive patients

Background Impaired coronary flow reserve (CFR) in patients with hypertension may be caused by epicardial coronary stenosis or microvascular dysfunction. Antihypertensive treatment has been shown to improve coronary microvascular dysfunction. The aim of this study was to evaluate the impact of uncontrolled blood pressure (BP) on diagnostic accuracy of CFR for detecting significant coronary stenosis.

Methods A total of 98 hypertensive patients scheduled for coronary angiography (CAG) due to chest pain were studied. Of them, 45 patients had uncontrolled BP (defined as the office BP ≥140/90 mmHg (1 mmHg=0.133 kPa) in general hypertensive patients, or ≥130/80 mmHg in hypertensive individuals with diabetes mellitus), and the remaining 53 patients had well-controlled BP. CFR was measured in the left anterior descending coronary artery (LAD) during adenosine triphosphate-induced hyperemia by non-invasive transthoracic Doppler echocardiography (TTDE) within 48 hours prior to CAG. Significant LAD stenosis was defined as >70% luminal narrowing. Diagnostic accuracy of CFR for detecting significant coronary stenosis was analyzed with a receiver operating characteristic analysis.

Results CFR was significantly lower in patients with uncontrolled BP than in those with well-controlled BP (2.1±0.6 vs. 2.6±0.9, P <0.01). Multivariate linear regression analysis of the study showed that the value of CFR was independently associated with the angiographically determined degree of LAD stenosis (β= –0.445, P <0.0001) and the presence of uncontrolled BP (β= –0.272, P=0.014). With a receiver operating characteristic analysis, CFR <2.2 was the optimal cut-off value for detecting LAD stenosis in all hypertensive patients (AUC 0.83, 95%CI 0.75–0.91) with a sensitivity of 75%, a specificity of 78%, and an accuracy of 77%. A significant reduction of diagnostic specificity was observed in patients with uncontrolled BP compared with those with well-controlled BP (67% vs. 93%, P=0.031).

Conclusions CFR measurement by TTDE is valuable in the diagnosis of significant coronary stenosis in hypertensive patients. However, the diagnostic specificity is reduced in patients with uncontrolled BP.

     

急性前壁心肌梗死心电图对左冠状动脉前降支病变的诊断价值

目的探讨心电图在ST段抬高型急性前壁心肌梗死时左冠状动脉前降支(LAD)病变部位的诊断价值。方法对89例经冠状动脉造影证实前降支为梗死相关动脉患者的18导联心电图进行回顾性分析。结果心电图STV2抬高≥3mm、STV3抬高≥2mm、STⅡ,Ⅲ,avF压低≥1mm对前降支近段闭塞的判断有较大的价值,其阳性率与前降支远段闭塞组差异有显著性意义,其诊断的特异性和敏感性均较高。结论ST段抬高型急性前壁心肌梗死时体表心电图与左冠状动脉前降支闭塞部位有明显相关性。     

RT-3DE在评价冠状动脉病变中的价值

目的：应用实时三维超声心动图（RT-3DE）评价左冠状动脉前降支供血的心肌节段的功能状态,探讨对其病变程度的判断价值.方法：103例行择期冠状动脉造影且存在前降支（LAD）狭窄病变的冠心病患者,分为50％≤狭窄＜75％组（A组）53例;狭窄≥75％组（B组）50例.选取同期冠状动脉造影正常者68例为对照组（N组）.均行RT-3DE检查,获取17节段容积-时间曲线,记录LAD支配的心肌节段的平均运动幅度（EA）、收缩期心室运动峰值时间（TS）、舒张末容积（sEDV）、收缩末容积（sESV）,计算节段射血分数（sEF）,并对部分参数进行ROC曲线分析及判别分析.结果：（1）B组左室前壁和前间隔中间段及心尖段EA值、前壁中间段和前间隔心尖段sEDV及sEF、前壁心尖段sESV及sEF均明显小于A组及N组（P＜0.05）,A组与N组之间均无明显差别（P＞0.05）.（2）ROC曲线分析显示前壁心尖段、中间段、前间隔心尖段sEF以及前壁和前间隔的中间段、心尖段EA均对冠脉狭窄有较高诊断价值,其中以前间隔心尖段EA和sEF更佳,前壁心尖段EA取值≤5.67时判断LAD狭窄≥75％的敏感度和特异度最佳,分别达91.27％和91.07％.（3）以前间隔心尖段sEF、EA为自变量建立的判别函数Y=0.461sEF＋0.672EA（P＜0.001）,判别临界值YLAD=0.438,对判断前降支狭窄程度≥75％的敏感性为88.00％,特异性为92.45％,总正确率为90.29％.结论：RT-3DE可准确、定量评价节段心肌运动幅度和收缩功能,推测相应供血冠脉的病变程度,选择适宜参数建立的判别函数可能成为预测冠脉介入治疗的指标.     

16层螺旋CT检测冠状动脉钙化斑块的狭窄程度

目的探讨冠状动脉钙化斑块的影像学特点及其与狭窄程度的关系。方法回顾性分析了20例经16层螺旋CT冠状动脉成像发现钙化斑块并接受冠状动脉造影患者的影像学资料。结果16层螺旋CT冠状动脉成像共发现钙化斑块84个,其中单纯小点钙(直径<0.15cm)16个,局部几乎无狭窄;单纯钙化斑块(直径≥0.15cm)56个,平均直径(0.27±0.09)cm,钙化斑块直径与局部管腔直径之比(C/V值)为0.85±0.33,75%的斑块狭窄程度小于50%,其狭窄程度与斑块直径及C/V值均无显著相关性(P>0.05);含钙化成分的混合斑块12个,其狭窄程度与混合斑块关系较密切。结论大部分钙化斑块表现为轻度狭窄,其狭窄程度与斑块直径无关,含钙化成分的混合斑块狭窄程度与混合斑块特点关系较密切。     

冠状动脉狭窄程度与冠心病危险因素的关系

为探讨不同冠状动脉造影病变程度与冠心病危险因素之间的关系,对1997～2001年间行选择性冠状动脉造影的649例住院患者进行冠心病危险因素分析.结果发现危险因素中高血压病史、糖尿病史、吸烟史、男性及高LDL组中冠状动脉狭窄的百分率均明显高于无危险因素组(P=0.000 1～0.016);冠状动脉造影病变组中年龄高低、高血压病程、糖尿病程、吸烟量、血Glu、SBP、TC、LDL和ApoA1的均值明显高于冠状动脉造影正常组(t=2.423～7.816,P=0.000 1～0.016);高龄、高血压病程、糖尿病程、吸烟量、血Glu、TC与病变冠脉积分、冠脉病变积分及病变支数呈显著正相关性(r=0.093～0.29,P=0.000 1～0.022).Logistic 回归分析显示,高龄(P=0.000 1)、高血压病程(P=0.007)、吸烟量(P=0.000 1)、高LDL(P=0.003)为冠心病的独立危险因素.     

非体外循环冠状动脉搭桥术后新发房颤的影响因素分析

目的:分析非体外循环冠状动脉搭桥(OPCABG)术后新发房颤的影响因素。方法:选取2019年1月—2019年8月择期行OPCABG术患者209例,术后住院期间确诊新发房颤患者36例（新发房颤组）,未新发房颤患者173例（非房颤组）。比较两组患者的临床资料,进一步采用Logistic回归分析OPCABG术后新发房颤的影响因素。结果:新发房颤组右冠状动脉近段狭窄≥75%的比例、主动脉内球囊反搏（IABP）辅助率明显高于非房颤组（均P<0.05）;两组间其他临床资料差异均没有统计学意义（均P>0.05）;采用Logistic回归分析:右冠状动脉近段狭窄≥75%（OR=3.999,95%CI:2.072～19.753,P<0.00１）,IABP辅助率（OR=6.397,95%CI:2.072～19.753,P<0.001）是OPCABG术后新发房颤的影响因素。结论:右冠状动脉近段狭窄≥75%,围术期需要IABP辅助是OPCABG患者术后新发房颤的影响因素。     

心肌桥合并冠状动脉粥样硬化的临床分析

目的探讨心肌桥合并冠状动脉粥样硬化病变的临床特点。方法回顾性分析159例通过冠脉造影术发现心肌桥的患者,对其冠脉病变与临床资料进行分析。结果1200例冠脉造影患者检出心肌桥159例,检出率为13．3％,心肌桥近端冠状动脉粥样硬化病变发生率96．1％,远端发生率3．9％,差异有显著性（P〈0．01）;心肌桥合并冠状动脉固定狭窄组中高血压（59．2％vs39．3％,P=0．01）、糖尿病（22．3％vs10．7％,P=0．04）、男性吸烟（49．5％vs19．6％,P=0．01）刚性率高于无固定狭窄组：HDL—ch（1．07±0．02vs1．22±0．05,P=0．01）、apoA（0．98±0．02vs1．08±0．02,P=0．01）在固定狭窄组低于无固定狭窄组。结论心肌桥可能导致其近端出现冠状动脉粥样硬化,冠心病传统危险因素仍可能是心肌桥患者中合并冠脉粥样硬化的重要原因,低HDL—ch、apoA可能是该人群中合并冠脉固定狭窄的特点。     

速度向量成像技术对冠心病左心室生物力学参数的检测及其在冠状动脉狭窄评估中的应用

目的：应用速度向量成像（VVI）技术检测冠心病（CAD）患者的心肌生物力学参数,评估冠状动脉狭窄程度。方法：将52例经冠状动脉造影检查（CAG）显示至少有一支冠状动脉狭窄的患者分为轻度狭窄组（21例,冠脉狭窄程度均＜75%）和重度狭窄组（31例,至少一支冠状动脉狭窄程度≥75%),选择同期冠脉造影显示无冠脉狭窄正常人20名作为正常对照组,应用VVI检测左室壁整体纵向应变（GLS）、整体圆周应变（GCS）和整体径向应变（GRS）,分析
冠状动脉狭窄心肌生物力学参数改变。结果：冠脉轻度狭窄组和重度狭窄组患者GLS、GRS、GCS的绝对值均较正常对照组下降（P<0.05）,且重度狭窄组整体应变参数下降更显著,与轻度狭窄组比较差异有统计学意义（P<0.05）;纵向应变明显下降节段的分布大体与冠脉造影显示狭窄率≥75%的病变冠脉的心肌灌注区域一致,以GLS的敏感性最高,正常对照组、冠脉轻度狭窄组和重度狭窄组GLS与左室射血分数（LVEF）呈负相关关系（r=－0.
58、－0.51和－0.43,P<0.05）。若以GLS为－16.14%作为截断点评估冠脉重度狭窄并需要施行PTCA治疗的灵敏度为96.8%,特异度为70%;Yuedden指数最高,为0.668。结论：VVI可检出冠心病患者左室应变明显下降,提示冠状动脉出现严重狭窄;可根据应变明显下降节段的分布
推测相应冠脉严重狭窄。
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Value of Acceleration Flow in the Left Anterior Descending Coronary Artery for the Detection of Coronary Artery Stenosis by Transthoracic Coronary Color Doppler Echocardiography

Transthoracic color Doppler echocardiographyhas been widely used to measure the coronary ar-tery flowvelocity reserve[1].It is useful to providei mportant informationfor diagnosis of coronary ar-tery disease and assessment of curative effect afterpercutaneous coronary artery intervention.Butthis evaluats onlythe effect of the stenosis on coro-nary artery flow velocity reserve during maxi malhyperemia reaction.Hemodynamics demonstratesthat localized flow acceleration is present at thestenotic s…     

平板运动试验对冠状动脉狭窄的诊断价值

目的：探讨平板运动试验对冠状动脉（冠脉）狭窄程度及范围的诊断价值。方法：98例胸痛患者平板运动试验结果与冠脉造影结果作对照分析。结果：平板运动试验诊断冠心病的敏感性为83．1％（49／59）,特异性为69．2％（27／39）,准确性为77．6％（76／98）。平板运动试验中ST段压低幅度越大,持续时间越长,运动中收缩期血压增量越小,冠状动脉狭窄程度就越重。试验中ST段压低幅度越大,持续时间越长,出现ST段压低的导联数目越多,运动中最大心率越小,冠脉狭窄范围就越广泛。结论：平板运动试验可初步估测冠脉狭窄程度及狭窄范围,不失为冠心病诊断中又一有效的无创性检查方法。     

Impact of depressed left ventricular function on outcomes in patients with three-vessel coronary disease undergoing percutaneous coronary intervention

Background  Patients with multivessel coronary artery disease and depressed left ventricular ejection fraction (LVEF) represent a high risk group of patients for coronary revascularization. There are limited data on percutaneous coronary intervention treatment in this population.  

Methods  Among a cohort of 4335 patients with three-vessel disease with or without left main disease undergoing percutaneous coronary intervention, 191 patients had LVEF <40% (low ejection fraction (EF)) and 4144 patients had LVEF ≥40%. In-hospital and long-term outcomes were examined according to LVEF.

Results  The estimated two-year rates of major adverse cardiac events, cardiac death, and myocardial infarction were significantly higher in the low EF group (19.64% vs. 8.73%, Log-rank test: P <0.01; 10.30% vs. 1.33%, Log-rank test: P <0.01, and 10.32% vs. 2.28%, Log-rank test: P <0.01 respectively), but there was no difference in the rates of target vessel revascularization (6.18% vs. 6.11%, Log-rank test: P=0.96). Using the Cox proportional hazard models, LVEF <40% was a significant risk factor for cardiac death, myocardial infarction, and major adverse cardiac events (OR (95% CI): 4.779 (2.369–9.637), 2.673 (1.353–5.282), and 1.827 (1.187–2.813) respectively), but was not a statistically significant risk factor for target vessel revascularization (OR (95% CI): 1.094 (0.558–2.147)).

Conclusion  Among patients undergoing percutaneous coronary intervention for multivessel coronary artery disease, left ventricular dysfunction remains associated with further risk of cardiac death in-hospital and during long-term follow-up.

     

冠心病患者血清胆红素水平与冠状动脉狭窄程度的关系

目的:探讨血清胆红素水平与冠状动脉狭窄程度的关系。方法:观察268例行冠状动脉造影术的患者,按冠状动脉造影结果将患者分为冠脉正常组78例;冠心病组190例。冠心病组根据冠状动脉受累的主要支数分为单支病变组68例、双支病变组56例、多支病变组66例。同时测定血清胆红素及各项生化指标。冠状动脉狭窄程度用冠状动脉病变支数和冠状动脉狭窄计分表示。结果:冠心病组血清胆红素水平明显低于对照组(p<0.01),并且随着病变严重程度的加重,血清胆红素水平逐渐降低(p<0.01)。血清胆红素水平与冠状动脉狭窄计分呈显著负相关。结论:血清胆红素水平与冠状动脉狭窄程度呈显著负相关,是冠心病的独立危险因素。     

Optimal morphometric and functional assessment of intermediate coronary lesions

Coronary lesions of intermediate severity,defined as 50％-70％ luminal diameter narrowing by visual estimation at angiography,are frequently encountered in patients with stable or unstable coronary artery disease.Clinical decision making for patients with intermediatecoronary stenosis is still challenging,but may be facilitated by assessing the morphology and physiological significance of these lesions.1 It is clear that angiographic stenosis is a highly unreliable surrogate for myocardial ischemia,as a significant proportion of anatomically high-grade lesions do not cause ischemia.Conversely,even for anatomically mild coronary lesions,a non-negligible rate of myocardial ischemia is consistently noted.Because the physiological significance of a lesion is mainly determined by both the severity of a stenosis and the amount of myocardium supplied,coronary angiography alone does not accurately predict the functional significance of intermediate coronary lesions.     

Comparison of two and three dimensional quantitative coronary angiography to intravascular ultrasound in the assessment of left main coronary artery bifurcation lesions

Background Angiographic evaluation of left main coronary artery （LMCA） bifurcation lesions is often limited, twodimensional （2D） quantitative coronary angiography （QCA） with segmental analysis provides accuracy for quantificationof the degree of stenosis in the main vessel and side branch ostium but can be affected by foreshortening and variablemagnification. The accuracy of three dimensional （3D） QCA has recently developed to overcome 2D QCA limitations,however, accuracy and precision of 3D bifurcation QCA measurements in LMCA bifurcation lesions has not beenestablished.Methods We investigated whether such 3D and 2D bifurcation QCA measurements differ in their accuracy in assessingsignificant LMCA bifurcation lesions defined by intravascular ultrasound （IVUS） as a minimum luminal area （MLA） 〈6 mm2of LMCA and MLA 〈4 mm2 of proximal left anterior descending （LAD） and/or proximal left circumflex （LCX）Results LMCA bifurcation lesions were assessed in 44 patients undergoing elective percutaneous coronary intervention.From 2D QCA measurements, MLA correlated moderately with threshold intravascular ultrasound MLA for LMCA （r=0.81,P 〈0.000 1）, LAD 0=0.54, P=0.000 1） and LCX （r=0.58, P 〈0.000 1）. Severity of lesion as MLA by derived 3D QCA,correlated moderately with threshold intravascular ultrasound MLA for LMCA （t=0.84, P 〈0.000 1）, LAD （t=0.53, P=0.000 2）;LCX （r=0.66, P 〈0.000 1）. Overall, the C statistics tended to be slightly higher for 3D QCA and 2D QCA measurementsin LMCA segment compared with proximal LAD and LCX segments, and there were no significant predictive power ofpercent diameter stenosis and percent area stenosis on 3D QCA for LCX IVUS MLA 〈4 mm2 （percent diameter stenosis：area under curve 0.55, cutoff 23%, sensitivity 88%, specificity 37%, P=0.618 6; percent arer stenosis： area under curve0.56, cutoff 41%, sensitivity 83%, specificity 38%, P=0.518 4, respectively）.Conclusions The accuracy of 3D bifurcation QCA in detecting significant LMCA bifurcation lesions is limited, especiallythe proximal LCX ostium. When IVUS is not available or contraindicated, 3D QCA may assist in the evaluation ofintermediate LMCA lesions with MLA.     

Association between non-alcoholic fatty liver disease and coronary artery disease severity

Background  Both non-alcoholic fatty liver disease (NAFLD) and coronary artery disease (CAD) are closely associated with many metabolic disorders. Invasive coronary angiography (CAG) is a common approach as an intervention for CAD. However, the association between angiographic severity of coronary artery and NAFLD remains controversial. This study aimed to evaluate the relationship between NAFLD and CAD.

Methods  Totally 542 consecutive patients who planned to undergo CAG due to a suspected CAD were enrolled. Abdominal computed tomography (CT) was performed before angiography to detect NAFLD. CAD was defined as stenosis of at least 50% in at least one major coronary artery. The severity of CAD was assessed by the number of vessels affected and the vessel score multiplied by the severity score (Gensini score). Significant stenosis was defined as 70% or greater reduction in lumen diameter. A probability value of P <0.05 was considered statistically significant.

Results  Of 542 patients studied, 248 (45.8%) were found to have NAFLD by abdominal CT, and 382 patients (88%) were found to have significant CAD by CAG. Age, diabetes mellitus, waist circumference, body mass index, and obesity were associated with NAFLD. According to the results of Logistic regression analysis, the presence of NAFLD independently increased the risk for CAD, as seen in CAG (odds ratio (OR), 95% confidence interval (CI): 7.585 (4.617–12.461); P <0.001). NAFLD was significantly more common in patients as CAD severity increased (P <0.001).

Conclusions  The presence of NAFLD is associated with high severity of CAD, requiring that patients with abdominal obesity be also investigated for NAFLD. Patients with NAFLD should be closely followed up for the presence and severity of CAD.