血红蛋白J Bangkok(曼谷)一例报告

血红蛋白J Bangkok(曼谷)是在上海市宝山县发现的一种快速β链异常的血红蛋白,其含量为50.1％,无明显的血液学改变,异丙醇试验及亨氏小体俭查均正常。家系调查发现先证者的父亲及祖父携带有相同的异常血红蛋白,用PCMB及CM—22纤维素柱层析分离异常β链,再用TPCK胰蛋白酶消化异常β链和指纹分析,以及异常肽链的氨基酸组成和顺序测定,证实其β链56位(D7)的甘氨酸被门冬氨酸替代,因此称为血红蛋白J Bangkok(α 2 β 2~(56(D7)Gly·ASP))。     

在北京市发现的异常血红蛋白——血红蛋白D旁遮普(HbD PunJab) 血红蛋白G考塞特(HbG Coushatta)——化学结构分析

1981年至1982年,我们用醋酸纤维素薄膜电泳法,对我院义务健康献血员进行异常血红蛋白普查时,发现二例慢速异常血红蛋白,其泳速基本相同,位于HbA与HbA₂之间,相当于HbD或G组。采集先证者血样进行化学结构分析,证明其中一例(例1)为血红蛋白D旁遮普(HbD PunJab),另一例(例2)为血红蛋白G考塞特(HbG Cou-shatta)。现报道如下。     

HbI~(a16(A14)Lys→Glu)一级结构的分析

作者于1980年间在南昌市普查血红蛋白病中发现一家系快泳异常血红蛋白,经一级结构分析确认为HbI~(a16)(A14)Ly→Glu。     

血红蛋白纽约症(Hb New York)一例及其家系调查

近来发现血红蛋白纽约症在我国人群中发病率较高。1980年我们在一名无症状者红细胞溶血液中,发现具有异常快速血红蛋白电泳区带,经家系调查、血红蛋白理化特性的测定、珠蛋白肽链柱层析分离、“指纹”分析和异常肽段的氨基酸组成测定,并用DABITC/PFTC微量双偶合法分析了异常肽段的氨基酸顺序,证实这种异常血红蛋白为血红蛋白纽约症,即β~(113V)a→Glu:现报告如下: 先征者周××,男,41岁,汉族,广西     

血红蛋白G Taibei(α_2 β_2 ~(22Glu→Gly))一例

1983年在杭州市血红蛋白病普查中发现1例慢速血红蛋白、醋酸纤维薄膜电泳(pH8.5)结果显示在HbA和HbA_2之间有一异常区带,属G组血红蛋白位置,经一级结构分     

一种血红蛋白新变种——Hb琼海(Quin-Hai)α_2β_278(EF_2)Leu—→Arg

在海南岛琼海县乐会公社进行异常血红蛋白病普查时,我们发现1例慢速的异常血红蛋白。未发现先证者有临床症状及血液学方面的异常。本文报告这种异常血红蛋白的一级结构研究结果。一、材料和方法(一) 常规分析:血液学常规按标准法。静脉采血经Na_2EDTA抗凝并按四氯化碳法制备10%溶血液。溶血液接受醋纤薄膜微量电泳法鉴定;Hb A_2及异常Hb含量测定采用醋     

一例快速异常血红蛋白—Hb J Lome(β59(E3)Lys→Asn)的一级结构分析

本文报告在河南省封丘县发现的一例快速异常血红蛋白,患者为13岁男孩,汉族。本例变异血红蛋白电泳迁移率属J组血红蛋白,其含量占血红蛋白总量的51.4％,没有临床表现者占17％,异丙醇试验阴性。一级结构分析结果显示本例变异血红蛋白是Hb J Lome(β59(E3)Lys→Asn)。这种变异血红蛋白在河南省是第一次发现。     

血红蛋白M Iwate(附一例报道)

本文报道了一例祖籍是上海市宝山县的遗传性青紫的病人,家系调查中发现,此病至少遗传了四代。应用醋酸纤维薄膜电泳能从患者溶血液中分离出一种快速异常的血红蛋白。通过血红蛋白理化性质测定和结构分析,证实其α链N端第87位的组氨酸被酪氨酸替代,即血红蛋白MIwate[α87(F8)His→Tyr]。该例异常血红蛋白在中国属首次报道。     

国内首次发现的血红蛋白Queens(α~(34(β15)Leu→Arg)β)_2

我们于1981年在上诲市宝山县发现一种异常血红蛋白的两个家系,经结构分析鉴定这种血红蛋白为Hb Queens。 本文报告了这两个家系共8个成员的血红蛋白的理化性质及其一级结构分析。pH8.5醋酸纤维素薄膜电泳中均分离出一种慢速的异常血红蛋白,泳速位于HbF与Hbs之间含量为7.2～18.0％,异丙醇试验阴性,红细胞经煌焦油蓝孵育法检查亨氏小体量很少,或无亨氏小体检出,用PCMB及CM—22纤维素柱层析分离异常肽链,再用TPCK胰蛋白酶消化异常α链,经高压液相分离层析,异常肽段的氨基酸组成测定及氨基酸顺序测定。证实其α链N端第34位的亮氨酸被精氨酸所替代,因此称为血红蛋白Queens(δ2~(?)Leu→Argβ2) Hb Qneens首先由Tatsis于1979年摘要报道一例,至今未见有其它文献报道。     

某些血液病继发血红蛋白异常的临床意义(附98例报告)

近年来,国内外一些文献报导,在一些获得性疾病而并不存在地中海贫血的患者有正常的血红蛋白A_2或HbF比率改变,少数出现HbH,这有可能造成误诊。但亦有希望通过此种获得性血红蛋白异常的研究进一步了解血红蛋白合成及调节的机制,这对于探索血红蛋白病的治疗和进一步了解某些疾病继发血红蛋白异常的规律性较有意义。例如当某些疾病缓解时,此种继发性的血红蛋白异常亦消失,这有助于对病情及预后判断。为了探索HbH、HbA_2及HbF在某些血液病的诊断意义。我院近2年对各种类型的白血病、血液系统肿瘤、再生障碍性贫血(再障)、阵发性睡眠性血红蛋白尿(PNH)等共98例进行治疗前的血红蛋白电泳检查,并分析其临床意义。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.