富阳农村居民的健康状况研究

目的探讨SF-36量表用于农村居民健康状况测定的可能性。方法用中文版SF-36量表测定富阳207名14岁以上的农村居民,分析其信度、效度。结果除了SF、RE维度,其余6维度内部一致性信度系数大于0.50,7维度内部一致性信度大于与其他维度的相关。因子分析产生3个主成份,累计方差贡献为64.6%。65岁以上者无应答,青年组与中年组各维度平均分数差异不显著;不同性别只在RP维度上差别显著。吸烟者与不吸烟者、饮酒者与不饮酒者的得分差异不显著。不同文化程度人群的得分差异不显著。结论尚需更多证据支持SF-36量表适用于农村居民健康状况测定。     

SF—36评价中风患者生命质量的信度和效度

目的 评价SF－36生命质量量表在中风患者中的信度和效度。方法 效度评价采用结构效度和判别效度。采用ADL、IADL、闲暇活动、社会支持、健康预测对SF－36的8个领域通过回归分析进行结构效度评价。采用神经功能缺损程度评价量表MESSS对SF－36进行判别效度的评价。信度采用重测信度法、内部一致性分析（Cronbach'α系数）。用自填法结合小人访谈法,由150例中风患者自己做出健康评价。结果 整个测量的重测相关系数均大于0．6（各领域P＜0．01）。内部一致性Cronbach'α系数除活力和精神健康两个领域为0．7－0．8以外,其他6个领域的内部一致性均很好（α＞0．8）。在结构效度评价中,回归分析的结果与事先的假设具有相当的一致性。SF－36的8个领域除疼痛领域以外,不同的神经功能缺损程度间均有显著差异（P＜0．05）。结论 采用自填法结合个人访谈,使用SF－36评价中风患者的生命质量是有效的、可靠的。     

美国简明健康测量量表与中国老年人生活质量调查表的对比研究

目的 探讨美国简明健康测量量表SF－36量表用于中国老年人生命质量 测量的可能性。方法 采用SF－36量表和中华医学会研制的老年人生活质量调查表两个量表同时对苏州市区167例老年人的生命质量进行测定,并对比分析其信度、效度。 结果 老年人生活质量调查表的信度、效度均比较好;SF－36量表较老年人生活质量量表的信度、效度更好,尤其在测试精神心理方面能更准确地表达老年人的心理。结论 SF－36量表可以用于中国老年人的健康状况评估。     

SF—36量表在血透患者中的性能测试

目的 探讨SF—36量表应用于血透患者生活质量研究的可行性。方法 采用整群抽样法，用SF—36量表对杭州市4家血透中心的181例血透患者进行自评量表式调查。参照国际生命质量评价项目的标准，进行信度、效度与反应度的测试。结果 SF—36量表的分半信度是0．91，8个维度的Cronbach α系数范围为0．56—0．90。除了PF维度，各维度的集合效度和区分效度成功率均为100％。因子分析产生两个主成分，分别代表生理健康和心理健康，解释了69．4％的总方差。SF—36量表总分与世界卫生组织生存质量测定量表总分以及患者自我总体健康评价得分的相关性分别为0．85和0.76。患者接受血透治疗后，PF、RP、BP、VT和SF维度得分显著提高。结论 SF—36量表是一份适合中国血透患者生活质量测评的量表。     

SF-36量表评价农村福利院五保老人生活质量的信度和效度

目的 评价SF-36量表在农村福利院五保老人生活质量的信度和效度。方法 采用分层整群随机抽样方法，抽取湖北省农村集中供养五保老人546例,由经过统一培训的调查员利用SF-36生活质量量表对老年人进行面对面访谈。采用相关分析﹑信度分析和因子分析方法对SF-36量表的信度（折半信度和内部一致性信度）和效度（结构效度和标准效度）进行评价。结果 SF-36量表Spearman-Brown 为0.816，内部一致性系数Cronbach′α系数除SF维度外均在 0.6 以上，8 个维度均呈正相关。结论 SF-36量表具有较好的信度和效度,适于评价农村福利院五保老人生活质量。 【关键词】SF-36量表 五保老人 生活质量　　信度　　效度     

适合中国弱视儿童的遮盖治疗量表的的研制及评价

目 的：研制中文版弱视治疗生存质量量表并评价其信度和效度。 方 法：选取英文版 弱视治疗生存质量量表经过翻译后形成中文版ATI量表。选取4-9岁单眼弱视 儿童109例, 4-8 小时/天 或全天遮盖。将量表条目分为对患儿的负面影响、依从性及社会心理三个维度,并对其进行信度和效度进行评价。并评估性别、年龄、弱视眼初始视力、 弱视眼视力提高程度及遮盖时间与量表各维得分的相关性。 结果： 中文版弱视治疗儿童生存质量量表由 19个条目组成,分为负面影响、依从性、和社会心理量三个维度。量表的各个条目及维度的相关系数较好,其内部一致性克朗巴赫ɑ系数 为 0.774,折半信度 r 为 0.783,重测信度为 0.998。整体得分和儿童年龄、性别、弱视眼初始视力、弱 视 眼 视力提高程 度及遮盖时间均无显著差异; 结 论：ATI 的中文版,有较好的可靠性和有效性。是一个有效的评价 4-9 岁儿童弱视治疗时生存质量的工具。     

SF-36量表在血透患者中的性能测试

目的探讨SF-36量表应用于血透患者生活质量研究的可行性.方法采用整群抽样法,用SF-36量表对杭州市4家血透中心的181例血透患者进行自评量表式调查.参照国际生命质量评价项目的标准,进行信度、效度与反应度的测试.结果 SF-36量表的分半信度是0.91,8个维度的Cronbach α系数范围为0.56～0.90.除了PF维度,各维度的集合效度和区分效度成功率均为100%.因子分析产生两个主成分,分别代表生理健康和心理健康,解释了69.4%的总方差.SF-36量表总分与世界卫生组织生存质量测定量表总分以及患者自我总体健康评价得分的相关性分别为0.85和0.76.患者接受血透治疗后,PF、RP、BP、VT和SF维度得分显著提高.结论 SF-36量表是一份适合中国血透患者生活质量测评的量表.     

SF-36健康调查问卷在起搏器植入患者中的信度和效度评价

目的评价SF-36健康调查问卷在起搏器植入患者中的信度和效度。方法在230例起搏器植入患者中采用重测信度、分半信度、内部一致性和结构效度等评价SF-36量表的信度和效度。结果躯体功能、生理职能、躯体疼痛、一般健康状况、生命力、社会功能、情感职能和心理健康8个维度的Cronbach系数分别为0.872、0.814、0.856、0.789、0.779、0.819、0.763和0.754。分半信度的相关系数为0.85;各条目得分与其维度得分之间相关均较大（均﹥0.60）。结论SF-36健康调查表内部一致性较好,具有较好的信度和效度,适合于起搏器植入患者的生活质量评价。     

SF-36量表用于海勤人员健康生命质量评价

目的 评价SF-36量表用于海勤人员生命质量评价的信度和效度,了解该群体健康生命质量的现状及影响因素。方法 采用SF-36量表对2016年在某地区部队医院接受健康体检的海勤官兵的生命质量进行测评。结果 发放问卷180份,回收162份,有效问卷149份。SF-36量表应用于海勤人员健康生命质量评价具有较好的内部一致性信度和分半信度,以及良好的量表集合效度和区分效度。男性在躯体疼痛、社会功能和情感职能3个维度的得分均低于女性,差异均有统计学意义（P均<0.05）。男性海勤人员在生理功能、生理职能、躯体疼痛、社会功能和情感职能维度的得分均低于全国性调查同年龄段男性得分,但是在一般健康状况维度的得分高于全国调查结果（P均<0.05）;女性海勤人员在一般健康状况和情感职能维度的得分均高于全国性调查同年龄段女性得分（P均<0.05）。相关因素分析显示患有慢性病、睡眠质量、性别以及近2周内有无身体不适是影响SF-36各维度得分的主要因素。结论 SF-36量表可用于海勤人员健康生命质量评价,提高睡眠质量、控制慢性病发生、减少短期内身体不适等有助于提高海勤人员的健康生命质量。     

慢性心力衰竭主观报告结局量表的反应度比较研究

目的：比较3种中西医结合治疗慢性心力衰竭主观报告结局量表,包括心功能不全症状积分表（ChineseMedicalSymptomRatingScaleforHeartFailure,CMSRS-HF）、明尼苏达心功能不全问卷（MinnesotaLivingwithHeartFailureQuestionnaire,MLHFQ）、简明健康状况问卷（MedicalOutcomesStudyShort-form36,SF-36）的反应度,为中西医结合临床疗效评价结局指标的选择提供依据。方法：对3个临床研究中心招募的156例慢性心力衰竭患者实施调查,采用治疗前后差异的配对t检验、效应量（effectsize,ES）和标准反应均数（standardizedresponsemeans,SRM）评价反应度。结果：（1）中西医结合干预2周后,中医症状评分表得分显著降低,MLHFQ身体领域、情绪领域及综合得分显著升高;SF-36的8个维度及生理领域、心理领域、总分显著升高（P=0．000）。（2）中医症状评分表的ES大于0．8,MLHFQ身体领域、情绪领域及综合得分的ES为0．37～0．61,SF-36的8个维度及生理领域、心理领域、总分的ES为0．14～0．49。（3）标准反应均数SRM：中医症状评分表大于0．8,MLHFQ身体领域、情绪领域及综合得分为0．53～0．92,SD36的8个维度及生理领域、心理领域、总分为0．23～0．83。（4）不同NYHA分级分层分析,各主观报告结局量表对中西医结合治疗中、重度（NHYAⅢ、Ⅳ级）慢性心衰更敏感。结论：中医症状评分表反应度较好,MLHFQ反应度适中,SF-36大部分维度反应度适中。慢性心力衰竭中西医结合临床疗效评价时,可根据实际情况选择应用不同的结局评价量表。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.