急性冠脉综合征患者经皮冠状动脉介入治疗术后Ghrelin、 obestatin水平变化及临床意义

目的 观察急性冠脉综合征（ACS）患者经皮冠状动脉介入治疗（PCI）术后经药物治疗1年血清Ghrelin、obestatin水平变化及意义.方法 选取92例ACS患者行冠状动脉造影,根据冠脉造影结果分为阴性组和阳性组.阳性组根据病情轻重分为植入支架组和未植入支架组,两组患者分别在入院时和药物综合治疗1年后测定血清Ghrelin、obestatin水平.结果 初次入院时阳性组患者血清Ghrelin水平低于阴性组（P＜0.05）,obestatin水平高于阴性组（P＜0.05）;阳性组中,植入支架组血清Ghrelin水平低于未植入支架组（P＜0.05）,obestatin水平高于未植入支架组（P＜0.05）.药物治疗1年后,阳性组患者血清Ghrelin水平高于入院时（P＜0.05）,obestatin水平低于入院时（P＜0.05）;植入支架组患者经过1年药物综合治疗后Ghrelin、obestatin水平的变化幅度均大于未植入支架组（均P＜0.05）.结论 Ghrelin、obestatin水平与ACS病情严重程度相关,可为ACS病情严重程度分析及预后判断提供依据.     

颈动脉狭窄支架置入与认知功能相关性的研究

目的:研究颈动脉狭窄患者支架置入术(CAS)与认知功能的相关性。方法:纳入2014年10月1日-2016年4月10日本院住院的颈动脉狭窄患者36例,均经DSA检查明确诊断,狭窄程度50%,对患者进行一般情况评估。23例患者行CAS治疗(CAS组),13例患者给予药物保守治疗(对照组)。所有患者在治疗前,治疗后6、12个月进行Mo CA评分。结果:CAS组患者治疗后6、12个月Mo CA量表总分及视空间与执行功能、注意力、延迟回忆力较治疗前均明显改善(P0.05),对照组患者认知功能改善不明显(P0.05)。治疗组与对照组比较,治疗后6个月认知功能显著改善,主要体现为视空间与执行功能、延迟回忆力的改善(P0.05);治疗后12个月CAS组Mo Ca量表总分、视空间与执行功能、命名能力、注意力、延迟回忆力较对照组均明显改善(P0.05)。结论:对于狭窄程度50%的颈动脉狭窄患者,颈动脉支架置入术能改善患者的认知功能,尤其是视空间与执行功能、注意力、延迟回忆力。     

输尿管支架管在肾结核治疗中的应用

目的:探讨输尿管支架管(双"J"管)在肾结核治疗过程中,对于提高抗结核药治疗效果、保留患肾结构和功能的临床意义.方法:34例肾结核(22例合并单侧肾积水)患者随机分为2组,A组进行单纯抗结核药物治疗,B组在药物治疗前在患肾侧置入输尿管支架管(双"J"管).抗结核药物治疗3个月后随访、复查.结果:治疗前两组尿常规、B超、静脉尿路造影(IVU)、CT和核素肾图检查结果无统计学差异,药物治疗3个月后随访显示两组间尿常规检查、红细胞沉降率异常、尿抗酸杆菌阳性率无统计学差异,而B超、CT检查、IVU和核素肾图结果差异具有统计学意义(P＜0.05).共21例患者行肾切除手术,A组15例(88.2%),B组6例(35.3%),具有统计学差异(P＜0.05).结论:肾结核药物治疗前在患肾侧置入输尿管支架管更有利于保留患肾的结构和功能,能降低患肾手术切除率.     

颈动脉支架成形术对颈内动脉狭窄患者认知功能的影响

目的:探讨颈动脉支架成形术对颈内动脉狭窄患者认知功能的影响?方法:选取行颈动脉支架成形术的颈内动脉狭窄患者97例,将有发生脑梗死或者短暂性脑缺血发作(TIA)的64例分为A组,无发生脑梗死或者TIA的33例分为B组?采用简易智能状态检查量表(MMSE)?Fuld物体记忆检验(FOM)和快速词汇测验(RVR)评估患者的认知功能?对比术前3 d内和术后第1个月?第6个月和第12个月患者的认知功能评估结果,同时对比不同颈内动脉狭窄率患者手术前后以及术前有症状和无症状患者的认知功能变化情况?结果:术前颈内动脉狭窄率为(80.17 ± 14.06)%,术后颈内动脉狭窄率为(20.83 ± 6.19)%,术后颈内动脉狭窄率显著低于术前(P < 0.05)?术后第12个月的MMSE评分为(26.96 ± 4.07)分,FOM评分为(18.41 ± 1.18)分,RVR评分为(28.68 ± 4.88)分,均显著高于术前?术后第1个月和术后第6个月(均P < 0.05);术前颈内动脉狭窄率>70%而≤85%和>85%患者的ΔMMSE?ΔFOM?ΔRVR均显著大于术前颈内动脉狭窄率>50%而≤70%的患者,且术前颈内动脉狭窄率>85%患者的ΔMMSE?ΔFOM?ΔRVR,均显著大于颈内动脉狭窄率>70%而≤85%的患者(均P < 0.05);TIA患者的ΔMMSE?ΔFOM?ΔRVR均显著大于脑梗死患者(均P < 0.05);而B组患者的ΔMMSE?ΔFOM?ΔRVR均显著大于A组患者(均P < 0.05)?结论:颈动脉支架成形术可有效治疗颈内动脉狭窄,同时改善患者的认知功能?     

经皮下隧道硬膜外腔置管注药治疗带状疱疹后神经痛

目的 探讨经皮下隧道硬膜外腔置管注药治疗带状疱疹后神经痛的疗效.方法 38例带状疱疹后神经痛患者分为两组,A组(16例)接受药物治疗;B组(22例)采用皮下隧道硬膜外腔置管注射复合镇痛液联合药物治疗,两组患者一般情况具有可比性(P＞0.05).采用视觉模拟评分法(VAS法),分别测评两组患者治疗前、治疗后3个月及6个月时VAS评分,同时评估两组的疗效和并发症.结果 治疗后3个月及6个月时,A、B两组的VAS评分均较术前降低(P＜0.01);两组间VAS评分比较,在3个月和6个月时B组较A组降低(P＜0.05),且B组有效率高于A组(P＜0.05).结论 治疗带状疱疹后神经痛,经皮下隧道硬膜外腔置管注射复合镇痛液方法 疗效显著,安全可靠.     

StentBoost技术在冠脉介入中的应用研究

目的 评价StentBoost在冠脉病变介入治疗中的应用价值.方法 选取107例介入治疗需要后扩张的冠脉病变患者,分为常规后扩张组(A组)和StentBoost指导下后扩张组(B组).对B组患者采用StentBoost指导下进行后扩张,直到支架完全扩张,贴壁良好.记录两组患者的临床资料、冠状动脉病变情况、DES植入情况,随访观察6个月内主要临床心血管事件,并在满6个月时复查冠状动脉造影.结果 两组在临床资料、冠状动脉病变情况及DES植入情况等方面差异无统计学意义(P＞0.05),两组患者随访期间心肌梗死、靶血管再次血运重建率差异无统计学意义(P＞0.05),A组患者支架内再狭窄率高于B组(P＜0.05).结论 StentBoost指导下进行支架后扩张能进一步降低患者的支架内再狭窄率.     

通心络胶囊对植入冠状动脉支架预后影响的研究

目的研究通心络胶囊对植入冠状动脉支架预后的临床影响.方法76例接受PTCA Stenting(PCI)的患者分为通心络干预治疗组(A组)和普通治疗组(B组),观察PCI后两组患者心绞痛的发作情况及超声心动图EF值的变化,随访6个月.结果A组的心绞痛发生率较B组明显减低(P＜0.01),EF值A组较B组明显改善(P＜0.01).结论通心络胶囊对植入冠状动脉支架后的心绞痛缓解及心功能的改善均有较好影响.     

早期不同频次高压氧联合亚低温对重度颅脑外伤患者脑神经功能的影响

目的 探讨早期不同频次高压氧联合亚低温对重度颅脑外伤(sTBI)患者脑神经功能的影响.方法 选取泰兴市人民医院2016年3月至2019年2月收治的86例sTBI患者为研究对象,分成A组和B组,每组43例.两组给予不同频次高压氧联合亚低温治疗,其中A组高压氧治疗每天2次,B组高压氧治疗每天1次.格拉斯哥预后(GOS)评分评估两组治疗后6个月的预后情况;治疗前、治疗后6个月采血,检测神经元特异性烯醇化酶(NSE)、髓鞘碱性蛋白(MBP)、神经胶质纤维酸性蛋白(GFAP)、S100B蛋白(S-100B)、天冬氨酸(Asp)、γ-氨基丁酸(GABA)、谷氨酸(Glu)水平;观察两组并发症发生率.结果 A组中度残疾率明显高于B组,重度残疾率明显低于B组(P＜0.05).两组治疗后血清NSE、MBP、GFAP、S-100B水平均明显低于治疗前,且A组明显低于B组(P＜0.05).两组治疗后血清Asp水平明显低于治疗前,GABA水平明显高于治疗前,且A组变化更明显(P＜0.05).两组肺不张、室性心律失常、坠积性肺炎、静脉血栓发生率比较差异无统计学意义(P＞0.05).结论 早期采用每天2次高压氧联合亚低温治疗sTBI患者,对脑神经功能保护作用更明显,可进一步改善预后.     

外科射频消融术治疗风湿性心脏病合并心房颤动疗效分析

目的 对比研究抗心律失常药物、导管介入消融和外科射频消融3种治疗方式治疗风湿性心脏病合并心房颤动的临床效果.方法 回顾性分析2004年7月～2005年7月于北京安贞医院确诊为风湿性瓣膜病合并心房颤动并施行瓣膜置换术的患者96例,根据AF治疗方式不同分为3组:A组28例单纯抗心律失常药物治疗,B组24例行术后导管介入消融术,C组44例行射频消融迷宫手术,术后随访12个月.结果 3组患者之间瓣膜置换数、心脏自动复跳例数、起褥器植入例数、LVEF以及30 d死亡人数之间差异无统计学意义(均P＞0.05).A组术后1个月1例(3.6%)患者死亡.体外循环(CPB)时间及主动脉阻断时间A、C组明显低于B组(均P ＜0.05),A、C组之间差异无统计学意义(均P＞0.05).B组住院天数明显多于A、C组,C组多于A组,差异均有统计学意义(均P ＜0.05).术后心室率A组明显高于B、C组,差别有统计学意义(均P＝0.00),B、C组之间差别无统计学意义(P＜0.05).术后即刻、出院时、术后3个月、术后6个月、术后12个月窦性心律转复人数比较发现,B、C两组窦性心律维持率均较高,尤其是C组,疗效满意,各组之间差别均有统计学意义(均P＜0.05).手术并发症主要有心包积液、胸腔积液和呼吸功能不全等,C组心包积液发生率高于A、B组,差别有统计学意义(均P ＜0.05).结论 瓣膜置换术合并进行射频消融术对于风湿性心脏瓣膜病合并心房颤动的治疗效果优于单纯抗心律失常药物或导管介入消融治疗,能成功扭转并稳定窦性心律.     

颈动脉支架置入术对颈动脉狭窄所致脑白质疏松与认知功能改变的影响

目的：探讨颈动脉狭窄与脑白质疏松（LA）、认知功能障碍的相关性及颈动脉支架置入术（CAS）后LA与认知功能的变化。方法：选取2014年8月至2017年8月在温州医科大学附属舟山医院经数字减影血管造影检查确诊颈动脉狭窄大于70%的住院患者共44例,支架组、对照组各22例。于治疗前、治疗后6个月行头颅MRI检查,治疗前及治疗后1个月、6个月分别行MMSE、WAIS-RC测验,比较2组的基线及随访结果。结果：控制相关危险因素后,LA体积仍与颈动脉狭窄程度相关（r=0.473,P＜0.05）,MMSE得分仍与颈动脉狭窄程度相关（r=-0.330,P＜0.05）。治疗后,支架组LA体积、MMSE得分较对照组明显改善（P＜0.05）。CAS后WAIS-RC得分较术前明显改善,主要体现在算术、数字广度、数字符号、木块图测验。结论：颈动脉狭窄与LA、认知功能相关,狭窄程度越重,LA体积越大,认知障碍越明显。CAS后LA体积缩小,认知功能改善。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Dr.Zhang Ren's Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.