经皮冠状动脉介入治疗对冠心病患者左室收缩和舒张功能的影响

目的观察经皮冠状动脉介入治疗（PCI）对冠心病患者近期左心室收缩和舒张功能的影响。方法对75例成功实施PCI的患者,通过彩色多谱勒超声心动图测量术前及术后6个月内的左室收缩和舒张功能指标,并根据是否急性心肌梗死或2型糖尿病分组比较。结果患者术后6个月内心功能明显改善（P〈0．05）,室壁节段性运动异常率降低。心肌梗死与非心肌梗死患者左室收缩功能均有改善,而舒张功能指标改善不明显。非糖尿病组患者左室收缩功能明显改善,而糖尿病组患者心功能改善与术前相比不明显。结论PCI术可改善冠心病患者近期内的左室收缩功能,舒张功能仅E峰指标改善。心肌梗死、非心肌梗死及非糖尿病患者左室收缩功能均有改善。糖尿病患者的PCI获益尚有待更大样本的证实。     

心肌梗死患者冠状动脉介入术后心功能的变化

目的评价经皮冠状动脉介入术（PCI）对心肌梗死并左心功能不全患者左心收缩功能的作用。方法62例心肌梗死并左心功能不全患者,其中急性心肌梗死32例,陈旧性心肌梗死30例。行经皮腔内冠状动脉成形术及支架植入术,术后随访3个月。超声心动图测定左室舒张末内径（LVED）、左房内径（LAD）、左室舒张末容积（LVEDV）、左室收缩末容积（LVESV）、左室射血分数（LVEF）和左室短轴缩短率（LVFS）,比较治疗前后各参数的变化。结果PCI治疗后LVED、LAD、LVEDV、LVESV较治疗前均明显减少。LVEF和LVFS明显增高（P〈0．01）,血运重建时间越早,心功能恢复越好。结论心肌梗死并左心功能不全患者尽早行PCI治疗,可改善心脏功能,逆转左室重构。     

冠状动脉介入治疗对冠心病合并心功能不全患者的临床疗效观察

目的：观察经皮冠状动脉介入治疗（PCI）对冠心病并左心功能不全患者的心衰改善作用。方法：45例冠心病并左心功能不全患者，均行PCI治疗。术前、术后行心脏彩超测定左室舒张末内径（LVEd），左室舒张末容积（LVEDV），左室收缩末容积（LVESV），左室射血分数（LVEF）。比较治疗前后各参数变化，及NYHA分级变化，随访期6个月。结果：PCI治疗后LVEd、LVEDV、INESV较治疗前均明显减小（P〈0．01），LVEF明显增高（P〈0．01），NYHA心功能分级由原Ⅱ～Ⅳ级提高至I－Ⅱ级。急性心肌梗死患者更为显著。患者临床症状明显改善，生活质量提高。结论：冠心病患者行PCI治疗可显著改善左室收缩功能及有效抑制左室重构。     

多普勒超声评估冠状动脉搭桥术前后左心室功能

目的：应用多普勒超声心动图评估冠状动脉搭桥术前后心功能的变化。方法：对行冠状动脉搭桥术的冠心病患者48例,于术前、术后3个月经胸多普勒超声心动图测量患者的左室射血分数（LVEF）、左室收缩末容积（ESV）、左室舒张末容积（EDV）、左室每搏搏出量（SV）、左室短轴缩短率（LVFS）、二尖瓣舒张早期和舒张晚期峰值速度比值（E/A）。结果：术后LVEF、LVFS、SV、E/A增大,ESV、EDV减小,差异均有统计学意义（P〈0.05）。结论：冠状动脉搭桥术后左室收缩和舒张功能得到明显改善,多普勒超声心动图是监测冠状动脉搭桥术后左室心功能的可靠指标。     

冠状动脉PCI术前后左室收缩及整体功能的超声心动图评价

目的探讨多普勒超声心动图评价冠状动脉PCI术前后左室收缩功能及整体功能变化的临床价值。方法对84例经冠脉造影证实单支和双支及以上病变,并以左主干病变为主的冠心病患者,PCI术前4h、术后1周及3个月分别经胸多普勒超声心动图技术,测算左室舒张末期前后径（LVDd）、收缩末期前后径（LVDs）、左室舒末容积（LVEDV）、左室缩末容积（LVESV）、左室射血分数（LVEF）、左室每搏量（SV）及左室整体Tei指数。结果 84例冠心病患者行PCI术后3个月的LVDd、LVDs、ESV、EDV、LVEF、SV及Tei指数与术前及术后1周比较,术后1周与术前比较,所有指标间均有统计学意义（P〈0.05）。结论冠心病PCI术后左室收缩功能及整体功能得到明显改善。     

超声评估心肌梗死患者冠状动脉搭桥术前后左心室收缩功能的变化

目的：应用多普勒超声评价冠状动脉搭桥术前及术后心功能的变化。方法：选取45例行冠状动脉搭桥术的冠心病心肌梗死患者。按照有无并发室壁瘤，分为室壁瘤组和无室壁瘤纽。分别于术前、术后3个月应用经胸多普勒超声技术测量患者的左室射血分数（LVEF）、左室收缩未容积（ESV）、左室舒张末容积（EDV）、左心室每搏搏出量（SV）、左室短轴缩短率（LVFS）。结果：术后无室壁瘤心肌梗死组较术前LVEF、SV、EDV增大，ESV减小，所有指标间差异均有统计学意义：术后室壁瘤心肌梗死组各指标与术前相比差异无统计学意义。结论：心肌梗死患者冠状动脉搭桥术后左心室收缩功能得到明显改善，但室壁瘤形成可能为冠状动脉搭桥术后心功能改善的一个不利影响因素。     

经皮冠状动脉成形术对左室重构和心功能的影响

目的探讨急性心肌梗死后延迟经皮冠状动脉介入治疗使梗死相关动脉开通对AMI晚期左室重构的影响。方法应用超声心动图观察30例心肌梗死患者PCI术前及术后随访期和28例标准药物治疗的心肌梗死患者初期、随访期的左室容量、室壁运动情况及左室功能指标的变化。20例正常人同时检查作为正常组。结果（1）与正常组比较，两组心肌梗死患者左室容量明显增大，局部及整体左室收缩功能明显降低，左室舒张功能降低。（2）PCI组随访期左室容量较术前明显降低，左室收缩功能及舒张功能改善。（3）对照组随访期左室容量较初期明显增加，局部收缩功能降低，左室射血分数降低，左室舒张功能指标受损加重。（4）与对照组相比较，PCI组术后随访期左室容量较小，左室局部及整体收缩功能和舒张功能好于对照组。结论PCI能明显改善急性心肌梗死晚期患者的左室功能，减少左室容量，阻止或延缓左室重构。     

急性心肌梗死并心功能不全患者择期冠状动脉介入治疗的临床意义

目的探讨急性心肌梗死并心功能不全患者择期冠状动脉介入治疗的有效性。方法将62例急性心肌梗死患者分为PCI组（32例）和保守治疗组（30例），所有患者分别在术前（30d内）和随访（6个月）接受超声心动图检查，比较超声心动图指标变化。结果与保守治疗组比较PCI组在缩小扩大的左心腔、提高LVEF有明显优势（P〈0．01）。结论急性心肌梗死择期PCI治疗，有利于心脏功能早期恢复，提高生活质量。     

冠状动脉病变支数及介入治疗对冠心病心功能的影响

目的:观察冠状动脉病变支数及介入治疗对冠心病病人心功能的影响。方法:对60例成功进行经皮冠状动脉成型和支架术的冠心病患者,术前和术后3月通过二维超声心动图观察冠状动脉病变不同支数组的左心室收缩功能的变化及对心功能的影响。结果:冠状动脉的病变支数与LVEF、FS值呈明显负相关;即冠状动脉病变累及越多,左室EF、FS值越低。术后各组左室射血分数及心功能分级均有不同程度改善。结论:冠状动脉的病变支数越多,左室收缩功能受损越明显。PC I能有效改善冠心病患者心脏收缩功能,减轻临床症状。     

介入治疗对冠心病心功能不全患者左心功能的影响

目的:观察经皮腔内冠状动脉成形术及支架置人术(PCI)对冠心病慢性心功能不全患者左室收缩和舒张功能的影响.方法:对36例冠心病慢性心功能不全患者行PCI术,手术前后分别用二维和多普勒超声心动图检测心脏收缩和舒张功能指标.结果:PCI术后左室射血分数(LVEF)、E峰值速度(E峰)均升高,左室舒张末内径(INDD)、左室收缩末内径(INDS)、A峰值速度(A峰)、峰值速度比值(A/E)均降低.结论:用经皮腔内冠状动脉成形术及支架置入术治疗冠心病慢性心功能不全的病人,能不同程度的改善左室收缩和舒张功能.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.