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本文用受体放射分析技术,建立人外周血淋巴细胞核T_3、T_4和rT_3受体测定法,并探讨其与甲状腺功能的关系。分离人外周血淋巴细胞采用聚蔗糖-泛影葡胺分层液密度梯度离心法。受体结合试验采用完整细胞分别与~(125)I-T_3、~(125)I-T_4、~(125)I-rT_3温育的方法,用0.0075%TritonX-100 SMT pH7.85溶液分离核,用Scatchard法分析受体结合的解离常数(Kd)和最大结合容量(MBC)。 相似文献
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In order to investigate the relationship between the nuclear receptors and thyroid functions, we have determined the circulating lymphocyte nuclear T_3R in normal subjects, in patients with hyper-and hypothyroidism and in hypothyroid patients on thyroid hormone substitution therapy. In hyperthyroid and hypothyroid patients, the nuclear affinity (kd) for T_3 was similar to that of normal subjects. In hyperthyroidism maximal binding capacity (MBC) of nuclear T_3R was unaltered, whereas in hypothyroidism the MBC was significantly increased up to 8.06±0.80 fmol/μg DNA, which was 2.1 times that of the control group. In hypothyroid patients treated with 90—120 mg desiccated thyroid daily the nuclear MBC was 4.34±0.72fmol/μg DNA, not different from that observed in euthyroid subjects. It was found that the nuclear T_3R MBC was negatively correlated with serum levels of T_3, T_4, FT_3, FT_4 and rT_3, but positively correlated with serum TSH concentration in hypothyroid patients. These results indicated hormonal modulation of the nuclear T_3R which exhibited up regulation in hypothyroidism. The increase in nuclear T_3R number might reflect a compensatory mechanism for the maintenance of cellular homeostasis in face of decreased serum concentrations of thyroid hormones. 相似文献
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36例柯兴综合征,血清rT_3均值为92.4±31.1ng/dl,明显高于单纯性肥胖症及正常对照组,血清T_3(0.92±0.2ng/ml)、T_3/rT_3比值(1.1±0.4)均明显低于正常对照组(P<0.001),血清T_4、TSH与正常组比较无明显差别。7例柯兴手术治疗后T_3、rT_3、T_3/rT_3比值恢复正常,T_3/rT_3 比值与上午8时血皮质醇、24小时尿17-OH、17=0均呈负相关(P<0.05)。提示:柯兴综合症甲状腺激素的变化与柯兴综合征的病情严重程度密切相关;分泌过多的糖皮质激素抑制5′脱碘酶活性可能是甲状腺激素变化的主要原因;柯兴症甲状腺激素的测定有助于柯兴症的鉴别诊断和疗效观察。 相似文献
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8例健康人、15例单纯乳溢症和18例闭经-乳溢综合征患者口服生麦芽煎剂或成药(100~200g/天)。健康人睡眠及灭吐灵试验时催乳素(PRL)释放高峰均受抑制;单纯乳溢症组13例乳溢症消失或缓解,2例无效,其中6例作灭吐灵试验 PRL 反应高峰不受抑制;闭经-乳溢综合征组2例乳溢缓解,另2例恢复月经,但无排卵征象。 相似文献
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本文报告23例(26例次)高催乳素血症或垂体瘤患者作药物治疗观察,6例首剂服澳隐亭2.5 mg后7小时血催乳素降至最低水平,一次剂量维持药效12小时,12例闭经乳溢综合征患者澳隐亨治疗一个月催乳素浓度全部降到正常水平,其中9例恢复排卵月经或妊娠。8例赛庚啶治疗也有一定降催乳素疗效。 相似文献