用放射性标记微小球方法测定肢体骨组织的血流

本文运用放射性标记微小球方法对成年狗肢体长骨组织进行骨血流的测定。实验结果表明:松质骨血流要比皮质骨血流高出近4倍。皮质骨又可分为内皮质骨和外皮质骨,两者的血流无显著性区别。本文还对微小球在骨组织标本中的数目与测定骨血流准确性之间的关系进行了研究。     

运动创伤外科临床研究动态

国内运动创伤外科发展很快,近年来,一批具有高水平研究成果的临床应用,使运动创伤的损伤机制,早期诊断,微创手术修复重建,康复治疗与术后康复等方面取得了长足的进展。尤其是肩关节、肘关节、膝关节等四肢大关节运动损伤后的诊断和微创治疗,都达到了国际先进水平,有力的促进了运动创伤的临床研究,明显提高治疗效果。     

地塞米松对脑损伤大鼠核转录因子-κB水平的影响

Objective To explore the effects of dexamethasone on nuclear factor-kB (NF-κB) expression in brain tissue after traumatic brain injury (TBI). Methods Forty rats were randomly divided into two groups: dexamethasone treatment and no treatment, and severe brain injury was produced by gas percussion in both groups. At 0, 6, 24, 72 and 120 hours after injury, 5 rats of each group were executed and the histopathological changes in brain tissue in rats were observed by hematoxylin-eosin (HE) stain. The expression of NF-κB in brain tissue of rats was detected by immunohistochemical method. Results NF-κB expression was significantly up-regulated at 6 hours in brain tissue of rats after TBI (P<0.05), reaching the highest level at 24 hours (P<0. 01). It showed a tendency to lower, but was still high at 120 hours after TBI (P<0. 05 or P<0. 01). After treatment with dexamethasone, NF-κB level was lowered at 6, 24 and 72 hours (all P<0. 01). Conclusion NF-κB expression is up-regulated in brain tissue in early period after TBI, and keeps on a high level, thus inducing inflammatory response to produce secondary injury to brain tissue. Dexamethasone shows protective effects by regulating the levels of NF-κB and prevents secondary injury which is caused by the inflammatory cytokines in rat brain tissue after TBI.     

三种口服避孕药在人工月经周期应用中对骨代谢的影响比较研究

目的：通过服用3种口服避孕药妈富隆、敏定偶、左旋18-甲基炔诺酮（18-甲），拟探讨3种口服避孕药对骨代谢的影响，阐明何种药物更适合于调整月经周期，提供新的理论依据和实践方法。方法：将试验对象随机分成3组，分别服用3种药物，进行人工月经周期。结果：血清前钙素、抗酒石酸酸性磷酸醇在妈富隆组和敏定偶组服药后呈现下降的趋势。结论：妈富隆和敏定偶对骨代谢的影响相似，而且要优于18-甲。提示我们经常短期应用激素类口服避孕药的青年女子应该慎重，以免产生积累性负面效应，18-甲更应该引起我们的注意。     

地塞米松对脑损伤大鼠核转录因子-κB水平的影响

Objective To explore the effects of dexamethasone on nuclear factor-kB (NF-κB) expression in brain tissue after traumatic brain injury (TBI). Methods Forty rats were randomly divided into two groups: dexamethasone treatment and no treatment, and severe brain injury was produced by gas percussion in both groups. At 0, 6, 24, 72 and 120 hours after injury, 5 rats of each group were executed and the histopathological changes in brain tissue in rats were observed by hematoxylin-eosin (HE) stain. The expression of NF-κB in brain tissue of rats was detected by immunohistochemical method. Results NF-κB expression was significantly up-regulated at 6 hours in brain tissue of rats after TBI (P<0.05), reaching the highest level at 24 hours (P<0. 01). It showed a tendency to lower, but was still high at 120 hours after TBI (P<0. 05 or P<0. 01). After treatment with dexamethasone, NF-κB level was lowered at 6, 24 and 72 hours (all P<0. 01). Conclusion NF-κB expression is up-regulated in brain tissue in early period after TBI, and keeps on a high level, thus inducing inflammatory response to produce secondary injury to brain tissue. Dexamethasone shows protective effects by regulating the levels of NF-κB and prevents secondary injury which is caused by the inflammatory cytokines in rat brain tissue after TBI.     

膝关节功能评估表的临床研究

目的:研究膝关节功能评分表(百分法)的临床意义。方法:83例患者,男44例,女39例,年龄19-40岁,平均31岁。受伤时间1—28天,平均8天。损伤情况:半月板损伤60例,其中左膝27例,右膝33例:前交叉韧带断裂合并半月板损伤23例,其中左膝9例,右膝14例。患者入院后,统一由一名康复治疗师分别使用膝关节功能评分表(百分法)和Lysholm评分表进行膝关节功能评估。将二组评分值进行双变量相关分析。结果:83例患者采用膝关节功能评估表(百分法)评估、评分为52.58±19.18;采用Lysholm评分表评估,评分为51.86±19.71。将二组评分数值进行双变量相关分析,结果r=0.975,P<0.01,显示二组资料具有显著相关性。结论:膝关节功能评估表(百分法)使用方便,门诊、病房应用时,医、患间易于沟通,符合中国人的生活习惯和对临床问诊问题的理解。临床评分结果经统计学处理,与目前国际上应用效率较高的Lysholm评分法显著相关,因此,具有可靠性和实用性的特点。     

双层隔离痰盂的研制与临床应用

为改善临床病人的分泌物对环境造成的污染及减少分泌物对人视觉的不良刺激,改善就医环境,减少交叉感染,2003年8月—2006年5月我科自行研制了一种新型痰盂———双层隔离痰盂,经临床初试、终试及不断的改进和完善,最终制成成品,并应用于临床,收到满意的效果。现报道如下。1资料与方法1.1一般资料病人均为本院呼吸科住院病人,共56例,其中男36例,女20例;年龄15岁~86岁,平均56.8岁。病种有慢性支气管炎、肺源性心脏病、肺炎、肺癌等。1.2痰盂选择双层隔离痰盂:由不透明塑料制作成中间有一个11cm小孔漏斗形的带边痰盂上部,下面用塑料制作成带有刻…     

地塞米松对脑损伤大鼠核转录因子-κB水平的影响

Objective To explore the effects of dexamethasone on nuclear factor-kB (NF-κB) expression in brain tissue after traumatic brain injury (TBI). Methods Forty rats were randomly divided into two groups: dexamethasone treatment and no treatment, and severe brain injury was produced by gas percussion in both groups. At 0, 6, 24, 72 and 120 hours after injury, 5 rats of each group were executed and the histopathological changes in brain tissue in rats were observed by hematoxylin-eosin (HE) stain. The expression of NF-κB in brain tissue of rats was detected by immunohistochemical method. Results NF-κB expression was significantly up-regulated at 6 hours in brain tissue of rats after TBI (P<0.05), reaching the highest level at 24 hours (P<0. 01). It showed a tendency to lower, but was still high at 120 hours after TBI (P<0. 05 or P<0. 01). After treatment with dexamethasone, NF-κB level was lowered at 6, 24 and 72 hours (all P<0. 01). Conclusion NF-κB expression is up-regulated in brain tissue in early period after TBI, and keeps on a high level, thus inducing inflammatory response to produce secondary injury to brain tissue. Dexamethasone shows protective effects by regulating the levels of NF-κB and prevents secondary injury which is caused by the inflammatory cytokines in rat brain tissue after TBI.     

炎症时血清淀粉样蛋白A和C反应蛋白的变化

血清淀粉样蛋白A(SAA)是组织淀粉样A蛋白的前体,它由淀粉样原纤维组成,与继发性淀粉样变性发病有关.SAA和C反应蛋白(CRP)均为主要的急性时相反应蛋白,临床上可用于监测急性期反应.CRP对细菌感染是一敏感指标,但对病毒感染因其浓度变化幅度小而敏感性较低.本文比较了SAA和CRP在病毒性感染和细菌感染时的变化,认为SAA对急性病毒性感染是一灵敏的监测指标.     

枕大孔区肿瘤显微手术治疗

目的:探讨显微手术切除枕大孔区肿瘤的各种手术入路的临床价值及其治疗体会.方法:2000～2005年6月间诊治的枕大孔区肿瘤32例患者根据肿瘤不同部位采用不同的手术入路治疗.结果:肿瘤全切30例(94%),次全切2例(6%).结论:根据肿瘤不同部位选择相应的手术入路对于切除肿瘤具有微创、暴露充分、全切率高、并发症少的优点.