放置下腔静脉过滤器在介入治疗深静脉血栓中的远期疗效观察

目的：探讨放置下腔静脉过滤器在介入治疗深静脉血栓中的远期治疗效果。方法选取20例接受介入治疗深静脉血栓患者作为研究对象,患者治疗前均先放置下肢静脉过滤器,之后进行深静脉血栓治疗,观察患者术后并发症发生情况,并对患者进行3～21个月的随访,观察患者过滤器放置后状态。结果20例患者手术均顺利进行,1例患者手术后出现移位,并发症发生率为5%。对患者进行为期3～21个月的随访,血管造影结果显示,显效12例（60%）、有效7例（35%）,无效1例（5%）,治疗总有效率为95%。结论在介入治疗深静脉血栓中放置下腔静脉过滤器能够有效预防肺栓塞,远期治疗效果令人满意,可推广使用。     

Minocycline Attenuates Microglial Response and Reduces Neuronal Death after Cardiac Arrest and Cardiopulmonary Resuscitation in Mice

The possible role of minocycline in microglial activation and neuronal death after cardiac arrest(CA) and cardiopulmonary resuscitation(CPR) in mice was investigated in this study. The mice were given potassium chloride to stop the heart beating for 8 min to achieve CA, and they were subsequently resuscitated with epinephrine and chest compressions. Forty adult C57BL/6 male mice were divided into 4 groups(n=10 each): sham-operated group, CA/CPR group, CA/CPR+minocycline group, and CA/CPR+vehicle group. Animals in the latter two groups were intraperitoneally injected with minocycline(50 mg/kg) or vehicle(normal saline) 30 min after recovery of spontaneous circulation(ROSC). Twenty-four h after CA/CPR, the brains were removed for histological evaluation of the hippocampus. Microglial activation was evaluated by detecting the expression of ionized calcium-binding adapter molecule-1(Iba1) by immunohistochemistry. Neuronal death was analyzed by hematoxylin and eosin(H&E) staining and the levels of tumor necrosis factor-alpha(TNF-α) in the hippocampus were measured by enzyme-linked immunosorbent assay(ELISA). The results showed that the neuronal death was aggravated, most microglia were activated and TNF-α levels were enhanced in the hippocampus CA1 region of mice subjected to CA/CPR as compared with those in the sham-operated group(P<0.05). Administration with minocycline 30 min after ROSC could significantly decrease the microglial response, TNF-α levels and neuronal death(P<0.05). It was concluded that early administration with minocycline has a strong therapeutic potential for CA/CPR-induced brain injury.     

双重癌20例分析

目的：探讨双重癌的流行病学、发病机理、诊断及治疗。方法：对20例双重癌患者临床资料进行分析。结果：412例肿瘤患者中，双重癌为20例，二次治疗疗效CR（完全缓解）15％，PR（部分缓解）15％，SD（稳定）25％，PD（疾病进展）45％，RR（有效率）（CR＋PR）30％，临床控制率（CR＋PR＋SD）55％。结论：双重癌积极治疗后仍可取得较高的有效率和临床控制率。     

再生障碍性贫血-阵发性睡眠性血红蛋白尿症转为急性白血病并发Sweet综合征一例

患者女，46岁。因面色苍白乏力1个月，低热5d于2005年9月9日入院。入院体检：贫血貌，余未见异常。血象WBC1．6×10^9／L，Hb65g，／L，RBC 1．93×10^12／L，网织红细胞（Ret）0．165，PLT60×10^9／L。骨髓象有核细胞增生减低，粒系以成熟粒细胞为主，红系以中晚幼红细胞常见，成熟红细胞大小不一。淋巴细胞相对增多。巨核细胞未找到，血小板少见。骨髓病理：骨髓增生极度减低，脂肪细胞增生，[第一段]     

螺旋CT对老年主动脉夹层动脉瘤的诊断体会

夹层动脉瘤是由于动脉壁病变，使内膜或中层撕裂，被高压血流冲击，造成中层逐渐分离形成积血、扩张，呈双腔状，有时其远端仍可以与血管腔相沟通。主要发生在胸主动脉，并可延至腹主动脉。既往诊断主要依靠X线、超声或DSA等检查方法，随着螺旋CT和MRI技术的发展，螺旋CT血管造影、电子束CT的血管造影和磁共振血管造影已用于临床并显示了优越性，对其诊断价值已经得到临床医生的认可。本文回顾分析我院2年来应用多排螺旋CT血管造影诊断主动脉夹层动脉瘤13例，以提高对本病的诊断水平。     

量子点靶向探针在医学中的应用

新型纳米荧光材料量子点具有优越的光学特性和强大的表面修饰能力,在此基础上,量子点结合多种生物分子或化学物质制成的靶向探针在生物医学领域发挥着重大作用.该探针具有的靶向作用可以使量子点在肿瘤诊断中定位更加准确,并可以在加强疗效的同时,减小对于非肿瘤细胞的不良反应.目前,量子点靶向探针在细胞分子识别、体内成像、生物传感器、疾病治疗等领域的研究进展迅猛.     

比较影像学在超声教学中的应用研究

为了改善超声教学效果,我们提出在超声教学中应用比较影像学的内容,并对此进行研究.……