排序方式: 共有71条查询结果,搜索用时 15 毫秒
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目的识别精神科住院患者猝死的潜在危险因素,为探讨如何进一步预防住院精神病患者的猝死提供依据。方法选取1987年1月至2006年12月在广州市精神病医院精神科住院期间发生猝死的患者作为猝死组,选取与猝死组同性别相同或相近年龄、入院时间及在猝死者猝死当日仍住院的非死亡病例作为对照组,进行1:1匹配的病例对照研究。结果共有47例住院精神病患者发生猝死,猝死发生率1.68‰,(95%CI 1.20‰~2.16‰)。与对照组相比,猝死组合并心血管疾病、QTc间期延长及联用抗精神病药物的情况较多,差异有统计学意义(均P〈0.05)。结论对住院精神病患者的猝死危险评估和预防时要充分考虑其发生猝死的相关因素。 相似文献
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目的 探讨精神分裂症患者血清可溶性白细胞介素-2受体(SIL-2R)水平及其临床意义。方法 用酶联免疫试验检测42例首发精神分裂症患者治疗前后及正常人SIL-2R含量,并进行有关量表评定。结果 精神分裂症患者治疗前SIL-2R明显高于正常组(P<0.05),男女患者间无差异;Ⅰ型精神分裂症血清SIL-2R浓度显著高于Ⅱ型和混合型(P<0.05),后两者之间无显著性差异;治疗前,SIL-2R浓度与起病年龄呈负相关(r=-0.469,P<0.05),与阴性和阳性症状量表(PANSS)总分呈正相关(r=0.446,P<0.05);氯氮平和利培酮能显著升高血清SIL-2R浓度(P<0.01,P<0.05);此外,治疗后血清SIL-2R水平升高与病程,治疗前的SIL-2R和PANSS总分显著相关。结论 血清SIL-2R升高可能与精神分裂症发病有关,亦可能成为其临床亚型分布和早期病情严重程度评价的新指标。非典型抗精神病药(尤其是氯氮平)可能通过升高SIL-2R血清浓度达到免疫抑制作用。 相似文献
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目的调查广州市城乡养老院老年人痴呆患病情况。方法采用分层整群抽样方法,将广州地区养老院分为市级、区级、民营、厂矿及农村乡镇,每层各抽取1个养老院进行调查。应查者为抽中养老院的人住者,年龄≥60岁。实查1105人,失访12人(1.07%)。按美国精神障碍诊断与统计手册第4版的标准诊断痴呆。结果(1)检出率:在1105名老人中,查出痴呆患者324例,检出率为29.32%。其中阿尔茨海默病(AD)为20、36%(225例)、血管性痴呆(VD)为7、69%(85例)、混合性痴呆为0145%(5例)、帕金森病痴呆为0.27%(3例)、其他类型痴呆为0、54%(6例)。(2)女性痴呆患者235例,检出率(31.8%)高于男性(89例,24.3%;P〈0.05)。(3)痴呆检出率随年龄增长而上升。(4)痴呆患者中轻度71例(占21、9%)、中度103例(占31.8%)、重度150例(占46.3%)。结论广州地区养老院老人的痴呆检出率为29.32%,其中AD检出率高于VD,女性高于男性,以重度者多见,且痴呆检出率随年龄的增长而升高。 相似文献
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首发精神分裂症脑脊液和血清细胞因子水平及其与临床特征的关系 总被引:3,自引:0,他引:3
目的检测首发精神分裂症患者脑脊液和血清细胞因子水平,探讨其与临床特征的关系。方法纳入42例首发未用药的精神分裂症患者,采用放射免疫法测定患者脑脊液和血清白细胞介素2(IL-2)、白细胞介素6(IL-6)和肿瘤坏死因子-α(TNF-α)的浓度,采用阳性和阴性症状量表(PANSS)评定其精神症状,脑脊液对照组为10例外科手术患者,血清对照组为试剂盒提供正常的健康者血清细胞因子浓度。结果患者组脑脊液和血清IL-2和TNF-α水平均显著低于对照组(P<0.05),脑脊液IL-6水平高于对照组(P<0.05),血清IL-6与对照组的差异无统计学意义(P>0.05)。患者组脑脊液和血清IL-2、IL-6和TNF-α水平与年龄、体重、病程、PANSS总分及其分量表分等的相关均无统计学意义(P>0.05),而血清TNF-α水平与发病年龄呈正相关(r=0.37,P<0.05)。结论首发精神分裂症患者中枢和外周均存在细胞免疫障碍,但未发现其与临床症状相关,血清TNF-α水平与精神分裂症早期发病可能密切相关。 相似文献
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白细胞介素—2与精神分裂症研究进展 总被引:14,自引:0,他引:14
本介绍了白细胞介素-2和其受体的分子生物学特点地其与精神分裂症病因、临床状况、以及抗精神病药治疗的改变等相关研究作一阐述。 相似文献
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目的:探讨精神分裂症凶杀行为特征。方法:用自编行为特征调查表,分别对83例精神分裂症行凶与62例精神正常行凶进行对照分析,并对前的精神症状特点进行分析。结果:精神分裂症行凶性格以内向及多疑为主,而精神正常行凶性格以外向及暴躁为主,精神分裂症行凶其作案目的不明或受病态支配为主,精神正常作案目的以贪利及激情作案为主,精神分裂症患多于白天在自己家中公开作案,伤害时象以家人为主,精神正常以伤害同事为主,精神分裂症患作案后多数不潜逃、不销毁工具,其作案工具以菜刀及身边物件为主。精神分裂症行凶其精神症状以被害妄想及幻听为主。其伤害的家人主要是妻子及母亲,大部分在起病3年内作案。结论:两组在个性特点、行为动机、作案方式、伤害时象、案发后表现及作案工具方面有显差异,可以作为评定辨认能力及控制能力的重要因素。为减少精神分裂症凶杀行为的发生,应尽量加强刚起病3年内的看护及治疗。 相似文献
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Objective To evaluate the association of 2616c/T polymorphism in iron regulatory protein 2(IRP2)gene with Alzheimer disease(AD)and Vascular dementia(VD).Methods In this study,281 patients with AD,60 with VD,and 285 normal aged were recruited.The 2616C/T polymorphism in IRP2 gene was analyzed by using polymerase chain reaction-restriction fragment length polymorphism.And the cognitive function was assessed with the Mini-Mental State Examination(MMSE).Results (1)No significant difieFences were demonstrated in IRP2 genotype or allele frequencies between AD patients and controls(χ2=2.46,P=0.292;χ2=2.17,P=0.141 respectively).However,when AD patients were stratified by disease severity.the frequency of T allele carriers in the moderate to severe AD patients was 78.0%,significantly higher than that in controls(69.8%;χ2=4.106,P<0.05).Logistic regression analysis demonstrated that the age-,sex-and ApoE-adiusted OR of modcrate to severe AD patient with T allele was 1.62(95% CI=1.03-2.54).The frequency of T allele carriers or T allele in VD patients was higher than that of controls,but the difference was not statistically significant(P>0.05).(2)The frequency of tit genotype or T allele in the moderate to severe AD patients was significantly higher than that in mild AD patients(25.8%vs.12.5%,χ2=5.477,P<0.05;51.9%vs.40.3%,χ2=5.803,P<0.05 respectively).(3)MMSE scores of the AD patients with TT genotype was significantly lower than ones with CC or CT genotype(P=0.028;P=0.014 respectively).Conclusion The 2616C/T polymorphism in the IRP2 gene is possibly associated with moderate to severe AD.but not associated with VD.And the TT genotype may be a risk factor for cognitive impairment of patients with AD in Chinese Han. 相似文献
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盐酸氨溴索口崩片与普通片人体生物等效性比较 总被引:2,自引:1,他引:2
目的:对国产盐酸氨溴索口腔崩解片和进口普通片进行生物等效性研究。方法:20名健康男性志愿者按2×2交叉试验方案设计,分别口服受试制剂和参比制剂各90mg,并采集服药后24h内动态血标本;采用HPLC-MS/MS法测定血浆中氨溴索质量浓度,计算药动学参数,并判定两种制剂是否生物等效。结果:受试制剂和参比制剂的主要药动学参数Cmax分别为(175.6±57.3)μg.L-1和(173.6±50.7)μg.L-1,tmax分别为(1.3±0.3)h和(1.3±0.4)h,AUC0-24分别为(772.1±275.3)μg.L-1.h和(760.3±205.7)μg.L-1.h,AUC0-∞分别为(862.5±300.8)μg.L-1.h和(839.9±241.5)μg.L-1.h,t1/2(ke)分别为(6.8±2.6)和(6.5±2.9)h,两制剂主要药动学参数经对数转换后进行方差分析及双单侧t检验,并计算90%置信区间,表明两种制剂生物等效,受试制剂的人体生物利用度为(100.3±16.5)%。结论:两种制剂生物等效。 相似文献
40.
Objective To evaluate the association of 2616c/T polymorphism in iron regulatory protein 2(IRP2)gene with Alzheimer disease(AD)and Vascular dementia(VD).Methods In this study,281 patients with AD,60 with VD,and 285 normal aged were recruited.The 2616C/T polymorphism in IRP2 gene was analyzed by using polymerase chain reaction-restriction fragment length polymorphism.And the cognitive function was assessed with the Mini-Mental State Examination(MMSE).Results (1)No significant difieFences were demonstrated in IRP2 genotype or allele frequencies between AD patients and controls(χ2=2.46,P=0.292;χ2=2.17,P=0.141 respectively).However,when AD patients were stratified by disease severity.the frequency of T allele carriers in the moderate to severe AD patients was 78.0%,significantly higher than that in controls(69.8%;χ2=4.106,P<0.05).Logistic regression analysis demonstrated that the age-,sex-and ApoE-adiusted OR of modcrate to severe AD patient with T allele was 1.62(95% CI=1.03-2.54).The frequency of T allele carriers or T allele in VD patients was higher than that of controls,but the difference was not statistically significant(P>0.05).(2)The frequency of tit genotype or T allele in the moderate to severe AD patients was significantly higher than that in mild AD patients(25.8%vs.12.5%,χ2=5.477,P<0.05;51.9%vs.40.3%,χ2=5.803,P<0.05 respectively).(3)MMSE scores of the AD patients with TT genotype was significantly lower than ones with CC or CT genotype(P=0.028;P=0.014 respectively).Conclusion The 2616C/T polymorphism in the IRP2 gene is possibly associated with moderate to severe AD.but not associated with VD.And the TT genotype may be a risk factor for cognitive impairment of patients with AD in Chinese Han. 相似文献