多次法根管治疗与一次性根管治疗牙体牙髓病临床疗效观察

目的分析牙体牙髓病患者接受多次法根管治疗与一次性根管治疗的临床疗效。方法将2019年6月~2020年9月作为研究时间段,选取期间我院接诊的74例牙体牙髓病患者,其中12例有牙源性上颌窦炎,另将随机数字表法作为分组依据,将全部病例分为对照组(行多次法根管治疗,纳入37例)、研究组(行一次性根管治疗,纳入37例),对组间牙齿咀嚼情况、治疗效果展开分析。结果研究组牙齿咬合力、牙龈指数(GI)、牙龈出血指数(SBI)在治疗后均优于对照组,且治疗效果(97.29%)优于对照组(78.38%),P<0.05。结论一次性根管治疗对改善牙体牙髓病患者牙齿咀嚼功能、临床症状有较好效果,值得推广。     

微信在鼻咽癌患者放疗后张口锻炼中的应用

目的 探讨微信随访对鼻咽癌放疗后出院患者张口困难的应用效果.方法 将60例鼻咽癌出院患者随机分为观察组和对照组,每组各30例.患者在住院期间,从放疗之日起,开始进行示范性功能锻炼及放疗相关知识、并发症等一对一的健康教育.对照组在出院时发放宣传手册,嘱咐患者每天坚持功能锻炼,不适随诊,并按医嘱3个月、6个月后来院复查.观察组首先建立微信平台,然后对相关医护人员进行培训,同时对每位出院患者进行基本信息的登记,并在自愿条件下邀请患者关注我科的公众号"岐黄飘香",3个月、6个月后进行复查.结果 观察组门齿距宽于对照组(P＜0.05),观察组满意度明显高于对照组(P＜0.05).结论 微信随访能提高鼻咽癌放疗出院患者功能锻炼的依从性,降低张口困难的发生率,改善生活质量,提高患者的满意度.     

下生殖道感染与子宫颈细胞学异常的相关性研究

Objective?To study the association between abnormal cervical cytology and bacterial vaginosis (BV), vulvovaginal candidiasis(VVC), trichomonas vaginitis(TV), high-risk human papillomavirus(HR-HPV) infection in women attending cervical cancer screening. Methods?The study recruited 3 300 women aged 21 to 64 years of age who participated in cervical cancer screening. Demographic information was collected. Cervical exfoliated cell specimens were collected for liquid-based cytological diagnosis and HR-HPV detection. Reproductive tract secretions specimens were collected for molecular vaginitis diagnostics from women who were diagnosed with negative for intraepithelial lesion or malignancy(NILM) and all HR-HPV positive or ≥atypical squamous cells of undetermined significance(ASC-US). The Logistic multivariate model was used to analyze the risk factors of abnormal cervical cytology. Results?645 women were included in the study, including 408 NILM, 182 ASC-US, 23 low-grade squamous intraepithelial lesion (LSIL), and 32 high-grade squamous intraepithelial lesions (HSIL). The positive rate of HR-HPV (14.7%, 39.0%, 78.3% and 87.5%) increased with the severity of cytology (P<0.001). The prevalence of BV in different cytological diagnosis (34.1%, 49.5%, 60.9% and 43.8%) were significantly different (P<0.001), and the prevalence of BV in ASC-US were significantly higher than that in women with NILM (P<0.05). The prevalence of VVC in different cytological diagnosis (14.2%, 4.9%, 8.7% and 3.1%) was significantly different (P<0.01), and the ASC-US group was significantly lower than the NILM group (P<0.001). There was also a significant difference in the distribution of the prevalence of TV (2.5%, 9.3%, 4.3%, and 6.3%, P<0.01). The prevalence of TV in women with abnormal cytology was higher than that in women with normal cytology(P<0.05). The Logistic analysis showed that HR-HPV infection, BV, TV, VVC, lower level of education, and postmenopause were related to abnormal cervical cytology. Conclusion?HR-HPV infection is the determinant of abnormal cervical cytology. BV, TV, VVC, lower level of education, postmenopause, etc. may associate with abnormal cervical cytology.     

应用BSP克隆测序检测肝细胞癌组织中Dynamin 3基因启动子区域甲基化水平

目的检测原发性肝细胞癌组织Dynamin 3(DNM3)基因启动子区域36个CpG的甲基化水平,分析其与肝细胞癌患者临床病理特征的关系,探讨DNM3基因甲基化在肝癌形成过程中的作用。方法提取30对患者肝细胞癌组织和癌旁组织DNA,经亚硫酸氢盐处理后,进行巢式PCR并联合克隆测序检测DNM3基因的甲基化水平。结果肝细胞癌患者的甲基化事件发生率为83.3%(25/30)。癌组织的DNM3基因启动子区域平均甲基化率为37.8%,癌旁组织为12.0%,两者比较差异有统计学意义(P0.05)。DNM3基因甲基化诊断肝癌的受试者工作特征曲线(ROC)曲线下面积(AUC)为0.831,对肝癌有较好的诊断价值。结论 DNM3作为肝细胞癌的一种抑癌基因,其启动子区域高度甲基化可能会促进肝细胞癌的形成。     

参麦注射液203例临床安全性集中监测结果分析

目的对参麦注射液进行上市后再评价,了解其临床使用情况和不良反应,总结合理使用经验。方法采用调查表的方式收集2011年7月—2013年4月我院参麦注射液临床使用情况和不良反应发生情况,并进行数据分析。结果 203份病例使用参麦注射液的不良反应发生率为0%。结论参麦注射液的不良反应概率较小,如临床能加强病例筛选和使用监护,使用仍较安全。     

儿童侵袭性肺炎链球菌病54例临床特点及耐药性分析

目的了解儿童侵袭性肺炎链球菌疾病(IPD)的临床特点及侵袭性肺炎链球菌(Sp)的耐药情况。方法回顾性分析2009年至2012年收治的54例IPD患儿临床资料以及54株侵袭性Sp的药敏结果。结果 54例IPD患儿中男女比为1.35∶1,以2岁的婴幼儿居多,夏季起病少;临床诊断以脓毒血症为主,其次为脑膜炎;患儿均有发热,且以中高热为主;44例出现白细胞计数增高,42例出现CRP增高;β-内酰胺类抗生素使用最多,其次为万古霉素。侵袭性Sp对青霉素的不敏感率达59.26%,多重耐药率高达96.30%。结论 IPD发病存在一定季节差异;临床表现多样,脓毒血症最常见;侵袭性Sp对青霉素耐药性较高。