温胆汤加味合奥美拉唑治疗胃食管反流病临床观察

胃食管反流病(GERD)是由多种因素造成的消化道动力障碍性疾病,是最常见的食管疾病,临床表现多样,容易反复发作。自2000年以来,以温胆汤加味合奥美拉唑治疗本病,控制其临床症状和减少复发取得较好疗效。1临床资料1.1诊断标准①年龄在20~65岁;②临床表现为不同程度的烧心、反酸、     

当归针穴位注射对慢性肾炎高血压大鼠PRA、AngⅡ的影响

目的　探讨当归针穴位注射对慢性肾小球肾炎高血压大鼠的影响及其机制。方法　采用阿霉素肾病结合二肾一夹高血压模型 ,当归针注射“曲池”、“肾俞”穴 ,共 2个疗程 ,以开博通作阳性对照。结果　当归针穴位注射具有与开博通相仿的降低血压和肾功能保护作用。当归针组血浆中 PRA、Ang 显著低于模型组 ( P<0 .0 0 1,P<0 .0 5 ) ,Ang 与开博通组比较无统计学差异。结论　当归针穴位注射可以降低慢性肾炎高血压大鼠血浆 PRA、Ang ,这与其降低血压的作用相一致     

Clinical observation on treatment of post-craniocerebral traumatic mental disorder by integrative medicine

Objective： To observe the clinical efficacy of integrative medical therapy in treating post-craniocerebral traumatic mental disorder （PCT-MD）. Methods： Sixty patients with confirmed diagnosis of PCT-MD were randomly assigned to the treated group and the control group equally. All were treated by conventional comprehensive Western medicine, but to patients in the treated group, modified Xufu Zhuyu Decoction （血府逐瘀汤, XFZY） was additionally given and the therapeutic course for both groups was 20 days. Changes in mental symptoms were observed and recorded on the 10th and 20th day and clinical efficacy as well as cranial CT image was estimated after termination of the treatment. Results： The clinical effective rate in the treated group and the control group was 96.67% and 83.30% respectively. Comparison between them showed significant difference （P〈0.05）. Significant differences were also shown in the comparisons between the two groups in improving mental symptoms, either on the 10th or on the 20th day （P〈0.05 and P〈0.01 respectively）, and in post-treatment cranial CT image （P〈0.05）. Conclusion： Better efficacy could be obtained by integrative medical therapy in treating PCT-MD.     

苦参碱诱导SMMC-7721细胞分化过程中侵袭转移相关指标的实验研究

目的：研究苦参碱诱导人肝癌SMMC-7721细胞分化过程中对其侵袭转移能力的抑制作用。方法：SMMC-7721细胞体外培养，0．5g/L、0．8g/L、1．0g/L浓度的苦参碱分别处理细胞，通过生长曲线测定、细胞形态观察、细胞粘附试验、运动试验、侵袭试验全面观察苦参碱对该细胞株的生长增殖、形态变化、侵袭转移等各方面的诱导分化作用。结果：经0．8g/L和1．0g/L浓度的苦参碱处理后，SMMC-7721细胞的生长增殖明显减缓，恶性细胞形态逐渐向成熟细胞分化，肿瘤细胞与FN的粘附力、细胞穿膜运动力、对基底膜的降解力等侵袭转移相关指标均受到显著抑制。结论：苦参碱是一种较好的诱导分化剂，不仅抑制细胞的生长增殖，诱导细胞形态分化，而且从细胞的粘附、运动、降解等多环节全面抑制SMMC-7721细胞的侵袭转移能力。