先天性心脏病患儿应用水合氯醛镇静后采集血气标本的临床效果观察

[目的]探索一种先心病患儿术前准备中简单易行的动脉血样采集方法。[方法]选取准备接受手术治疗的住院先天性心脏病患儿60例,随机分为实验组和对照组,实验组血气标本采集时机选择在应用水合氯醛镇静后;对照组在常规入院后次日上午清醒时,比较两组患儿采血前、中、后的心率及血氧饱和度的变化、一次穿刺成功率及穿刺部位皮下血肿的发生情况、成功采集血气标本时患儿哭闹持续时间及完成采血时间。r结果]两组患儿采血前心率、血氧饱和度无差异（P〉0．05）;实验组患儿采血中及采血后1rain、5rain、10rain的心率低于对照组（P〈0．05）,血氧饱和度高于对照组（P〈0．05）;一次动脉穿刺成功率高于对照组（P〈0．05）,穿刺部位皮下血肿的发生率低于对照组（P〈0．05）;实验组成功采集血气标本患儿的哭闹时间及完成采血时间均明显低于对照组（P〈0．05）。[结论]水合氯醛镇静后采集血气标本增加了先天性心脏病患儿围术期术前护理操作的安全性,减少了患儿的痛苦,提高了护士的工作效率。     

住院老年癌症患者跌倒的原因分析及防范

目的通过对住院老年癌症患者跌倒危险因素分析及采取防范措施提高住院患者的安全。方法对2010-10住院癌症患者中跌倒的原因分析及防范措施。结果住院癌症患者的跌倒不仅与年龄有关,也与原发疾病、药物因素、放、化疗、病区环境和护理人力有关。对跌倒的危险因素进行分析,明确高危人群,并提出防范措施。在管理上,制定跌倒报告与伤情认定与报告制度和程序,落实防范措施。结论实施跌倒防范措施后有效预防癌症患者住院期间意外事件的发生,确保住院安全。     

促排卵治疗低促性腺激素性闭经并发OHSS 1例分析

低促性腺激素性闭经是由垂体功能衰竭导致的一类闭经,其表现为无排卵、闭经与不孕.应用促性腺激素(Gn)、绒毛膜促性腺激素(HCG)促排卵治疗,促使月经来潮、排卵与妊娠,在国内外已有报道,但促排卵后发生卵巢过度刺激综合征(ovarian hyperstimulation syndrome,OHSS)者较少见.现将我院发生的此例报道如下.     

非小细胞肺癌组织中COX-2表达及其与微血管和微淋巴管密度的关系

目的 探讨非小细胞肺癌组织中COX-2表达的临床病理学意义,及其与微血管密度(MVD)和微淋巴管密度(MLD)的关系。方法采用免疫组化PV-9000法检测80例非小细胞肺癌组织中COX-2的表达,同时标记CD34和D2-40,分别检测非小细胞肺癌组织中微血管和微淋巴管密度。结果 80例非小细胞肺癌组织中COX-2的阳性表达率为88.75%(71/80),COX-2的表达与患者性别、肿瘤位置、组织学类型无关(P>0.05),而与肿瘤大小、组织学分级、淋巴结转移及其临床病理分期密切相关(P<0.05);COX-2表达阳性者的MVD和MLD均明显高于COX-2表达阴性者(P<0.05)。结论 COX-2可能通过促进肿瘤的血管和淋巴管形成而参与非小细胞肺癌细胞的浸润和转移。     

双侧原发性乳腺癌ER、PR、Her-2、Ki-67的表达及意义

目的:本研究探讨双侧原发性乳腺癌ER、PR、Her-2、Ki-67的表达及意义.方法:回顾新疆医科大学附属肿瘤医院2000年～2008年期间38例双侧原发性乳腺癌的临床病理资料,同时选取62例单侧乳腺癌作为对照.结果:①双侧原发性乳腺癌中第一原发癌的组织学分级及淋巴结转移率较第二原发癌高,差别具有统计学意义(P<0.0...     

Dangfei Liganning Capsules (当飞利肝宁胶囊) Attenuate the Susceptibility of Rat Nonalcoholic Fatty Liver to Carbon Tetrachloride Toxicity

Objective: To test whether nonalcoholic hepatic steatosis sensitizes carbon tetrachloride (CCl4)-induced liver injury, and to assess the therapeutic effect of Chinese medicine extracts of Dangfei Liganning capsules (当飞利肝宁胶囊) and their potential underlying mechanisms. Methods: Male Wistar rats were fed a high-fat diet to induce nonalcoholic fatty liver disease (NAFLD) or a normal diet (N). Eight weeks later, a nonlethal dose of CCl4 was applied intraperitoneally. From the start, HF-CCl4 rats were administered daily Dangyao extracts (D), Dangfei Liganning capsules (DF), or Diammonium Glycyrrhizinate (G) intragastrically. Rats were sacrificed 48 h after CCl4 administration. In addition to serum biochemistry, liver histopathology was observed using hematoxylin-eosin (HE) and oil red O staining, and hepatic levels of triglyceride (TG), malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), caspase-3 activation and cytochrome P450 (CYP2E1) expression were assessed. Results: There was almost no response to the nonlethal dose of CCl4 in the N control group. However, the HF group demonstrated massive steatosis, and elevated levels of serum ALT and AST, liver MDA, CYP2E1, and caspase-3 activation, whereas the levels of GSH and SOD were significantly decreased. All indexes assessed were dramatically worse in the HF-CCl4 group compared to the HF group, in addition to the more severe steatosis, hepatocyte ballooning, and inflammatory infiltration apparent in the centrilobular area. The medicines we tested affected the pathological changes in HF-CCl4 rats to differing degrees: DF and G led to improvements in all of the above examined indexes, including an obvious improvement in histopathology, and DF improved serum ALT and MDA levels more markedly than G, whereas D extracts produced only mild liver injury attenuation. Conclusion: Liver with NAFLD is more sensitive to hepatotoxicity; furthermore, the disrupted balance of oxidative stress and anti-oxidant defense contributes to the underlying mechanisms. Dangfei Liganning capsules potentially decrease this toxic susceptibility and alleviate liver injury in non-alcoholic fatty liver.     

D-二聚体及纤维蛋白原水平在类风湿关节炎中的临床意义

目的 了解类风湿关节炎(RA)患者血浆D-二聚体(DD)和纤维蛋白原(FIB)的水平及其与RA病情活动指标的关系.方法 检测RA患者及健康对照者血浆DD及FIB水平,分析RA血浆DD和FIB与血沉(ESR)、C反应蛋白(CRP)、血小板(PLT)、疾病活动度评分(DAS28)及血红蛋白(Hb)的相关性.结果 RA患者血...     

郑州地区2332例一般人群中医体质类型构成比分析

目的:了解郑州地区一般人群中医体质分布情况,为进一步健康管理提供依据。方法:根据2 332例体质辨识人群不同年龄、不同性别等进行分析。结果:2 332例人群中平和质人群有771人,占33.06%,偏颇体质人群有1 561人,占66.94%。居于前3位的偏颇体质类型为阳虚质、湿热质、痰湿质,分别占18.57%、10.33%、9.31%。男女体质分布存在差异,2 332例人群中,男性1 279例,平和质有566人,占44.25%,偏颇体质713人,占55.75%,具有前3位的是湿热质、阳虚质、痰湿质,分别占13.21%、11.10%、9.70%%。结论:阳虚质、湿热质、痰湿质是郑州地区一般人群的常见偏颇体质类型,且多种体质兼夹也是郑州居民的体质特点。     

加减秦艽牛蒡汤治疗湿热蕴肤型慢性荨麻疹及对血清IL-4，IgE和IFN-γ的影响

[目的]观察加减秦艽牛蒡汤治疗湿热蕴肤型慢性荨麻疹的临床疗效及对血清白细胞介素4(IL-4),免疫球蛋白E(IgE)和干扰素γ(IFN-γ)的影响。[方法]将90例慢性荨麻疹患者分为治疗组和对照组,每组45例。治疗组予加减秦艽牛蒡汤中草药口服;对照组给予氯雷他定10 mg,每日1次。治疗6周后观察症状总积分、血清IL-4,IgE和IFN-γ的变化,统计其临床疗效。[结果]治疗6周后,治疗组症状、中医证候总积分明显低于对照组;血清IL-4和IgE水平低于对照组,IFN-γ高于对照组,比较差异均有统计学意义(P0.05)。治疗组与对照组临床疗效总有效率分别为91.11%、71.11%,比较差异有统计学意义(P0.05)。[结论]加减秦艽牛蒡汤能明显改善慢性荨麻疹患者瘙痒、风团症状;可以降低血清IL-4,Ig E水平和提高血清IFN-γ水平。