An Experimental Study on Somatostatin Receptors in the Brains of Hepatic Encephaiopathy Rats

(张宗明)(裘法祖)(陈孝平)ＡｎＥｘｐｅｒｉｍｅｎｔａｌＳｔｕｄｙｏｎＳｏｍａｔｏｓｔａｔｉｎＲｅｃｅｐｔｏｒｓｉｎｔｈｅＢｒａｉｎｓｏｆＨｅｐａｔｉｃＥｎｃｅｐｈａｉｏｐａｔｈｙＲａｔｓ￥ＺＨＡＮＧＺｏｎｇ－ｍｉｎｇ；ＱＩＵＦａ－ｚｕ；ＣＨＥＮＸｉａｏ...     

Effects of Amrinone on Cardiac Contraction and Relaxation in Isolated，Perfused Rat Heart

(马业新)(赵华月)ＥｆｆｅｃｔｓｏｆＡｍｒｉｎｏｎｅｏｎＣａｒｄｉａｃＣｏｎｔｒａｃｔｉｏｎａｎｄＲｅｌａｘａｔｉｏｎｉｎＩｓｏｌａｔｅｄ，ＰｅｒｆｕｓｅｄＲａｔＨｅａｒｔ￥ＭＡＹｅ－ｘｉｎ；ＺＨＡＯＨｕａ－ｙｕｅ（ＤｅｐａｒｔｍｅｎｔｏｆＩｎｔｅｒｎ...     

Effect of Tripterygium Vilfordii on Adrenal Cortex in Rat with Adjuvant Arthritis

(张明敏)(刘沛霖)(叶望云)ＥｆｆｅｃｔｏｆＴｒｉｐｔｅｒｙｇｉｕｍＶｉｌｆｏｒｄｉｉｏｎＡｄｒｅｎａｌＣｏｒｔｅｘｉｎＲａｔｗｉｔｈＡｄｊｕｖａｎｔＡｒｔｈｒｉｔｉｓ￥ＺＨＡＮＧＭｉｎｇ－ｍｉｎ；ＬＩＵＰｅｉ－ｌｉｎ；ＹＥＷａｎｇ－ｙｕｎ（Ｔｏｎｇｊｉ...     

Effect of Diallyl Trisulfide on the Activation of T Cell and Macrophage－mediated Cytotoxicity

(冯作化)(张桂梅)(郝天玲)(周斌)(张慧)(姜志尧)ＥｆｆｅｃｔｏｆＤｉａｌｌｙｌＴｒｉｓｕｌｆｉｄｅｏｎｔｈｅＡｃｔｉｖａｔｉｏｎｏｆＴＣｅｌｌａｎｄＭａｃｒｏｐｈａｇｅ－ｍｅｄｉａｔｅｄＣｙｔｏｔｏｘｉｃｉｔｙ￥ＦＥＮＧＺｕｏ－ｈｕａ；ＺＨＡＮＧＧｕｉ－...     

Clinical Effects of Chinese Medicine in Treating Asthma

ＣｌｉｎｉｃａｌＥｆｆｅｃｔｓｏｆＣｈｉｎｅｓｅＭｅｄｉｃｉｎｅｉｎＴｒｅａｔｉｎｇＡｓｔｈｍａＣｌｉｎｉｃａｌＥｆｆｅｃｔｓｏｆＣｈｉｎｅｓｅＭｅｄｉｃｉｎｅｉｎＴｒｅａｔｉｎｇＡｓｔｈｍａＬＩＨｏｎｇ－ｆｅｎ（李洪芬）；ＺＭＡＮＧＹｉ－ｆａｎｇ（...     

Antagonistic Effect of Poria Cocos on Ototoxicity of Kanamycin in Guinea－Pigs

ＡｎｔａｇｏｎｉｓｔｉｃＥｆｆｅｃｔｏｆＰｏｒｉａＣｏｃｏｓｏｎＯｔｏｔｏｘｉｃｉｔｙｏｆＫａｎａｍｙｃｉｎｉｎＧｕｉｎｅａ－ＰｉｇｓＬＩＵＹａｏ－ｃｈｕｎ（刘耀春）；ＬＩＵＧｕｉ－ｙｉｎｇ（刘桂英）；ＬＩＵＲｕ－ｌｉｎ（刘儒林）；ＣＨＥＮＧＸｉｕ－...     

Macrophages in Degradation of Calcium Phosphate Compound Artificial Bone： An in vitro Study

(夏志道)(朱通伯)(杜靖远)(郑启新)(汪岚)ＭａｃｒｏｐｈａｇｅｓｉｎＤｅｇｒａｄａｔｉｏｎｏｆＣａｌｃｉｕｍＰｈｏｓｐｈａｔｅＣｏｍｐｏｕｎｄＡｒｔｉｆｉｃｉａｌＢｏｎｅ：ＡｎｉｎｖｉｔｒｏＳｔｕｄｙ￥ＸＩＡＺｈｉ－ｄａｏ；ＺＨＵＴｏｎｇ－ｂｏ；ＤＵＪｉ...     

Effects of Cordycaps slnensis on Malondialdehyde Content of Renal Cortex in Ischernic Acute Renal Fallure in Rats

ＥｆｆｅｃｔｓｏｆＣｏｒｄｙｃａｐｓｓｌｎｅｎｓｉｓｏｎＭａｌｏｎｄｉａｌｄｅｈｙｄｅＯｏｎｔｅｎｔｏｆＲｅｎａｌＣｏｒｔｅｘｉｎＩｓｃｈｅｒｎｉｃＡｃｕｔｅＲｅｎａｌＦａｌｌｕｒｅｉｎＲａｔｓＬｉａｏＨｏｎｇ－ｊｕｎ（廖洪军）；ＣｈｅｎＸｉａｎｇ－...     

Application of Anticancer Agent Embolism in Miles'Operation

ＡｐｐｌｉｃａｔｉｏｎｏｆＡｎｔｉｃａｎｃｅｒＡｇｅｎｔＥｍｂｏｌｉｓｍｉｎＭｉｌｅｓ＇ＯｐｅｒａｔｉｏｎＬＩＵＦｅｉ－ｌｏｎｇ（刘飞龙）；ＹＩＥＱｉ－ｆａ（叶启发）；ＹＡＮＧＣｈｕａｎ－ｙｕａｎ（杨传勇）；ＺＨＡＯＣｕｉ－ｌａｎｇ（赵翠兰）；Ｄａｉ...     

Observation on Clinical Effects of Herba Andrographidis in Patients with Chronic Cor Pulmonale

ＯｂｓｅｒｖａｔｉｏｎｏｎＣｌｉｎｉｃａｌＥｆｆｅｃｔｓｏｔＨｅｒｂａＡｎｄｒｏｇｒａｐｈｉｄｉｓｉｎＰａｔｉｅｎｔｓｗｉｔｈＣｈｒｏｎｉｃＣｏｒＰｕｌｍｏｎａｌｅｚｈｕＹｉｎｇ－ｃｈｕｎ（朱迎春）；ＺｈａｎｇＹａｏ－ｚｈｅｎ（张瑶珍）；ＮｉｕＲｕ－...     

Effect of Increasing Biliary Tract Pressure on House Rabbit Blood Dynamics in Acute Cholangitis of Severe Type

ＥｆｆｅｃｔｏｆＩｎｃｒｅａｓｉｎｇＢｉｌｉａｒｙＴｒａｃｔＰｒｅｓｓｕｒｅｏｎＨｏｕｓｅＲａｂｂｉｔＢｌｏｏｄＤｙｎａｍｉｃｓｉｎＡｃｕｔｅＣｈｏｌａｎｇｉｔｉｓｏｆＳｅｖｅｒｅＴｙｐｅＺＨＥＮＧＱｉ－ｃｈａｐｇ（郑启昌），ＱＩＬｉ－ｈａｎｇ（齐立...     

The role of vague nerve in the hemodynamic changes induced by acute biliary tract pressure increase

Summary In order to explore the mechanism of hemodynamic changes caused by high biliary tract pressure, we established an animal model of high biliary tract pressure, in which the disturbance of hemodynamics developed. The cervical or abdominal vague nerve was then blocked. It was observed that when the biliary tract pressure was increased to 16 kPa and kept for 1 h, the arterial blood pressure and cardiac output decreased immediately and parallelly (P<0.05). When the cervical or abdominal vague nerve were blocked or the pressure of the biliary tract was decreased to zero, both indices returned to normal immediately (P> 0. 05). The change of cardiac output lags a little behind that of arterial blood pressure. It suggests that the signal of biliary tract pressure increase can be sent to the cardiovascular center through vague nerve, and the balance between sympathic and parasympathic nerve was broken, which led to the weakening of cardiac contraction and decrease of cardiac output. Due to the peripheral effects of vague nerve, hemodynamic resistance of vessels decreased, which brought about redistribution of peripheral blood flow. Both were the causes of hemodynamic disturbances. After the blood pressure decreased markedly, it showed a jump to normal state when cervical vague nerve was blocked. And the amplitude of diastolic blood pressure restored more than that of systolic blood pressure. This suggests that the cardiac output and peripheral blood resistance are important factors that cause the decrease of blood pressure.     

Hormone Secretion by Cell Culture of Human GH-PRL Secreting Pituitary Adenomas: Effects of Bromocriptine

Acuteobstructivesuppurativecholangitis(AOSC)isasurgicalsyndromewithveryhighmorbidity.Hypotensionand/orshockthatdevelopattheverybeginningareimportantcausesofdeath.AcuteintraductalpressureincreasingisthemostsignificantpathophysiologicalfeatureofAOSC.Previousstudiesshowedthathypotensionorshockcouldbeinducedbyhighintraductalpressure,whichwasrelatedtomajorsplanchnicnerved].Buttheroleofparasympathicnerveinthisprocessremainsunknown.Thisstudywasconductedtoinvestigatetheeffectsofvaguenerveonthehemo…     

阻断迷走神经对胆管加压所致心血管活动的影响

目的　以迷走神经为对象 ,研究胆管加压所致机体心血管活动变化的神经机理。方法　采用自制“盲囊”导管制成家兔急性胆管加压模型 ,观察动物的动脉血压及心输出量改变情况。结果　持续胆道加压 ,家兔的动脉血压和心输出量几乎平行快速下降 (P <0 .0 5 ) ;这种变化在阻断颈部或腹部迷走神经后 ,又很快恢复至加压前水平 (P >0 .0 5 ) ,但动脉血压和心输出量的恢复速度 ,按迷走神经的阻断部位不同而有所差异。结论　胆道高压所致的家兔血液动力学变化 ,与迷走神经的活动有关 ,并且推断可能是一种神经反射机制。     

Effects of biliary tract pressure on dynamics of the Oddi’s sphincter and its nerve mechanism

Summary In order to explore the effect of biliary tract pressure on Oddi’s sphincter and the mechanism of development of high pressure of biliary tract during acute obstructive and suppurative cholangitis (AOSC), house rabbits were used to establish model of high biliary pressure in acute biliary duct caecus. It was observed that when the pressure of the acute biliary tract was increased to 8 kPa, the electric activity of Oddi’s sphincter was obviously enhanced, the pressure of Oddiœs sphincter increased remarkably (P <0. 05), and even constant spasm appeared with accompanying increase of discharge frequency of the right greater splanchnic nerves (P <0. 05) and progressive decrease of mean arterial pressure. However, when lidocaine of 0. 6 % was used to block the right celiac plexus, no above-mentioned reaction happened when the biliary tract pressure was increased again. The results indicated that the acute biliary tract obstruction might induce the contraction or spasm of Oddi’s sphincter and bring about a vicious cycle. Its mechanism is related to splanchnic nerves reflection and it is one of important factors in the development of AOSC course. This project was supported by National Educational Committee Grant for Overseas Chinese Scholars (No. 9130219).     

急性缺氧复合运动对清醒山羊心肺血流动力学的影响

观察了8只雌性山羊在急性缺氧(模拟4000m高原)条件下运动时心肺血流动力学的改变。急性缺氧可致肺动脉压升高,心率增加,心输出量和体动脉压无明显变化。平原运动时,肺动脉压、心输出量和心率均有明显增加。但在急性缺氧条件下运动时,肺动脉压并来进一步升高,其原因可能与急性缺氧条件下山羊的pHa升高有关。     

前列腺素E1对栓塞性肺动脉高压动物的作用

目的　研究前列腺素E1对栓塞性肺动脉高压的作用。方法　测定栓塞性肺动脉高压的小猪静脉注射前列腺素E1前后的血流动力学、D 二聚体、一氧化氮 (NO)和血气分析的变化。结果　栓塞动物模型使用前列腺素E1后 ,肺动脉压有显著下降 ,心搏指数增加 ,血氧分压改善 ,NO下降 ,与对照组比较有显著差异 (P <0 0 5 )。结论　前列腺素E1可明显降低栓塞引起的肺动脉高压 ,增加心输出量 ,改善氧合。     

Effect and Clinical Value of Splanchnic Nerve Block of Hemodynamics in ACST

Thedevelopmentoftheacutecholangitisofseveretype(ACST)isoftenoverwhelmingandoftentheurgentpressuredecreaseofthebinarytractisneededtosavethelifeofthepatients:Manyreportsindicatedthatthepurulentbileinthebinarytractretrogradedlyenteredthehepaticsinusoidunderthehighpressureduetoobstruction,andflowedintothevenaecavaeviathehepaticveins,whichcouldbringaboutsepticemiaandinfectiousshock.TheretrogradeflowinbinarytractisthecriticalreasonfortheworseningofACST[1].Ourpreviousstudyshowedthatbesidestheabove…     

腹腔压力对急性肺损伤家猪呼吸力学及血流动力学的影响

目的探讨不同腹腔内压力(IAP)对急性肺损伤(ALI)家猪呼吸力学及血流动力学的影响。方法将8只家猪经耳缘持续静脉泵入油酸0.1 mL/kg制作急性肺损伤模型,采用氮气气腹法制作不同腹腔压力模型,随机将IAP设置为0、15和25 mm Hg,即分为IAP0组、IAP15组和IAP25组,动态监测心率(HR)、平均动脉压(MAP)、中心静脉压(CVP),采用脉搏轮廓持续心排出量监测(PiCCO)法动态监测心排出量(CO)、胸腔内血容量指数(ITBVI)等血流动力学指标,同时置入食管内压管动态监测食管内压(Pes)的变化。结果 IAP15组、IAP25组与IAP0组比较,Pes和气道峰压(Ppeak)均显著增加(P<0.01),肺顺应性(Cstat)则显著下降(P<0.05),跨肺压(Ptp)呈下降趋势,PaO2亦呈下降趋势,PaCO2则呈上升趋势,但均无统计学意义(P>0.05)。IAP15组、IAP25组与IAP0组比较,HR和CVP显著增加(P<0.05),CI和ITBVI则显著下降(P<0.05),但MAP无明显改变(P>0.05);ΔPes与CI的变化(ΔCI)呈负相关(r=-0.648,P<0.05)。结论急性肺损伤时,腹腔内压增高引起胸腔内压力增高,导致肺顺应性下降和心排出量下降。     

胆道梗阻程度在重症胆管炎病程中的作用及其临床意义

本文分析了我院近十年的36例重症胆管炎(ACST)患者,结果显示:依梗阻是否完全,ACST可分成急性梗阻化脓性胆管炎(AOSC)和急性化脓性胆管炎(ASC),前者发展凶猛,死亡率极高,后者则预后较好。另外本文采用44只日本种长耳家兔以不同胆道梗阻制成胆道管炎模型,结果也证实,完全梗阻组48小时血压下降幅度达7.6kpa(55mmHg),较不全梗阻组(4kpa)为高(p<0.05),作者认为:胆道梗阻程度是ACST病情发展的重要因素。文中发现血内毒素与血压变化并不平行,可能存在其它影响因素。