国产偏心封堵器在治疗室间隔缺损的应用

目的探讨国产偏心型封堵器介入治疗室间隔缺损的临床疗效。方法2006年3月-2008年8月,46室间隔缺损患者使用国产偏心型封堵器,其中21例为膜周型室间隔缺损,18例为嵴下型室间隔缺损,7例为嵴内型室间隔缺损。经胸超声心动图提示室间隔缺损（VSD）的直径为4～10mm,术中行左室造影、建立股动静脉轨道、经右心系统释放封堵器,并分别于术后2周、1个月、3个月、6个月进行随访。结果46例中43例封堵器均成功置入。1例术中封堵器影响主动脉辩,2例出现较大残余分流而放弃介入改开胸手术,3例术后造影存在微量至少量残余分流,6个月后行超声检查分流消失。结论经导管植入国产偏心封堵器治疗VSD是一种安全有效的微创介入治疗方法,操作简便,成功率高,近期疗效可靠。     

室间隔缺损介入封堵治疗63例的临床观察

目的评价介入封堵治疗室间隔缺损（VSD）的安全性及临床疗效。方法63例VSD患者,其中53例为膜部型（17例合并膜部瘤）,7例为嵴下型,3例为嵴内型。膜部型VSD使用对称型封堵器,其余类型的VSD使用偏心型封堵器,膜部瘤形成合并多孔型使用对称型封堵器或大边封堵器。结果左心室造影测量缺损直径6～16（9．6±2．6）mm,缺损上缘距主动脉根部2—6（3．9±1．7）mm。63例均封堵成功,成功率为100％。VSD封堵器直径6—16（10．5±2．6）mm。1例术中出现右束支传导阻滞,术后随访6个月无明显变化。结论介入封堵治疗室间隔缺损创伤小,成功率高,手术安全可靠。     

经导管介入治疗90例室间隔缺损疗效观察

目的  评价经导管介入治疗先天性室间隔缺损（VSD）的疗效及并发症。方法  2005~2007年我科共收治VSD患者90例,经导管介入治疗成功86例,对所有病例的临床资料、手术前后心电图、心脏超声、术中心脏造影、选择封堵器械及随访资料进行回顾性分析。结果  90例VSD患者中,男40例,女50例,年龄分布2~34岁（平均8.9岁）。87例为膜部室间隔缺损,3例为嵴内型,1例为VSD外科修补术后残余瘘,1例合并动脉导管未闭（PDA）。封堵成功86例,技术成功率为95.6%。VSD右室面最大直径为1.5～8.8mm,植入封堵器直径为4~18mm。17例采用AGA  Amplatzer封堵器,13例采用国产小腰大边封堵器,52例采用国产同心圆型封堵器,2例采用国产偏心型封堵器。平均随访时间18个月。并发症30例,包括：完全性右束支传导阻滞（CRBBB）3例,不完全性右束支传导阻滞（ICRBBB）2例,左前分支传导阻滞（LABB）7例,CRBBB并LABB1例,1例术中出现间歇性Ⅲ度房室传导阻滞（AVB）,2例术后出现交替性CRBBB及完全性左束支传导阻滞（CLBBB）,加速性交界性自主心律6例,均为一过性,随访1周~3个月消失。残余分流3例,其中1例合并机械性溶血,对症处理后好转出院。主动脉瓣少量返流2例,三尖瓣返流3例,均为少量~中量返流,未行特殊处理。结论  经导管封堵VSD是一种安全有效的治疗方法。手术成功率高,严重并发症少,传导阻滞是VSD介入治疗术后的主要并发症,及时发现、及时处理是治疗关键,对心内传导系统远期的影响仍需进一步评价。     

用国产零偏心封堵器介入封堵嵴内型室间隔缺损七例的疗效观察

近年来介入封堵先天性心脏病室间隔缺损(VSD)特别是膜部缺损,具有疗效确切、创伤小、并发症少、不需用体外循环等优点,已成为治疗的首选[1-2],但对于嵴内型VSD,因其解部位置特殊,邻近瓣膜组织,部分病例可因缺乏支撑而致主动脉瓣脱垂于缺损内并伴有主动脉瓣关闭不全,而封堵后也有可能引起瓣膜功能不全[3],是否行介入封堵尚有争议.我们应用国产零偏心封堵器成功封堵7例嵴内型VSD,近期效果良好,现报告如下.     

儿童膜部室间隔缺损介入治疗的方法学和临床效果

目的 总结评价Amplatzer法介入治疗膜部室间隔缺损的方法及临床治疗效果.方珐308例膜部室间隔缺损的患儿,应用Amplatzer封堵器行室间隔缺损封堵术.造影结果显示室间隔缺损口平均(5.8±3.1)mm,其中69例伴有膜部瘤形成,7例为多发孔型缺损,4例为嵴内型缺损,3例造影显示有轻度主动脉瓣脱垂.结果 308例患儿中295例(95.8%)封堵成功,其中257例应用对称型封堵器,22例应用非对称型封堵器,16例应用小腰大边型封堵器.手术时间(68±31)min,X线透视时间(27±18)min.所选的封堵器大小为(7.8±2.5)mm.69例伴有膜部瘤形成的室间隔缺损患儿中68例成功封堵.4例嵴内型缺损均选用非对称型封堵器.3例造影有轻度主动脉瓣脱垂者.封堵术后行主动脉根部造影显示主动脉瓣反流消失.295例封堵成功的患儿中,术后造影显示即刻完伞封堵263例(89.2%),残余分流32例(10.9%).术后24 h超声心动图检查完伞封堵者为287例(97.3%),术后1、6和12个月超声心动图检查示封堵成功的患儿均无残余分流.随访过程中无封堵器的移位及破裂.2例术后即刻出现Ⅲ度房室传导阻滞,1例术后1个月出现Ⅲ度房室传导阻滞,治疗3-4 d内均转为正常.结论 Amplatzer法介入治疗膜部室间隔缺损具有较高的成功率,是一种安伞有效的方法,伴有膜部瘤形成的室间隔缺损是介入治疗良好的适应证,部分嵴内型缺损和伴有轻度主动脉瓣反流的病例可采用该方法.     

超声心动图在经导管室间隔缺损封堵术中的应用

目的探讨超声心动图(UCG)在经导管室间隔缺损封堵术中的应用价值。方法选取2006年8月-2012年12月在广东省中山市人民医院行经导管室间隔缺损(VSD)封堵术的患者23例,年龄5～52岁,平均(31±17)岁,男性16例,女性7例,应用UCG对患者进行术前检查,了解VSD的位置、大小、缺损残端与主动脉右冠瓣间距离;术中UCG进行实时监测以及术后进行UCG复查,了解封堵器的形态、位置情况、各瓣膜返流情况、VSD有无残余分流。结果 23例VSD患者中,术前UCG提示:17例为膜周型VSD,其中7例合并膜部瘤;5例为嵴内型VSD;1例为心肌梗死后室间隔心尖段穿孔。术前UCG测量:VSD平均直径为4～9mm,平均5.9mm;与主动脉瓣右冠瓣间距离为1～5mm,平均3.5mm。术中左室造影测量显示:VSD平均直径为2～9mm,平均5.3mm。23例VSD患者中,有21例成功进行VSD封堵术。术中UCG发现残余分流2例(分流束分别约1mm、5mm)、轻度主动脉瓣返流1例、三尖瓣脱垂并中度返流1例,术后UCG复查无明显变化。结论应用超声心动图能对室间隔缺损患者进行封堵术前、术中、术后观测,是经导管室间隔缺损封堵术的重要观测手段。     

膜部室间隔缺损介入分类及封堵器选择的探讨

目的:探讨介入治疗室间隔缺损(VSD)的临床分类、封堵器选择和评价该分类方法的可行性、安全性及疗效.方法:采用膜部VSD封堵器介入治疗(VSDO)患者215例(合并膜部瘤的有200例).按VSD右室侧形态膜部瘤及大小分为Ⅰ、Ⅱ、Ⅲ型.搬据左室造影上缺损缘距主动脉右冠瓣距离是否≥2mm将Ⅰ、Ⅱ型VSD再分为a、b型;将Ⅲ型VSD分为A、B型.封堵术后1天、7天、3月、1年时复查超声心动图、心电图.结果:211例患者封堵成功,技术成功率98.14%.Ⅰ a型、Ⅱa型、部分Ⅱb型、ⅢA型和部分ⅢB型选用对称型封堵器;Ⅰ b型、部分Ⅱb型选择偏心型封堵器;ⅢB型中66.67%选择小腰大边型封堵器.1例Ⅱ8型病例早期术中释放封堵器时发生右房室瓣中量返流,1例Ⅱb型患者使用偏心型封堵器封堵后出现主动脉瓣中量返流放弃介入治疗,ⅢB型有2例有中量残余分流放弃治疗.结论:应用膜部VSD0 VSD是安全有效的,VSD0的介入治疗根据该分类方法治疗效果良好.     

经导管介入治疗小儿膜周部室间隔缺损疗效评价(附30例报道)

目的探讨经导管介入治疗小儿膜周部室间隔缺损（PMVSD）的临床价值。方法 30例经临床结合彩色多普勒超声心动图诊断的小儿PMVSD病人,年龄3-10岁。男17例,女13例。体重14～29公斤,缺损大小2.3～8.0mm,采用美国AGA公司生产的Amplatzer室间隔封堵器和北京华医圣杰有限公司生产的室间隔封堵器。结果手术技术成功率90%。3例病人术前超声显示VSD大小3mm,但造影VSD直径为1～2mm,6F输送鞘未能通过VSD,结束手术。其余病例均选用封堵器腰部直径比VSD大3～4mm成功堵闭。国产封堵器首先选用对称型封堵器,如有主动脉瓣返流再换用偏心型封堵器。其中3例病人术前超声显示室间隔上缘距主动脉右冠瓣2mm,但造影示主动脉右冠瓣下无室间隔组织,均选用偏心型封堵器成功堵闭,其中1例术后主动脉瓣微少量返流,术后3个月返流消失。本组病例造影显示半数病人（16例）有膜部瘤形成,其中1例为巨大膜部瘤,有两个分流口,分别为4、6mm,术后即刻造影有少-中量残余分流,术后3个月有少量残余分流。其余病例均成功堵闭。所有病人术后常规静脉应用地塞米松5天。术后发生各种心律失常10例,包括不完全右束支传导阻滞6例,完全右束支传导阻滞2例,阵发性室上性心动过速2例。心律失常多发生在术后2～6天,经术后静脉注射地塞米松,重症换用甲基强的松龙,心律失常大多于术后4～10天消失。随访1年有1例遗留完全性右束支传导阻滞,2例遗留不完全右束支传导阻滞。结论掌握好手术适应证是成功介入封堵的关键之一。缺损大小3～8mm易于成功封堵。如果室间隔缺损膜部瘤的分流口较大且数目多不易完全堵闭。小儿主动脉右冠瓣下无室间隔组织的病例不是手术禁忌。介入治疗PMVSD安全性较高,疗效显著,并发症少,但要高度重视其可能发生的并发症,尤其是要做好心律失常的防治。     

室间隔缺损(VSD)介入治疗中封堵器的个体化应用

 目的  研究室间隔缺损(ventricular septal defect,VSD)介入治疗中封堵器个体化选择对疗效和并发症的影响。方法  选择符合介入治疗标准的137例VSD患者为研究对象,男性71例,女性66例,年龄3~76 (31.52±16.13)岁。其中膜周部98例,单纯肌部10例,嵴内型12例,外科修补术后残余分流VSD11例,心肌梗死后室间隔穿孔VSD 5例,外伤引起的室间隔肌部穿孔VSD 1例。根据左心室造影VSD的形态、大小、与主动脉瓣及三尖瓣的关系进行个体化选择封堵器介入治疗,术后即刻、24 h、1个月、3个月、6个月和12个月观察随访其疗效、并发症、心腔大小和肺动脉压力的变化。结果  124例患者成功封堵(90.51%),共使用了126个封堵器(2例患者分别使用了2个封堵器)：对称型封堵器26个(20.6%),边3型18个(14.3%),边4型44个(34.9%),边5 型13个(10.3%),偏心型14个(11.1%),肌部11个(8.7%)。29例(23.4%)术后出现心律失常,分别是Ⅰ度房室传导阻滞、左前分支传导阻滞、完全性左束支传导阻滞、不完全性右束支传导阻滞、完全性右束支传导阻滞、室上性早搏和加速性交界性心动过速,总恢复率为96.6%,无Ⅲ度AVB。左心房前后径和左心室舒张末内径在术后24 h明显缩小(P=0.001及0.002);左心室收缩末内经在术后24 h及术后1个月均缩小(P=0.007);左心室射血分数在术前术后、24 h、术后随访中变化无明显统计学意义。肺动脉收缩压术后24 h较术前有明显下降(P=0.001),术后1、3、6、12个月均未见进一步下降(P=0.820)。结论  经导管介入治疗VSD,封堵器应个体化选择,选择合适的封堵器既能有效封堵VSD,又可减少发生或避免医源性并发症。     

经导管封堵治疗50例室间隔缺损的疗效和安全性

目的:观察应用室间隔缺损封堵器经导管介入封堵先天性室间隔缺损(VSD)的疗效和安全性。方法：50例VSD患者术前由经胸超声心动图确诊,在透视及经胸超声心动图监视下经导管置入室缺封堵器封堵VSD,术后1, 3, 6个月分别行经胸超声心动图、心电图评价治疗效果。结果：50例VSD患者术中经左心室造影明确缺损直径为1.8～13.4（5.54±2.75）mm,封堵成功率96.0％（48/50）,手术并发症发生率为16.7％（8/48）,封堵术后3个月超声复查左室舒张末径较术前明显缩小。结论：经导管封堵VSD是一种成功率较高、并发症少、创伤小、疗效可靠的介入治疗方法。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.