Clinical Analysis for the Acupuncture Treatment in 42 Cases of GoutyRenal Damage

Objective: To observe the therapeutic effects of acupuncture on gouty renal damage. Method: 72 cases of gouty renal damage were randomly divided into a treatment group of 42 cases and a control group of 30 cases to observe the therapeutic effects and the changes in 24-hour urinary protein content, blood creatinine, uric acid and urea nitrogen in blood before treatment and one month after treatment. Results:The total effective rate in the treatment group reached 95.24%, which was remarkably higher than 63.33% in the control group. After one month of treatment, the indexes were found reduced in both groups, but the reduction rate in the treatment group was obviously superior to that in the control group.Conclusion: The patients with repeated attacks of gout may have a higher possibility to suffer from renal damage. Therefore, attention should be paid to its early diagnosis and treatment. Acupuncture may exert good therapeutic effects on early gout complicated with renal damage by adjusting the metabolism and improving the renal function.     

Clinical Observation on Treatment of Acute Gouty Arthritis byTongfengkang(痛风康)

Objective To objectively evaluate the clinical therapeutic effect of Tongfengkang (TFK) in treating acute gouty arthritis. Methods: Adopting randomized single blinded controlled trial, the 40 patients were equally divided into two groups. The tested group was treated with TFK, the control group was treated with indomethacin and allopurinol, the therapeutic course for both groups was 10 days. Results: The clinical cure rate in the tested group and the control group was 30% and 35% respectively, and the total effective rate 90% and 95% respectively, with no significant difference between the two groups (P>0.05).The scores of blood uric acid and symptom significantly lowered in both groups after treatment (P <0.01), but showed no significant difference between them (P>0.05). Adverse reaction to the treatment was shown in 3 patients in the control group. Conclusion: The therapeutic effect of TFK is similar to that of indomethacin plus allopurinol but with less adverse reaction, it is an effective and safe re     

Effects of Rebixiao Granules(热痹消颗粒剂) on Blood Uric Acid in Patients with Repeatedly Attacking Acute Gouty Arthritis

Objective:To observe the clinical effect of Rebixiao granule (热痹消颗粒剂, RBXG) in treating repeatedly attacking acute gouty arthritis and through experimental study on blood uric acid to explore RBXG's therapeutic mechanism. Methods: Ninety repeatedly attacking acute gouty arthritis patients were divided into the treated group (n= 60) and control group (n = 30). The treated group was treated with RBXG, and the control group was treated with Futalin tablets (diclofenac sodium). The baseline treatment including good rest, Iow purine diet, sufficient water drinking and urine alkalization, etc. was then given to both groups. Hypoxanthine 600 mg/kg and niacin 100 mg/kg was applied to hyperuricemic mice by gastrogavage to establish the animal models. Results: The clinical effective rate of the treated group was 95.0% and that of the control 90.0 %. Good therapeutic effects were won, insignificant difference (P＞0.05)was shown between the two groups. However, the cure rate of the treated group was 26.7% while that of the control group was 10.0%, with significant difference (P＜0.01) shown between them. The treated group had its blood uric acid lowered, which was significantly different (P＜0.05) from that of the control group. The animal experiment indicated that all the three groups treated with different dosages of RBXG, as well as the Ash bark and Smilax glabra rhizome groups had their blood uric acid content reduced in the hyperuricemic mice. Conclusion: RBXG has a quicker initiation and better treatment effects than sole anti-inflammatory and analgesic agents on the treatment of repeatedly attacking acute gouty arthritis, showing no obvious toxic or adverse reactions and therefore good for long-term administration and likely to be a safe TCM preparation to control the symptoms and reduce the onsets of repeatedly attacking of acute gouty arthritis. The animal experiment shows that both the compound preparation and part of the single ingredients in the recipe have the function of reducing blood uric acid. However, the compound recipe has better therapeutic effects, proving to be superior to single drugs.     

The study of early application with Dixiong Decoction (地芎汤) for non-small cell lung cancer to decrease the incidence and severity of radiation pneumonitis: A prospective, randomized clinical trial

Objective： To evaluate the efficacy of compound Dixiong Decoction （地芎汤, a Chinese herbal decoction） on early prevention of radiation pneumonitis. Methods： Forty-six patients with non-small cell lung cancer who were planning to receive radiotherapy were randomly assigned to the treatment group treated with the compound Dixiong Decoction and the control group treated with a commonly used herbal decoction which has the effects of supplementing qi and nourishing yin, clearing heat and detoxifying at the time of radiotherapy. Primary measure was the incidence of radiation pneumonitis after radiotherapy. Secondary outcomes included Watters clinical radiographic physiologic （CRP） dyspnea score, the Radiation Therapy Oncology Group （RTOG） grading score, Karnofsky Performance Status （KPS） score, and the application of corticosteroids. Results： The incidence of radiation pneumonitis in the treatment group was 10.0%, while that in the control group was 26.3% （P=0.0032）. The Watters CRP dyspnea score and RTOG grading score in the treatment group were significantly lower than those in the control group （P0.05）. The KPS score in the treatment group was significantly higher than that in the control group （P0.01）. The dosage of corticosteroids was smaller with a shorter duration of therapy in the treatment group than that in the control group. Conclusion： The early application of the Chinese herbal decoction compound Dixiong Decoction can decrease the incidence of radiation pneumonitis, reduce the injury of the lung, and improve the life quality of the patients.     

Clinical Observation of Shuanghuang Shengbai Granule(双黄升白颗粒) on Prevention and Treatment of Myelosuppression Caused by Chemotherapy in Cancer Patients

Objective: To study the efficacy and safety of Shuanghuang Shengbai Granule(双黄升白颗粒, SSG), a traditional Chinese herbal medicine, on myelosuppression of cancer patients caused by chemotherapy. Methods: A total of 330 patients were randomly assigned to the treatment group(220 cases, analysed 209 cases) and the control group(110 cases, analysed 102 cases) with a 2:1 ratio by envelope method. The patients in the treatment group at the first day of chemotherapy started to take SSG for 14 days, while the patients in the control group took Leucogon Tablets. The changes of the blood routine, clinical symptoms and immune function in both groups were observed for safety and efficacy evaluation. Results: At the 7th day of chemotherapy, the white blood cells(WBCs) level in the treatment group was significantly higher than that in the control group(P0.05). After treatment, the WBCs rate in the normal range accounted for 50.2% in the treatment group, the myelosuppression of WBCs and neutrophil were mainly grade Ⅰ, while 8.1% and 5.7% of patients emerged grade Ⅲ and grade Ⅳ myelosuppression, respectively. The incidence of myelosuppression of the treatment group was significantly lower than that of the control group(P0.05). The total effective rate of Chinese medicine syndrome in the treatment group was significantly higher than that in the control group(84.2% vs. 72.5%, P0.05). The immune cell levels in both groups were maintained in the normal range. Compared with that before treatment, the levels of CD3~+ and CD4~+ cells were significantly increased in the treatment group after treatment(P0.05). The discrepancy of CD3~+ and CD4~+ cell activity before and after treatment in both groups were significantly different(P0.05). No obvious adverse event occurred in both groups. Conclusion: SSG had a protection effect on bone marrow suppression, and alleviated the clinical symptoms together with clinical safety.     

Effect and Safety of Tongyan Spray (通咽喷雾剂) on Hyoid Motion in Patients with Dysphagia after Ischemic Stroke

Objective: To observe the effects and safety of Tongyan Spray (通咽喷雾剂) on the range and time of hyoid motion in patients with ischemic post-stroke dysphagia. Methods: Seventy-two patients with ischemic post-stroke dysphagia were selected and randomly assigned to a treatment group (36 cases) and a control group (36 cases) by a random number table from January 2013 to October 2014. All patients swallowed 4 kinds of barium meals with different traits respectively, and each patient underwent video fluoroscopy (VF) examination twice. In the treatment group, Tongyan Spray was sprayed to the pharynx on both sides and the middle part once respectively. The spray was applied 30 min before the second examination. Purified water at room temperature was used as placebo in the control group. The changes in the range and time of hyoid motion in both groups were observed before and after treatment. Results: Six patients dropped out in each group, and 60 patients completed the study and were included in the final analysis. Significant improvement was observed in the range of superior hyoid excursion distance and the time of hyoid motion in the treatment group compared with the control group (P<0.05). There were no obvious adverse reactions observed in oral mucosa in both groups during the whole study. Conclusion: Tongyan Spray was an effective and safe medicine for improving swallowing function in patients with ischemic post-stroke dysphagia.     

Clinical Observation on the Effect of Zengse Pill (增色丸) in Treating Patients with Vitiligo of Qi-stagnancy and Blood-stasis Syndrome Type

Objective:To observe the clinical efficacy of Zengse Pill(增色丸,ZSP)on patients with vitiligo of qi-stagnancy and blood-stasis syndrome type(V-QB),and to preliminarily explore its mechanism of action.Methods:Sixty-five V-QB patients,with their diagnosis confirmed by clinical examination,were randomized by digital table method into two groups,with 31 patients in the control group and 34 in the treatment group.Cobamamide(2 tablets)was administered orally to all patients,and Psoralea tincture(a self-formulated preparation)was applied externally thrice a day.In addition,for patients in the treatment group,ZSP was given orally,at 5 pills per dose,3 times every day.The therapeutic course for both groups was 3 months.Patients were re-examined every half-month,and changes in the skin lesions were observed and recorded.The levels of lymphocyte subsets,serum immune globulin,and complement C3 and C4 in patients were determined before and after the therapeutic course and compared with the corresponding indexes determined in 21 healthy subjects.Results:The total effective rate in the treatment group was 82.4%,which was markedly higher than that in the control group(54.8%),showing a significant difference(P<0.05).After treatment,CD_4~ percentage,CD_4~ /CD_8~ ratio,and blood levels of C3 and C4 increased,while CD_8~ percentage decreased in the treatment group(P<0.05 or P<0.01).All these indexes remained unchanged in the control group,and the respective comparisons between groups showed significant differences(P<0.01).Conclusion:ZSP has a definite clinical effect on the treatment of V-QB but with no evident adverse reactions,and it can increase the CD_4~ percentage,CD_4~ /CD_8~ ratio,and the levels of serum C3 and C4,thus regulating the immunity of the organism,which might be one of its mechanisms of action.     

Clinical effect and action mechanism of Weicao Capsule (威草胶囊) in treating gout

Objective： To study the therapeutic effect of Weicao Capsule （威草胶囊, WCC） on gout. Methods： Two hundred gout patients were assigned to two groups. The treated group was treated with WCC and the control group was treated with Tongfengding Capsule （痛风定胶囊）. Both groups were given the respective treatments orally 3 times a day, 2 capsules each time with 2 weeks as one course and all patients received 2 successive courses of treatment. Changes of blood β2- microglobulin （13 2-M）, hemoglobin （Hb）, 24 h urinary protein （24 h UP）, pH value of urine and blood uric acid （BUA） as well as kidney function were observed. Results： After treatment, level of β 2-M got lowered significantly, Hb and 24 h UP, blood urea nitrogen, serum creatinine and the clearance rate of creatinine, as well as blood lipids all improved obviously in the treated group （all P〈0.01）, while these parameters remained unchanged in the control group （P〉0.05）. The pH value of urine was improved in both groups showing an insignificant difference between them （P〉0.05）. BUA was decreased in both groups with a decrease to a larger extent in the treated group （P〈0.01）. The total effective rate was 87% in the treated group, which was superior to that in the control group （62%, P〈0.05）. Conclusion： WCC has a favorable therapeutic effect on gout and its mechanism of action for improving renal function and reducing urinary protein could be related with the lowering of blood β 2-M, BUA and lipids.     

Treatment of 60 Cases of Gouty Arthritis with Modified Simiao Tang

Objective:To observe the clinical effect of a modified Simiao Tang(加味四妙汤 Modified Decoction of Four Wonderful Drugs)for gouty arthritis and its influence on uric acid in blood.Methods:120 cases of gouty arthritis were randomly divided into the treatment group and control group with 60 cases in each group.Modified Simiao Tang(MST)was orally administered to the patients in the treatment group and allopurinol tablet was orally administered to the patients in the control group.The clinical effects of two groups were evaluated after one-week treatment and uric acid(UA)and C-reactive protein(CRP)levels in blood were determined after 1-month treatment.Results:The total effective rate in the treatment group was significantly higher than in the control group,86.7%vs.68.3%(P<0.01).And the treatment group was also significantly better than the control group in decreasing UA and CRP(P<0.05 or P<0.01).Conclusions:MST can significantly improve the symptoms and signs of gouty arthritis and decrease the levels of UA and CRP It is good for gouty arthritis.     

丙磺舒联合别嘌呤醇治疗痛风间歇期临床研究

目的：探讨丙磺舒联合别嘌呤醇在痛风间歇期临床治疗中的应用。方法整群选取大庆市第五医院2014年1月—2015年9月收治的81例痛风性关节炎患者(均处于痛风间歇期)为研究对象,随机分为两组进行治疗,观察组的41例患者单独采用别嘌呤醇进行治疗,治疗组的40例患者应用丙磺舒联合别嘌呤醇进行治疗,并比较了两组患者治疗后的疗效和血尿酸值。结果经治疗,对照组总有效率78.04%,治疗组总有效率95%,治疗组疗效明显优于对照组,差异具有统计学意义(P<0.05);治疗后,对照组血尿酸水平由(680.24±78.53)μmol/L下降到(380.43±52.14)μmol/L,治疗组血尿酸水平由(684.37±75.42)μmol/L下降到(313.49±45.75)μmol/L,两组患者血尿酸水平均有下降,治疗前后差异具有统计学意义(P<0.05),而且治疗组血尿酸下降幅度明显高于对照组,差异具有统计学意义(P<0.05)。结论在痛风性关节炎患者的临床治疗中应用丙磺舒联合别嘌呤醇进行治疗,疗效明显,充分降低了血尿酸值,值得在临床上推广应用。     

蠲痹历节清方治疗急性痛风性关节炎湿热证疗效观察

目的：观察蠲痹历节清方治疗急性痛风性关节炎湿热证的临床疗效。方法将急性痛风性关节炎患者110例随机分为观察组及对照组各55例。观察组口服蠲痹历节清方,对照组口服秋水仙碱及别嘌醇,疗程1个月。观察比较两组临床疗效及治疗前后患者的血尿酸及血沉水平。结果两组患者的临床疗效比较,观察组的总有效率为92.7%,对照组为78.2%,两组差异具有统计学意义（P＜0.05）;两组治疗后血尿酸、血沉均较治疗前下降（P〈0．05）,且观察组下降更为显著（P〈0．05）。结论蠲痹历节清方能提高急性痛风性关节炎的临床疗效,降低患者血尿酸及血沉水平,同时可以减少复发率和不良反应的发生,值得临床推广。     

加味四妙散口服联合四黄散加味外敷治疗痛风性关节炎临床研究

目的:观察加味四妙散口服联合四黄散加味外敷治疗痛风性关节炎的临床疗效。方法:选择痛风性关节炎患者100例为研究对象,随机分为观察组和对照组,各50例。其中观察组采用加味四妙散口服,四黄散加味外敷治疗,对照组患者采用常规西药治疗。于治疗后对两组患者的临床疗效进行综合评价。结果:观察组临床有效率为94.00%(47/50),对照组为76.00%(38/50),两组比较,差异有统计学意义(P0.05)。观察组生理指标包括血尿酸(uric acid,UA)、C反应蛋白(C reactive protein,CRP)、血沉(erythrocyte sedimentation rate,ESR)水平分别为(354.87±30.27)μmol·L~(-1)、(10.64±2.01)mg·L~(-1)、(19.26±4.89)mm·h~(-1),对照组分别为(420.19±39.58)μmol·L~(-1)、(13.37±2.42)mg·L~(-1)、(24.20±4.71)mm·h~(-1),两组比较,差异有统计学意义(P0.05),提示观察组的生理指标改善情况良好。观察组不良反应发生率为2.00%(1/50),对照组为18.00%(9/50),两组比较,差异有统计学意义(P0.05),提示观察组治疗方法安全性良好。观察组在治疗后及随访12个月时,患者疼痛视觉模拟评分(visual analogue score,VAS)分别为(4.62±1.09)分、(1.58±0.34)分,显著低于对照组的(5.94±1.37)分、(1.95±0.41)分,提示观察组对疼痛改善效果更好。结论:加味四妙散口服联合四黄散加味外敷对痛风性关节的治疗效果显著,能够提高临床疗效,改善患者的各项生理指标,有效缓解患者的疼痛感,且用药安全性好。     

痛风洗剂治疗急性痛风性关节炎

目的：探讨痛风洗剂治疗急性痛风性关节炎的临床疗效。方法选取我院2013年7月—2015年7月急性痛风性关节炎患者98例,并按年龄、病程及疾病严重程度随机分为3组,即痛风洗剂组33例、热水组33例及对照组32例。所有患者均于就诊当晚服用依托考昔60 mg,痛风洗剂组应用痛风洗剂外用浸泡患处,3次/ d,30 min /次;热水组应用热水浸泡患处,3次/ d,30 min /次;对照组仅服用依托考昔,而不外用。结果浸泡患处1次后,痛风洗剂组 VAS 分值由（7.11±1.47）下降至（4.18±1.14）,热水组 VAS 分值由（6.97±1.54）下降至（5.71±1.55）,对照组 VAS 分值由（6.95±1.55）下降至（6.28±1.88）,痛风洗剂组与热水组、对照组比较均具有统计学意义,但热水组与对照组比较无统计学意义;外用浸泡患处6次,即48 h 后,各组间 VAS 评分无统计学意义。结论痛风洗剂能迅速缓解急性痛风性关节炎患者的痛苦,具有快速止痛之功效。     

基于数据挖掘的朱仁康治疗湿疹的内服方药规律研究

目的 分析朱仁康治疗湿疹的方剂规律,明晰隐藏的处方用药经验与学术思想,以期指导湿疹临床治疗并提高临床疗效.方法 以朱仁康教授门诊病历、文献医案为数据源,运用中国中医科学院中医药信息研究所研发的古今医案云平台V1.4软件,采用频数分析、关联规则分析方法进行数据挖掘,确定处方中核心药物组合、用药模式及药物间的关联规则等.结...     

"清热利湿、化瘀祛浊"法治疗痛风高尿酸伴高脂血症疗效观察

目的 探讨酸酯清胶囊对痛风高尿酸伴高脂血症之血尿酸(UA)、血脂中血清总胆固醇(TC)、甘油三酯(TG)含量的影响.方法 将60例原发性痛风高尿酸伴高脂血症患者随机分为2组,中药组服用具有“清热利湿、化瘀祛浊“功效的酸脂清胶囊,对照组服用中成药痛风舒胶囊.两组用药一月后检测血尿酸、血脂值.结果 中药组优于对照组(P ＜ 0.05).结论 酸酯清胶囊不仅对痛风高尿酸血症具有明显的治疗效果, 而且对血脂亦有良好的调节作用.     

羟氯喹在痛风症的临床疗效观察

目的 观察羟氯喹(hydroxychloroquine)对痛风关节炎患者血尿酸的影响及安全性.方法 将2009年1月-2010年4月期间在我院风湿科门诊就诊的43例原发性痛风患者随机分为治疗组26例和对照组20例.治疗组采用一般治疗、控制尿酸药物及羟氯喹治疗,对照组采用一般治疗、控制尿酸药物及小剂量秋水仙碱治疗.治疗前...     

柔肝合剂与鳖甲煎丸抗肝纤维化疗效比较

目的　观察柔肝合剂抗慢性乙型肝炎肝纤维化的作用 ,寻找抗肝纤维化的简单、价廉的有效方剂。方法　选择慢性乙型肝炎肝纤维化患者 12 0例 ,随机分为柔肝合剂治疗组 6 4例和鳖甲煎丸对照组 5 6例 ,进行疗程相同的对照治疗。观察项目为血清透明质酸 (HA)、Ⅲ型前胶原 (PCⅢ )、层黏蛋白 (LN)、Ⅳ型胶原 (Ⅳ -C)。结果　治疗组与对照组治疗后HA、PCⅢ、LN、Ⅳ -C均有明显下降 ,而 2组间比较则无显著差异 (P >0 .0 5 )。结论　柔肝合剂的抗肝纤维化作用与鳖甲煎丸疗效相近 ,是一种抗肝纤维化的简单、价廉的有效方剂     

中药内外兼治急性痛风性关节炎并高尿酸血症临床观察

目的：观察中药内服、外敷法兼治急性痛风性关节炎并高尿酸血症的临床疗效。方法采用数字表法将急性痛风性关节炎患者随机分为观察组和对照组,两组患者均给予生活调整、饮食控制及碱化尿液等基础治疗。观察组在此基础上加用加味四妙散口服及四黄散加味外敷治疗,对照组予口服秋水仙碱及别嘌醇片等西医常规治疗。观察两组治疗前后血尿酸(UA)、血肌酐（Scr）、尿素氮（BUN）、血清C反应蛋白（CRP）、血沉（ESR）变化及关节红肿疼痛改善情况,治疗观察2周。结果观察组总有效率为90.3%,对照组总有效率为74.2%,差异有统计学意义(P＜0.05);两组治疗前后UA比较,治疗后均较治疗前明显降低(P＜0.05);治疗后组间比较,观察组较对照组降低(P＜0.05);Scr和BUN两组治疗前后差异无统计学意义(P＞0.05);两组治疗前后CRP、ESR比较,治疗后均较治疗前降低(P＜0.05);治疗后组间比较,观察组较对照组降低(P＜0.05)。结论中药内外兼治急性痛风性关节炎和高尿酸血症安全有效,并在降低UA、ESR、CRP方面有一定优势。