羟氯喹在痛风症的临床疗效观察

目的 观察羟氯喹(hydroxychloroquine)对痛风关节炎患者血尿酸的影响及安全性.方法 将2009年1月-2010年4月期间在我院风湿科门诊就诊的43例原发性痛风患者随机分为治疗组26例和对照组20例.治疗组采用一般治疗、控制尿酸药物及羟氯喹治疗,对照组采用一般治疗、控制尿酸药物及小剂量秋水仙碱治疗.治疗前...

Clinical efficacy of hydroxychloro quine in gout

Objective To observe the impact and safety of hydroxychloroquine（HCQ） on serum uric acid in gout arthritis.Methods 43 rheumatology clinic patients with primary gout who were treated in our hospital during January 2009 to April 2010 were randomly divided into treatment group（26 cases） and control group（20 cases）.Treatment group accepted the general treatment,controlling uric acid and hydroxychloroquine.Control group accepted the general treatment,controlling uric acid and small dose of colchicine.Serum uric acid and lipid levels of patients were detected before treatment and after 1,3,6 months of treatment.Results Both groups of patients had significant difference in serum HDL concentration decrease between pretreatment and 3,6 months after treatment（P0.05）.At the end of the 3 month,blood TC,LDL,UA levels decreased significantly（P0.05）.At the end of the 6 month,blood TC,LDL,UA levels decreased significantly（P0.01）.Acute gouty arthritis and reduction of the frequency of recurrence had no significant difference（P0.05）.Conclusion HCQ can reduce the number of attacks of gout arthritis and decrease blood uric acid and blood lipids with good tolerability and safety.