重症肌无力患者报告结局指标量表的研制——计量心理学测评

目的：为考察用于中西医临床疗效评价的重症肌无力（myasthenia gravis, MG）患者报告结局指标（patient-reported outcome, PRO）量表的科学性,对其计量心理学特征进行评价。 方法：用MG-PRO量表对200例样本（100名健康人和100名重症肌无力患者）进行自评量表式调查,应用经典测量理论和项目反应理论方法对其信度、效度、个体差异指数和条目功能差异（differential item functioning, DIF）等计量心理学特征进行考评。 结果：经典测量理论分析结果显示,总量表以及各领域的分半信度系数大于0.7,各领域Cronbach＇s α系数大于0.80;每个方面与其所属领域的相关系数均大于其与其他领域的相关系数。从结构效度来看,探索性因子分析提取出4个主成分,反映了生理、心理、社会、治疗4个领域,累计贡献率为55.54%;重症肌无力患者与健康人在每个方面的测评结果比较,差异均有统计学意义（P〈0.01）。项目反应理论分析结果显示,每个模型的个体差异指数均大于0.8,所有条目都没有一致性DIF和非一致性DIF。 结论：MG-PRO量表反映了WHO关于生存质量的内涵和重症肌无力患者的特殊问题,而且具有良好的信度（分半信度、内部一致性信度）和效度（内容效度、结构效度、区分效度）,具有良好的项目反应理论模型的计量心理学特征。     

癌症疼痛病人伴随阿片类药物导致便秘的中医汤剂标准化治疗：一项多中心前瞻性随机对照试验

Objective： To observe the efficacy and the influence on quality of life （QOL） of syndrome differentiation treatment with Chinese medicine （CM） for opioid-induced constipation as well as the safety and influence on analgesic effect of opioids. Methods： Totally 406 cases enrolled from 53 collaborating medical centers were randomly assigned to a CM group and a control group. The CM group were treated with CM decoction based on syndrome differentiation, and the control group were treated with Phenolphthalein Tablet. Both groups were treated for 14 days. Cleveland constipation score （CCS）, numedcal rating scale （NRS） of pain and Chinese version of European Organisation for Research and Treatment of Cancer, Quality of Life Questionnaire-C30 V3.0 （EORTC QLQ-C30 V3.0） were used to evaluate the efficacy, pain controlled and QOL status. Results： The comparisons of CCS score reduction and QOL between the two groups after treatment suggested that the improvements of constipation and QOL in the CM group were better than that in the control group （P〈0.05）. The total efficiency of the CM group was better than the control group （93.5% vs. 86.4%, P〈0.05）. There was no significant difference in NRS scores between before and after treatment in both groups. There was no serious drug-related adverse event during the course of study. Conclusion： CM decoction could effectively treat opioid-induced constipation and improve patients＇ QOL at the same time. It is safe and doesnt affect the analgesic effect of opioids when treating constipation.     

Chinese Medicine Improves Postoperative Quality of Life in Endometriosis Patients: A Randomized Controlled Trial

Objective:To investigate the effect of Chinese medicine(CM) and Western medicine(WM) on quality of life(QOL) after conservative surgery for endometriosis.Methods:A total of 320 patients with endometriosis were randomized into two groups by using random block design,CM group(160 cases,activating blood circulation and removing blood stasis treatment based on syndrome differentiation) and WM group(160 cases,gonadotropin-releasing hormone agonist or gestrinone treatment) after conservative surgery.Treatment was given for 3-6 months(according to the revised American Fertility Society scoring system stage),and the World Health Organization QOL-BREF(WHOQOL-BREF) was applied to patients before and after treatment to assess QOL.Results:There were 136 cases in the CM group and 141 cases in the WM group completing therapy.In the CM group,the use of the WHOQOL-BREF showed that the physical,psychological and environmental scores post- treatment were significantly higher than those at pre-treatment(P<0.05),and for 12 items(pain and discomfort, energy and fatigue,sleep and rest,mobility,activities of daily living,work capacity,negative feelings,health and social care:accessibility and quality,participation in and opportunities for recreation/leisure activities,appetite, QOL score,overall health status and QOL),the difference in scores was significant(P<0.05).In the WM group,4 items(pain and discomfort,opportunities for acquiring new information and skills,QOL score,overall health status and QOL) had significantly different scores post-treatment compared with those at pre-treatment(P<0.05).Before treatment,the QOL in the two groups of patients showed no significant difference(P>0.05).After treatment,the scores for physical health in the CM group were significantly higher than those of the WM group(P<0.05) and the scores of 4 items(mobility,activities of daily living,sexual activity,QOL score) in the CM group were significantly higher than those in the WM group(P<0.05).Conclusions:CM and WM treatment could improve the QOL of patients with endometriosis after conservative surgery.CM treatment is more effective than WM.     

The treatment of non-small cell lung cancer by interstitial I-125 seeds implantation combined with chemotherapy and Chinese medicine

Objective:To investigate the effects of brachytherapy with computed tomography-guided percutaneous radioactive 1-125 seeds interstitial implantation(ISI) synchronized chemotherapy and Chinese medicine(CM) for the treatment of advanced stage of non-small cell lung cancer(NSCLC).Methods:Ninety patients diagnosed with NSCLC by biopsy were randomly assigned to three groups:the synchronized therapy group(A),the chemotherapy plus CM-treated group(B),and the chemotherapy-treated group(C);a 2-month course of treatment was administered to them all.The effectiveness of treatment was evaluated based on tumor size,tumor markers(carcinoembryonic,squamous cell carcinoma-associated antigen,and cytokeratin 19 fragment),clinical symptoms,and quality of life(QOL) in patients.Results:The total effective rates of Groups A to C were 83.33%,46.67%,and 43.33%,respectively.The tumor markers were reduced obviously in Group A,showing significant difference compared with those in the other two groups.Additionally,QOL was elevated and cancer-related symptoms were alleviated more significant in Group A than those in Group C(all P<0.05). Conclusion:The synchronized therapy of 1-125 implantation with chemotherapy and CM was a safe therapeutic method and can be regarded as a new mode for treatment of advanced-stage NSCLC.     

Meta-analysis of the effectiveness of Chinese and Western integrative medicine on medium and advanced lung cancer

<正>Objective:To summarize the effectiveness of Chinese and Western integrative medicine in treating medium and advanced lung cancer,and to provide guidelines for clinical application.Methods:For this metaanalysis, a comparative search of Chinese medicine data in Chinese National Knowledge Infrastructure(CNKI) and Chinese BioMedical Literature Database(CBM) was undertaken to identify articles related to randomized comparative research of Chinese and Western integrative medicine in treating medium and advanced lung cancer between 1996 to 2006.Quality of life(QOL) was estimated using RevMan 4.2 software for data processing, adopting the odd ratio(OR) and the 95%confidence interval(CI).Results:Through meta-analysis of 10 qualified articles,the results were as follows:the merging effectiveness of QOL[OR=3.80,95%CI(2.65,5.47)];the rate of survival[OR=3.44,95%CI(2.04,5.80)];the tumor response rate[OR=1.88,95%CI(1.37,2.58)];the tumor developing rate[OR=0.33,95%CI(0.23,0.48)].Significant differences existed between the Chinese and Western integrative medicine treatment group and the Western treatment group(P0.01).Conclusions:Chinese and Western integrative medicine treatment of medium and advanced lung cancer has shown to improve patients' QOL and survival rate;it also can control tumor development in the short term.     

Development and Evaluation of Chinese Medicine Fire-Heat Syndrome Scale in Oral Cavity for Measuring Chinese Herb Toothpaste

Objective: To formulate the standard measuring tool for the evaluations on ?re-heat syndrome in oral cavity by means of Chinese medicine (CM). Methods: The measuring scale for fire-heat syndrome in the oral cavity by means of CM was investigated by symptom collection, item pool formulation, item selection, pre-investigation, evaluations on the reliability, validity and reactivity of the measuring scale, according to the principles for measuring scale design and under the guidance of CM theories. Results: The measuring scale was composed of two integrative parts: the self-?lling section and the interview section. As far as the reliability was concerned, the total Cronbach α coef?cient of the measuring scale was 0.866, the total test-retest reliability coef?cient was 0.726 and the split-half reliability coef?cient was 0.851. As far as the validity was concerned, the scores for the subjects of fire-heat syndrome in oral cavity and healthy people in their oral cavity in the items of symptoms were statistically different (P<0.01); three common divisors were extracted according to the theoretical dimensions, the accumulated contribution rate was 63.468%. As far as the reactivity was concerned, the difference between the symptom scores before and after the test in which 3. subjects used the Chinese herb toothpaste was statistically significant (P<0.01). Conclusions: This measuring scale has relatively good reliability, validity and reactivity, and it can be used in an objective quantitative evaluation on patients suffering from ?re-heat syndrome in oral cavity, and thus lay the foundations for the evaluations on the therapeutic effects of Chinese herb toothpaste on ?re-heat syndrome in oral cavity.     

扶正化瘀片治疗肝炎后肝硬化的研究

Objective: To investigate the efficacy and safety of the Fuzheng Huayu Tablet (扶正化瘀片, FZHYT), which is used to reinforce qi and resolve stasis in patients with posthepatitic cirrhosis (PHC). Methods: A multicenter, randomized, controlled clinical trial was conducted in 180 patients with PHC. The patients were randomly assigned using random numbers to a treatment group treated with FZHYT and a placebo group; the treatment course was 6 months for both groups. Overall response, adverse events (AEs), and the 2-year survival rate were assessed after treatment. Evaluations were made on changes in liver function, liver fibrosis, coagulation, hemodynamics, degrees of esophagogastric varices, ascites, quality of life (QOL), and scores of main symptoms. Results: The overall response was significantly higher in the treatment group than the placebo group (86.7% vs. 62.2%, P<0.01). Patients in both groups had signi?cant improvements in liver function [total bilirubin (TBIL), albumin (ALB)], liver fibrosis [hyaluronic acid (HA), type Ⅳ collagen (CⅣ)], coagulation [prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), and thrombin time (TT)], hemodynamics portal venous flow (PVF), and splenic vein flow (SVF) after treatment. Between-group comparisons showed that compared with the placebo group patients in the treatment group achieved significantly greater improvements in TBIL, ALB, HA, C Ⅳ, PT, APTT, PVF, SVF, time to ascites resolution, 2-year survival, QOL, and symptom scores (P<0.05 or P<0.01). There were no significant AEs during the treatment. Conclusions: FZHYT is effective and safe for the treatment of hepatic cirrhosis as it is associated with improved liver function, liver ?brosis, coagulation, portal hypertension state, QOL, 2-year survival rate, and fewer AEs.     

胃病1号方治疗脾胃虚寒性功能性消化不良：一项多中心、双盲、安慰剂对照试验

Objective

To assess the efficacy and safety of Gastrosis No.1 compound in the treatment of functional dyspepsia with Spleen (Pi) and Stomach (Wei) deficiency-cold syndrome.

Methods

A randomized, double-blind, placebo-controlled trial was performed in 5 centers. Patients with functional dyspepsia (FD) of Spleen-deficiency and qi-stagnation syndrome (162 cases) were randomly assigned to groups given Chinese herbal medicine (CHM) Gastrosis No.1 compound or placebo in a 2:1 ratio. This trial included a 4-week treatment period and a 4-week follow-up period. The outcomes were the dyspepsia symptom scores (measured by total dyspepsia symptom scale and single dyspepsia symptom scale) and syndromes of traditional Chinese medicine score (measured by traditional Chinese medicine syndrome scale). The outcomes were noted at weeks 0, 4 and 8.

Results

Compared with patients in the placebo group, patients in the CHM group showed significant improvement in the dyspepsia symptom scores as rated by patients and investigators (P <0.01), and also showed improvement in syndromes of traditional Chinese medicine score (P <0.01). No serious adverse event was reported. Safety tests obtained after 4 weeks of treatment showed no abnormal values.

Conclusion

CHM Gastrosis No.1 compound was effective and safe in the treatment of functional dyspepsia with Spleen and Stomach deficiency-cold syndrome     

Experimental study on effect of renal failure granule in treating uremia

Objective: To observe the efficacy of Renal Failure Granule (RFG) in treating uremia and explore its mechanism. Methods: Platt's method was used to establish the chronic renal failure model. Forty-eight rats were divided into normal group, model group, Jiangzhuo recipe (降浊方) group, Fuzheng recipe (扶正方) group, RFG group and aldehyde-oxygen encapsulated starch group, 8 rats in each group, to observe the effects of RFG on serum creatinine (SCr), blood urea nitrogen (BUN), plasma calcium (Ca), plasma phosphorus (P), parathyroid hormone (PTH), middle molecular substance (MMS), methylguanidine (MG), guanidinosuccinic acid (GSA) and other parameters. Results: Comparison of SCr and BUN changes after medication for 30 and 60 days, the RFG group, the Fuzheng recipe group and the Jiangzhuo recipe group, with the aldehyde-oxygen encapsulated starch group or model group, demonstrated that the difference was significant (P<0.05, P<0.01), For PTH, Ca, P, MMS, MG and GSA, RFG was clearly different with the model group (P<0.05, P<0.01). Jiangzhuo recipe and Fuzheng recipe group also were variously efficacious in above-mentioned parameters. Conclusions: RFG can retard the development of uremia, and its mechanism may be related to the decrease of uremic toxin.     

Clinical study on therapeutic effect of shuwei decoction on functional dyspepsia

Objective

To explore the clinical effectiveness and therapeutic mechanism of Shuwei Decoction in treating functional dyspepsia (FD).

Methods

A total of 124 FD patients were randomly divided into two groups: Shuwei Decoction group (60 cases) and the control group (64 cases) treated with cisapride. After one month treatment, all patients were examined with motilin and electrogastrography (EGG).

Results

The therapeutic effectiveness of Shuwei Decoction group was much better than that of the control group (P<0. 05), while the changes on motilin and EGG in the two groups were relatively similar (P<0.05).

Conclusion

Shuwei Decoction could effectively raise motilin level, promote gastric movement and improve the clinical symptoms in FD patients.     

Clinical Efficacy and Safety of Bathing with Chinese Medicine Taohong Siwu Decoction (桃红四物汤) for Treatment of Diffuse Cutaneous Systemic Sclerosis: A Randomized Placebo-Controlled Trial

Objective:To examine the efficacy and safety of bathing therapy with Taohong Siwu Decoction(桃红四物汤,TSD) in the treatment of early-stage,mild-moderate diffuse cutaneous systemic sclerosis(dc SSc).Methods:This randomized,placebo-controlled trial enrolled 148 men and women(18–60 years) with dc SSc(disease duration 12 months) and baseline modified Rodnan skin score(MRSS) 10.Patients were randomized into a TSD group(71 cases bathing with TSD plus oral prednisone) or control group(71 cases bathing with placebo plus oral prednisone).Bathing(40 ℃,30 min) of the upper and lower limbs was carried out once daily for 12 consecutive weeks.The primary outcome measure was MRSS;secondary outcomes were Raynaud's phenomenon(RP) score,quality of life(QOL),physician visual analogue scale(VAS),patient VAS,percent predicted diffusing capacity for carbon monoxide(DLCO),percent predicted forced vital capacity(FVC),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP) level and overall treatment effect.Results:The final analysis included 135 patients(control group,68 cases;TSD group,67 cases).Primary and secondary outcome measures after 2 weeks of treatment showed no improvement(versus baseline) in both groups,with no differences between groups.At 12 weeks,QOL,physician VAS,patient VAS,ESR and CRP were improved in both groups,but MRSS and RP score were improved only in the TSD group(all P0.05).MRSS,RP score,QOL,physician VAS,patient VAS,ESR and CRP differed significantly between groups(all P0.05).Meanwhile,the overall treatment effect was significantly higher in the TSD group than in the control group(P0.05).Adverse events in the two groups were similar(P0.05).Conclusions:Bathing with TSD plus oral prednisone achieves better outcomes than oral prednisone alone in patients with dcS Sc and is not associated with serious adverse events.     

Clinical and Psychometric Validation of the Quality of Life Assessment System for Advanced Gastric Cancer Based on Traditional Chinese Medicine

Objective

To establish questionnaire scaling and reliability and examine the clinical and psychometric validity of the quality of life assessment based on Traditional Chinese Medicine for advanced gastric cancer (QLASTCM-Ga).

Methods

The QLASTCM-Ga was developed based on programmed decision procedures with multiple nominal and focus group discussions, in-depth interview, pretesting and quantitative statistical procedures. The questionnaire was administered to 240 patients diagnosed with advanced gastric cancer before and after treatment. Structured group methods were employed to establish a general and a specifific module respectively. The psychometric properties of the scale were evaluated with respect to validity, reliability and responsiveness.

Results

The three identified scales of the QLASTCM-Ga and the total score demonstrated good psychometric properties. Test-retest reliability of the total scale and all domains ranged from 0.90 to 0.94, and internal consistency ranged from 0.86 to 0.93. Correlation and factor analysis demonstrated good construct validity. Signifificant difference in the subscales and the total score were found among groups differing in traditional Chinese medicine syndrome, supporting the clinical sensitivity of the QLASTCM-Ga. Statistically signifificant changes were found for each scale and the total score. Responsiveness was also good.

Conclusions

The QLASTCM-Ga demonstrates good psychometric and clinical validity to assess quality of life in patients with advanced gastric cancer undergoing traditional Chinese medicine therapy. This study is an important fifirst step for future research in this area.

     

Effects of puerarin on plasma endothelin and serum tumor necrosis Factor-α in type 2 diabetes mellitus patients with vascular complications

Ｔｈｅｉｎｃｉｄｅｎｃｅｏｆｄｉａｂｅｔｅｓｍｅｌｌｉｔｕｓ（ＤＭ）ｈａｓｄｒａｓｔｉｃａｌｌｙｉｎｃｒｅａｓｅｄａｔｔｈｅｐｒｅｓｅｎｔｔｉｍｅｗｉｔｈｍｉ ｃｒｏｖａｓｃｕｌａｒａｎｄｌａｒｇｅｖａｓｃｕｌａｒｄｉｓｔｕｒｂａｎｃｅｓａｓｔｈｅｍｏｓｔ     

应用重复测量方差分析研究痰热对中风患者神经功能缺陷的作用

Objective

To explore the effect of phlegm-heat syndrome on the degree of neurological deficit and provide some data support for the correct recognition of the relationship between phlegm-heat syndrome and neurological deficits in stroke patients.

Methods

Clinical information were collected on 294 patients with acute ischemic stroke (AIS) whose syndrome and National Institute of Health stroke scale (NIHSS) score were checked at baseline (within the first 3-day admission) and at 7, 14, 28, and 90 days after admission to our clinical research centre. We explored the effect of phlegm-heat syndrome on the degree of neurological deficit following stroke by applying a repeated measures analysis of variance.

Results

Stroke patients with phlegm-heat syndrome had higher NIHSS score than patients without the syndrome (P <0.01), and there appeared to be a decrease in NIHSS score over time in all patients (P <0.01).

Conclusions

Phlegm-heat syndrome in patients who have suffered stroke has an effect on the degree of neurological deficiency. Disappearance of phlegm-heat syndrome may improve the degree of neurological deficit observed in stroke patients.     

Outcomes of a group education/exercise intervention in a population of patients with non-specific low back pain: a 3-year review

Background

Low back pain (LBP) can prove resistant to treatment. Conservative management in form of education and exercise is advocated as a first-line treatment option. The format of exercise programmes varies, as does the scale of improvement. Individual and group models of care are commonly utilised.

Aims

To determine the effectiveness of a group education/exercise intervention in a cohort of patients with LBP in a teaching hospital in the south east of Ireland. In addition, the study explores which factors are predictive of a positive outcome.

Methods

Patients aged 18–65 years with LBP > 6 months, who completed the programme between January 2008 and December 2010 were included. Outcome measures were coded, entered into PASW 18 and cleaned. Pre and post scores were analysed with paired t tests and χ ² analysis. Multiple regression modelling was used to determine which baseline variables were independent predictors of positive outcome.

Results

In total, 668 patients completed the programme. The mean age of patients was 45.9 ± 11.3 years and the majority of patients (69 %) were female. Three months post programme, significant improvements in all self report and objective physical measures were demonstrated (p < 0.001). Factors associated with a positive outcome included lower levels of baseline disability and distress, less baseline functional impairment, shorter duration of symptoms and not being involved in litigation.

Conclusion

This group-based education/exercise programme proved effective in terms of decreasing pain, improving physical function and improving psychosocial status. Identifying factors predictive of positive outcome may help maximise patient outcomes.     

利用SPECT脑血流显像评价电针治疗儿童孤独症疗效

Objective:To explore the effectiveness of electro-acupuncture(EA)in the treatment of childhood autism(CA)and evaluate its effectiveness using single photon emission computed tomography(SPECT).Methods:A total of 55 CA patients(4.52±2.73 years)were enrolled in this study.All patients received EA treatments and were examined by SPECT before and after treatments.Results:Following treatment,the intracerebral multiple focal radioactivity distribution defect areas of CA patients were observed to be partially filled.Specifically,significant differences in the ratios of regional cerebral blood flow and global cerebral blood flow before(Fb)and after(Fe)EA treatment in different lesions were observed(in the left prefrontal cortex,t=5.01,P0.01;in the right prefrontal cortex,t=2.32,P0.05;in the left temporal lobe,t=4.54,P0.01;in the right temporal lobe,t=2.90,P0.05;in the left Broca's area,t=5.82,P0.01).After EA treatment,the patients exhibited symptomatic relief.Conclusion:EA is useful to treat CA and SPECT can be used to evaluate the effectiveness of this treatment.     

Effect of Jianpiyiqi granule on ocular myasthenia gravis in children prepared with a formula from Traditional Chinese Medicine

Objective

To investigate the effect of Jianpiyiqi granule, prepared according to a Traditional Chinese Medicine (TCM) formula, on the ocular type of myasthenia gravis (MG) caused by a defect in synaptic transmission at the neuromuscular junction.

Comprehensive patient care improves quality of life in transfusion dependent patients with β-thalassemia

Objectives:

To investigate levels of quality of life (QOL) among thalassemia patients at the Hereditary Blood Disorders Center in Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia.

Methods:

A cross-sectional study was performed on 43 transfusion dependent thalassemia patients compared with 43 normal subjects, as a control, using the World Health Organization Quality Of Life - Brief questionnaire between May 2012 and September 2012 at the Hereditary Blood Disorders Center, Maternity and Children Hospital in Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia.

Results:

Forty-three thalassemia patients were examined, 23 males and 20 females, and compared with 43 peers (control group), 24 males and 19 females. There was no statistical difference between patients and controls for psychological domains (53.4 versus 56.9, p=0.059) and environmental domains (56.6 versus 57.0, p=0.884). Patients had better social QOL than the control group (39.3 versus 31.7, p=0.003), while the control group had better physical QOL (55.4 versus 61.9, p=0.047). Among patients, there was no statistical difference in QOL domains for variables of age, desferroxamine use, serum ferritin level, disease severity, presence of complications; splenectomy status, hepatitis C virus status, or family history.

Conclusion:

Quality of life in thalassemia patients is similar to the control group particularly social life, though physical health is less. Improvement of patients care from all aspects will improve their QOL. More studies in this field are needed with a bigger sample size.β-Thalassemia disorders are characterized by defective production of hemoglobin and excessive destruction of red blood cells.1 Thalassemia effects physical health such as physical deformities, growth on retardation, and delayed puberty, may have an impact on physical appearance, for example: bone deformities and short stature, all of which contribute to poor self-image. Other severe complications such as heart failure, cardiac arrhythmia, liver disease, endocrine complications and infections are common among patients with β-thalassemia and may impact negatively on patients’ quality of life (QOL).2 Therefore, β-thalassemia major and its complications carry a profound psychological impact on the patients.3 The aim of regular blood transfusion is to eliminate the primary complication of severe thalassemia by ameliorating anemia and suppressing erythropoiesis.3 Morbidity and mortality related to thalassemia have been reduced significantly with modern medical treatment, and QOL should now be considered an important index of effective health care and an essential outcome when considering options for treatment for individual patients and the allocation of health care resources.4 As per the World Health Organization (WHO) definition, QOL is individuals’ perceptions of their position in life in the context of the culture and value systems in which they live, and in relation to their goals, expectations, standards and concerns.5 In clinical practice the QOL assessments will assist clinicians in making judgments in regards to the areas in which a patient is most affected by disease, and in making treatment decisions.5 Only a few studies have been conducted on QOL worldwide on patients with β-thalassemia. Various studies have shown that thalassemia is stressful, and patients face a variety of physical, psychological, and social problems. The findings also showed that culture and education play a major role in illness experiences.6 For these reasons, we need to have a baseline assessment for our patients so that we can develop strategies to improve their QOL. The present study aimed to compare levels of QOL among patients with β-thalassemia at the Hereditary Blood Disorders Center in Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia with their healthy peers in terms of physical health, psychological, social relationships, and environmental domains.     

Effects of ixeris sonchifolia on platelet function and hemorrheology of type 2 diabetes mellitus patients

Objective: To observe the effects of Ixeris sonchifolia Hance (ISH) on platelet function and hemorrheology in type 2 diabetes mellitus (DM) patients. Methods: Thirtythree type 2 DM patients were treated with 20 ml ISH per day, intravenously dripping for 15 days; 31 patients in the red sage treated group were treated with composite red sage injection intravenous dripping for 15 days, and their changes of platelet membrane glycoprotein Ⅱb/Ⅲa compound (GPⅡb/Ⅲa), granular membrane protein140 (GMP140), platelet aggregation rate (PAgR) and hemorrheology were observed. Results: After treatment with ISH, the GPⅡb/Ⅲa compound positive rate of 33 type 2 DM patients were lowered (P<0.05), GMP140 showed lowering trend, PAgR obviously reduced, and compared with before treatment it showed significant difference; comparison between the two groups after treatment,it showed significant difference (P<0.05, P<0.01). At the same time, the various parameters of hemorrheology displayed significant improvement. There was no adverse effect during the course of treatment. Conclusion: ISH could improve platelet function and abnormal hemorrheology of type 2 DM patients, which is vital for the treatment of DM and their vascular lesion.     

Effect of new zhengtian pill on expression of whole blood platelet membrane adhesion molecules in patients of migraine

Objective

To investigate the effect of New Zhengtian Pill (NZTP) on expression of whole blood platelet membrane adhesion molecules (PMAM) in patients of migraine.

Methods

Sixty-eight patients were divided into two groups, the 35 patients in the treated group treated by NZTP orally and the 33 patients in the control group treated by Fuguiqin Capsule with a therapeutic course of 30 days for both groups. Changes of PMAM GP II b/III a (CD₄₁) and P-selectin (CD₆₂P) were observed by flow-cytometry and compared with those in healthy persons.

Results

The markedly effective rate and total effective rate in the treated group was higher than those in the control group respectively (P<0.05 andP<0.01). The PMAM expression was also higher in patients, both at onset stage and intermittent stage, than in healthy persons (P<0.01), NZTP treatment could reduce their increased expression significantly (P<0.01).

Conclusion

NZTP could reduce the PMAM expression and inhibit the activation of platelet.