氧自由基与肾小球疾病发病关系及抗氧化剂的防治作用

用阿霉素（ＡＤＲ）和阳离子化牛血清白蛋白（Ｃ－ＢＳＡ）分别诱导大鼠ＡＤＲ肾病和原位性肾炎模型，发病率各达１００％。前者血及肾皮质丙二醛（ＭＤＡ）明显增高，后者血及肾皮质ＭＤＡ、还原型谷胱甘肽（ＧＳＨ）明显增高，超氧化物歧化酶（ＳＯＤ）明显降低。选用抗氧化剂ＳＯＤ及具有抗＊化作用的中药脚剂阿魏硬钠、赶盖灵芝、敢双醋钠、人参皂苷等分别对模型进行干扰，结果显示治疗组大鼠模型尿蛋白、血生化指标、肾病理损害明显改善，特别是血和肾皮质ＭＤＡ、ＧＳＨ明显降低、ＳＯＤ明显升高。说明ＡＤＲ肾病和Ｃ－ＢＳＡ原位性肾炎的发生、发展与氧自由基（ＯＦＲ）及脂质过氧化（ＬＰＯ）密切相关。这些药物的治疗作用可能主要是通过清除ＯＦＲ，抑制ＬＰＯ而实现的。这为临床中西医结合防治肾小球肾炎提供了理论依据，也为临床提供新的防治手段。     

百春肝泰灵对小鼠免疫性肝损伤及免疫功能的影响

了解百春肝泰灵对小鼠免疫性肝损伤及免疫功能的影响。方法采用丙酸杆菌（ＣＰ）加脂多糖（ＬＰＳ）诱导小鼠免疫性肝损伤模型和环磷酰胺（Ｃｙ）所致小鼠ＤＴＨ反应增高模型进行观察。结果百春肝泰灵（３、９、２７ｇ·ｋｇ－１，ｑｄ×１０ｄ，ｉｇ）可使免疫性肝损伤小鼠升高的血清ＡＬＴ、ＡＳＴ和肝脏指数降低（Ｐ＜０．０１），并使小鼠肝脏损伤性病理变化减轻；同时能使Ｃｙ所致小鼠增高的ＤＴＨ反应及Ｔ淋巴细胞增殖反应降低（Ｐ＜０．０１）。结论百春肝泰灵对小鼠免疫性肝损伤有明显的保护作用     

青石棉加苯并（a）芘气管染尘大鼠肺组织中SOD和LPO变化的研究

作者用青石棉、苯并（ａ）芘、青石棉加苯并（ａ）芘对大鼠经气管注入染尘，在染尘后９０、１８０、２７０、３６０和５４０天时动态观察肺组织超氧化物歧化酶（ＳＯＤ）和脂质过氧化物（ＬＰＯ）及ＳＯＤ／ＬＰＯ比值的变化。结果表明，青石棉加苯并（ａ）芘可诱发大鼠肺内Ｏ－２自由基反应增强，脂质过氧化反应增高，ＬＰＯ含量升高，同时抗氧化能力降低，ＳＯＤ／ＬＰＯ比值降低，体内抗氧化和脂质过氧化平衡失调     

依托咪酯与硫喷妥钠用于全麻诱导的血流动力学比较

目的：比较依托咪酯与硫喷妥钠在全麻诱导中对血流动力学的影响。方法：用依托咪酯与硫喷妥钠进行全麻诱导时，分别记录患者收缩压（ＳＰ）、舒张压（ＤＰ）、及心率（ＨＲ）等各项指标。结果：用药后与诱导前相比，硫喷妥钠对ＳＰ、ＤＰ、ＨＲ的影响有显著性差异（Ｐ＜００５）。用依托咪脂诱导，其各项指标与诱导前无显著性差异（Ｐ＞００５）。结论：依托咪酯用于全麻诱导较硫喷妥钠更安全，更适宜心功能较差的危重病人。     

声带显微手术不同麻醉方法的心血管反应及术毕苏醒的比较

本文比较了保留自主呼吸的静脉复合麻醉（Ⅰ组）和异丙酚诱导的气管插管全麻（Ⅱ组）对声带显微手术期间的心血管反应和术毕苏醒情况．结果Ⅰ组的HR、BP、RPP在诱导后、置入支撑喉镜即刻、置入后5min均显著增高。（P＜0．01），SpO2在诱导后明显降低（P＜0．01）。Ⅰ组的HR、BP、RPP在诱导后稍降低，置入支撑喉镜即刻明显增高（P＜0．01），5min后接近术前水平。术毕恢复情况及清醒质量Ⅱ组明显优于Ⅰ组．说明，用异丙酚诱导的气管插管全麻具有减少心肌耗氧、心血管反应小、术毕恢复快、清醒质量高等特点，尤其适用于高血压、冠心病和某些老年病人。     

供者特异性抗原经外周输注诱导免疫耐受的研究

为探索诱导免疫耐受的途径和方法，作者采用大鼠异位心脏（颈部）移植模型，经外周途径输注不同品系供者的不同特异性抗原，包括供体特异性输血（ Ｄ Ｓ Ｔ）、供体特异性脾细胞（ Ｄ Ｓ Ｓ Ｌ）、供体特异性骨髓细胞（ Ｄ Ｓ Ｂ Ｍ）。结果显示： Ｄ Ｓ Ｔ、 Ｄ Ｓ Ｓ Ｌ和 Ｄ Ｓ Ｂ Ｍ 均能诱导受者对移植物产生特异性免疫耐受，其中以脾细胞和骨髓细胞效果最好，平均移植物存活时间分别达到 ４２９±６６７ 和 ４０３±１１６ 天。混合淋巴细胞反应（ Ｍ Ｌ Ｒ）和 Ｔ 亚群（ Ｃ Ｄ８＋ ）检测在一定程度上反映了机体 Ｔ 细胞免疫状态，有助于对耐受的评价。成分输注供者特异性抗原作为刺激抗原，可望成为较理想的临床耐受诱导途径。     

青石棉加苯并（a）芘气管染法大鼠肺组织中SOD和LPO变化的研究

作者用青石棉、苯并（ａ）芘、青石棉棉加苯并（ａ）芘对大鼠经气管注入染尘，在染尘后９０、１８０、２７０、３６０和５４０天时动态观察肺组织超氧物皮化酶（ＳＯＤ）和脂质过氧化物＊（ＬＰＯ）及ＳＯＤ／ＬＰＯ比值的变化。结果表明，青石棉加苯并（ａ）芘可诱发大鼠肺内Ｏｉ自由基反应增强，脂质过氧化反应增高，ＬＰＯ含量升高，同时抗氧化能力降低，ＳＯＤ／ＬＰＯ比值降低，体内抗氧化和脂质过氧化平衡失调。     

异丙酚诱导气管插管对心肌氧供需平衡的影响

目的比较异丙酚及联合硬膜外阻滞全麻诱导气管插管时的心肌氧供需平衡的变化。方法胸外科患者２２例（ＡＳＡ分级Ⅱ～Ⅲ级），随机分为异丙酚组（Ｐ组）和异丙酚联用硬膜外阻滞组（Ｅ组），用ＸＸＧ－Ｅ型心血管功能测定仪记录各项指标。结果两组病人应用异丙酚插管后平均动脉压和心脏指数未明显增高，Ｅ组总外周阻力和冠状动脉灌注压在硬膜外阻滞后和异丙酚诱导后均明显降低。插管后亦未提高，但Ｐ组总外周阻力在气管插管后增高；两组ＥＫＧ、心肌氧耗指数和心肌耗氧量在诱导插管前后均无明显变化，Ｅ组在硬膜外阻滞后及异丙酚诱导后下降，但在正常范围。结论异丙酚及联合硬膜外阻滞全麻诱导气管插管时对心肌氧供需平衡没有明显影响     

溃疡性结肠炎患者血清粒细胞集落刺激因子和C-反应蛋白检测及意义

目的：研究血清中粒细胞集落刺激因子（Ｇ－ＣＳＦ）和Ｃ－反应蛋白（ＣＲＰ）在溃疡性结肠炎时的（ＵＣ）作用和意义。方法：用酰联免疫吸附法测定了３３例ＵＣ患者及正常对照组４０例血清Ｇ－ＣＳＦ、Ｃ－反应蛋白（ＣＲＰ）和中性粒细胞水平。结果：活动性ＵＣ患者血清中Ｇ－ＣＳＦ和ＣＲＰ水平明显增高,并与病情的轻重有关（Ｐ〈０．０５）。结论：血清中Ｇ－ＣＳＦ水平增高可能参与ＵＣ的炎症发展,Ｇ－ＣＳＦ和ＣＲＰ可作为ＵＣ病情判断的指标。     

三株抗人B淋巴细胞表面抗原单克隆抗体的研制及初步鉴定

用慢性Ｂ淋巴细胞白血病患者外周血白血病细胞免疫ＢＡＬＢ／ｃ小鼠，以Ｂ淋巴细胞杂交瘤技术产生了三种单克隆抗体，分别命名为ＳＭＵ＿（１０）、ＳＭＵ＿（１１）ＳＭＵ＿（１２）。初步鉴定的结果表明，（１）ＳＭＵ＿（１０）、ＳＭＵ＿（１１）是抗成熟阶段Ｂ细胞及浆细胞的单抗，二者的特性及反应谱相类似；（２）ＳＭＵ＿（１２）是一非系限性单抗，与成熟Ｔ细胞、分化后期的Ｂ细胞及部分粒单细胞反应；（３）ＳＭＵ＿（１０）、ＳＭＵ＿（１１）、ＳＭＵ＿（１２）可较好地判明白血病细胞的来源及Ｂ细胞的分化阶段，在白血病的免疫学分型中具有实用价值；（４）三株单抗是新的抗Ｂ细胞特异性单抗。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.