定制人工膝关节假体在骨肉瘤保肢治疗中的应用

目的探讨定制人工膝关节假体在骨肉瘤保肢术中应用价值。方法采用定制的人工膝关节假体治疗在本科住院的膝关节周围(股骨下段、胫骨上段)骨肉瘤患者6例,4例为股骨下段骨肉瘤,2例为胫骨上段骨肉瘤,6例均采用定制的人工膝关节假体进行关节重建,对其中2例胫骨近端骨肉瘤患者同时行腓肠肌、比目鱼肌肌瓣移植。结果 6例患者术后随访12～48个月(平均为30个月),按Enneking法评定功能,≥23分4例,15～22分1例,<15分1例,优良率达到83.33%。膝关节平均活动度为伸0°、屈85°～135°。1例肿瘤复发而截肢,1例1年后出现肺部转移而死亡。结论定制的人工膝关节假体是治疗骨肉瘤较好的保肢方法,能减少患者致残率,改善生活质量,术后关节功能、疗效满意。     

定制人工膝关节假体治疗膝关节周围恶性骨肿瘤

目的 :探讨定制人工膝关节假体在膝关节周围恶性骨肿瘤保肢治疗中的临床效果。方法 :对19例股骨远端或胫骨近端恶性骨肿瘤行瘤段骨广泛切除、定制人工膝关节假体置换术。结果 :随访 1年 5个月～ 5年 ,膝关节活动度为伸 0° ,屈 90°～ 10 5°。 19例患者中发生假体周围积液和行走后踝关节痛各 1例 ,无感染、假体松动及断裂 ,无肿瘤复发。 1例发生肺转移 ,带瘤存活 ,2例因肺及其他部位转移死亡。结论 :定制人工膝关节假体治疗膝关节周围恶性骨肿瘤能尽早及较好地恢复膝关节功能 ,尤其适合于骨破坏严重 ,骨支架作用基本丧失者。     

人工假体置换在膝关节周围恶性骨肿瘤中的临床应用

目的 探讨人工假体在膝关节周围恶性骨肿瘤保肢术中的临床应用效果.方法 膝关节周围骨肿瘤患者22例.对化疗敏感的,由肿瘤内科行正规静脉化疗,术前72小时内常规行血管造影及瘤体动脉栓塞,行骨肿瘤广泛切除或根治性切除后,采用人工膝关节假体置换重建.结果 22例患者术后随访12-60个月,其中17例患者无局部复发或远处转移, 4例出现复发.膝关节活动 0°-110°,根据Insall评分标准治疗后效果优15例,良3例,可4例,优良率85%.结论 人工假体是一种治疗膝关节周围恶性骨肿瘤较好的保肢方法,能降低局部并发症及提高临床疗效.     

腓肠肌及比目鱼肌瓣在胫骨近端恶性骨肿瘤保肢术的应用

目的　探讨带血管蒂腓肠肌、比目鱼肌肌瓣移植在胫骨近端恶性骨肿瘤保肢术中的应用价值。方法　行胫骨近端恶性骨肿瘤保肢术患者共 2 6例 ,其中行腓肠肌、比目鱼肌肌瓣移植 16例 ,未行肌瓣移植 10例。结果　肌瓣移植者中有 1例发生肌瓣坏死及骨筋膜室综合征 ;非移植者中有 2例发生切缘皮瓣坏死深部感染 ,3例切口脂肪液化浅表感染。 19例术后平均随访 38个月 ,按Enneking法评定功能 ,≥ 2 3分 6例 ,15～ 2 2分 8例 ,<15分 5例 ,优良率为 73.7%。结论　胫骨近端骨恶性肿瘤保肢术中采用带血管蒂腓肠肌、比目鱼肌肌瓣移植可重建软组织缺损、降低局部并发症及提高临床疗效。     

人工假体置换在膝周恶性骨肿瘤中的临床应用

目的 探讨人工假体在膝关节周围恶性骨肿瘤保肢术中的临床效果.方法 28例膝关节周围恶性骨肿瘤瘤段广泛切除后,采用人工膝关节假体置换重建.结果 28例患者术后根据Enneking评分标准评定疗效优18例,良6例,可4例,优良率85%.随访4～48个月,其中20例患者无局部复发或远处转移,8例复发或转移.结论 人工假体置换重建膝关节周围骨肿瘤手术可改善膝部恶性骨肿瘤患者的早期生活质量,减少致残率,严重并发症少,患者术后关节功能、效果较满意.     

人工膝关节置换在膝周恶性骨肿瘤保肢术中的应用

目的 探讨在膝关节周围恶性肿瘤行瘤段切除和肿瘤型铰链式人工膝关节置换术的临床效果.方法 回顾19例膝关节周围恶性骨肿瘤采用瘤段切除及肿瘤型铰链式人工膝关节置换来修复和替代切除的股骨远端或胫骨近端.结果 随访8～76个月,平均21.3个月,19例中存活17例.假体置换后功能评定优良率达89%.结论 肿瘤型铰链式人工膝关节置换是膝关节周围恶性骨肿瘤保肢重建的一种疗效可靠的方法 .     

旋转铰链型膝关节置换术在膝部骨肿瘤中应用的临床研究

目的探讨旋转铰链型人工膝关节置换术在膝部骨肿瘤中应用的疗效。方法选择2009年7月～2012年6月湖北医药学院附属襄阳医院行手术治疗的膝部良恶性骨肿瘤患者32例,其中股骨远端18例,胫骨近端14例,分别是骨肉瘤17例,骨巨细胞瘤12例,骨巨细胞瘤合并动脉瘤样骨囊肿3例。骨肉瘤患者术前均接受1～2个疗程新辅助化疗,术后继续3-4个疗程正规化疗。观察术后Enneking肢体功能评分、影像学评价。结果所有患者均得到随访,随访12～36个月（平均24个月）;未见肿瘤复发、假体松动;1例术后出现肢端麻木：1例术后出现感染;股骨下端组Enneking肢体功能评分平均24．7分;胫骨上端组平均24．1分。结论旋转铰链型膝关节置换术是治疗膝部良恶性骨肿瘤较理想的保肢方法。     

人工肩关节置换治疗肱骨上段恶性骨肿瘤

目的 探讨用特制的人工肩关节置换治疗肱骨上段恶性骨肿瘤的临床应用效果。方法对9例单侧肱骨上段恶性骨肿瘤患者均使用定制的人工肩关节假体置换行保肢术，患者平均年龄37．0岁，术后平均随访3．7年（11～96个月）。结果术后肩关节功能按国际保肢学会（ISOLS）的评估标准评分，优5例，良2例，可1例，差1例，优良率为77．8％，术后未出现明显假体松动。结论临床应用特制的人工肩关节置换治疗肱骨上段恶性骨肿瘤，可达到保肢的目的，是一种疗效较好的方法，不仅保留了患肢的形态，也保留了上肢的大部分功能。     

膝关节周围恶性骨肿瘤不同保肢手术方法的比较

目的　回顾性总结膝关节恶性骨肿瘤不同保肢手术方法的临床效果 ,比较其各自的优缺点。方法　自1990年 1月 - 2 0 0 2年 3月行保肢手术的膝关节恶性骨肿瘤 6 3例 ,其中瘤段灭活再植 2 8例、异体骨移植 2 2例、人工假体置换 13例 ,按照Enneking方法分期 ,其中IB期 3例、IIA期 2例、IIB期 5 8例 ,比较 3种保肢手术后的局部复发率、并发症和膝关节功能MSTS评分。结果　局部复发率 :瘤段灭活再植的局部复发率为 2 1.4 % ,异体骨移植为 18.2 % ,假体置换为 15 .4 % ,三者之间没有显著性差异 ;人工假体置换的并发症明显小于其他两组。根据MSTS评分 ,人工假体置换组为 86 % ,瘤段灭活再植与异体骨移植分别为 6 5 %和 70 % ,差异显著性。结论假体置换具有并发症少 ,恢复快 ,功能好的优点 ,但对于青少年膝关节恶性骨肿瘤患者 ,尤其是骨骺没有愈合的 ,瘤段灭活再植及异体骨移植仍然是简单有效的方法     

腓肠肌内侧头肌瓣在胫骨上端骨肿瘤保肢术中的应用研究

目的 探讨带血管蒂腓肠肌肌瓣移植在胫骨近端骨肿瘤保肢术中的应用价值.方法 行胫骨近端骨肿瘤保肢术患者共38例,出院后所有患者完成随访.结果 肌瓣移植者中有1例发生肌瓣坏死及骨筋膜室综合征;3例切口浅表感染.38例术后全部做到随访,平均随访时间40个月.结论 胫骨近端骨骨肿瘤保肢术中采用带血管蒂腓肠肌肌瓣移植可重建软组织缺损、降低局部并发症及提高临床疗效.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.