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目的 在接受急诊冠脉介入术(PCI)的急性ST段抬高型心肌梗死患者中,评价术前使用安心颗粒联合血栓抽吸术对心肌灌注的影响。方法 160例接受急诊冠脉介入术的急性ST段抬高型心肌梗死患者被随机分为安心颗粒组(术前顿服安心颗粒8.8 g,术后安心颗粒4.4 g/次,每日2次)和对照组。所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀。术后观察心肌呈色分级(MBG)、心电图ST段回落百分比、肌钙蛋白(cTnI)和肌酸激酶同工酶(CK-MB)峰值、左室射血分数(LVEF)、主要不良心脏事件(MACE)。结果 安心颗粒组术后的MBG分级较高(P<0.05),达到MBG 3级的患者比例较多(P<0.05),术后ST段回落百分比>70%的患者数较对照组多(P<0.05),cTnI(P<0.01)和CKMB(P<0.05)峰值时间提前。术后第30天,安心颗粒组患者的左室射血分数明显高于对照组(P<0.01)。第(30±1)天时,2组患者主要不良心脏事件发生人数无显著性差别(P>0.05)。结论 急诊冠脉介入术前使用安心颗粒,联合血栓抽吸术,能改善心肌灌注和泵功能,但对短期内主要不良心脏事件无影响。 相似文献
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Objective:To investigate whether blood-brain barrier(BBB)served a key role in the edema-relief effect of bloodletting puncture at hand twelve Jing-well points(HTWP)in traumatic brain injury(TBI)and the potential molecular signaling pathways.Methods:Adult male Sprague-Dawley rats were assigned to the shamoperated(sham),TBI,and bloodletting puncture(bloodletting)groups(n=24 per group)using a randomized number table.The TBI model rats were induced by cortical contusion and then bloodletting puncture were performed at HTWP twice a day for 2 days.The neurological function and cerebral edema were evaluated by modified neurological severity score(mNSS),cerebral water content,magnetic resonance imaging and hematoxylin and eosin staining.Cerebral blood flow was measured by laser speckles.The protein levels of aquaporin 4(AQP4),matrix metalloproteinases 9(MMP9)and mitogen-activated protein kinase pathway(MAPK)signaling were detected by immunofluorescence staining and Western blot.Results:Compared with TBI group,bloodletting puncture improved neurological function at 24 and 48 h,alleviated cerebral edema at 48 h,and reduced the permeability of BBB induced by TBI(all P<0.05).The AQP4 and MMP9 which would disrupt the integrity of BBB were downregulated by bloodletting puncture(P<0.05 or P<0.01).In addition,the extracellular signal-regulated kinase(ERK)and p38 signaling pathways were inhibited by bloodletting puncture(P<0.05).Conclusions:Bloodletting puncture at HTWP might play a significant role in protecting BBB through regulating the expressions of MMP9 and AQP4 as well as corresponding regulatory upstream ERK and p38 signaling pathways.Therefore,bloodletting puncture at HTWP may be a promising therapeutic strategy for TBI-induced cerebral edema. 相似文献
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抗冻蛋白(antifreeze protein,AFP)是一类结构多样的蛋白质,具有热滞效应(thermal hysteresis,TH,降低冰点而不改变熔点)和重结晶抑制效应(recrystalization inhabition,RI).通过非共价吸附抑制机制吸附到冰核表面,限制冰晶生长和抑制冰晶重结晶,从而保护有机体免受结冰引起的伤害.由于抗冻蛋白具有阻止冰晶生长而不破坏细胞的特点,因而利用抗冻蛋白在低温中长期保存各种细胞、组织和器官,特别在器官移植中可能具有很好的应用前景. 相似文献
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Song Wu Feng Wan Yong-shun Gao Zhe Zhang Hong Zhao Zhong-qi Cui Ji-yan Xie 《中国医学科学杂志(英文版)》2014,29(4):208-213
Objective To assess clinical effectiveness of using bilateral pectoralis major or plus rectus abdominis muscle flaps in treating deep sternal wound infection (DSWI) following median sternotomy. Methods Between January 2009 and December 2013, 19 patients with DSWI after median sternotomy for cardiac surgery were admitted to our hospital, including 14 males (73.7%) and 5 females (26.3%), aged 55±13 (18-78) years. According to the Pairolero classification of infected median sternotomies, 3 (15.8%) patients were type II, and the other 16 (84.2%) were type III. Surgical procedure consisted of adequate debridement of infected sternum, costal cartilage, granulation, steel wires, suture residues and other foreign substances. Sternal reconstruction used the bilateral pectoralis major or plus rectus abdominis muscle flaps to obliterate dead space. The drainage tubes were placed and connected to a negative pressure generator for adequate drainage. Results There were no intraoperative deaths. In 15 patients (78.9%), bilateral pectoral muscle flaps were mobilized sufficiently to cover and stabilize the defect created by wound debridement. 4 patients (21.0%) needed bilateral pectoral muscle flaps plus rectus abdominis muscle flaps because their pectoralis major muscle flaps could not reach the lowest portion of the wound. 2 patients (10.5%) presented with subcutaneous infection, and 3 patients (15.8%) had hematoma. They recovered following local debridement and medication. 17 patients (89.5%) were examined at follow-up 12 months later, all healed and having stable sternum. No patients showed infection recurrence during the follow-up period over 12 months. Conclusion DSWI following median sternotomy may be effectively managed with adequate debridement of infected tissues and reconstruction with bilateral pectoralis major muscle or plus rectus abdominis muscle flap transposition. 相似文献
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病人,女,81岁.40年前在工作时双上肢不慎被火烧伤,当年在大连化工厂医院烧伤科给予取自体腹部皮肤行前臂植皮术,术后植皮区域皮肤成活修复良好.4年前无明显诱因双侧前臂植皮区域肤色逐渐变深,无意中发现皮肤明显松弛,无不适感.近3个月自觉植皮区域疼痛不适,局部无红肿等,轻微牵拉皮肤时疼痛明显.自发病起4年皮损未见扩大.患者既往体健,否认家族有类似病患者. 相似文献
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1 临床资料 患者,男,23岁,因左下肢疼痛20 d来医院就诊.询问病史:患者2 d前在上级医院诊断为坐骨神经痛.既往健康,无药物过敏史.门诊当日给予维生素B1 100 mg,维生素B12 250靏肌注,用药约5 min时患者感到头晕、胸闷、呼吸困难、寒战,面色苍白,脉搏105次·min-1,血压80/50 mmHg,考虑为药物所致过敏性休克,立即给予平卧,氧气吸入,肾上腺素1 mg肌注,地塞米松10 mg静注,5 min后患者恢复正常. 相似文献
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草苁蓉多糖的抗肿瘤作用及免疫调节作用 总被引:3,自引:0,他引:3
目的:观察草苁蓉多糖对荷瘤小鼠免疫器官的调节作用及对免疫功能的影响。方法:接种肝癌细胞H22的荷瘤小鼠随机分为50、100、200和400 mg•kg-1•d-1草苁蓉多糖组、阴性对照组及阳性对照组(环磷酰胺组),按剂量给药。10 d后处死小鼠,分别称量脾重、胸腺重,检测荷瘤小鼠脾脏指数和胸腺指数;采用MTT法测定NK细胞活性;淋巴细胞转化实验测定T淋巴细胞转化率(LTT);中性红比色法观察小鼠腹腔巨噬细胞的吞噬能力;通过称量各小鼠实体瘤的重量,计算抑瘤率。结果:草苁蓉多糖能够显著抑制肿瘤生长,抑瘤率达38.86%;与阴性对照组比较,实验组荷瘤小鼠的脾脏指数显著提高(P<0.01),胸腺指数则有降低趋势,T淋巴细胞的转化率、NK 细胞的活性、巨噬细胞的吞噬能力显著增强(P<0.01),与给药剂量存在正相关关系。结论:草苁蓉能抑制肿瘤生长,对小鼠免疫功能具有调节作用。 相似文献
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【摘要】 目的 探讨丹参多酚酸盐联合氯沙坦钾对老年糖尿病肾病(DN)患者肾功能、凝血功能及血管内皮功能的影响。方法 选取我院2016年10月~2017年10月期间收治的老年DN患者120例,随机分为对照组和观察组两组,每组各60例,对照组采用常规内科治疗,并给予氯沙坦钾片治疗;观察组在对照组基础上加用丹参多酚酸盐。比较两组患者临床疗效及治疗前后肾功能、凝血功能、血管内皮功能、血清炎性因子及血脂等相关指标变化情况。结果 治疗后,观察组总有效率明显高于对照组,差异有统计学意义(P=0001);治疗后,两组患者SCr、BUN、24小时 Upro、FIB、PT、ET 1、vWF、hs CRP、TNF α、IL 6、TG、TC、LDL C水平均降低(P<005),且观察组降低幅度明显大于对照组,差异有统计学意义(P<005);治疗后,两组患者APTT、NO、HDL C水平升高(P<005),且观察组变化明显大于对照组,差异有统计学意义(P<005)。结论 丹参多酚酸盐联合氯沙坦钾治疗老年DN患者,可明显改善肾功能、纤溶活性及内皮功能,有效降低炎性因子水平。 相似文献
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John C. Clifford 《Canadian Medical Association journal》1984,130(4):513-514
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1 临床资料 我科 2001 05 /2003 05行开胸手术 50 (男 38,女 12)例.平均年龄 (60±11 48)岁.其中肺癌 29例,食管癌21例.术前向患者及家属说明手术及麻醉引起的呼吸反应,术后可能出现的并发症以及卧床对呼吸功能的影响,使患者认识到进行呼吸功能锻炼的重要性,指导患者进行呼吸功能训练,包括缩唇呼吸,腹式呼吸.原则是量力而行每次 10 ~15min,每天 3~4次, 3~5d有效咳嗽训练反复练习.抽取股动脉血标本送检进行血气分析(SaO2 );最大通气量、时间肺活量检测,专业医师在肺功能室测定.脉搏氧饱和度采用脉搏氧饱和度监测仪夹住食指末端测量.入院后… 相似文献
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S P Calloway 《British medical journal (Clinical research ed.)》1984,288(6414):400-401
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R Gillon 《British medical journal (Clinical research ed.)》1981,283(6307):1633-1639