小剂量芬太尼复合异丙酚用于微波子宫内膜去除手术麻醉

目的 :探讨小剂量芬太尼复合异丙酚在微波子宫内膜去除术 (MEA)的麻醉作用。方法 :选择MEA 6 0例 ,随机分为三组 ,A组静注芬太尼 1μg/kg及异丙酚 2mg/kg ,B组芬太尼 2 μg/kg及异丙酚 2 0mg/kg ;C组异丙酚 2mg/kg。记录异丙酚用量、微波和苏醒时间、呼吸抑制和术毕镇痛效应。结果 :A、B两组异丙酚用量均少于C组 (P <0 .0 1)。A、C两组呼吸抑制发生率均低于B组 (P <0 .0 5 )。A、B两组术毕无痛率均优于C组(P <0 .0 5 )。结论 :1μg/kg芬太尼复合异丙酚用于MEA麻醉可加强镇痛 ,减少异丙酚用量。     

芬太尼与瑞芬太尼复合丙泊酚用于无痛人工流产术的观察

目的：比较几种不同静脉麻醉方法行无痛人工流产术的麻醉效果。方法：择期行无痛人工流产术患者90例，随机分为丙泊酚组（A组）、芬太尼加丙泊酚组（B组）、瑞芬太尼加丙泊酚组（C组）三组，每组各30例。A组单纯使用丙泊酚2．5mg／kg静注；B组先给予1μg／kg芬太尼再静注丙泊酚1．5mg／kg；C组先给予0．75μg／kg瑞芬太尼再静注丙泊酚1．5mg／kg，注药完毕患者入睡后开始手术。术中有影响手术操作的肢动静脉给予0．5mg／kg的丙泊酚。结果：B组、C组与A组相比，镇痛更满意，术中丙泊酚用量明显减少（P〈0．01），术毕清醒及离院时间更短（P〈0．01）结论：芬太尼及瑞芬太尼复合丙泊酚均可安全用于无痛人工流产，麻醉效果满意。     

异丙酚联合芬太尼、阿托品在无痛人工流产中的应用

目的观察异丙酚联合芬太尼、阿托品在人工流产手术中的麻醉疗效。方法ASAI-Ⅱ级人工流产受术者100例，随机分为A、B两组，A组单纯使用异丙酚2．5mg／kg静注，B组用异丙酚2mg／kg静注、芬太尼10μg／kg，阿托品0．3mg／5ml静注，观察并记录两组患者苏醒时间、异丙酚用量、诱导前及诱导后2minBP、HR、SPO2的变化和两组病人的麻醉效果。结果A组异丙酚平均用量164mg，B组异丙酚平均用量102mg，苏醒时间B组少于A组（P〈0．05），异丙酚用量B组少于A组（P〈0．01），两组诱导后2min均有BP下降，SP02降低，但A组中HR下降，B组中的HR稍增快，B组麻醉效果优于A组（P〈0．05）。结论异丙酚联合芬太尼、阿托品用于人工流产手术的麻醉可加强镇痛、提高麻醉效果，减少异丙酚用量，同时使用麻醉苏醒更加迅速，是一种较为安全有效的麻醉配伍方法，可达到无痛人工流产的良好效果。     

芬太尼与瑞芬太尼复合丙泊酚用于无痛人工流产术的观察

目的:比较几种不同静脉麻醉方法行无痛人工流产术的麻醉效果。方法:择期行无痛人工流产术患者90例,随机分为丙泊酚组(A组)、芬太尼加丙泊酚组(B组)、瑞芬太尼加丙泊酚组(C组)三组,每组各30例。A组单纯使用丙泊酚2.5mg/kg静注;B组先给予1μg/kg芬太尼再静注丙泊酚1.5mg/kg;C组先给予0.75μg/kg瑞芬太尼再静注丙泊酚1.5mg/kg,注药完毕患者入睡后开始手术。术中有影响手术操作的肢动静脉给予0.5mg/kg的丙泊酚。结果:B组、C组与A组相比,镇痛更满意,术中丙泊酚用量明显减少(P<0.01),术毕清醒及离院时间更短(P<0.01)结论:芬太尼及瑞芬太尼复合丙泊酚均可安全用于无痛人工流产,麻醉效果满意。     

异丙酚复合芬太尼用于人工流产手术麻醉的观察

目的 :研究异丙酚联合应用小剂量芬太尼在人工流产手术的麻醉作用。方法 :ASAⅠ～Ⅱ级人工流产患者 12 0例 ,随机分为A、B两组。A组 6 0例为对照组 ,B组 6 0例为实验组。A组单纯用异丙酚 ,B组先缓慢静推芬太尼 1ug/kg ,后用异丙酚。两组异丙酚静注速度均为 10ml/min。研究中分别观察两组诱导及苏醒时间 ,用药总量 ,记录术中呼吸、循环参数改变和术中、术后不良反应。术后由手术医生评定麻醉效果。结果 :麻醉诱导时间B组明显短于A组 (P <0 .0 1) ,苏醒时间B组短于A组 (P <0 .0 5 ) ,异丙酚用量B组明显少于A组(P <0 .0 1) ,而且B组麻醉效果优于A组 (P <0 .0 5 )。A ,B两组呼吸抑制发生率却接近。结论 :小剂量(1ug/kg)芬太尼用于人工流产手术麻醉可加强镇痛 ,减少异丙酚用量 ,是一种较为安全的配伍方法。     

异丙酚与不同剂量芬太尼配伍在人工流产术中的应用

目的观察异丙酚与不同剂量的芬太尼配伍在人工流产手术中的麻醉效果。方法ASAⅠ～Ⅱ级行人工流产术患者60例,随机分为三组,每组20例,A组静注异丙酚2.0mg/kg,B组静注异丙酚2.0mg/kg+芬太尼1.0μg/kg,C组静注异丙酚2.0mg/kg+芬太尼2.0μg/kg。观察三组患者诱导及苏醒时间,异丙酚用量及呼吸抑制情况。结果B、C两组诱导时间均快于A组(P<0.05),苏醒时间B组快于C组,C组快于A组,异丙酚用量B、C两组均少于A组(P<0.05),呼吸抑制发生率C组大于A、B两组(P<0.05)。结论1.0μg/kg芬太尼与异丙酚配伍用于人流术,不仅能提供满意的镇痛,而且可减少异丙酚的用量及并发症的发生,是一种安全有效的配伍方法。     

异丙酚芬太尼用于无痛人工流产术麻醉疗效观察

目的本文通过异丙酚和异丙酚伍用不同剂量芬太尼用于人工流产术麻醉的比较观察，旨在探讨人工流产术较为理想的麻醉方法。方法200例早期妊娠患者，随机分为3组，A组(n=40)单用异丙酚，B组(n=80)异丙酚伍用芬太尼0．5ug／kg，C组(n=80)异丙酚伍用芬太尼1．0ug／kg。比较各组异丙酚用量、镇痛效果、苏醒时间、离院时间、并发症发生率。结果B、C组异丙酚用量少于A组，而镇痛效果优于A组，术中并发人流综合征、术中躁动发生率也低于A组。B、C组间上述指标差异无统计学意义。3组病人苏醒时间、离院时间相近。结论异丙酚伍用小剂量芬太尼用于人工流产术，可降低异丙酚用量，增加麻醉效果，降低并发症发生率。无证据提示芬太尼用量大于0．5ug／kg更有意义。     

异丙酚复合小剂量芬太尼静脉麻醉用于人工流产术的临床观察

目的　探讨异丙酚加小剂量芬太尼静脉麻醉在人工流产手术中的安全性与有效性。方法　ASAI Ⅱ级患者15 0例 ,随机分为三组 ,每组 5 0例。A组为对照组 ,静注异丙酚 2 .5～ 3mg/kg ,B组静注芬太尼 0 .6μg/kg及异丙酚 2 .5～3mg/kg ,C组静注芬太尼 1μg/kg及异丙酚 2 .5～ 3mg/kg。观察患者的异丙酚用量 ,对呼吸、循环的抑制情况及肢动情况。结果　异丙酚用量A组明显高于B、C两组 (P <0 .0 5 )。对呼吸抑制 ,SpO2 下降明显 ,但三组之间无显著差异 (P >0 .0 5 )。对循环功能影响较轻。肢动情况A组明显高于B、C组 ,A组为 46% ,B组为 2 2 % ,C组为 2 4%。结论　异丙酚加小剂量芬太尼可增强麻醉效果 ,减少异丙酚用量 ,减少肢动。异丙酚配伍 0 .6μg/kg芬太尼对呼吸抑制较弱 ,是一种较为安全有效的麻药配方。     

异丙酚、芬太尼在无痛人工流产时联合用药效果观察

目的观察不同剂量异丙酚联合芬太尼在人工流产手术中的麻醉作用，探讨无痛人工流产手术的有效方法。方法ASAⅠ～Ⅱ级人工流产术150例。随机分为3组，A组：首次静推异丙酚1．5mg／kg 芬太尼1μg／kg；B组：首次静推异丙酚2mg／kg 芬太尼1μg／kg；C组：首次静推异丙酚2mg／kg。术中根据镇痛效果，追加异丙酚用量，观察各组诱导及苏醒时间，异丙酚总用量及呼吸抑制情况。结果麻醉起效时间A、B组小于C组，意识恢复时间A、B组小于C组，异丙酚用量A、B组少于C组，术中出现疼痛反应B组少于A、C组，用药后SpO2、RR均下降。结论异丙酚2mg／kg与芬太尼1μg／kg配伍应用于人工流产手术，麻醉起效时间短，不良反应小，麻醉效果佳，是一种较安全有效的人工流产麻醉方法。     

丙泊酚配伍不同镇痛药用于人工流产的临床观察

目的观察丙泊酚配伍曲马多或芬太尼用于人工流产术的麻醉效果及安全性。方法108例自愿接受人工流产患者随机分为A、B、C三组,每组36例,A组单纯静注丙泊酚2mg／kg,B、C组先分别静注曲马多1．0mg／kg和芬太尼1μg／kg,30秒后均静注丙泊酚2mg／kg。记录患者MAP、HR、SpO2、RR的变化;记录患者诱导及苏醒时间、丙泊酚总用量及术中呼吸抑制等情况。结果A组麻醉后1min、3min的MAP、HR较麻醉前降低且差异性显著（P〈0．01）,B、C组MAP、HR则无明显变化（P〉0．05）,B、C组诱导及苏醒时间明显短于A组,B组和C组丙泊酚总用量较A组明显减少（P〈0．01）三组患者均有不同程度呼吸抑制,其中以C组最为严重,与A组比较差异性显著（P〈0．05）,A组有25例患者术中出现体动反应,与B、C组比较差异性显著（P〈0．01）。结论丙泊酚配伍曲马多或芬太尼用于人工流产术,均能提高麻醉镇痛效果,减少丙泊酚的用量,缩短诱导及恢复时间,但芬太尼和曲马多均可增加丙泊酚的呼吸抑制作用,故麻醉中要加强生命体征监测和呼吸管理。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.