解剖型钢板治疗股骨髁粉碎性骨折57例

目的:探讨解剖型钢板治疗股骨髁粉碎性骨折的方法。方法:分析治疗57例股骨髁粉碎性骨折的临床资料,采用AO分类法,其中C1型骨折34例,C3型骨折23例,均行解剖型钢板内固定。术后视骨折固定的稳定程度不同,给予4～6 w的石膏固定,并进行合理的康复治疗。结果:57例骨折术后随访10～22个月,大部分骨折均愈合,愈合时间12～28周,平均18 w。按膝关节KSS评分标准[1],优30例,良20例,可5例,差2例,优良率87.7%。结论:股骨髁粉碎性骨折应用解剖型钢板治疗,多数可获得满意疗效。     

解剖型髁钢板内固定治疗股骨下端复杂粉碎性骨折29例

目的评价解剖型髁钢板内固定治疗复杂粉碎性股骨下端骨折的疗效。方法对29例股骨下段复杂粉碎性骨折患者应用切开复位解剖型髁钢板内固定治疗。结果29例随访10-48个月,平均16个月,骨折愈合28例,不愈合1例。29例中优19例,良7例,可2例,差1例,优良率89.66%。结论解剖型髁钢板内固定治疗股骨下段复杂粉碎性骨折固定牢靠,效果显著。     

解剖型钢板内固定治疗股骨远端骨折

目的 探讨股骨远端解剖型钢板内固定治疗股骨远端骨折的临床效果.方法 采用股骨远端解剖型钢板内固定治疗股骨远端骨折55例.按A0分型:A1型11例,A2型12例,A3型12例;C1型8例,C2型9例,C3型3例;合并胫骨粉碎性骨折13例,合并髌骨骨折3例.结果 骨折完全愈合时间6-12个月,平均10个月.膝关节功能按kolment标准评定:优35例,良19例,可9例,差2例.优良率80%.结论 股骨远端解剖型钢板,符合人体生物力学要求,可以获得早期坚强内固定的目的,是治疗股骨远端骨折一种较好的方法.     

股骨远端微创锁定钢板治疗股骨远端粉碎性骨折探讨

目的:探讨股骨远端微创锁定钢板治疗股骨远端粉碎性骨折的临床效果。方法:回顾性分析应用股骨远端解剖型锁定钢板微创手术治疗股骨远端复杂粉碎性骨折15例的临床资料。结果:术后平均随访12.5个月(10～15个月),骨折均在6～10个月内愈合,无不愈合。按HSS评分标准,优10例,良2例,可3例,优良率为80%。结论:股骨远端解剖型锁定钢板微创治疗股骨远端粉碎性骨折创伤小、固定可靠、保护局部血运、骨折愈合率高,值得临床推广。     

双侧股骨髁解剖钢板治疗复杂股骨远端粉碎性骨折18例

目的 总结双侧股骨髁解剖钢板治疗复杂股骨远端粉碎性骨折经验.方法 18例复杂股骨远端粉碎性骨折,采用内、外侧联合入路,解剖复位后分别在两侧放置股骨髁解剖钢板,术后石膏托保护4-8周.结果 随访 8 -20 个月,骨折均骨性愈合.根据Kolmert膝关节功能评定标准：优5肢,良9肢,可3肢,差1肢.结论 双侧股骨髁解剖钢板治疗复杂的股骨远端粉碎性骨折具有对位良好、固定可靠、骨折愈合快、并发症少等特点.     

股骨髁解剖钢板治疗股骨髁上及髁间骨折

目的分析股骨髁解剖钢板在治疗股骨髁上及髁间骨折特点。方法应用股骨髁解剖钢板治疗股骨髁上及髁间骨折12例,手术后疗效分析。结果随访12～18个月,骨折愈合良好,患者膝关节功能优良率达到83%。结论用股骨髁解剖钢板是治疗此类骨折较为理想的内固定材料。     

解剖钢板治疗股骨远端粉碎性骨折16例的疗效分析

目的探讨用解剖钢板内固定治疗股骨远端粉碎性骨折的临床疗效。方法股骨远端粉碎性骨折患者16例，采用股骨远端解剖钢板进行切开复位内固定，术后随访6—18个月，平均12个月。结果2例（C2型1例，C3型1例）出现骨不愈合，经取自体髂骨移植后6—12个月骨折完全愈合。1例愈合过程中出现钢板断裂，骨折端移位。取出钢板改行逆行带锁髓内钉固定后8个月骨折完全愈合。根据Kolmenrt股骨远端功能评定标准，优10例，良4例，一般1例，差1例，优良率87．5％。结论解剖钢板治疗股骨远端粉碎性骨折能最大限度获得骨折复住和膝关节功能的恢复，临床疗效满意，是治疗股骨远端粉碎性骨折较理想的方法。     

股骨远端粉碎性骨折髁钢板固定42例疗效分析

目的对股骨远端粉碎性骨折髁支持钢板固定治疗进行疗效分析。方法42例股骨远端骨折根据A0分型,A111例,A212例,A38例,B12例,B22例,C13例,C23例,C31例,42例均以股骨髁支持钢板内固定治疗。结果术后摄片骨折达解剖复位,骨性愈合,优25例,良14例,可2例,差1例,膝关节功能优良率93%。结论股骨髁支持钢板治疗股骨远端骨折,固定坚强,失败率低,恢复好,疗效满意。     

股骨远端骨折的手术治疗

目的:探讨股骨远端骨折手术内固定治疗的疗效。方法:2001年6月~2006年8月应用手术内固定治疗股骨远端骨折MullerA型、C型共82例,其中异型股骨髁支持钢板固定65例,倒置钉固定17例;随访时间3～35个月。结果:本组82例,优79例,良3例,可0例,差0例,优良率100%。结论:异型股骨髁支持钢板适宜股骨远端骨折MullerA型、C型固定,疗效满意;倒置钉不适宜股骨髁间骨折关节面广泛粉碎者。     

股骨远端解剖型锁定钢板治疗股骨远端粉碎性骨折

目的探讨股骨远端解剖型锁定钢板治疗股骨远端粉碎性骨折的临床效果。方法回顾性分析2007年9月～2009年5月应用股骨远端解剖型锁定钢板手术治疗股骨远端复杂粉碎性骨折17例的临床资料。结果随访12～33个月,骨折均在6～8个月内愈合,无不愈合。按Kolmenrt评定标准,优12例,良3例,一般1例,差1例,优良率为88%。结论股骨远端解剖型锁定钢板治疗股骨远端粉碎性骨折效果良好,值得临床推广。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.