利用NAT实现医院局域网连接INTERNET

本文介绍使用WindowsServer2003自带的路由和远程访问服务来实现医院局域网与INTERNET的连接,简述了服务器和客户机的设置方法。利用WindowsServer2003的路由和远程访问服务中提供的NAT+基本防火墙,使用私有IP地址的内部网络客户端可以快速、安全地访问INTERNET。     

多出口校园网的路由设计

目的设计一个多出口校园网的路由,解决教育网用户高速访问CERNET以外的资源的需求。方法使用CISCO6509交换机和CISCO路由器,采用策略路由与NAT技术,对多出口校园网路由问题进行了研究和探讨。结果使用策略路由及地址翻译（NAT）技术解决了此类问题并给出了具体实现办法。结论：使用多出口的路由设计方法解决教育网用户高速访问互联网的问题切实可行。     

基于LVS和虚拟化技术的负载均衡系统建设研究

目的：通过LVS技术和虚拟化技术的运用,实现多层体系架构中间层的负载均衡,提高系统整体效率。方法：建立基于Linux系统的LVS作为负载调度器,集中调度和管理通过虚拟化技术构建的8台服务器构成的中间层服务器群,完成中间层服务器负载均衡系统建设。结果：中间层系统实现了高可靠性、高伸缩性和高度冗余。     

医院网站服务器群负载均衡解决方案

通过对医院网站主要目的及功能设计原则的定位分析,指出医院网站站群系统是基于服务器群来实现的.介绍能够适应服务器群设备性能优化需求的负载均衡技术及其发展历程,提出医院网站服务器群负载均衡的解决方案,以满足系统稳定性、安全性及高效性的需要.     

软路由技术在图书馆数字资源扩展应用中的研究

论文介绍了电子阅览室NAT服务器运行状况，提出采用软路由的方式来替换现有Windows server系统NAT服务器，提高网络的稳定性和安全性，并详细叙述了设置步骤。     

基于负载均衡技术的网络作业系统访问压力解决方案

为解决网上作业系统访问压力与数据阻塞问题,提出了一种应用缓存技术、负载均衡技术的解决方案,并对网上作业系统的信息载入慢、服务器压力大、成绩试算次数过多3个关键问题设计了相应的解决算法。经兰州大学网络教育学院网上作业系统运行验证,表明实施解决方案后,能够有效地降低因访问过于集中而引起的网络阻塞和死锁问题,提高作业系统的稳定性和有效性。     

基于域名的负载均衡技术在多院区的应用研究

随着医院业务的高速发展,多院区建设呈现趋势化发展态势,加快医院双活或多活数据中心的建设,对构建信息系统容灾备份体系具有重要意义。以烟台毓璜顶医院为例,通过分析多院区内网应用多活数据库中心建设中存在的业务系统单点故障、服务器负载不均衡、网络资源浪费等问题与难点,结合实践提出基于智能DNS、负载均衡和超融合技术在多院区应用的解决方案,根据应用服务器资源使用情况、客户端地理范围匹配值等因素,动态分配各院区应用服务器,解决网络拥堵问题,服务器集群横向扩展,避免关键部位单点故障,提高服务器响应速度,为用户提供更好的访问质量。     

N-乙酰化转移酶1基因分型及其与炎症性肠病相关性研究

目的:探讨药物代谢酶N-乙酰化转移酶1(NAT1)基因多态性在中国人群中的分布及其与炎症性肠病(IBD)的相关性。方法:应用PCR-RFLP和AS-PCR技术检测中国湖北地区无血缘关系的IBD患者105例,其中溃疡性结肠炎组(UC组)87例与克罗恩病组(CD组)18例,和正常对照120例的NAT1基因多态性。结果:IBD组中,NAT1*3,NAT1*4,NAT1*10和NAT1*11等位基因频率分别是20.48%,50.00%,21.90%和7.62%,与正常对照组比较无显著差异。CD组NAT1*10等位基因频率略高于UC组(25.00%比21.26%),但差异无显著性(P>0.05);将NAT1基因型分为快代谢和慢代谢乙酰化基因型,与正常对照组比较亦无显著差异。UC组快代谢基因型(NAT1*10纯合子)与CD组相比有增高趋势(16.67%比12.64%),但差异无显著性(P>0.05)。结论:NAT1基因多态性与炎症性肠病不存在关联。     

利用ASP技术实现WWW在线咨询

为实现网站的在线咨询功能，构建基于浏览器／服务器结构的数据库系统。本文简要介绍了ASP技术及ASP访问数据库技术，并提供了利用这种技术在WWW上进行在线咨询的部分程序代码。     

大容量医学影像存储、传输和容灾的负载分流

讨论了在大容量医学影像环境中，如何设计和实现PACS系统的负载分流机制、高可用机制和容灾机制，达到有效缓解PACS影像服务器负载、提升临床调阅速度，以及PACS系统可靠性的目的；同时介绍了PACS存储服务器集群网络的构建以及各种机制的实现方法。     

基于路由和远程访问的网络安全

目的：基于路由和远程访问技术，保护医院网络安全。方法利用路由解析设备对Windows server 2003自带的路由和远程访问服务进行配置，建立医院网络的“防火墙”。结果有效地隐藏了互联网网站服务器与医院业务网站服务器直连网段。结论对路由和远程访问服务进行配置，在一定程度上保障了医院业务网站服务器的安全。     

e印本文库:网络环境中的一种学术交流平台

e印本文库是通过作者自存档方式收集学术论文电子版本的网络数据库平台,向全球互联网用户开放存取,并基于开放存取计划(Open Access Initiative,OAI)向信息增值服务者提供收录e印本的元数据记录。现论述e印本文库的发展背景、交流理念、主要特点及发展策略。     

基于OAUTH的区域医疗信息平台安全访问机制

目的：对区域医疗信息平台安全访问控制机制进行研究与探讨,提出安全、开放的认证机制。方法：借鉴目前流行的电子商务安全访问机制,使用OAUTH技术对区域医疗信息平台进行访问授权。结果：以电子病历客户端、医院信息系统（HIS）服务器为例,详细描述了区域医疗信息平台的授权认证过程。结论：使用OAUTH技术将区域医疗信息平台建设成一个安全、开放的平台,能方便快捷地满足不同医疗机构及其相关业务单位对区域医疗信息平台的信息交互需求。     

MIStore: a Blockchain-Based Medical Insurance Storage System

Currently, blockchain technology, which is decentralized and may provide tamper-resistance to recorded data, is experiencing exponential growth in industry and research. In this paper, we propose the MIStore, a blockchain-based medical insurance storage system. Due to blockchain’s the property of tamper-resistance, MIStore may provide a high-credibility to users. In a basic instance of the system, there are a hospital, patient, insurance company and n servers. Specifically, the hospital performs a (t, n)-threshold MIStore protocol among the n servers. For the protocol, any node of the blockchain may join the protocol to be a server if the node and the hospital wish. Patient’s spending data is stored by the hospital in the blockchain and is protected by the n servers. Any t servers may help the insurance company to obtain a sum of a part of the patient’s spending data, which servers can perform homomorphic computations on. However, the n servers cannot learn anything from the patient’s spending data, which recorded in the blockchain, forever as long as more than n ? t servers are honest. Besides, because most of verifications are performed by record-nodes and all related data is stored at the blockchain, thus the insurance company, servers and the hospital only need small memory and CPU. Finally, we deploy the MIStore on the Ethererum blockchain and give the corresponding performance evaluation.     

视频脑电图与神经元特异性烯醇化酶在儿童癫痫及假性癫痫发作中的诊断意义

目的:确定神经元特异性烯醇化酶(NSE)与视频脑电图(video-EEG)在区分假性癫痫发作中的诊断价值.方法:对35例有癫痫样发作的病儿48 h内同时进行video-EEG及NSE的检测.结果:23例病儿video-EEG有痫样放电,其中16例NSE的检测结果明显高于对照组NSE的平均值.仅有2例NSE正常但脑电图显示有明显痫样放电.结论:NSE作为脑损伤的生化指标,结合video-EEG描记可作为鉴别假性癫痫发作的有利证据.     

Protective effect of a platelet activating factor antagonist in experimental liver injury

The present study was conducted to observe the effect of platelet activating factor antagonist-WEB 2086 on the galactosamine/endotoxin (GalN/E)-induced rat liver injury. The results showed that the WEB 2086 (1, 20 or 40 mg/kg, ip) diminished significantly GaIN/E induced elevations of ALT.AST and ACP in the serum (P less than 0.01). Histological changes of the liver were also found to be improved significantly by WEB 2086 administration. Additionally, WEB 2086 decreased significantly the GaIN/E-induced increase of Malondialdehyde (MDA) and Myeloperoxidase (MPO) in the liver (P less than 0.05-0.01), and prevented the decreasing of superoxide dismutase (SOD) in the liver (P less than 0.01). The results obtained with WEB 2086 confirm that platelet activating factor (PAF) has an important role in the pathophysiology of liver injury, PAF-antagonists may have protective effects on liver injury.     

基于WEB的全院性PACS体系改进与优化

为适应我国复杂的医院信息环境,需要不断地对PACS系统的建设进行优化。广安门医院在对Full—PACS系统进行升级的过程中,对原系统体系架构应用中存在的问题进行深入分析,实施了一种基于WEB的Full—PACS系统建设方案,通过合理配置硬件资源搭建WEB平台进行功能管理,使系统应用性能和效率得到优化。     

血小板活化因子拮抗剂对犬重症急性胰腺炎血循环障碍的干预

目的：探讨重症急性胰腺炎（SAP）血循环障碍的发病机制及其血小板活化因子拮抗剂（WEB2170）的干预效果。方法：实验分三组：正常对照组（NC，n＝5）、重症急性胰腺炎组（SAP，n=6），和WEB2170干预组（WEB,n=6）。用5％牛磺胆酸钠和牛胰蛋白酶混合液胰管注入，制备犬SAP模型。WEB组于模型制备后15min和12h分别静脉注射WEB2170（5mg/kg)。术后动态观察各组以下指标：血液流变学，血小板活化因子（PAF）、血栓素TXA2（TXA2），前列腺素I2（PGI2）、内皮素（ET）和一氧化氮（NO）。结果：SAP组TXA2、PGI2、ET、NO、PAF较NC组显著升高（P＜0．01），血液流变学指标也有显著的改变（P＜0．01）；WEB2170对PAF有显著的干预（P＜0．01），对其它指标也有明显的干预（P＜0．05）。结论：血液流变学、炎性介质PAF、两对血管活性物质即TXA2／PGI2和ET／NO均是介导SAP胰腺血循环障碍的重要因素，血小板活化因子拮抗剂是其有效的干预措施之一。     

基于VMware的服务器虚拟技术在医院信息化建设中的应用

采用VMware服务器虚拟化技术构建虚拟平台,把物理服务器资源整合为逻辑资源,解决现阶段医院服务器资源紧张的问题,以有效提高资源的利用率,保障医院业务的连续性,同时降低物理服务器运行维护成本。     

Secure Dynamic Access Control Scheme of PHR in Cloud Computing

With the development of information technology and medical technology, medical information has been developed from traditional paper records into electronic medical records, which have now been widely applied. The new-style medical information exchange system "personal health records (PHR)" is gradually developed. PHR is a kind of health records maintained and recorded by individuals. An ideal personal health record could integrate personal medical information from different sources and provide complete and correct personal health and medical summary through the Internet or portable media under the requirements of security and privacy. A lot of personal health records are being utilized. The patient-centered PHR information exchange system allows the public autonomously maintain and manage personal health records. Such management is convenient for storing, accessing, and sharing personal medical records. With the emergence of Cloud computing, PHR service has been transferred to storing data into Cloud servers that the resources could be flexibly utilized and the operation cost can be reduced. Nevertheless, patients would face privacy problem when storing PHR data into Cloud. Besides, it requires a secure protection scheme to encrypt the medical records of each patient for storing PHR into Cloud server. In the encryption process, it would be a challenge to achieve accurately accessing to medical records and corresponding to flexibility and efficiency. A new PHR access control scheme under Cloud computing environments is proposed in this study. With Lagrange interpolation polynomial to establish a secure and effective PHR information access scheme, it allows to accurately access to PHR with security and is suitable for enormous multi-users. Moreover, this scheme also dynamically supports multi-users in Cloud computing environments with personal privacy and offers legal authorities to access to PHR. From security and effectiveness analyses, the proposed PHR access scheme in Cloud computing environments is proven flexible and secure and could effectively correspond to real-time appending and deleting user access authorization and appending and revising PHR records.