胶体果胶铋治疗慢性胃炎和消化性溃疡的临床观察

胶体果胶铋胶囊是我国自行设计研究成功的一种治疗慢性胃炎和消化性溃疡的药物。该药是用果胶酸取代其他酸根制备的铋盐类药物。我们对其治疗慢性胃炎和消化性溃疡的疗效进行了临床观察。结果显示，果胶铋对慢性胃炎症状减轻有效率为87．7％，病理好转有效率为82．5％，Hp清除率为68．1％，且对慢性浅表性胃炎和慢性萎缩性胃炎的疗效相近。果胶铋对消化性溃疡症状减轻有效率为84．4％，病理好转有效率为77．8％，Hp清除率为69．2％，溃疡愈合的总有效率为97．8％，愈合率为80．0％，且十二指肠球部溃疡和胃溃疡在以上诸方面疗效相近。果胶铋在临床应用中，未见有明显不良反应，值得在临床上推广使用。     

血糖平对实验性糖尿病鼠血糖的影响

采用四氧嘧啶制备糖尿病大、小鼠模型，观察血糖平对其血糖的影响。血糖平２．５ｇ／ｋｇ，灌胃，ｑｄ，连续７ｄ，对糖尿病小鼠血糖有明显的降低作用，而对正常小鼠血糖无降低作用。血糖平１．５ｇ／ｋｇ或０．７５ｇ／ｋｇ灌胃，ｑｄ，７ｄ或１４ｄ，对糖尿病大鼠血糖都有明显降低作用，并有剂量、时间依赖性。１４ｄ时对糖尿病大鼠血脂和血清脂质过氧化物也有明显降低作用，提示血糖平均的抗氧化活性与其降糖作用可能有一定关系。     

抗幽门螺旋杆菌等联合治疗门脉高压性胃病

目的观察泮托拉唑、阿莫西林／舒巴坦纳、果胶铋治疗门脉高压胃病（priG）的临床疗效。方法268例患者分成对照组134例,口服西米替丁0．1g,3次/d,阿莫西林0．3g,3次／d口服,硫糖铝1g,3次,d。治疗组134例,用泮托拉唑40mg静脉滴注,每日1次,阿莫西林3g,每日2次静点,果胶铋100mg,3次／d口服。采用电子胃镜双衰胃黏膜病变。结果治疗组临床症状总有效率,HP根除率与对照组比较有显著差异（P〈0．05）。结论用泮托拉唑、阿莫西林／舒巴坦钠、果胶铋联合应用可提高PHG的疗效。     

胃宝冲剂对实验性胃粘膜损伤的保护作用

观察胃宝冲剂对乙醇和醋所致的大鼠胃粘膜急,慢性损伤的保护作用。方法用乙醇和醋酸灼致大鼠急,慢性胃粘膜损伤方法,观察胃宝冲剂５ｇ／ｋｇ、２．５ｇ／ｋｇ、１．２５ｇ／ｋｇ灌胃给药后对胃粘膜损伤的保护作用。并与胃苏冲剂比较。结果胃宝冲剂可使胃粘膜损伤面积缩小,损伤的病理改变明显的减轻。结论胃宝冲剂具有护胃粘膜的作用。     

三叶肽因子2、前列腺素E2在果胶铋对大鼠胃粘膜保护机制中的作用

目的研究果胶铋对胃粘膜损伤的保护机制,探讨胃粘膜细胞中三叶肽因子2信使核糖核酸(TFF2mRNA)表达及前列腺素E2(PGE2)在果胶铋胃粘膜保护机制中的作用.方法建立阿斯匹林胃粘膜损伤模型,细胞原位杂交结合图像分析检测TFF2mRNA表达水平并以阳性细胞平均光度值(OD)表示,放射免疫法测胃粘膜PGE2浓度,Guth法计算胃粘膜损伤指数.结果果胶铋组与未用药组TFF2mRNA的OD值分别为0.56±0.09、0.28±0.04,PGE2浓度分别为(4.20±0.85)Hg/ml、(1.18±0.14)Hg/ml,果胶铋组高于未用药组,二项结果相比均有显著性差异(P＜0.05);果胶铋组损伤指数为(8.60±2.20)极明显低于未用药组(29.72±6.53),P＜0.01;经相关分析,果胶铋组胃粘膜细胞TFF2mRNA的表达水平增加与胃粘膜PGE2浓度增加无相关性(r=0.48,P＞0.05).结论果胶铋对阿斯匹林引起的胃粘膜损伤有显著的保护作用,可能与其增加TFF2mRNA的表达及促进胃粘膜PGE2合成有关.     

奥曲肽治疗急性胃粘膜病变及应激性溃疡出血疗效观察

目的：探讨生长抑素类似物奥曲肽治疗急性胃粘膜病变及应激性溃疡出血的临床疗效。方法：应用奥曲肽治疗急性胃粘膜病变及应激性溃疡出血１１１例（男性７０例，女性４１例，平均年龄４３．６岁），给予奥曲肽０．１ｍｇ，静脉滴注，１次／８ｈ共维持３ｄ。结果：２４．４８及７２ｈ止血率分别为１８．９％、２８．８％和３７．８％，３ｄ总止血率为８５．６％，无效率为１４．４％。未发现明显的毒副反应。结论：奥曲肽对严重创伤、     

蜂花粉水提取液对实验性胃粘膜损伤的保护作用

目的研究蜂花粉水提取液对胃粘膜的保护作用。方法分别用无水乙醇、０．６ｍｏｌ／ＬＨＣｌ对小鼠灌胃复制实验性胃粘膜损伤的动物模型，用福尔马林固定后观察并记录胃粘膜损伤程度，并与事先用蜂花粉水提取液灌胃的小鼠进行比较分析。结果无水乙醇、０．６ｍｏｌ／ＬＨＣｌ对小鼠胃粘膜均可导致小鼠胃粘膜出血及溃疡性损伤，但事先用蜂花粉水提取液灌胃，可显著减轻无水乙醇、０．６ｍｏｌ／ＬＨＣｌ所致的小鼠实验性胃粘膜损伤的程度，主要表现为胃粘膜出血点减少、溃疡面积缩小。结论蜂花粉水提取液对胃粘膜具有保护作用。     

复方川断散对兔骨痂羟脯氨酸和钙含量的影响

复方川断散按０．５ｇ／ｋｇ和１．０ｇ／ｋｇ给骨折家兔连续灌胃４０ｄ。经生物力学及组织化学等检查证实，本品可促进家兔骨折的愈合，并可增加骨痂羟脯氨酸的含量和钙的含量。     

静脉注射人血丙种球蛋白治疗毛细支气管炎疗效与实验室观察

目的：阐明人血丙种球蛋白（ＩＶＩＧ）治疗毛细支气管炎的新方法及其对患儿体液免疫功能的影响。方法：采用不同剂量人血丙种球蛋白治疗毛细支气管炎２０例，并作对照，应用单向免疫扩散法测定血清免疫球蛋白。结果：静脉注射人血丙种球蛋白可使患儿迅速退热和改善症状，从而缩短病程，减少并发症，疗效优于常规治疗组，且未见明显毒副作用；０．５ｇ／ｋｇ·ｄ组与０．２ｇ／ｋｇ·ｄ组疗效无明显差异，治疗后１周两组血清中ＩｇＧ均明显升高。结论：提示０．２ｇ／ｋｇ·ｄ治疗毛细支气管炎是一疗效好、相对经济的剂量。     

蒲元胃康胶囊对实验性胃溃疡的影响

目的 观察蒲元胃康胶囊对实验性大鼠和小鼠胃溃疡的影响。方法 用剂量为０．５,１．０,２．０ｇ／ｋｇ体质量蒲元胃康及４．０ｇ／ｋｇ体质量胃苏冲剂对大鼠灌胃,连用７ｄ小鼠采用０．６,１．２,２．４ｇ／ｋｇ体质量蒲元胃康胶囊和６．０ｇ／ｋｇ体质量胃苏冲剂灌胃,连用７ｄ观察各药对应激型,幽门结扎型,醋酸型大鼠溃疡模型和乙醇型小鼠胃溃疡模型的影响。用碱滴定法测定胃液游离酸度,总酸度,用Ａｎｓｏｎ法测定胃蛋白     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.