中医药对微创保胆取石后预防胆囊结石复发的研究

目的：采用中医药方法，降低微创保胆内镜取石术后患者胆囊结石的复发。方法：将135例行微创保胆取石术后患者，随机分成对照组与防石胶囊组及防石胶囊加推按运经仪组，每组45例，分别予不同治疗，观察胆囊壁的厚度及胆囊收缩功能的变化；结果：防石胶囊加推按运经仪组胆囊壁厚度明显变薄，胆囊收缩功能明显增强，其次为防石组，最后为对照组（P〈0．001），对照组有2例结石复发；结论：该治疗方法能减轻或消除胆囊壁的炎症，增强胆囊的收缩功能，有助于防止胆囊结石的复发。     

利胆防石散对微创保胆取石术后胆囊结石复发的预防作用

目的评价选择性保胆取石术后利胆防石散内服预防胆囊结石复发的临床应用价值。方法将我院2007—2009年符合内镜微创保胆取石术条件的60例胆囊结石患者,按随机排列表将患者分为两组,各30例。两组患者通过腹腔镜切开胆囊底,应用纤维胆道镜进行取石,保留功能良好的胆囊。治疗组患者术后5d服利胆防石散3个月。对照组患者除不服利胆防石散外,其余护理、饮食等与治疗组相同。术后2年复查胆囊壁厚度及胆囊收缩功能,比较两组有无差异。结果60例保胆取石术均获成功,无严重并发症,3～5d均痊愈出院。两组患者术前胆囊壁厚度、胆囊收缩功能间差异均无统计学意义（P〉0.05）,术后2年两组患者胆囊壁厚度、胆囊收缩功能间差异均有统计学意义（P〈0.05）。结论保胆取石术后患者服用利胆防石散,能使胆囊壁的厚度明显减少,既能减轻胆囊的炎症反应,还能增强胆囊的收缩功能,对胆囊结石的复发有一定的预防作用。     

腹腔镜联合胆道镜行微创保胆取石术治疗胆囊结石的临床应用

目的：探究腹腔镜联合胆道镜行微创保胆取石术对胆囊结石的治疗效果。方法：选取2009年12月至2011年12月我院收治的胆囊结石患者120例,将其随机分为观察组和对照组,每组60例。其中对照组患者采取纤维胆道镜取石术,观察组采取腹腔镜联合胆道镜行微创保胆取石术。术后对患者跟踪随访1年,观察并比较两组患者的结石清除情况、术后并发症、生活质量评分和胆囊壁厚度及胆囊收缩情况。结果：观察组术中出血量明显少于对照组,术后3个月、1年后患者的FACT—G评分较术前明显提高,且观察组术后1年的FAcT—G评分较对照组高;术后1年两组患者的胆囊壁厚度较术前均明显变薄、胆囊收缩功能均明显加强,且观察组患者的胆囊壁厚度较对照组薄,收缩功能较对照组强;观察组术后结石清除率为98．33％,较对照组的76．67％高,并发症发生率、1年后结石复发率分别为1．67％、3．33％,明显低于对照组,P〈0．05,具有统计学意义。结论：腹腔镜联合胆道镜行微创保胆取石术治疗胆囊结石的疗效较好,不仅保留了胆囊的完整性,且术后引起的并发症较少。     

52例微创保胆取石术临床应用

目的探讨微创保胆取石术治疗胆囊结石的临床应用价值和安全性。方法回顾性分析我院3年间52例胆囊结石患者行微创保胆取石术治疗的临床资料。术前B超检查胆囊壁厚均〈3mm,测定胆囊收缩功能良好。术后2周B超复查胆囊壁厚度并测定胆囊收缩功能。结果完成微创保胆取石术52例,手术成功率100%。术后无出血、胆瘘、急性胆囊炎、胰腺炎、继发性胆总管结石及切口感染等并发症发生,无死亡病例。患者当日均可下床,次日进流食,3-5d出院。术后2周B超检查胆囊壁均光整无增厚,胆囊收缩功能良好,符合正常胆囊超声表现。门诊随访6月-3年,结石无复发。无胆囊癌发生。结论微创保胆取石术具有安全性高、创伤小、痛苦少、恢复快等特点,并且保护了胆道的完整性及胆囊功能,提高了患者生存质量,临床上具有良好应用前景。     

B超评价胆囊功能在微创保胆取石术中的应用分析

目的研究B超在胆囊结石手术之前检查患者胆囊的功能,为胆囊手术中腹腔镜的选择进行指导,为微创保胆取石术提供参考.方法选取2009年5月~2012年5月的137例胆囊结石患者,利用脂餐试验,分析胆囊结石的B超声像,将其分成两种类型,选出胆囊壁的厚度在4mm之下、脂餐后胆囊收缩面积高于30%的胆囊结石病例进行保胆取石手术,对病例保存研究.结果137例保胆取石术都很成功,B超复查后复发率仅有2.1%.结论利用B超在术前对胆囊功能进行评价有利于配合微创保胆取石术的顺利完成.     

B超评价胆囊功能在微创保胆取石术的应用

目的通过B超声像评价胆囊结石患者胆囊功能,指导选择腹腔镜联合输尿管镜微创保胆取石术。方法根据胆囊结石的声像图特征将结石分为A、B2组,并选择胆囊壁厚度〈4m,胆汁为液性无回声暗区,脂餐后胆囊收缩面积〉30%的胆囊结石病例实施腹腔镜联合输尿管镜微创保胆取石术,共186例。结果 186例均手术顺利,无中转剖腹,术后1个月、3个月、6个月、1年,以后每年复查1次B超,（18±12）个月复发率仅2.7%。结论 B超评价胆囊结石患者胆囊功能在腹腔镜联合输尿管镜微创保胆取石术有临床应用价值。     

防石方防治内镜微创保胆取石术后胆囊结石复发的临床观察

目的探讨中药防石方防治内镜微创保胆取石术后胆囊结石复发的临床疗效.方法将我院2000～2002年符合内镜微创保胆取石术条件的120例胆囊结石患者分为对照组、观察组各60例,两组均先行内镜微创保胆取石术,对照组术后服消炎利胆片治疗,观察组术后服防石方治疗,比较两组疗效.结果观察组、对照组3年内胆囊结石复发率分别为1.67%、13.33%;观察组慢性胆囊炎症状消失较对照组理想(P＜0.05),有显著性意义.结论防石方减少内镜微创保胆取石术后胆囊结石复发、减轻慢性胆囊炎症状的功效较消炎利胆片为优.     

微创保胆取石术与腹腔镜胆囊切除术治疗胆囊结石的临床疗效对比

目的:探讨微创保胆取石术与腹腔镜胆囊切除术治疗胆囊结石的临床疗效。方法:随机抽选2016年8月至2017年8月期间来我院就诊的胆囊结石患者60例作为研究对象,按照随机数字法分为观察组以及对照组,观察组30例实行微创保胆取石术治疗,对照组30例实行腹腔镜胆囊切除术治疗,实验结束后,分析患者的手术时间、术中出血量、肛门排气时间、住院时间以及并发症发生率。结果:观察组患者手术时间、术中出血量、肛门排气时间、住院时间以及并发症发生率相对于对照组较低,P0.05。结论:微创保胆取石术与腹腔镜胆囊切除术治疗胆囊结石均具有一定效果,但微创保胆取石术效果更加显著,可有效缩短住院时间,降低并发症发生率,值得临床推广应用。     

腹腔镜联合胆道镜保胆取石术对患者胆囊收缩功能及胆囊壁厚度的影响

目的研究腹腔镜联合胆道镜保胆取石术对患者胆囊收缩功能及胆囊壁厚度的影响。方法选取2015年6月至2016年6月于郑州市金水区总医院治疗的胆囊结石患者74例,根据治疗方案将患者分为对照组和观察组,每组37例。对照组接受腹腔镜下胆囊切除术,观察组接受腹腔镜联合胆道镜保胆取石术。比较两组患者相关手术指标、并发症发生情况;对观察组患者随访1 a,观察胆囊收缩功能及厚度变化情况。结果两组患者手术相关指标比较,差异无统计学意义(P>0.05);对照组并发症发生率比观察组高,差异有统计学意义(P<0.05);术后1 a,观察组胆囊收缩功能较术前提高,且胆囊厚度降低,差异均有统计学意义(P<0.05)。结论腹腔镜联合胆道镜进行保胆手术治疗,可有效降低患者并发症发生率,安全性高,能够有效恢复患者胆道收缩功能,降低胆囊壁厚度。     

微创保胆取石术前后胆囊收缩功能的超声评价

目的超声评价微创保胆取石术前后胆囊收缩功能的变化,为临床提供重要手术参考依据。方法应用超声评价40例微创保胆取石术患者手术前后胆囊收缩功能的变化。结果本组病例中,术前胆囊收缩功能良好(A组)21例术后胆囊收缩率均恢复正常;术前收缩功能尚可(B组)12例66%恢复正常;术前收缩功能欠佳和差(C组)7例71%收缩功能恢复正常或改善。3组患者术后3个月胆囊收缩率比较术前均有统计学差异(P<0.05)。结论超声评价诊断胆囊结石疾病及胆囊功能具有重要的临床作用,为微创保胆取石术前后胆囊功能的评估提供了重要的依据,本组病例提示,微创保胆取石术患者术后胆囊收缩功能基本可恢复正常或接近正常。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.