肺心病合并脑梗塞患者的血液流变学变化分析

检测了60例肺心病患者和31例肺心病合并脑梗塞者的血液流变学各项指标。与对照组比较,慢性肺心病合并脑梗塞患者的全血粘度、血浆粘度、红细胞压积、血小板粘附率、纤维蛋白原与血沉均显著升高(P<0.05);血红蛋白无显著改变。表明这些患者的血液呈高凝和高粘滞状态,强调肺心病在常规治疗的基础上应用血液流变学药物的治疗具有重要的临床意义。     

肺心病的血液流变性改变与脑梗塞

本文通过21例肺心病与脑梗塞血液流变学的对比研究,表明:1.肺心病血液流变学全血粘度低切变率、血浆粘度、纤维蛋白原、血沉均高于或明显高于对照组和脑梗塞组(统计学处理具有显著意义).2.肺心病人尽管存在血液的高粘、高凝、高聚,但发生脑梗塞者却极少占14.29%.3.血液流变学障碍在脑梗塞的发病中并不起主要作用.     

脑血栓、肺心病血液流变学分析

目的　应用血液流变学检查客观评价脑血栓及肺心病患者与正常对照组的差异。方法　通过 5 0例脑血栓、2 0例肺心病患者和 15 0例正常对照组血液流变学指标测定 ,进行统计学处理。结果　脑血栓、肺心病患者与正常对照组血液流变学有显著差异 (P <0 .0 1)。结论　血液流变学检查对于脑血栓、肺心病的防治有一定意义。     

中重度慢性阻塞性肺疾病患者脑循环动力学变化及其相关因素分析

目的：探讨中重度慢性阻塞性肺疾病（COPD）患者脑循环动力学（CVA）的变化及其相关因素。方法：对50例中重度COPD患者行CVA、血气分析、血液流变学、纤维蛋白原（Fg）检测,设正常对照组30例,行CVA检测,分别列表对照分析。结果：COPD组较正常对照组CVA参数有明显异常改变,差异有统计学意义（P〈0.05~0.01）。缓解期患者较急性发作期时CVA参数有明显改善,差异有统计学意义（P〈0.05~0.01）。对CVA参数影响显著的因素依次为Fg↑、血黏度↑、二氧化碳分压升高（PaCO2↑）、动脉氧分压降低（PaO2↓）、红细胞压积增大等。结论：中重度COPD患者CVA存在异常改变,且随病情加重而加重,并与血黏度、纤维蛋白原等指标密切相关。     

慢性支气管炎,肺气肿,肺心病患者血液流变学变化

探讨慢性支气管炎(简称慢支)、肺气肿、肺心病患者不同时期血液流变学变化及其关系。方法慢支、肺气肿、肺心病患者均空腹抽静脉血4ml,测定高切变率下的粘度(高切)、低切变率下的粘度(低切)、血浆粘度、血沉、压积、纤维蛋白原及聚集指数,三组间对比,并与正常组对照。结果慢支、肺气肿、肺心病患者血液流变学指标异常,且由慢支到肺气肿、肺心病其高切、低切、压积、聚集指数逐渐增高,而血浆粘度、血沉和纤维蛋白原逐渐降低。结论慢支发展为肺气肿、肺心病时,由于缺氧、红细胞代偿性增多、酸中毒等原因致血液的浓(红细胞增多)、粘(血液粘度增高)、聚(聚集指数增高)逐渐加重;而由于肝淤血、缺氧及消耗等原因使血浆粘度及纤维蛋白原逐渐降低。     

短暂性脑缺血发作患者血液流变学变化的研究

目的研究短暂性脑缺血发作患者血液流变学改变及其临床意义。方法将50例短暂性脑缺血发作患者的血液流变学指标与正常对照组进行比较分析。结果短暂性脑缺血发作组的各项血液流变学指标高于对照组(P<0.05),红细胞压积和纤维蛋白原明显高于对照组(P<0.01)。结论红细胞压积和纤维蛋白原含量增高是造成血液粘度增高的重要因素。     

孕产期颅内静脉栓塞患者脂质代谢及血液流变学变化

目的:探讨孕产期颅内静脉栓塞的发病因素.方法:对31例孕产期颅内静脉栓塞患者酶法测定甘油三酯(TG),低密度脂蛋白(LDL),高密度脂蛋白(HDL),并行血液流变学检查;另选30例正常孕产期妇女测定相同指标作为对照组.结果:血液流变学检查示孕产期颅内静脉栓塞患者静脉体外血栓长度、全血粘度、纤维蛋白原定量、红细胞比积,均高于对照组(P<0.01).结论:孕产期颅内静脉栓塞患者脂质代谢和血液流变学均有变化,血液高凝和血脂增高与本病发生有关.     

肺心病合并脑梗死的血液流变学变化分析

目的　探讨肺心病合并脑梗死患者的血液流变学指标变化。方法　用国产SDZ -V型全自动血液流变学检测仪分别检测 6 0例单纯肺心病患者和 31例肺心病合并脑梗死患者的血液流变学各项指标并做比较。结果　慢性肺心病合并脑梗死患者的全血粘度、血浆粘度、红细胞压积、血小板粘附率、纤维蛋白原含量及血沉值与单纯肺心病患者的各值相比 ,差异有显著性意义 (P <0 0 5 ) ;而血红蛋白含量与单纯肺心病患者的比较 ,差异无显著性意义(P >0 0 5 )。结论　肺心病合并脑梗死患者的血液呈高凝和高粘滞状态 ,强调肺心病在常规治疗基础上应使用抗凝药物治疗     

老年与老年前期肺心病人血液流变学观察

本文报导31例老年肺心病患者和25例老年前期肺心病患者发作期血液流变学检测结果,发现肺心病患者老年组与老年前期组血液流变学改变除血浆粘度差有显著性(P<0.05)外,其余各项差别无显著性(P>0.05)。而肺心病患者较正常对照组的全血粘度比,血浆粘度比、红细胞电(?)时间、红细胞压积差别有显著性(P<0.05或P<0.01),血沉差别无显著性(P>0.05)。同时还发现患者组与对照老年组不同性别之间的全血粘度比差别无显著性(P>0.05)。此外,还检测了免疫球蛋白和纤维蛋白原,发现其与血浆粘度增高密切相关。     

老年脑梗死患者血脂和血液流变学的研究分析

目的:探讨老年脑梗死患者血脂和血液流变学指标的改变。方法:应用血粘度仪测定112例老年脑梗死患者和60例健康老年人的全血粘度、血浆粘度;免疫比浊法测定纤维蛋白原;魏氏法测定血沉;离心法测定压积;酶法测定甘油三酯和胆固醇。结果:男性脑梗死患者30(1/s)、200(1/s)切变率下的全血粘度、压积与正常对照组比较,差异无显著性(P>0.05),全血粘度[在1(1/s)、5(1/s)下]、纤维蛋白原、血沉、甘油三酯、血浆粘度和胆固醇显著高于正常对照组(P<0.05);老年女性患者的全血粘度、压积与正常对照组比较,差异无显著性(P>0.05),纤维蛋白原、血沉、甘油三酯、血浆粘度和胆固醇显著高于正常对照组(P<0.05)。结论:老年脑梗死患者均出现血脂升高;血液流变学检测结果显示男性患者符合部分高粘滞综合征指标,女性患者与健康老人相比变化不大,表明随着年龄增长压积降低,老年脑梗死患者和健康老人血液流变学指标差异缩小,血液流变学检测对老年脑梗死患者的诊断、治疗的价值有待进一步探讨。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.