基牙牙槽骨吸收对固定义齿应力分布的影响

目的 观察基牙牙槽骨发生一定程度吸收时,固定义齿应力分布的变化.方法 建立右侧下颌第一磨牙缺失的牙列模型,设计正常基牙的对照模型及基牙牙槽骨Ⅱ度吸收的实验模型,在ANSYS 5.5软件中进行有限元分析,观察最大应力值及其分布.结果 与对照组相比,单个基牙牙槽骨Ⅱ度吸收时,固定义齿最大应力值及其分布无明显变化;当两侧基牙牙槽骨均有Ⅱ度吸收时,则基牙受力显著增加.结论 从应力分布角度看,固定义齿修复中,当两侧基牙牙槽骨均有Ⅱ吸收时,增加基牙数目是有利的.     

牙槽骨吸收对冠外附着体义齿基牙及牙周组织应力分布的影响

目的：探讨牙槽骨吸收对冠外附着体义齿基牙及牙周组织应力分布的影响,为附着体义齿临床应用提供理论依据。方法：应用三维有限元方法测定基牙牙槽骨吸收不同时附着体义齿基牙及牙周组织应力分布情况,并与单端固定桥比较。结果：单端固定桥基牙及牙周组织最大应力为(3.63E+5)Mpa;基牙牙槽骨正常时附着体义齿基牙及牙周组织最大应力为（1.27E+5）Mpa,小于单端固定桥;基牙牙槽骨吸收1/3时为(3.87E+5)Mpa,稍大于单端固定桥;基牙牙槽骨吸收1/2时为(1.38E+6）Mpa,明显大于单端固定桥。结论：附着体义齿可减轻基牙及牙周组织应力,随着基牙牙槽骨吸收,基牙所受应力增加;基牙牙槽骨正常时,以C45 为基牙单侧设计冠外附着体义齿修复下颌游离端缺失是适宜的;基牙牙槽骨吸收达1/3,此种修复要慎重,应减少侧向力,当基牙牙槽骨吸收达1/2 不可单侧设计此种修复,应增加基牙或双侧设计。     

桥基牙数目对支持骨组织应力影响的三维有限元法分析

目的：探讨多基牙固定局部义齿在牙周组织受损条件下,桥基牙数目与支持骨组织内应力变化的关系。方法：采用三维有限元方法,通过改变基牙数目与牙槽骨的支持高度建立八个有限元模型进行计算分析。结果：牙槽骨高度降低条件下,基牙牙槽骨组织应力值增大;固定义齿修复后,支持骨组织应力值下降;随着基牙数目的增多,支持骨组织应力值降低,但与基牙数目的增多不成比例;与垂直向载荷相比,斜向载荷易导致支持组织的应力集中,应力分布规律有明显的改变。结论：本实验建立的有限元模型为固定义齿的设计提供了参考依据。     

下颌固定义齿桥基牙数目对支持骨组织应力的影响

目的探讨多基牙固定义齿在牙周组织受损条件下,桥基牙数目与支持骨组织内应力变化的关系。方法采用三维有限元方法,通过改变基牙数目与牙槽骨的支持高度建立有限元模型进行计算分析。结果牙槽骨高度降低的条件下,基牙牙槽骨组织应力值增大;固定义齿修复后,支持骨组织应力值下降;随着基牙数目的增多,支持骨组织应力值降低,但与基牙数目的增多不成比例;与垂直向载荷相比,斜向载荷易导致支持组织应力集中,应力分布规律有明显的改变。结论下颌后牙固定桥的应力分布与基牙数量在一定程度内具有相关性。     

圆锥形套筒冠义齿修复末端游离缺失伴基牙牙槽骨不同程度吸收的支持组织应力分析

目的：分析套筒冠义齿修复末端游离缺失伴基牙牙槽骨不同程度吸收条件下的受力情况。方法：采用三维有限元方法,通过改变牙槽骨的支持高度建立8个有限元模型对基牙和缺牙区周围支持组织进行应力的计算分析。结果：牙周组织支持应力随吸收程度增加而逐渐增加,基托下组织的应力增加比基牙明显。近缺隙侧基牙的吸收情况对应力影响大。结论：本实验结果为套筒冠义齿的设计提供了参考依据。     

Mini-SG~ F冠外附着体在游离端义齿修复中对基牙牙周健康的影响

目的观察Mini-SG~ F附着体在游离端义齿修复中对基牙牙周健康的影响。方法纵向观察Mini-SG~ F附着体修复游离端缺失前后第一基牙、第二基牙牙周病常用指标及牙槽骨吸收情况的变化。结果Mini-SG~ F附着体在修复前、修复后6月内义齿稳定、固位良好,第一、第二基牙牙龈指数、菌斑指数、牙周探诊深度、牙槽骨吸收等差异均无统计学意义,修复前基牙的松动度在进行联冠修复后明显降低。结论Mini-SG~ F附着体在游离端义齿修复中对基牙牙周健康无明显不利影响,基牙的联冠修复形式有利于基牙的健康和稳定。     

Mini-SG(R) F 冠外附着体在游离端义齿修复中对基牙牙周健康的影响

目的:观察Mini-SG(R)F附着体在游离端义齿修复中对基牙牙周健康的影响.方法:纵向观察Mini-SG(R) F附着体修复游离端缺失前后第一基牙、第二基牙牙周病常用指标及牙槽骨吸收情况的变化.结果:Mini-SG(R) F附着体在修复前、修复后6月内义齿稳定、固位良好,第一、第二基牙牙龈指数、菌斑指数、牙周探诊深度、牙槽骨吸收等差异均无统计学意义,修复前基牙的松动度在进行联冠修复后明显降低.结论:Mini-SG(R) F附着体在游离端义齿修复中对基牙牙周健康无明显不利影响,基牙的联冠修复形式有利于基牙的健康和稳定.     

Mini-SG(R) F 冠外附着体在游离端义齿修复中对基牙牙周健康的影响

目的：观察Mini-SG（R）F附着体在游离端义齿修复中对基牙牙周健康的影响.方法：纵向观察Mini-SG（R） F附着体修复游离端缺失前后第一基牙、第二基牙牙周病常用指标及牙槽骨吸收情况的变化.结果：Mini-SG（R） F附着体在修复前、修复后6月内义齿稳定、固位良好,第一、第二基牙牙龈指数、菌斑指数、牙周探诊深度、牙槽骨吸收等差异均无统计学意义,修复前基牙的松动度在进行联冠修复后明显降低.结论：Mini-SG（R） F附着体在游离端义齿修复中对基牙牙周健康无明显不利影响,基牙的联冠修复形式有利于基牙的健康和稳定.     

近远中(牙合)支托对末端游离缺失修复应力分布的影响

目的 研究下颌末端游离缺失修复中近中与远中(牙合)支托设计对加载时基牙及支持组织应力分布的影响。方法 将初始模型导入HyperMesh 7.0 软件建立下颌双侧末端游离缺失模型（765-567缺失）,模型导入UG 5.0软件设计近中支托与远中支托修复方案,导入HyperMesh 7.0软件进行修复方案的有限元网格划分,分别建立近中(牙合)支托（M模型）与远中（D模型）(牙合)支托修复有限元模型。分析和比较两种模型在双侧垂直加载时基牙及支持组织最大应力及其分布情况。结果 在基牙及其牙周膜,D模型基牙牙冠、牙根及牙周膜的最大应力均显著大于M模型; D模型应力分布主要集中于4-4牙根,M模型43-34牙根应力分布较为均匀。在缺牙区黏膜,M模型最大应力显著大于D模型, 两种修复方案模型应力分布分别位于4-4远中位置和76-67位置。两种修复方案模型缺牙区牙槽骨最大应力接近,其中M模型应力分布更广泛。结论 采用常规可摘局部义齿修复末端游离缺失时,应优先选择近中(牙合)支托设计。     

两种不同结构的用于下颌单侧游离缺失精密附着体义齿摘戴过程中的三维有限元应力分析

目的探讨两种精密附着体摘戴过程的应力特征,为临床选用附着体提供理论依据。方法以牙槽骨吸收C876缺失成年男性为研究对象,建立快套式和太极扣式附着体义齿修复C876缺失三维有限元模型,对两者的应力特征进行比较性研究。结果太极扣戴入后对第一磨牙基牙、牙周膜的Von Mises等效应力值为16.528 Mpa、3.086 Mpa,对第二磨牙基牙、牙周膜的Von Mises等效应力值为24.026 Mpa、3.713 Mpa,再次戴入对牙槽骨的Von Mises等效应力值3.048 Mpa,上述应力值摘戴前后变化幅度均小于快套式。结论太极扣式附着体义齿修复下颌单侧游离缺失的应力特征优于快套式,值得进一步推广应用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.