腑通丸对胃肠平滑肌电活动与胃肠运动的影响

采用改进的整体同步记录的电生理方法，观察腑通丸对胃肠平滑肌电活动及运动效应的影响。大鼠以腑通丸１．５ｇ／ｋｇ灌胃可显著增加胃肠电慢波平均振幅及胃运动总振幅，而对肠运动总振幅无明显影响；以３．５ｇ／ｋｇ灌胃可显著增加胃肠电慢波平均振幅及胃肠运动总振幅，但两个剂量对胃肠电慢波频率及胃肠运动频率均无明显影响。     

禁食对大鼠胃肠电活动的影响及神经机制

本实验观察了禁食对大鼠胃肠电活动的影响及其与迷走神经的关系。结果表明：禁食后，大鼠胃电活动增强，十二指肠可记录到规律的ＩＤＭＥＣ活动，但其慢波和快波振幅明显降低（Ｐ＜０．０１），快波发生率则显著增多（Ｐ＜０．００１）。切除迷走神经后，小肠ＩＤＭＥＣ周期和Ⅱ相时程明显延长（Ｐ＜０．０５），禁食对胃电活动的增强基本恢复，但对十二指肠电活动的影响无明显改善。     

运动疲劳后恢复期脑电变化的探讨

目的 通过对运动疲劳前后脑电变化的比较,研究体育运动对神经系统的影响.方法 利用MEEG-903多功能脑电检测分析仪设备,对北京体育大学体育教育系12名男生进行运动疲劳后脑电测试30 min.结果 适宜强度运动后休息30 min后,α2指数与安静时相比增加,且两组比较有显著性差异(P＜0.05),以α波为主导的大脑皮层神经元电活动的同步化程度提高,大脑皮层神经元的代谢得到了改善.结论 适当强度的体育锻炼可以增强神经系统功能.     

猴正中、尺神经切断的电生理改变

１１只雌猴的正中、尺神经在距腕关节６～８ｃｍ处被切断，一侧作神经束间分离至大、小鱼际肌后作神经吻合，一侧神经切断后即作神经吻合，连续进行电生理观察。作神经束间分离者，术后１～２ｄ出现失神经电位，且不能测出运动传导速度（ＭＣＶ）及Ｍ波；未分离者３～４ｄ出现失神经电位，术后２４～６５．５ｈ与术前的ＭＣＶ比较变化不大（Ｐ＞０．０５），后期Ｍ波振幅明显降低时，ＭＣＶ轻度减慢，随术后时间延长，Ｍ波振幅逐渐降低，二者呈负相关关系（Ｐ＜０．０１）。文章最后对上述电生理改变进行了讨论     

阻断交感神经功能和切除迷走神经对狗十二指肠电活动的影响

在狗的十二指肠浆膜面埋植银—氯化银双极电极,进行慢性实验,记录清醒状态下禁食18小时后的十二指肠电活动,观察静脉注射心得安、酚妥拉明阻断交感神经功能或切除迷走神经后,对十二指肠消化间期综合肌电周期性活动的影响。结果发现静注酚妥拉明阻断交感神经α受体后,Ⅰ相缩短,Ⅱ相增长,Ⅱ相中快波和慢波的振幅增加,快波的出现率增多。切除迷走神经后效应相反,但对消化间期综合肌电周期性活动的影响则不明显。     

运动所致血浆K+和血pH值的变化对肌肉疲劳和表面肌电图的影响

目的探讨血K^ 、H^ 与肌肉疲劳和肌电变化的关系。方法对同一批受试者在200W和120w蹬功率车之前和运动至疲劳后即刻、5min、10min、20min时,测定血浆K^ 、血pH值以及活动肌和非活动肌定量负荷等长收缩10s的肌电图(EMG)。结果两次运动后血浆K^ 和活动肌平均功率频率(AM—MPF)均明显改变(P＜0．01),二者高度负相关,并在20min时基本恢复。200W运动后20min内血pH值一直明显低于安静值(P＜0.01),但在120w运动后无变化,并与肌电无相关关系。120W运动后20min内的非活动肌积分肌电图值(IM—IEMG)明显低于安静值(P＜0．05)。结论细胞外高K^ 是肌肉疲劳和AM—MPF下降的主要因素之一,并可能也是IM—IEMG下降的原因之一。H^ 不是疲劳形成的主因,并对肌电无直接影响。     

平板运动试验诱发QRS波与ST段电交替一例

平板运动试验诱发ＱＲＳ波与ＳＴ段电交替一例附属湘雅医院老干科文定涛关键词心电描记术；平板运动试验；病例报告平板运动试验中，ＳＴ段抬高型电交替现象少见，而ＳＴ殷压低型电交替，特别是ＳＴ段压低与ＱＲＳ波同时电交替的复合电交替，国内外鲜见报道。笔者收治一例...     

电针"脾俞"对胃窦部溃疡大鼠胃肠平滑肌电活动的干预作用及其机制探讨

目的：观察电针“脾俞”对胃窦部溃疡大鼠胃肠平滑肌电活动的影响，并探讨其作用机制。方法：采用冰醋酸损伤法复制急性胃窦部溃疡动物模型；分别植入记录电极于肾上腺交感神经、胃窦部、十二指肠和大肠；用RM-86多导生理记录仪和SMUP计算机软件分析系统，同步记录胃窦部溃疡模型大鼠针刺“脾俞”前后胃肠平滑肌电活动和心率变异性(HRV)动态变化曲线、肾上腺交感神经放电情况。结果：电针刺激“脾俞”后，胃肠平滑肌电活动抑制，LF／HF比值上升至0.99，肾上腺交感神经放电活动频率上升。结论：低频疏密波刺激“脾俞”，可使急性胃窦部溃疡大鼠自主神经系统重新建立动态平衡，并与肾上腺内分泌活动共同参与针刺调整消化道运动功能。     

兔离体十二指肠平滑肌细胞电活动与肌收缩活动关系

本工作采用玻璃微电极记录兔离休十二指肠平滑肌细胞内电变化，并同步记录兔离休平滑肌条的收缩，从而分析慢波，前电位和动作电位与肌收缩的关系。结果表明：（１）慢波能引起兔十二指肠近端平滑肌收缩，并呈１：１的关系；（２）在慢波引起肌收缩的基础上，前电位可使肌收缩进一步加强；（３）兔十二指肠近端的平滑肌自发放电产生的动作电位，其幅度为５２．１±８．５ｍｖ（ｎ＝３０），在形式上有的呈单一放电，有的呈簇状放电，前者放电频率为１～４次／秒，后者为６次／秒；（４）三种电活动引起肌条收缩的幅度以动作电位最大，前电位次之，慢波最小。上述资料表明，兴奋性高的兔十二指肠近端的平滑肌细胞内不同的电活动可引起不同的收缩。     

牛磺酸对家兔膈肌诱发电位和跨膈压的影响

持续电刺激膈神经３０～４０ｍｉｎ复制膈肌疲劳（ＤｉＦ），分别测量伤前及伤后３０ｍｉｎ、６０ｍｉｎ、９０ｍｉｎ、１２０ｍｉｎ的跨膈压（Ｐｄｉ）及膈肌诱发电位（ＤＥＰ）变化，实验发现：复制ＤｉＦ后，Ｐｄｉ减少４４．２％；ＤＥＰ幅度降低４８．０３％；ＤＥＰ潜伏期延长２３．７％．上述变化可被静脉注射牛磺酸１００ｍｇ／ｋｇ所对抗．结果表明：ＤＥＰ可以作为评价膈肌疲劳的一项指标；牛磺酸对电刺激致伤膈肌有保护作用．     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.