溴隐亭治疗垂体腺瘤23例临床观察

对ＣＴ或ＭＲＩ确诊的垂体腺瘤２３例分析表明，垂体微腺瘤和巨腺瘤血清泌乳素（也称催乳素）分别为１１７．７５±８６．５５和２６８．７３±１２５．５μｇ／Ｌ，两组差别有显著性意义（Ｐ＜００１）；经溴麦角隐亭（简称嗅隐亭）治疗后６０ｄ，两组泌乳素水平显著降低，分别为２３．６９±８．７４和８５．６２±２７．３５μｇ／Ｌ（Ｐ＜０．００１），而且巨腺瘤组血清睾酮也由３．４３±１．４９降至２．６９±１．２３ｎｍｏｌ／Ｌ（Ｐ＜００５），两组妊娠率无统计学差异。资料提示，血清泌乳素水平可用于垂体腺瘤的诊断及治疗效果评价，较大剂量的溴隐亭可降低血清睾酮。     

经蝶显微手术治疗鞍上扩展型垂体腺瘤

目的 探讨鞍上扩展型垂体腺瘤（ＳＥＰＡ）的诊断、经蝶显微手术治疗的效果。方法 对经ＣＴ或ＭＲＩ证实的２４８例向鞍上扩展型垂体腺瘤（肿瘤均向鞍上扩展〉１０ｎｍ）,采用经蝶入路,在显微镜下行肿瘤切除术。结果 １９６例（７９．０％）肿瘤获全切除;４１例Ｚ（１６．５％）达次全切除;１１例（４．４％）系哑铃型或纤维性瘤行部分切除;手术无死亡。其中２２７例平均随访观察３．５年,１７６例（７７．５％）恢复良好,     

垂体催乳素瘤与高催乳素血症的临床研究

将垂体催乳素瘤和高催乳素血症４１例，经测定血清催乳素（ＰＲＬ）值，结合ＣＴ及／或ＭＲＩ检查后分为垂体巨腺瘤组、垂同腺癌组和特发性主催乳素症残暴居腺瘤及４例微腺瘤患者曾被施行手术或加放疗。全癌症全部口服溴隐亭并长期随访（平均３１．１±１９．１月）。结果：月经恢复率为８６．５％，妊娠率达７０．８％，微腺瘤组和特发性高催化乳素血症组的疗效比巨腺瘤组显著（Ｐ〈０．０５）。单用溴隐亭者性腺功能恢复更好（Ｐ〉     

听神经瘤CT与MRI诊断比较

目的：（１）回顾性分析经ＣＴ和ＭＲＩ检查，手术及病理证实的听神经瘤表现，（２）比较二者的敏感性和定性诊断效果；（３）探讨微听神经瘤的检出方法。方法：１９（男９，女１０）例听神经瘤，ＣＴ平扫后１５例增强扫描，ＭＲＩ检查用ＳＥ序列，平扫及增强扫描，结果：ＣＴ正确诊断１５／１９例，漏诊４／１９例，ＭＲＩ检出率为１９／１９例，并可检出５ｍｍ的微听神经瘤，结论：ＣＴ漏诊率为２１％，分析其原因是没有采用ＣＴ薄     

扩大双额下入路治疗巨大垂体腺癌

巨大垂体腺瘤可同时向鞍内外生长 ,并累及蝶窦、筛窦、鞍上、鞍旁、前颅底或上斜坡 ,采用何种手术入路 ,至今尚有争论。我院自１９９５年至１９９８年对１２例巨大垂体腺瘤采用经扩大双额下入路治疗 ,效果满意 ,报道如下。１．一般资料 :本组男７例 ,女５例 ;年龄２０～４０岁４例 ,４０～６０岁５例 ,６０岁以上３例。临床表现为双眼视力渐进性下降 ,入院时左眼视力０．１～０．３ ,右眼视力０．２～０．６,均伴有双颞侧偏盲。男性患者有性欲减退 ,女性患者有原发性闭经。ＣＴ及ＭＲＩ检查显示１２例的肿瘤均向上侵入鞍上池 ,并向鞍旁生长 …     

垂体腺瘤的MRI诊断

１ＭＲＩ诊断垂体腺瘤的价值ＭＲＩ（磁共振成像）为多平面成像,具有多序列选择能力,无骨及牙齿伪影,无电离辐射,对软组织分辨力高,对垂体微腺瘤的诊断有独特的优越性。据统计,其诊断敏感性为８３％,而ＣＴ为４２％。对大腺瘤则可清楚显示肿瘤向鞍外延伸的范围及是...     

MRI对癫痫病因诊断的价值

目的探讨磁共振成像（ＭＲＩ）对癫痫病因诊断的意义。②方法随机选择２００例不同发作类型的癫痫病人进行颅脑ＭＲＩ检查,并与其中８７例颅脑ＣＴ检查结果进行比较。③结果ＭＲＩ的异常率为５８．５％,ＣＴ异常率仅为１１．５％（χ２＝５４．３,Ｐ＜０．００１）。７７例ＣＴ正常者,经ＭＲＩ检查有４５例病人呈异常改变。ＭＲＩ异常表现者中约１／３～１／２为脑萎缩性改变,１／４为脑血管病变。④结论ＭＲＩ对癫痫病因诊断具有一定的价值,其灵敏度明显高于ＣＴ．     

兔眼球后非磁性异物CT和MRI诊断

将３５枚非磁性异物（金属异物８枚，非金属异物２７枚。异物大小为２ｍｍ×１．５ｍｍ×１．５ｍｍ～９ｍｍ×６ｍｍ×１ｍｍ）置入２２只兔眼球后肌锥内行ＣＴ和ＭＲＩ检查，探讨ＣＴ和ＭＲＩ对眼球后异物的诊断价值。结果：ＣＴ、ＭＲＩＴ１ＷＩ、Ｔ２ＷＩ和Ｆｌａｓｈ２ｄ序列眼球后异物检出阳性率分别为８９％（３１／３５）、９７％（３４／３５）、８６％（３０／３５）和１００％；ＣＴ上３枚干木异物密度低于球后脂肪，２８枚呈高密度而被确定，４枚塑料ＣＴ未显示；ＭＲＩＴ１ＷＩ漏检１枚青枝柳条；ＭＲＩ球后异物多呈低信号。结果提示：ＣＴ和ＭＲＩ均为检出眼球后异物的有效检查，ＳＥ序列Ｔ１ＷＩ和Ｆｌａｓｈ２ｄ序列是ＭＲＩ检出眼球后异物的优选序列     

兔眼玻璃体内非磁性异物CT和MRI诊断

将４６枚大小介于１ｍｍ×０．５ｍｍ×０．５ｍｍ～５ｍｍ×３ｍｍ×２ｍｍ的非磁性异物（非金属异物３４枚，金属异物１２枚）放入２３只兔的４６眼玻璃体内，并在置入异物２ｈ内完成ＣＴ和ＭＲＩ扫描。结果：ＣＴ检出玻璃体异物阳性率为９１％（４２／４６），ＭＲＩＴ１ＷＩ、ＰＤＷＩ、Ｔ２ＷＩ和Ｆｌａｓｈ２ｄ序列检出玻璃体异物的阳性率分别为６３％（２９／４６）、８７％（４０／４６）、１００％（４６／４６）和１００％（４６／４６）；４枚塑料异物ＣＴ未显示，而ＭＲＩ正确诊断；１２枚金属异物中１１枚ＣＴ图像上有线束状伪迹，而ＭＲＩ则无。结果提示：ＣＴ和ＭＲＩ均是检出眼内非铁磁性异物的有效方法，２者联合应用，可提高眼内异物的检出率及定位准确率；ＭＲＩ检出木质和塑料异物优于ＣＴ；ＳＥ序列Ｔ２ＷＩ和Ｆｌａｓｈ２ｄ序列是检出玻璃体内异物的优选序列     

眼眶内木质异物CT和MRI诊断

将１６枚兔眶内木质异物和３例（４枚）患者眶内木质异物的ＣＴ和ＭＲＩ资料进行比较分析，探讨ＣＴ和ＭＲＩ对眶内木质异物的诊断价值。１６枚兔眶内木质异物包括干杨木块５枚、干竹片６枚、青枝柳条５枚，异物大小为１．５ｍｍ×１ｍｍ×１ｍｍ～９ｍｍ×４．２ｍｍ×４．２ｍｍ，埋置异物后２ｈ内完成ＣＴ和ＭＲＩ。３例患者４枚异物中２枚为木块，２枚为竹签，大小为３ｍｍ×２ｍｍ×１ｍｍ～２５ｍｍ×７ｍｍ×７ｍｍ。伤后至ＣＴ、ＭＲＩ检查时间为２０～６０ｄ。结果：１６枚兔眶内异物ＣＴ检出１２枚，ＣＴ值介于－１４５～６３．８Ｈｕ；ＭＲＩＳＥ序列Ｔ１ＷＩ、ＰＤＷＩ和Ｔ２ＷＩ分别检出１１枚、８枚和１６枚，Ｆｌａｓｈ２ｄ序列全部检出；３例患者４枚异物ＣＴ仅检出１枚，ＭＲＩ全部检出。结果提示：ＭＲＩ诊断眶内木质异物优于ＣＴ，ＭＲＩＳＥ序列Ｔ２ＷＩ和Ｆｌａｓｈ２ｄ序列是检出眶内木质异物的优选序列；木质异物在眶内滞留水份进入可致ＣＴ密度和ＭＲＩ信号增高     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.