急症一期切除吻合术治疗左半结肠癌梗阻36例体会

目的：探讨左半结肠癌致急性肠梗阻的手术处理方法。方法：回顾性分析1995－2000年间36例左半结肠癌致肠梗阻一期切除吻合术的外科临床效果。结果：全组36例病人均采用梗阻近端肠管减压灌洗,并留置盲肠造瘘管术后接负压吸引,术后均一期愈合,未出现吻合口漏。随访12例中,半年死亡1例,1年死亡4例,3年死亡5例,5年死亡例。结论：只要病情允许,严格掌握手术适应症和基本操作,对左半结肠癌急性肠梗阻行一期切除吻合手术是可行的。     

左半结肠癌并急性肠梗阻一期切除吻合26例治疗体会

目的：总结一期切除吻合治疗左半结肠癌急性肠梗阻治疗效果。方法：回顾1996年1月至2002年12月经一期切除吻合治疗左半结肠癌急性肠梗阻26例临床资料进行分析。结果：经积极的术前准备，术中彻底的肠减压及结肠灌洗，积极防治术后并发症，26例均治愈出院，发生切口感染4例。结论：选择好手术适应症，术中灌洗彻底，一期切除吻合治疗左半结肠癌病急性肠梗阻是一种安全有效的方法。     

左半结肠癌致急性肠梗阻术式探讨

目的：探讨左半结肠癌致急性肠梗阻术式选择。方法：回顾性分析2000年7月～2008年6月我院收治的32例左半结肠癌致急性肠梗阻的病例资料。结果：行一期肠切除吻合16例,行结肠次全切术6例,分期手术8例,行姑息结肠造口2例。术后切口感染3例,无吻合口漏,无手术死亡病例。结论：左半结肠癌致急性肠梗阻术式应根据患者的具体情况而定。一期切除吻合是安全可行的,结肠次全切术亦可获得良好效果,值得推行。     

左半结肠癌致急性肠梗阻一期切除吻合术

目的：探讨左半结肠癌致急性结肠梗阻一期切除吻合术的疗效和可行性。方法：运用术中结肠灌洗对12例左半结肠癌致急性结肠梗阻患者行一期切除吻合术。结果：12例患者全部达到一期愈合,术后无吻合口瘘发生。结论：使用术中结肠灌流行一期切除吻合术,对治疗左半结肠癌致急性结肠梗阻疗效好,方法可行。     

48例左半结肠癌并急性梗阻一期切除吻合术应用体会

目的探讨左半结肠癌并急性梗阻一期切除吻合术的治疗效果。方法回顾性分析48例左半结肠癌并急性梗阻的一期手术病例资料及外科处理方式。结果48例患者均行急诊一期左半结肠癌切除吻合术后无手术死亡病例,吻合口漏1例,术后切口感染9例,均经积极处理后痊愈。结论治疗左半结肠癌致急性肠梗阻．严格掌握手术适应证,完善术中及围手术期处理,行一期吻合手术安全、有效。     

左半结肠癌伴急性肠梗阻采用一期吻合术的手术方法

目的：探讨左半结肠癌伴急性肠梗阻采用一期切除吻合术的可行性。方法：回顾性分析我院1996—2002年间手术治疗左半结肠癌并发急性肠梗阻26例，术中均行肠道顺行灌洗，一期肿瘤切除吻合。结果：26例中，无吻合漏、腹腔脓肿等严重并发症；无围手术期死亡；术后发生切口裂开1例，切口感染2例。结论：一期切口吻合术在急性梗阻性左半结肠癌中应用是完全可行的。     

左半结肠癌并急性肠梗阻一期手术治疗的探讨

目的：探讨左半结肠癌并急性肠梗阻一期手术治疗的可行性。方法：回顾性分析35例左丰结肠癌并急性肠梗阻使用术中结肠灌洗方法施行左侧半结肠一期切除吻合术的治疗情况。结果：全组无死亡病例，未出现吻合口瘘等严重并发症。切口感染5例，占14.3％。结论：左半结肠癌并急性肠梗阻，使用术中结肠灌洗方法，加强围术期处理，一期切除吻合是安全可行的。     

左半结肠癌致急性肠梗阻的外科治疗

目的 探讨左半结肠癌致急性肠梗阻的外科治疗效果.方法 回顾性分析2005～2010年收治20例左半结肠癌致急性肠梗阻的病例资料.结果 20例左半结肠癌致急性肠梗阻患者行一期肠切除吻合术18例(90%),行姑息性结肠造瘘2例(10%),术后切口感染3例,无吻合口漏,无手术死亡.结论 左半结肠癌致急性肠梗阻外科治疗行一期切除是安全、可行的.     

20例左半结肠癌致急性肠梗阻的外科治疗

目的 探讨左半结肠癌致急性肠梗阻行结肠一期切除吻合术的可行性,以促进手术疗效的提高.方法 回顾性分析2004年6月～2010年6月收治的20例左半结肠癌致急性肠梗阻的临床资料,讨论手术时机及其手术方式在左半结肠癌致急性肠梗阻中的应用.结果 20例患者均行结肠一期切除吻合术,出现吻合口瘘1例.结论 合理选择手术时机及手术方式是提高左半结肠癌致急性肠梗阻疗效的重要措施.     

一期肠切除吻合治疗左半结肠癌并发急性肠梗阻32例体会

目的：探讨左半结肠癌并发急性肠梗阻行一期肠切除吻合的可行性。方法：对2000年1月～2007年6月32例左半结肠癌并发急性肠梗阻患者行一期肠切除吻合手术的临床资料进行回顾性分析，术中采用肠道灌洗，并重视围手术期处理。结果：本组病例无一例手术死亡，术后并发症3例，1例腹腔感染，1例切口感染，1例吻合口瘘，经抗感染、换药、肠内外营养支持疗法后治愈。结论：一期肠切除吻合治疗左半结肠癌并发急性肠梗阻可行。选择合适的病例，术中正确操作，重视围手术期的处理，是手术成功的关键。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.