贝复济治疗Ⅱ期以上褥疮22例护理观察

目的观察贝复济治疗Ⅱ期以上褥疮的效果。方法将44例Ⅱ、Ⅲ、Ⅳ期褥疮病人随机分为两组,观察组22例采用清创、吹氧、贝复济湿敷治疗,对照组采用清创、吹氧、聚维酮碘涂抹敷料包扎疗法。结果观察组总有效率明显高于对照组,治愈时间明显缩短(P<0.05或0.01)。结论贝复济治疗Ⅱ期以上褥疮效果显著。     

银锌霜与美皮康联合治疗Ⅲ期压疮38例的临床观察及护理

目的:观察银锌霜与美皮康敷贴联合治疗Ⅲ期压疮的疗效及护理要点.方法:将38例压疮患者按入院时间先后分成两组,观察组22例,采用常规治疗后创面涂以适量银锌霜,烤灯照射后用美皮康敷贴创面.结果:观察组平均愈合时间(12.45±6.52)天;对照组平均愈合时间(27.93±11.55)天,两者有非常显著性差别(P＜0.01).结论:使用银锌霜与美皮康联合治疗Ⅲ期压疮是非常理想的治疗手段.     

磺胺嘧啶银油纱条联合清创胶治疗III期窦道型压疮的疗效观察

目的：探讨磺胺嘧啶银油纱条联合清创胶治疗Ⅲ期窦道型压疮的疗效。方法将115例符合诊断标准的压疮患者随机分为对照组和观察组。对照组56例,压疮创面常规处理后用利凡诺黄纱条填塞;观察组59例,压疮创面常规处理后采用磺胺嘧啶银油纱条联合清创胶治疗;其他护理措施两组相同,分别观察两组治愈率、总有效率及平均愈合时间。结果观察组治愈率和总有效率分别为74.60%和100.00%,明显高于对照组的32.10%和70.00%,差异均有统计学意义(P<0.05);观察组平均治愈时间为(33.00±10.70) d,明显短于对照组的(45.00±11.50) d,差异均有统计学意义(P<0.05)。结论磺胺嘧啶银油纱条联合清创胶治疗Ⅲ期窦道型压疮可缩短疮面愈合时间,提高治愈率。     

银锌霜治疗压疮的疗效观察

目的行银锌霜治疗压疮的疗效观察。方法采用凯新银锌霜治压疮,并与其他疗法作对照研究。结果银锌霜治疗压疮效果比对照组好,两组差异具有显著性(P=0.01)。结论银锌霜治疗压疮作用快,治愈率高。*     

创灼膏与rhEGF促进褥疮创面修复的研究

目的:探讨创灼膏与重组人表皮细胞生长因子联合对促进褥疮创面愈合的作用。方法:把36例Ⅱ期褥疮患者随机分为观察组和对照组,每组18例。观察组为创灼膏1支和rhEGF 40 U混合涂在创面上,1次/d;对照组为10%的碘伏清创面后,外用丁胺卡那霉素换药,1次/d。结果:观察组患者创面愈合时间为(12.8±1.7)d,对照组为(20.6±2.4)d,比较有显著性差异(P<0.05)。结论:创灼膏与rhEGF联合使用能加快修复褥疮创面,值得临床推广。     

锌油膜剂治疗烧伤创面疗效观察

目的 探讨锌油膜剂治疗浅Ⅱ度、深Ⅱ度烧伤,残余肉芽小创面抗感染和促进创面愈合瘢痕治疗的作用。方法 分组方法为同体两侧或同侧上下分组,治疗组清创后应用锌油膜剂创面的表面,对照组应用1％磺胺嘧啶银霜覆盖创面。结果 深Ⅱ度烧伤创面治疗组(18.00±2.73)d愈合,对照组(21.14±3.63)d愈合。治疗组与对照组用药中...     

银锌抑菌霜联合重组人表皮生长因子凝胶在皮肤碾挫伤创面中的应用

目的探讨银锌抑菌霜联合重组人表皮生长因子凝胶在皮肤碾挫伤创面中的疗效。方法选取2017年4月至2018年12月在我院门诊换药室换药的皮肤碾挫伤患者50例,随机分为对照组和观察组,每组25例。对照组运用碘伏油纱常规换药,观察组运用银锌抑菌霜联合重组人表皮生长因子凝胶换药,比较两组伤口换药次数、伤口愈合时间、治疗有效率。结果观察组的换药次数为(8.16±1.21)次,显著少于对照组的(17.92±1.93)次,创面愈合时间为(17.56±2.62)d,显著短于对照组的(30.16±3.09)d,差异有统计学意义(P0.05)。观察组的治疗有效率为96.0%(24/25),高于对照组的60.0%(15/25),差异有统计学意义(P0.05)。结论皮肤碾挫伤创面使用银锌抑菌霜联合重组人表皮生长因子凝胶可减少创面换药次数,缩短创面愈合时间,安全有效,值得临床推广应用。     

褥疮祛腐生肌散治疗巨大褥疮的临床观察

目的评价褥疮祛腐生肌散治疗巨大褥疮的作用效果。方法选择经一般方法治疗无效的褥疮病人586例,首先清除创面内的坏死组织及四周的瘢痕;生理盐水冲洗干净创面后把褥疮祛腐生肌散撒在创面上,观察创面变化。结果用药后创面有渗出现象,见效时间III期深度(5.0±0.3)天,III期浅度(3.0±0.2)天,II期深度(1.0±0.2)天,愈合时间分别为(195±93)天、(75±21)天、(3±6)天。治愈率99.3%。结论褥疮祛腐生肌散对巨大褥疮具有良好的治疗作用。     

胰岛素和高渗糖外敷治疗褥疮的疗效观察与护理

目的 :观察胰岛素和高渗糖外敷治疗褥疮的疗效 ,总结褥疮护理经验。方法 :采用胰岛素和高渗糖外敷治疗褥疮病人 14例 (实验组 ) ,以湿润烧伤膏作对照 ,观察褥疮愈合情况。结果 :II度褥疮试验组 4例 6处的愈合时间为 (11 6± 2 7)d ,对照组 3例 5处的愈合时间为 (12 9± 3 4)d ,两组比较差异无显著性 (P >0 .0 5 )。Ⅲ度褥疮试验组 8例 12处的愈合时间为 (2 2 3± 4 3)d ,对照组 5例 8处的愈合时间为 (2 4 8± 3 9)d ,两组比较差异有显著性 (P <0 .0 5 )。结论 :胰岛素和高渗糖外敷能促进褥疮疮面愈合     

康复新液配合红外线治疗褥疮76例疗效观察

目的 探讨康复新液配合红外线治疗褥疮的临床效果,提高褥疮治疗效率,改善患者预后.方法 采用随机数字表法将152例褥疮患者随机分为观察组和对照组,各76例.观察组采用康复新液联合红外线照射治疗,对照组采用传统治疗方法 进行治疗,比较两组患者疗效,治疗疗程,治疗费用和患者满意度.结果 观察组患者住院时间为(24.5±7.4)d、褥疮治疗费用为(2425.7±269.5)元、患者舒适度评价(18.4±4.8)、患者者满意度评价为(90.4±10.7),对照组分别为(32.4±11.2)d、(4678.4±667.2)元、(14.4±5.6)分、(86.6±16.5)分,组间比较差异具有统计学意义(t=26.670、114.733、18.839、36.367;P<0.01).观察组痊愈56例、显效11例,对照组痊愈42例、显效15例组间比较差异具有统计学意义(χ2=84.237,P<0.01).结论 康复新液配合红外线治疗褥疮疗效确切,值得临床推广.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.