Prosima盆底重建术治疗盆底器官脱垂的临床分析

目的：评价Prosima盆底重建术治疗盆腔器官脱垂的近期疗效。方法：40例因盆腔多个部位缺陷的盆腔脏器脱垂患者行全盆底重建术,其中采用Prolift全盆底重建系统行全盆底重建术20例,采用Prosima盆底重建系统行全盆底重建术20例,分析比较两组患者的术中平均出血量、手术时间、住院时间及术后疼痛率。结果：Prosima组术中平均出血量、平均手术时间、平均住院时间、术后疼痛率均明显少于Prolift组（P﹤0.001）。结论：Prosima盆底重建术易于掌握,创伤小、无术后疼痛等并发症,术后近期疗效好。     

加速康复外科理念在异体乳房重建术患者康复中的应用效果

目的探讨加速康复外科理念(ERAS)在异体乳房重建术后康复的应用效果。方法选取2013年1月至2017年1月安徽省太和县人民医院收治的接受异体乳房重建术80例患者为研究对象,依据随机数字表法将其分为ERAS组和术后传统恢复途径(TRAS组),均为40例,分别采用ERAS和TRAS护理。比较两组患者术前主观舒适度评分、手术情况、术后情况、并发症发生率。结果 ERAS组术前30分钟饥饿感、恶心感、口渴感、焦虑感评分低于TRAS组,差异有统计学意义(P <0. 05),ERAS组患者术前30分钟饥饿感、恶心感、口渴感、焦虑感评分低于术前3小时,差异有统计学意义(P <0. 05),TRAS组患者术前30分钟恶心感、口渴感、焦虑感评分高于术前3小时,差异有统计学意义(P <0. 05); ERAS患者双侧手术率和即刻重建率均高于TRAS组差异有统计学意义(P <0. 05),两组患者手术时间相近(P> 0. 05),但ERAS组患者术中失血量少于TRAS组,差异有统计学意义(P <0.05); ERAS组患者进食时间、下床活动时间、术后引流液体总量、术后引流管保留时间以及住院时间均少于TRAS组,差异均有统计学意义(P <0. 05),两组患者急诊科就诊率与再住院率比较,差异无统计学意义(P> 0. 05); ERAS组患者并发症发生率(12. 5%)低于TRAS组(35. 0%),差异有统计学意义(P <0. 05)。结论 ERAS运用于异体乳房重建术患者,效果显著,可明显改善患者术前舒适度,降低术后并发症发生率。     

盆底重建术治疗女性盆底功能障碍的临床效果

目的观察为女性盆底功能障碍患者应用盆底重建术治疗的临床价值。方法取笔者所在医院产科2015年6月至2018年5月诊疗女性盆底功能障碍患者46例为分析对象,根据为患者提供的治疗方案差异,将其以每组23例分为对照组与重建组,对应女性盆底功能障碍保守治疗、盆底重建术治疗。比较两种治疗方案对女性盆底功能障碍患者的病情改善效果。结果在完成治疗后随访3个月,对其盆腔器官脱垂定量分度以及盆底功能障碍评分进行评估,重建组患者所得数据均显著优于对照组,差异有统计学意义(P0.05);末次随访对两组患者相关临床症状改善有效性进行评价,包括子宫脱垂、尿失禁、性生活质量以及盆底肌力恢复等,重建组患者各项有效性均更为优越(P0.05);记录重建组患者手术时间、导尿管留置时间、术中出血量以及出院时间等,所得数据均在令人满意范围内;重建组患者术后相关并发症发生率为4.3%(1/23)。结论为女性盆底功能障碍患者应用盆底重建术方案治疗相对于保守治疗手段能够更有效地改善相关临床症状,提高患者生活质量,且手术对患者机体影响程度控制在合理范围内,值得推广。     

两种全盆底重建手术的围手术期情况及短期疗效比较

目的 比较两种不同的全盆底重建手术方案:Gynemesh全盆底重建及ProliftTM系统的围手术期情况及短期疗效,以确定一种经济有效、适合中国人的全盆底重建术式.方法 回顾性分析2006-2009年我院119例盆腔器官脱垂患者,其中79例行Gynemesh全盆底重建术,40例行ProliftTM全盆腔悬吊术,所有患者均以至少一个区域存在Ⅱ度以上脱垂为手术指征,评估两组手术患者的围手术期情况及短期疗效和并发症情况.结果 两组患者在手术时间、住院天数,盆底解剖恢复情况、网片侵蚀及手术相关的出血及下尿路症状发生率方面,差异无统计学意义.结论 ProliftTM系统是目前通用的用于盆底重建手术的标准化系统,采用Gynemesh网片裁剪后进行的微创全盆底重建,在短期随访中具有可重复性高、安全有效、费用低廉等优势,是一种值得进一步推广的全盆底重建术式.     

补片在前盆底重建术中的应用价值

目的研究补片在前盆底重建术中的应用价值。方法采用经闭孔无张力聚丙烯补片前盆底重建手术对60例阴道前壁脱垂患者进行治疗，采用PFDI-20量表对其生活质量进行评价。结果手术有效率为100％，术后尿失禁症状均显著改善，生活质量明显提高。术后随访1年未见复发病例。结论经闭孔无张力聚丙烯补片前盆底重建手术结合TOT术治疗效果显著，可有效改善患者症状，提高患者生活质量。     

常用盆底重建术的临床疗效及其并发症的分析

盆底功能障碍性疾病是由于盆底支持系统的薄弱导致的盆腔脏器脱垂，从而引起一系列解剖和功能异常，它严重影响了患者的身心健康。治疗方式包括非手术治疗和手术治疗，目前手术治疗以各种盆底重建手术为主，现将常用的盆底重建术作一综述。     

加速康复外科在肺癌围术期管理中的应用

加速康复外科(ERAS)是一种综合的围手术期管理理念，涉及多个学科领域，通过对围手术期各阶段进行优化，实现患者术后快速康复的目的。随着现代科学技术的大力发展，使ERAS理念得以在胸外科领域推广，形成了具有胸外科专科特色的ERAS管理模式。综合近年来胸外科肺癌领域ERAS理念的临床应用经验和研究进展，从术前准备、术中管理、术后康复等方面，对目前肺癌围术期管理经验进行总结述评，以期为临床医师将ERAS理念应用在肺癌诊疗时的决策提供参考。     

改良盆底重建术联合TVT—O治疗盆底功能障碍性疾病临床分析

目的：评价改良盆底重建术联合TVT-O治疗盆底功能障碍性疾病（FED）的近期疗效。方法：对2010年3月-2011年9月收治的18例盆腔脏器脱垂（POP）伴压力性尿失禁患者行改良盆底重建术联合TVT-O,回顾性分析术后的疗效和并发症发生情况。结果：平均手术时间为95min;平均手术出血量为100ml;平均住院时间12d,无术中严重并发症发生,以POP-Q评分为疗效的客观评价指标,手术有效率达100％。结论：改良全盆底重建术联合TVT-O治疗盆底功能障碍性疾病是治疗的有效方法。改良盆底重建术作为一种新术式,能更好地修补缺陷、实现结构重建和组织替代,其复发率低、短期疗效稳定,长期疗效有待进一步观察。     

老年女性盆底功能障碍疾病治疗的临床探讨

 目的比较应用补片的全盆底重建术与传统阴式全子宫切除及阴道前后壁修补在老年性盆底功能障碍患者治疗中的疗效差异。方法随机选取我院2007年9月至2009年2月间的92例老年盆底功能障碍患者,70例(全盆底重建组)采用补片的全盆底重建术,其中合并压力性尿失禁12例,4例同时行经闭孔阴道无张力尿道中段悬吊带手术(TVT-O);22例(对照组)应用传统阴式全子宫切除及阴道前后壁修补,合并压力性尿失禁3例。结果术后3～18个月门诊复查,全盆底重建组未见术后复发,盆腔器官脱垂(POP)评分法测定均为0度,治愈率达100%;对照组术后复发7例,复发病例均为阴道前壁膨出,其中5例术后POP评分Ⅱ度,2例POP评分Ⅲ度,即阴道穹隆完全膨出,治愈率68%;对于同时合并压力性尿失禁患者,盆底重建组中,通过应用TVT-O或前路补片提升的办法,尿失禁均治愈,对照组中患者症状无明显改善,2例症状加重。结论应用替代材料的全盆底重建术在治疗老年盆底功能障碍中疗效确切。     

网片修补在盆底重建术中的临床效果观察

目的：分析网片修补在盆底重建术的临床疗效及并发症情况。方法选取大庆龙南医院2011年1月～2013年1月期间行盆底重建手术患者16例临床资料进行分析，对其手术过程和术后随访分析。结果16例患者均经阴道完成手术，其中13例进行子宫切除，保留子宫3例。手术时间为（123±28）min，术中出血量为（142±58）mL，治愈14例（87.5%），复发1例（6.3%），近期并发症2例（12.5%），远期并发症1例（6.3%）。结论盆底重建术中网片修补的应用能有效的提高治疗效果，对盆腔器官脱垂的治疗是安全、有效的。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.