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张琳琪教授对慢性肾脏病的治疗必审证求因,辨证施治,灵活遣方用药。该病病机复杂,病位广泛,寒热虚实夹杂,本虚标实互见,临床辨治一方面要固本扶正,以免攻伐太过,时时勿忘健脾补肾,力倡扶正为先;另一方面对于外邪、水湿、痰浊、瘀血、毒邪等标实之象,既要祛邪,又不可伤正,巧用活血化瘀、祛湿降浊之品每获良效。 相似文献
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本文报告了腔内心电图(EKG)定位技术在儿童PICC置管中应用的重要意义,从国内外儿童患者PICC置管过程中EKG的应用情况、EKG定位工具的选择、引导方式、如何通过P波变化判断导管尖端位置,并分析了影响儿童EKG稳定性的相关因素,展望了EKG定位技术在儿童PICC置管中的应用前景,并提出了建议,便于对临床提供指导。 相似文献
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OBJECTIVE:To observe E-calcium sticky protein(E-cadherin) expression in kidney tissues in a rat model of unilateral ureter ligation and the effect of Yishen Huayu Fang(formula of tonifying the kidney and dissolving accumulated blood stasis) on the expression.METHODS:A total of 150 clean grade male rats were randomly divided into a control group,model group,low-dose Yishen Huayu Fang group(low-dose group),high-dose Yishen Huayu Fang group(high-dose group),and Lotensin group.A renal fibrosis model was established with unilateral ureteral obstruction(UUO).Pathological changes of rat renal tissue were observed with light microscopy on days 3,7,14,21,and 28 after UUO.Changes in kidney tissue E-cadherin expression were observed with immunohistochemistry.RESULTS:Three days after modeling,kidney edema appeared followed by gradual inflammatory cell infiltration,and part of the small tubules disappeared while the renal cortex thinned.Meanwhile,the E-cadherin expression level dropped,which was negatively correlated with the obstruction time.After intervention,E-cadherin expression was increased in all treatment groups(P<0.01 or P<0.05),while there were no significant differences between the high-dose and Lotensin groups.CONCLUSION:Yishen Huayu Fang delays the renal fibrosis process by promoting E-cadherin expression in renal tissues and reducing extracellular matrix deposition. 相似文献
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特发性水肿是指排除心肝肾等器质性病变,以体重增加及全身浮肿为特征的一组水盐代谢紊乱综合征。多见于生育期年龄的女性,一般认为是由内分泌功能失调和体位的反应异常所致。中医学认为该病属“水肿…‘气肿”“肤胀”范畴。张琳琪教授现任河南省中医学院第一附属医院主任医师,从医执教20余年, 相似文献
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TGF-β1/Smad信号传导通路是肾间质纤维化发生发展重要的通路之一。随着分子生物学、中药药理学等研究的不断深入,无论中药单方及其有效成份或复方中药,通过调控TGF-β/Smad信号通路拮抗肾间质纤维化已显现出广泛的药理作用:如直接抑制TGF-β1的产生,或抑制TGF-β1刺激的下游因子CTGF等,或抑制Smads磷酸化,或调节TβR、Smad的表达等,显示出多途径、多层次、多靶点对TGF-β1/Smads通路及信号蛋白的调控效应。但由于复方中药成分复杂,应更深入全面地阐明其对TGF-β/Smad信号通路的各个环节、不同靶点及与其他信号通路相互作用的调控机制,并通过拆方研究、有效部位筛选、有效组分分析等,明确各药物之间的协调作用,以筛选出临床疗效可靠、无不良反应的基础方药及其药物最佳配伍剂量或形式,此为复方中药研究应寻找的最佳突破点之一。 相似文献