全文获取类型
收费全文 | 178711篇 |
免费 | 16116篇 |
国内免费 | 9433篇 |
专业分类
耳鼻咽喉 | 2028篇 |
儿科学 | 2599篇 |
妇产科学 | 3514篇 |
基础医学 | 20425篇 |
口腔科学 | 3686篇 |
临床医学 | 21887篇 |
内科学 | 28070篇 |
皮肤病学 | 2358篇 |
神经病学 | 9437篇 |
特种医学 | 6825篇 |
外国民族医学 | 59篇 |
外科学 | 18865篇 |
综合类 | 25135篇 |
现状与发展 | 33篇 |
一般理论 | 23篇 |
预防医学 | 12056篇 |
眼科学 | 4661篇 |
药学 | 18707篇 |
149篇 | |
中国医学 | 8837篇 |
肿瘤学 | 14906篇 |
出版年
2024年 | 331篇 |
2023年 | 2216篇 |
2022年 | 4088篇 |
2021年 | 8198篇 |
2020年 | 5999篇 |
2019年 | 5520篇 |
2018年 | 5855篇 |
2017年 | 5397篇 |
2016年 | 5007篇 |
2015年 | 7708篇 |
2014年 | 9607篇 |
2013年 | 9776篇 |
2012年 | 14201篇 |
2011年 | 15174篇 |
2010年 | 10163篇 |
2009年 | 8291篇 |
2008年 | 10622篇 |
2007年 | 10478篇 |
2006年 | 9922篇 |
2005年 | 9143篇 |
2004年 | 6675篇 |
2003年 | 6060篇 |
2002年 | 5033篇 |
2001年 | 4197篇 |
2000年 | 3943篇 |
1999年 | 3755篇 |
1998年 | 1913篇 |
1997年 | 1801篇 |
1996年 | 1451篇 |
1995年 | 1363篇 |
1994年 | 1256篇 |
1993年 | 718篇 |
1992年 | 1250篇 |
1991年 | 1079篇 |
1990年 | 935篇 |
1989年 | 804篇 |
1988年 | 736篇 |
1987年 | 629篇 |
1986年 | 509篇 |
1985年 | 404篇 |
1984年 | 265篇 |
1983年 | 233篇 |
1982年 | 120篇 |
1981年 | 126篇 |
1979年 | 176篇 |
1978年 | 131篇 |
1977年 | 105篇 |
1976年 | 96篇 |
1974年 | 118篇 |
1972年 | 105篇 |
排序方式: 共有10000条查询结果,搜索用时 18 毫秒
1.
2.
Zeyu Li Erwei Hao Rui Cao Si Lin Linghui Zou Tianyan Huang Zhengcai Du Xiaotao Hou Jiagang Deng 《中草药(英文版)》2022,14(4):479-493
Zedoary tumeric (Curcumae Rhizoma, Ezhu in Chinese) has a long history of application and has great potential in the treatment of liver cancer. The anti liver cancer effect of zedoary tumeric depends on the combined action of multiple pharmacodynamic substances. In order to clarify the specific mechanism of zedoary tumeric against liver cancer, this paper first analyzes the mechanism of its single pharmacodynamic substance against liver cancer, and then verifies the joint anti liver cancer mechanism of its "pharmacodynamic group". By searching the research on the anti hepatoma effect of active components of zedoary tumeric in recent years, we found that pharmacodynamic substances, including curcumol, zedoarondiol, curcumenol, curzerenone, curdione, curcumin, germacrone, β-elemene, can act on multi-target and multi-channel to play an anti hepatoma role. For example, curcumin can regulate miR, GLO1, CD133, VEGF, YAP, LIN28B, GPR81, HCAR-1, P53 and PI3K/Akt/mTOR, HSP70/TLR4 and NF-κB. Wnt/TGF/EMT, Nrf2/Keap1, JAK/STAT and other pathways play an anti hepatoma role. Network pharmacological analysis showed that the core targets of the "pharmacodynamic group" for anti-life cancer are AKT1, EGFR, MAPK8, etc, and the core pathways are neuroactive live receiver interaction, nitrogen metabolism, HIF-1 signaling pathway, etc. At the same time, by comparing and analyzing the relationship between the specific mechanisms of pharmacodynamic substance and "pharmacodynamic group", it is found that they have great reference significance in target, pathway, biological function, determination of core pharmacodynamic components, formation of core target protein interaction, in-depth research of single pharmacodynamic substance, increasing curative effect and so on. By analyzing the internal mechanism of zedoary tumeric pharmacodynamic substance and "pharmacodynamic group" in the treatment of liver cancer, this paper intends to provide some ideas and references for the deeper pharmacological research of zedoary tumeric and the relationship between pharmacodynamic substance and "pharmacodynamic group". 相似文献
3.
4.
Her-Shyong Shiah Nai-Jung Chiang Chia-Chi Lin Chia-Jui Yen Hui-Jen Tsai Shang-Yin Wu Wu-Chou Su Kwang-Yu Chang Ching-Chiung Wang Jang-Yang Chang Li-Tzong Chen 《The oncologist》2021,26(4):e567-e579
Lessons Learned
- SCB01A is a novel microtubule inhibitor with vascular disrupting activity.
- This first‐in‐human study demonstrated SCB01A safety, pharmacokinetics, and preliminary antitumor activity.
- SCB01A is safe and well tolerated in patients with advanced solid malignancies with manageable neurotoxicity.
5.
人工智能(Artificial Intelligence,AI)的蓬勃兴起为现代社会带来了前所未有的机遇,中医药是中华民族传承千年的文化瑰宝。随着人工智能技术不断在中医药领域的科技创新中崭露头角,二者的融合不断加深,人工智能在中医药领域的发展前景、争议挑战也引发了诸多思考。本文将从人工智能在中医药领域的应用入手,对人工智能辅助中医诊断、智能决策与数据挖掘、健康管理及中草药现代化研究等方面,就近年来国内外研究进展进行总结与分析,以期为AI视域下实现中医药现代化、智能化赋能。 相似文献
6.
Depeng Meng Yichen Meng Bingyang Li Guigang Zeng Bin Zhang Chunlin Hou Haodong Lin Yueping Ouyang 《Journal of orthopaedic science》2021,26(3):409-414
BackgroundComminuted patellar fractures are not rare, and the ideal treatment method remains controversial. The present study was conducted to evaluate effects and compare complications of two different methods used to treat comminuted patellar fractures.MethodsFrom March 2010 to August 2016, 102 cases of 34-C2 or 34-C3 comminuted patellar fractures were treated at our hospital, wherein patients received two different treatments: titanium cable tension band with cerclage method (group A) and intrafragmentary screws with X-shaped plating technique (group B). At follow-ups, articular step-off, range of motion (ROM), Lysholm scores, time of union, and complications were recorded and analyzed. Radiographic and clinical data as well as rate of complications were statistically analyzed.ResultsIn total, 87 patients were included in the final analysis (n = 47 in group A and n = 40 in group B). No significant differences were noted in terms of cost of implant, age, gender, rate of 34-C3 fractures, rate of layered inferior pole fractures, postoperative articular step-off and union time. At 2-year follow-up, average Lysholm scores, ROM and rate of complications were (89.0 ± 4.5), (122°±12°) and (27.7%) in group A and (90.2 ± 3.9), (124°±11°) and (17.5%) in group B, respectively, with no significant differences (p > 0.05). The mean time of surgery in group B was shorter than that in group A with significant difference (p < 0.05).ConclusionsTreatment using the intrafragmentary screws and plate method for amenable comminuted patellar fractures achieved similar complication rate and favorable functional outcomes at the 2-year follow-up, which was comparable to the titanium cable tension band with cerclage method. Thus, the intrafragmentary screws and plate method is effective, safe and convenient for 34-C2/C3 comminuted patellar fractures, especially appropriate for patients with layered fragments. 相似文献
7.
8.
目的:探讨姑息性胃切除联合术后化疗评分在腹膜转移的胃癌患者预后评估中的临床意义。方法:回顾性分析2010年1月至2016年12月7年间收治的287例发生腹膜转移的胃癌患者的临床病理资料。通过χ2检验分析评分与患者临床病理因素间的关系。通过Kaplan-Meier法绘制生存曲线,Log-rank检验比较患者生存率的差异;采用Cox比例风险回归模型对患者进行预后分析。结果:与评分中得分为2分和1分的患者相比,得分为0分的患者肿瘤侵润至T4b 期的患者较少[31%(18/58)比50.8%(63/124)、56.2%(59/105),P=0.039]。全组患者的中位生存时间仅为8.7月。对患者进行单因素预后分析结果显示,血清白蛋白浓度(≤40 g/L),腹水,腹膜转移范围较大,肿瘤T分期较晚,评分得分较高的患者预后较差(均P<0.05)。将上述因素纳入Cox多因素分析结果显示:评分[HR(95%CI):1.384(1.165~1.644),P=0.000],血清白蛋白浓度[HR(95%CI):0.759(0.593~0.971),P=0.028],肿瘤T分期[HR(95%CI):1.493(1.216~1.832),P=0.000]是患者预后的独立危险因素。结论:评分对于胃癌伴腹膜转移患者的预后生存评估具有重要的临床意义。 相似文献